Mostra el registre parcial de l'element
dc.contributor.author | Mellström, Britt |
dc.contributor.author | Sahún, Ignasi |
dc.contributor.author | Ruiz Nuño, Ana |
dc.contributor.author | Murtra, Patricia |
dc.contributor.author | Gómez Villafuertes, Rosa |
dc.contributor.author | Savignac, Magalí |
dc.contributor.author | Oliveros, Juan C. |
dc.contributor.author | González, Paz |
dc.contributor.author | Kastanauskaite, Asta |
dc.contributor.author | Knafo, Shira |
dc.contributor.author | Zhuo, Min |
dc.contributor.author | Higuera Matas, Alejandro |
dc.contributor.author | Errington, Michael L. |
dc.contributor.author | Maldonado, Rafael, 1961- |
dc.contributor.author | De Felipe, Javier |
dc.contributor.author | Jefferys, John G.R. |
dc.contributor.author | Bliss, Tim V. P. |
dc.contributor.author | Dierssen, Mara |
dc.contributor.author | Naranjo, José R. |
dc.date.accessioned | 2015-03-23T08:49:18Z |
dc.date.available | 2015-03-23T08:49:18Z |
dc.date.issued | 2014 |
dc.identifier.citation | Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M et al. DREAM controls the on/off switch of specific activity-dependent transcription pathways. Mol Cell Biol. 2014 Mar;34(5):877-87. DOI: 10.1128/MCB.00360-13 |
dc.identifier.issn | 0270-7306 |
dc.identifier.uri | http://hdl.handle.net/10230/23255 |
dc.description.abstract | Changes in nuclear Ca(2+) homeostasis activate specific gene expression programs and are central to the acquisition and storage of information in the brain. DREAM (downstream regulatory element antagonist modulator), also known as calsenilin/KChIP-3 (K(+) channel interacting protein 3), is a Ca(2+)-binding protein that binds DNA and represses transcription in a Ca(2+)-dependent manner. To study the function of DREAM in the brain, we used transgenic mice expressing a Ca(2+)-insensitive/CREB-independent dominant active mutant DREAM (daDREAM). Using genome-wide analysis, we show that DREAM regulates the expression of specific activity-dependent transcription factors in the hippocampus, including Npas4, Nr4a1, Mef2c, JunB, and c-Fos. Furthermore, DREAM regulates its own expression, establishing an autoinhibitory feedback loop to terminate activity-dependent transcription. Ablation of DREAM does not modify activity-dependent transcription because of gene compensation by the other KChIP family members. The expression of daDREAM in the forebrain resulted in a complex phenotype characterized by loss of recurrent inhibition and enhanced long-term potentiation (LTP) in the dentate gyrus and impaired learning and memory. Our results indicate that DREAM is a major master switch transcription factor that regulates the on/off status of specific activity-dependent gene expression programs that control synaptic plasticity, learning, and memory. |
dc.description.sponsorship | This work was supported by grants from Spanish Ministry of Health and Science, Madrid Community, La Marató, La Caixa, Reina Sofía and Areces Foundations, the EU 6th Framework Program (NeuroNE, CureFXS), the ERA-NET Program (Neuron and E-Rare), and the Medical Research Council. S.K. has a postdoctoral contract from the Ramón y Cajal Program of the Ministry of Science and Innovation. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | American Society for Microbiology |
dc.relation.ispartof | Molecular and cellular biology. 2014 Mar;34(5):877-87 |
dc.rights | © 2014, American Society for Microbiology. All Rights Reserved. doi:10.1128/MCB.00360-13. The authors have paid a fee to allow immediate free access to this article |
dc.subject.other | Proteïnes |
dc.subject.other | Genètica |
dc.subject.other | Cervell |
dc.title | DREAM controls the on/off switch of specific activity-dependent transcription pathways |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1128/MCB.00360-13 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |