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Age-associated inflammation inhibits epidermal stem cell function

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dc.contributor.author Doles, Jason
dc.contributor.author Storer, Mekayla, 1981-
dc.contributor.author Cozzuto, Luca
dc.contributor.author Roma, Guglielmo
dc.contributor.author Keyes, William M., 1973-
dc.date.accessioned 2015-04-30T07:23:57Z
dc.date.available 2015-04-30T07:23:57Z
dc.date.issued 2012
dc.identifier.citation Doles J, Storer M, Cozzuto L, Roma G, Keyes WM. Age-associated inflammation/ninhibits epidermal stem cell function. Genes Dev. 2012 Oct 1;26(19):2144-53. DOI: 10.1101/gad.192294.112
dc.identifier.issn 0890-9369
dc.identifier.uri http://hdl.handle.net/10230/23506
dc.description.abstract Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.
dc.description.sponsorship J.D. is supported by an EMBO long-term fellowship, and M.A.S. is funded by a La Caixa bank studentship. This work was funded in part by a Plan Nacional grant to W.M.K. from the Spanish/nMinistry for Science and Innovation (SAF2010-18829)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)
dc.relation.ispartof Genes & Development. 2012 Oct 1;26(19):2144-53
dc.rights Copyright © 2012, Genes and Development by Cold Spring Harbor Laboratory Press. Published version available at http://genesdev.cshlp.org/
dc.subject.other Envelliment
dc.subject.other Epidermis -- Citologia
dc.subject.other Inflamació
dc.subject.other Cèl·lules mare -- Citologia
dc.title Age-associated inflammation inhibits epidermal stem cell function
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1101/gad.192294.112
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-18829
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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