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Macrophage plasticity and the role of inflammation in skeletal muscle repair

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dc.contributor.author Kharraz, Yacine
dc.contributor.author Guerra, Joan
dc.contributor.author Mann, Christopher J.
dc.contributor.author Serrano, Antonio L.
dc.contributor.author Muñoz Cánoves, Pura, 1962-
dc.date.accessioned 2015-04-01T07:06:58Z
dc.date.available 2015-04-01T07:06:58Z
dc.date.issued 2013
dc.identifier.citation Kharraz Y, Guerra J, Mann CJ, Serrano AL, Muñoz-Cánoves P. Macrophage plasticity and the role of inflammation in skeletal muscle repair. Mediators of Inflammation. 2013;2013:491497. DOI: 10.1155/2013/491497
dc.identifier.issn 0962-9351
dc.identifier.uri http://hdl.handle.net/10230/23325
dc.description.abstract Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity. Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration. We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions. Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair.
dc.description.sponsorship Funding from MICINN (SAF2009-09782, FIS-PS09/01267, SAF2012-38547, PLE2009-0124, and CIBERNED), AFM, Fundación Marató-TV3, MDA, EU-FP7 (Myoage, Optistem, and Endostem). Y. Kharraz was supported by a postdoctoral fellowship from AFM
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof Mediators of Inflammation. 2013;2013:491497
dc.rights Copyright © 2013 Yacine Kharraz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject.other Teixits -- Remodelació
dc.subject.other Cèl·lules mare
dc.title Macrophage plasticity and the role of inflammation in skeletal muscle repair
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1155/2013/491497
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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