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Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene

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dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Herrero, Carmen
dc.contributor.author Ozalla, Dolores
dc.contributor.author Sala, Maria
dc.contributor.author Ribas Fitó, Núria
dc.contributor.author Grimalt Obrador, Joan
dc.contributor.author Basagaña Flores, Xavier
dc.date.accessioned 2015-04-01T07:07:01Z
dc.date.available 2015-04-01T07:07:01Z
dc.date.issued 2002
dc.identifier.citation Sunyer J, Herrero C, Ozalla D, Sala M, Ribas-Fitó N, Grimalt J, Basagaña X. Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene. Environmental Health: A Global Access Science Source. 2002;1(1):1. DOI: 10.1186/1476-069X-1-1
dc.identifier.issn 1476-069X
dc.identifier.uri http://hdl.handle.net/10230/23326
dc.description.abstract Background: Porphyria cutanea tarda (PCT) is caused by hexachlorobenzene (HCB) in several species of laboratory mammals, but the human evidence is contradictory. In a study among adults of a population highly exposed to HCB (Flix, Catalonia, Spain), the prevalence of PCT was not increased. We aimed at analysing the association of individual urinary porphyrins with the serum concentrations of HCB and other organochlorine compounds in this highly exposed population. Methods: A cross-sectional study on total porphyrins was carried out in 1994 on 604 inhabitants of the general population of Flix, older than 14 years. Of them, 241 subjects (comprising a random sample and the subgroup with the highest exposure) were included for the present study. The porphyrin profile was determined by high-pressure liquid chromatography. Serum concentrations of HCB, as well as common organochlorine compounds, were determined by gas chromatography coupled to electron capture detection. Results: Coproporphyrin I (CPI) and coproporphyrin III (CPIII) were the major porphyrins excreted, while uroporphyrins I and III were only detected in 2% and 36% of the subjects respectively, and heptaporphyrins I and III in 1% and 6%, respectively. CPI and CPIII decreased with increasing HCB concentrations (p < 0.05). This negative association was not explained by age, alcohol, smoking, or other organochlorine compounds. No association was found between uroporphyrin I and III excretion, nor heptaporphyrin excretion, and HCB. CPIII increased with smoking (p < 0.05). Conclusion: HCB exposure in this highly exposed population did not increase urinary concentrations of individual porphyrins.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Environmental Health: A Global Access Science Source. 2002;1(1):1
dc.rights © 2002 Sunyer et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
dc.subject.other Hexaclorobenzè -- Toxicologia
dc.subject.other Hidrocarburs
dc.subject.other Dermatologia
dc.subject.other Aire -- Contaminació -- Espanya
dc.subject.other Indústries químiques -- Aspectes ambientals
dc.title Serum organochlorines and urinary porphyrin pattern in a population highly exposed to hexachlorobenzene
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1476-069X-1-1
dc.subject.keyword Coproporphyrin I
dc.subject.keyword Coproporphyrin III
dc.subject.keyword Hexachlorobenzene
dc.subject.keyword Organochlorinated compounds
dc.subject.keyword Porphyria
dc.subject.keyword Uroporphyrin
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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