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Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy

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dc.contributor.author Mendez, Michelle A.
dc.contributor.author García Esteban, Raquel
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Vrijheid, Martine
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Goñi, Fernando
dc.contributor.author Fochs, Silvia
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2015-04-08T10:14:48Z
dc.date.available 2015-04-08T10:14:48Z
dc.date.issued 2011
dc.identifier.citation Mendez MA, Garcia-Esteban R, Guxens M, Vrijheid M, Kogevinas M, Goni F, Fochs S et al. Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy. Environmental Health Perspectives. 2011;119(2):272-8. DOI: 10.1289/ehp.1002169
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/23354
dc.description.abstract Background: Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and it is uncertain how early in life any effects may begin. Objectives: We explored whether prenatal exposure to several organochlorine compounds (OCs) is associated with rapid growth in the first 6 months of life and body mass index (BMI) later in infancy. Methods: Data come from the INMA (Infancia y Medio-Ambiente) Child and Environment birth cohort in Spain, which recruited 657 women in early pregnancy. Rapid growth during the first 6 months was defined as a change in weight-for-age z-scores > 0.67, and elevated BMI at 14 months, as a z-score ≥ the 85th percentile. Generalized linear models were used to estimate the risk of rapid growth or elevated BMI associated with 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), hexachlorobenzene, β-hexachlorohexane, and polychlorinated biphenyls in first-trimester maternal serum. Results: After multivariable adjustment including other OCs, DDE exposure above the first quartile was associated with doubling of the risk of rapid growth among children of normal-weight (BMI < 25 kg/m2), but not overweight, mothers. DDE was also associated with elevated BMI at 14 months (relative risk per unit increase in log DDE = 1.50; 95% confidence interval, 1.11–2.03). Other OCs were not associated with rapid growth or elevated BMI after adjustment. Conclusions: In this study we found prenatal DDE exposure to be associated with rapid weight gain in the first 6 months and elevated BMI later in infancy, among infants of normal-weight mothers. More research exploring the potential role of chemical exposures in early-onset obesity is needed.
dc.description.sponsorship This work was supported by grants from the Spanish Ministry of Health (FIS-PI041436), Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), the Generalitat de Catalunya-CIRIT (Consejo Interdepartamental de Investigación e Innovación Tecnológica) (1999SGR 00241), and the Fundació Roger Torner
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environmental Health Perspectives. 2011;119(2): 272-8
dc.rights Reproduced with permission from Environmental Health Perspectives
dc.subject.other Infants -- Desenvolupament
dc.subject.other Obesitat en els infants
dc.title Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1002169
dc.subject.keyword β-hexachlorohexane
dc.subject.keyword Body mass index
dc.subject.keyword Dichlorodiphenyldichloroethylene
dc.subject.keyword Hexachlorobenzene
dc.subject.keyword Infant
dc.subject.keyword Obesity
dc.subject.keyword Polychlorinated biphenyls
dc.subject.keyword Prenatal
dc.subject.keyword Weight gain
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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