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Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study

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dc.contributor.author Valvi, Damaskini, 1983-
dc.contributor.author Mendez, Michelle A.
dc.contributor.author Martínez Muriano, David
dc.contributor.author Grimalt Obrador, Joan
dc.contributor.author Torrent Quetglas, Maties
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2015-04-09T08:14:34Z
dc.date.available 2015-04-09T08:14:34Z
dc.date.issued 2012
dc.identifier.citation Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, Vrijheid M. Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect. 2012;120(3):451-7. DOI: 10.1289/ehp.1103862
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/23367
dc.description.abstract Background: Recent experimental evidence suggests that prenatal exposure to endocrine-disrupting chemicals (EDCs) may increase postnatal obesity risk and that these effects may be sex or diet dependent. Objectives: We explored whether prenatal organochlorine compound (OC) concentrations [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and dichlorodiphenyltrichloroethane (DDT)] were associated with overweight at 6.5 years of age and whether child sex or fat intakes modified these associations. Methods: We studied 344 children from a Spanish birth cohort established in 1997–1998. Overweight at 6.5 years was defined as a body mass index (BMI) z-score ≥ 85th percentile of the World Health Organization reference. Cord blood OC concentrations were measured and treated as categorical variables (tertiles). Children’s diet was assessed by food frequency questionnaire. Relative risks (RRs) were estimated using generalized linear models. Results: After multivariable adjustment, we found an increased RR of overweight in the third tertile of PCB exposure [RR = 1.70; 95% confidence interval (CI): 1.09, 2.64] and the second tertile of DDE exposure (RR = 1.67; 95% CI: 1.10, 2.55), but no association with DDT exposure in the population overall. Associations between overweight and PCB and DDE concentrations were strongest in girls (p-interaction between 0.01 and 0.28); DDT was associated with overweight only in boys. For DDT we observed stronger associations in children with fat intakes at or above compared with below the median, but this interaction was not significant (p-interaction > 0.05). Conclusions: This study suggests that prenatal OC exposures may be associated with overweight in children and that sex and high-fat intake may influence susceptibility.
dc.description.sponsorship This study was funded by grants from the Spanish Ministry of Health (FIS-97/0588 and FIS-00/0021-02), the Instituto Carlos III (Red INMA G03176 and predoctoral grant PFIS 2010, Register FI10/00399), the Fundació La Caixa (00/007-00), the RecerCaixa (Register 2010ACUP 00349), and the European Commission (Concerted Action, contract QLK4-2000-00263)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environmental Health Perspectives. 2012;120(3):451-7
dc.rights Reproduced with permission from Environmental Health Perspectives
dc.subject.other Obesitat en els infants
dc.subject.other Contaminants persistents -- Toxicologia -- Epidemiologia
dc.title Prenatal concentrations of polychlorinated biphenyls, DDE, and DDT and overweight in children: a prospective birth cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1103862
dc.subject.keyword Body mass index
dc.subject.keyword Dichlorodiphenyldichloroethylene (DDE)
dc.subject.keyword Dichlorodiphenyltrichloroethane (DDT)
dc.subject.keyword Environmental obesogens
dc.subject.keyword High-fat intakes
dc.subject.keyword Obesity
dc.subject.keyword Persistent organic pollutants
dc.subject.keyword Polychlorinated biphenyls (PCBs)
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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