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Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior

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dc.contributor.author Viñals Álvarez, Xavier, 1985-
dc.contributor.author Molas Casacuberta, Susanna, 1985-
dc.contributor.author Gallego, Xavier
dc.contributor.author Fernández Montes, Rubén D.
dc.contributor.author Robledo, Patricia, 1958-
dc.contributor.author Dierssen, Mara
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2015-04-08T10:13:40Z
dc.date.available 2015-04-08T10:13:40Z
dc.date.issued 2012
dc.identifier.citation Viñals X, Molas S, Gallego X, Fernández-Montes RD, Robledo P, Dierssen M et al. Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior. Drug Alcohol Depend. 2012 May 1;122(3):247-52. DOI: 10.1016/j.drugalcdep.2011.09.027
dc.identifier.issn 0376-8716
dc.identifier.uri http://hdl.handle.net/10230/23350
dc.description.abstract Recent studies have revealed that sequence variants in genes encoding the α3/α5/β4 nicotinic acetylcholine receptor subunits are associated with nicotine dependence. In this study, we evaluated two specific aspects of executive functioning related to drug addiction (impulsivity and working memory) in transgenic mice over expressing α3/α5/β4 nicotinic receptor subunits. Impulsivity and working memory were evaluated in an operant delayed alternation task, where mice must inhibit responding between 2 and 8s in order to receive food reinforcement. Working memory was also evaluated in a spontaneous alternation task in an open field. Transgenic mice showed less impulsive-like behavior than wild-type controls, and this behavioral phenotype was related to the number of copies of the transgene. Thus, transgenic Line 22 (16-28 copies) showed a more pronounced phenotype than Line 30 (4-5 copies). Overexpression of these subunits in Line 22 reduced spontaneous alternation behavior suggesting deficits in working memory processing in this particular paradigm. These results reveal the involvement of α3/α5/β4 nicotinic receptor subunits in working memory and impulsivity, two behavioral traits directly related to the vulnerability to develop nicotine dependence.
dc.description.sponsorship Funding for this study was provided by the DG Research of the European Commission (PHECOMP, no. LHSM-CT-2007-037669), the Spanish ‘Instituto de Salud Carlos III’ (RD06/001/001; PI082038/nand PI10/01708, EU/FIS PS09102673, ERARare), the Spanish ‘Ministerio de Educación y Ciencia’ (SAF2007-64062; SAF2007-60827; SAF2007-31093-E; SAF2010-16427), Fundación Ramón Areces, Reina Sofia, Marató TV3, and CIBERER, The Catalan Government (SGR2009-00131; 2009SGR-1313) and the ICREA Foundation (ICREA Academia-2008)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Drug and Alcohol Dependence. 2012 May 1;122(3):247-52
dc.rights © Elsevier http://dx.doi.org/10.1016/j.drugalcdep.2011.09.027
dc.subject.other Genètica de la conducta
dc.subject.other Proteïnes
dc.subject.other Nicotina
dc.title Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.drugalcdep.2011.09.027
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/037669
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-60827
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-31093
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16427
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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