Mostra el registre parcial de l'element
dc.contributor.author | Puighermanal Puigvert, Emma, 1983- |
dc.contributor.author | Busquets Garcia, Arnau, 1985- |
dc.contributor.author | Maldonado, Rafael, 1961- |
dc.contributor.author | Ozaita Mintegui, Andrés, 1969- |
dc.date.accessioned | 2015-03-27T08:00:56Z |
dc.date.available | 2015-03-27T08:00:56Z |
dc.date.issued | 2012 |
dc.identifier.citation | Puighermanal E, Busquets-Garcia A, Maldonado R, Ozaita A. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63. DOI: 10.1098/rstb.2011.0384 |
dc.identifier.issn | 0962-8436 |
dc.identifier.uri | http://hdl.handle.net/10230/23298 |
dc.description.abstract | Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system. |
dc.description.sponsorship | EP is a recipient of an EMBO Fellowship with the support of European Commission (EMBOCOFUND2010, GA-2010-267146) and Marie Curie Actions. AB-G is a recipient of a predoctoral fellowship, Spanish Ministry of Education and Culture. This study was supported by grants from La Marató de TV3 (#090910 to AO), Grants from the Spanish Ministry of Science and Innovation (#SAF2009-07309 to AO and/n#SAF2011-29864 to RM); Instituto de Salud Carlos III (RD06/0001/0001 to RM); PLAN E (Plan Español para el Estímulo de la Economía y el Empleo); Generalitat de Catalunya (SGR-2009-00731 to RM and SGR-2009-00718 to RdlT); ICREA (Institució Catalana de Recerca i Estudis Avançats) Academia to RM |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Royal Society |
dc.relation.ispartof | Philosophical Transactions of the Royal Society B: Biological Sciences. 2012 Dec 5;367(1607):3254-63 |
dc.rights | © The Royal Society. http://dx.doi.org/10.1098/rstb.2011.0384 |
dc.subject.other | Trastorns de la cognició |
dc.subject.other | Cannabinoides |
dc.title | Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1098/rstb.2011.0384 |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/267146 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/SAF2009-07309 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |