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Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors

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dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author Estarlich, Marisa
dc.contributor.author Fernández Somoano, Ana
dc.contributor.author Lertxundi, Aitana
dc.contributor.author Lertxundi, Nerea
dc.contributor.author Mendez, Michelle A.
dc.contributor.author Tardón, Adonina
dc.contributor.author Vrijheid, Martine
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author INMA (Infancia y Medio Ambiente) Project
dc.date.accessioned 2015-04-08T10:15:04Z
dc.date.available 2015-04-08T10:15:04Z
dc.date.issued 2012
dc.identifier.citation Guxens M, Aguilera I, Ballester F, Estarlich M, Fernandez-Somoano A, Lertxundi A et al. Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors. Environ Health Perspect. 2012;120(1):144-9. DOI: 10.1289/ehp.1103469
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/23359
dc.description.abstract Background: Air pollution effects on children’s neurodevelopment have recently been suggested to occur most likely through the oxidative stress pathway. Objective: We aimed to assess whether prenatal exposure to residential air pollution is associated with impaired infant mental development, and whether antioxidant/detoxification factors modulate this association. Methods: In the Spanish INfancia y Medio Ambiente (INMA; Environment and Childhood) Project, 2,644 pregnant women were recruited during their first trimester. Nitrogen dioxide (NO2) and benzene were measured with passive samplers covering the study areas. Land use regression models were developed for each pollutant to predict average outdoor air pollution levels for the entire pregnancy at each residential address. Maternal diet was obtained at first trimester through a validated food frequency questionnaire. Around 14 months, infant mental development was assessed using Bayley Scales of Infant Development. Results: Among the 1,889 children included in the analysis, mean exposure during pregnancy was 29.0 μg/m3 for NO2 and 1.5 μg/m3 for benzene. Exposure to NO2 and benzene showed an inverse association with mental development, although not statistically significant, after adjusting for potential confounders [β (95% confidence interval) = –0.95 (–3.90, 1.89) and –1.57 (–3.69, 0.56), respectively, for a doubling of each compound]. Stronger inverse associations were estimated for both pollutants among infants whose mothers reported low intakes of fruits/vegetables during pregnancy [–4.13 (–7.06, –1.21) and –4.37 (–6.89, –1.86) for NO2 and benzene, respectively], with little evidence of associations in the high-intake group (interaction p-values of 0.073 and 0.047). Inverse associations were also stronger in non-breast-fed infants and infants with low maternal vitamin D, but effect estimates and interactions were not significant. Conclusions: Our findings suggest that prenatal exposure to residential air pollutants may adversely affect infant mental development, but potential effects may be limited to infants whose mothers report low antioxidant intakes.
dc.description.sponsorship This study was funded by grants from the Spanish Ministry of Health-Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-PI041436, FIS- PI081151, FIS-PI042018, FIS-PI09/02311, FIS-PI06/0867, FIS-PS09/00090, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, and 09/02647), Generalitat de Catalunya-CIRIT (Consell Interdepartamental de Recerca i Innovació Tecnològica) (1999SGR 00241), Conselleria de Sanitat Generalitat Valenciana, Universidad de Oviedo, Obra social Cajastur, Department of Health of the Basque Government (2005111093 and 2009111069), the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001), and Fundación Roger Torné
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environmental Health Perspectives. 2012;120(1):144-9
dc.rights Reproduced with permission from Environmental Health Perspectives
dc.subject.other Infants -- Creixement
dc.subject.other Vitamines en nutrició humana
dc.subject.other Infants -- Alimentació
dc.subject.other Nodrissons -- Alimentació
dc.title Prenatal exposure to residential air pollution and infant mental development: modulation by antioxidants and detoxification factors
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1103469
dc.subject.keyword Aromatic hydrocarbons
dc.subject.keyword Breast-feeding
dc.subject.keyword Child development
dc.subject.keyword Cognition
dc.subject.keyword Environmental pollution
dc.subject.keyword Fruit
dc.subject.keyword Intelligence
dc.subject.keyword Nitrogen dioxide
dc.subject.keyword Vegetables
dc.subject.keyword Vitamin D
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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