Welcome to the UPF Digital Repository

Gathering and exploring scientific knowledge in pharmacovigilance

Show simple item record

dc.contributor.author Lopes, Pedro
dc.contributor.author Nunes, Tiago
dc.contributor.author Campos, David
dc.contributor.author Furlong, Laura I., 1971-
dc.contributor.author Bauer-Mehren, Anna
dc.contributor.author Sanz, Ferran
dc.contributor.author Carrascosa Baena, María Carmen, 1972-
dc.contributor.author Mestres i López, Jordi
dc.contributor.author Kors, Jan A.
dc.contributor.author Singh, Barat
dc.contributor.author van Mulligen, Erik M.
dc.contributor.author van der Lei, Johan
dc.contributor.author Diallo, Gayo
dc.contributor.author Avillach, Paul
dc.contributor.author Ahlberg Helgee, Ernst
dc.contributor.author Boyer, Scott
dc.contributor.author Díaz, Carlos
dc.contributor.author Oliveira, José Luis
dc.date.accessioned 2015-05-21T10:57:56Z
dc.date.available 2015-05-21T10:57:56Z
dc.date.issued 2013
dc.identifier.citation Lopes P, Nunes T, Campos D, Furlong LI, Bauer-Mehren A, Sanz F et al. Gathering and exploring scientific knowledge in pharmacovigilance. PLoS ONE. 2013;8(12):e83016. DOI: 10.1371/journal.pone.0083016
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23608
dc.description.abstract Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers’ analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/.
dc.description.sponsorship This work was supported by the European Commission (EU-ADR, ICT‐215847), FCT (PTDC/EIA‐CCO/100541/2008), and Instituto de Salud Carlos III FEDER (CP10/00524). The Research Programme on Biomedical Informatics (GRIB) is a node of the Spanish National Institute of Bioinformatics (INB)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2013;8(12):e83016
dc.rights © 2013 Lopes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subject.other Medicaments
dc.subject.other Farmacologia
dc.subject.other Internet
dc.title Gathering and exploring scientific knowledge in pharmacovigilance
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0083016
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/215847
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking