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Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa

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dc.contributor.author Fadhlaoui-Zid, Karima
dc.contributor.author Haber, Marc, 1980-
dc.contributor.author Martínez Cruz, Begoña
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Elgaaied, Amel Benammar
dc.contributor.author Comas, David, 1969-
dc.date.accessioned 2015-05-15T07:10:30Z
dc.date.available 2015-05-15T07:10:30Z
dc.date.issued 2013
dc.identifier.citation Fadhlaoui-Zid K, Haber M, Martínez-Cruz B, Zalloua P, Elgaaied AB, Comas D. Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa. PLoS ONE. 2013;8(11):e80293. DOI: 10.1371/journal.pone.0080293
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23586
dc.description.abstract The geostrategic location of North Africa as a crossroad between three continents and as a stepping-stone outside Africa has evoked anthropological and genetic interest in this region. Numerous studies have described the genetic landscape of the human population in North Africa employing paternal, maternal, and biparental molecular markers. However, information from these markers which have different inheritance patterns has been mostly assessed independently, resulting in an incomplete description of the region. In this study, we analyze uniparental and genome-wide markers examining similarities or contrasts in the results and consequently provide a comprehensive description of the evolutionary history of North Africa populations. Our results show that both males and females in North Africa underwent a similar admixture history with slight differences in the proportions of admixture components. Consequently, genome-wide diversity show similar patterns with admixture tests suggesting North Africans are a mixture of ancestral populations related to current Africans and Eurasians with more affinity towards the out-of-Africa populations than to sub-Saharan Africans. We estimate from the paternal lineages that most North Africans emerged 15,000 years ago during the last glacial warming and that population splits started after the desiccation of the Sahara. Although most North Africans share a common admixture history, the Tunisian Berbers show long periods of genetic isolation and appear to have diverged from surrounding populations without subsequent mixture. On the other hand, continuous gene flow from the Middle East made Egyptians genetically closer to Eurasians than to other North Africans. We show that genetic diversity of today's North Africans mostly captures patterns from migrations post Last Glacial Maximum and therefore may be insufficient to inform on the initial population of the region during the Middle Paleolithic period.
dc.description.sponsorship This study was supported in parts by Spanish Government MCINN grant CGL2010-14944/BOS and Programa de Cooperación Interuniversitaria e Investigación Científica, Spanish Ministry of Foreign Affairs and Cooperation grants A75180/06, A/8394/07, B/018514/08, A1/040218/11
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2013;8(11):e80293
dc.rights © 2013 Fadhlaoui-Zid et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject.other Genètica humana -- Variació
dc.subject.other Genètica de poblacions humanes -- Àfrica del Nord
dc.title Genome-wide and paternal diversity reveal a recent origin of human populations in North Africa
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0080293
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2010-14944
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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