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CAPS-DB: A structural classification of helix-capping motifs

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dc.contributor.author Segura, Joan
dc.contributor.author Oliva Miguel, Baldomero
dc.contributor.author Fernández Fuentes, Narcís
dc.date.accessioned 2015-04-07T09:36:23Z
dc.date.available 2015-04-07T09:36:23Z
dc.date.issued 2012
dc.identifier.citation Segura J, Oliva B, Fernandez-Fuentes N. CAPS-DB: A structural classification of helix-capping motifs. Nucleic Acids Research. 2012;40(D1):D479-D485. DO:I 10.1093/nar/gkr879
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10230/23345
dc.description.abstract The regions of the polypeptide chain immediately preceding or following an α-helix are known as Nt- and Ct cappings, respectively. Cappings play a central role stabilizing α-helices due to lack of intrahelical hydrogen bonds in the first and last turn. Sequence patterns of amino acid type preferences have been derived for cappings but the structural motifs associated to them are still unclassified. CAPS-DB is a database of clusters of structural patterns of different capping types. The clustering algorithm is based in the geometry and the (ϕ–ψ)-space conformation of these regions. CAPS-DB is a relational database that allows the user to search, browse, inspect and retrieve structural data associated to cappings. The contents of CAPS-DB might be of interest to a wide range of scientist covering different areas such as protein design and engineering, structural biology and bioinformatics. The database is accessible at: http://www.bioinsilico.org/CAPSDB.
dc.description.sponsorship Research Councils United Kingdom Academic Fellow scheme (to N.F.F.); internal scholarship awarded by the Leeds Institute of Molecular Medicine (to J.S.M.); MICINN and FEDER (BIO2011-22568) to B.O. Funding for open access charge: Research Councils United Kingdom (RCUK)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Nucleic Acids Research. 2012;40(D1):D479-D485
dc.rights © Segura J, Oliva B, Fernandez-Fuentes N [2012]. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0
dc.subject.other Aminoàcids
dc.subject.other Pèptids
dc.subject.other Proteïnes -- Estructura
dc.title CAPS-DB: A structural classification of helix-capping motifs
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/nar/gkr879
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-22568
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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