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Before the endless forms: embodied model of transition from single cells to aggregates to ecosystem engineering

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dc.contributor.author Solé Vicente, Ricard, 1962-
dc.contributor.author Valverde, Sergi
dc.date.accessioned 2015-05-13T08:08:19Z
dc.date.available 2015-05-13T08:08:19Z
dc.date.issued 2013
dc.identifier.citation Solé RV, Valverde S. Before the endless forms: embodied model of transition from single cells to aggregates to ecosystem engineering. PLoS ONE. 2013;8(4):e59664. DOI: 10.1371/journal.pone.0059664
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23568
dc.description.abstract The emergence of complex multicellular systems and their associated developmental programs is one of the major problems of evolutionary biology. The advantages of cooperation over individuality seem well known but it is not clear yet how such increase of complexity emerged from unicellular life forms. Current multicellular systems display a complex cell-cell communication machinery, often tied to large-scale controls of body size or tissue homeostasis. Some unicellular life forms are simpler and involve groups of cells cooperating in a tissue-like fashion, as it occurs with biofilms. However, before true gene regulatory interactions were widespread and allowed for controlled changes in cell phenotypes, simple cellular colonies displaying adhesion and interacting with their environments were in place. In this context, models often ignore the physical embedding of evolving cells, thus leaving aside a key component. The potential for evolving pre-developmental patterns is a relevant issue: how far a colony of evolving cells can go? Here we study these pre-conditions for morphogenesis by using CHIMERA, a physically embodied computational model of evolving virtual organisms in a pre-Mendelian world. Starting from a population of identical, independent cells moving in a fluid, the system undergoes a series of changes, from spatial segregation, increased adhesion and the development of generalism. Eventually, a major transition occurs where a change in the flow of nutrients is triggered by a sub-population. This ecosystem engineering phenomenon leads to a subsequent separation of the ecological network into two well defined compartments. The relevance of these results for evodevo and its potential ecological triggers is discussed
dc.description.sponsorship This work has been supported by grants of the James McDonnell Foundation (RVS, SV), Fundación Marcelino Botín (RVS, SV), FIS2004-05422 (RVS) and by the Santa Fe Institute
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2013;8(4):e59664
dc.rights © 2013 Solé, Valverde. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subject.other Cèl·lules Interacció
dc.subject.other Morfogènesi
dc.title Before the endless forms: embodied model of transition from single cells to aggregates to ecosystem engineering
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0059664
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/FIS2004-05422
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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