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Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study.

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dc.contributor.author Pascual, Sergi, 1979-
dc.contributor.author Feimer, Jan
dc.contributor.author De Soyza, Anthony
dc.contributor.author Sauleda Roig, Jaume
dc.contributor.author Haughney, John
dc.contributor.author Padullés, Laura
dc.contributor.author Seoane, Beatriz
dc.contributor.author Rekeda, Ludmyla
dc.contributor.author Ribera, Anna
dc.contributor.author Chrystyn, Henry
dc.date.accessioned 2015-06-11T07:46:00Z
dc.date.available 2015-06-11T07:46:00Z
dc.date.issued 2015
dc.identifier.citation Pascual S, Feimer J, De Soyza A, Sauleda Roig J, Haughney J, Padullés L. et al. Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study. NPJ Prim Care Respir Med. 2015 Apr 30;25:15018. doi: 10.1038/npjpcrm.2015.18.
dc.identifier.issn 2055-1010
dc.identifier.uri http://hdl.handle.net/10230/23784
dc.description.abstract BACKGROUND: The specific attributes of inhaler devices can influence patient use, satisfaction and treatment compliance, and may ultimately impact on clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). AIMS: To assess patient preference, satisfaction and critical inhaler technique errors with Genuair (a multidose inhaler) and Breezhaler (a single-dose inhaler) after 2 weeks of daily use. METHODS: Patients with COPD and moderate to severe airflow obstruction were randomised in a cross-over, open-label, multicentre study to consecutive once-daily inhalations of placebo via Genuair and Breezhaler, in addition to current COPD medication. The primary end point was the proportion of patients who preferred Genuair versus Breezhaler after 2 weeks (Patient Satisfaction and Preference Questionnaire). Other end points included overall satisfaction and correct use of the inhalers after 2 weeks, and willingness to continue with each device. RESULTS: Of the 128 patients enrolled, 127 were included in the safety population (male n=91; mean age 67.6 years). Of the 110 of the 123 patients in the intent-to-treat population who indicated an inhaler preference, statistically significantly more patients preferred Genuair than Breezhaler (72.7 vs. 27.3%; P<0.001). Mean overall satisfaction scores were also greater for Genuair than for Breezhaler (5.9 vs. 5.3, respectively; P<0.001). After 2 weeks, there was no statistically significant difference in the number of patients who made ⩾1 critical inhaler technique error with Breezhaler than with Genuair (7.3 vs. 3.3%, respectively). CONCLUSIONS: Patient overall preference and satisfaction was significantly higher with Genuair compared with Breezhaler. The proportion of patients making critical inhaler technique errors was low with Genuair and Breezhaler.
dc.description.sponsorship The study was funded by Almirall S.A., Barcelona, Spain, and Forest Laboratories LLC, a subsidiary of Actavis PLC, New York, USA. Medical writing support was funded by Almirall S.A., Barcelona, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group:
dc.relation.ispartof npj Primary Care Respiratory Medicine. 2015 Apr 30;25:15018
dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons/nlicense, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit ttp://creativecommons.org/licenses/by/4.0/
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Pulmons -- Malalties obstructives -- Tractament
dc.title Preference, satisfaction and critical errors with Genuair and Breezhaler inhalers in patients with COPD: a randomised, cross-over, multicentre study.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/npjpcrm.2015.18
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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