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Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

 

Recent Submissions

  • Vyas, Chirag M.; Ogata, Soshiro; Reynolds, Charles F. 3rd; Mischoulon, David; Chang, Grace; Cook, Nancy R.; Manson, JoAnn E.; Crous-Bou, Marta; De Vivo, Immaculata; Okereke, Olivia I. (Public Library of Science (PLoS), 2020)
    Mitochondrial DNA copy number (mtDNAcn) is a putative biomarker of oxidative stress and biological aging. Modifiable factors, including physical activity (PA), avoidance of heavy alcohol use and smoking, and maintaining ...
  • Elbatreek, Mahmoud; Sadegh, Sepideh; Anastasi, Elisa; Guney, Emre; Nogales, Cristian; Kacprowski, Tim; Hassan, Ahmed; Teubner, Andreas; Huang, Po-Hsun; Hsu, Chien-Yi; Schiffers, Paul M. H.; Janssen, Ger M.; Kleikers, Pamela W.M.; Wipat, Anil; Baumbach, Jan; De Mey, Jo G.R.; Schmidt, Harald H.H.W. (Public Library of Science (PLoS), 2020)
    Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves impaired endothelium-dependent vasodilation ...
  • Prieto-Potin, Iván; Carvajal, Nerea; Plaza-Sánchez, Jenifer; Manso, Rebeca; Aúz-Alexandre, Carmen Laura; Chamizo, Cristina; Zazo, Sandra; López-Sánchez, Almudena; Rodríguez-Pinilla, Socorro María; Camacho Díaz, Laura; Longarón Rozalen, Raquel; Bellosillo Paricio, Beatriz; Somoza, Rosa; Hernández-Losa, Javier; Fernández-Soria, Víctor Manuel; Ramos-Ruiz, Ricardo; Cristóbal, Ion; García-Foncillas, Jesús; Rojo, Federico (PeerJ Inc., 2020)
    Background: Next-generation sequencing (NGS) is a high-throughput technology that has become widely integrated in molecular diagnostics laboratories. Among the large diversity of NGS-based panels, the Trusight Tumor 26 ...
  • Andrade-Campos, Marcio; López de Frutos, Laura; Cebolla, Jorge J.; Serrano-Gonzalo, Irene; Medrano-Engay, Blanca; Roca-Espiau, Mercedes; Gómez-Barrera, Beatriz; Pérez-Heredia, Jorge; Iniguez, David; Giraldo, Pilar (BioMed Central, 2020)
    Background: Since enzyme replacement therapy for Gaucher disease (MIM#230800) has become available, both awareness of and the natural history of the disease have changed. However, there remain unmet needs such as the ...
  • Fernández-Bergés, Daniel; Dégano, Irene R.; Subirana Cachinero, Isaac; Martí-Almor, Julio; Vila, Joan; Pérez-Fernández, Silvia; Martí-Almor, Julio; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; ATHOS investigators (BMJ Publishing Group, 2020)
    Objective: Primary percutaneous coronary intervention (P-PCI) has demonstrated its efficacy in patients with ST segment elevation myocardial infarction (STEMI). However, patients with STEMI ≥75 years receive less P-PCI ...
  • Liaño-Pons, Judit; Lafita-Navarro, M. Carmen; García-Gaipo, Lorena; Colomer, Carlota; Rodríguez, Javier; von Kriegsheim, Alex; Hurlin, Peter J.; Ourique, Fabiana; Delgado, M. Dolores; Bigas Salvans, Anna; Espinosa Blay, Lluís; León, Javier (Nature Research, 2021)
    MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix-loop-helix proteins that heterodimerize with MAX in a mutually exclusive manner, and bind ...
  • Casal, Miguel A.; Galella Toledo, Santiago; Vilarroya, Óscar; García Ojalvo, Jordi (American Institute of Physics (AIP), 2020)
    Recurrent neuronal networks are known to be endowed with fading (short-term) memory, whereas long-term memory is usually considered to be hard-wired in the network connectivity via Hebbian learning, for instance. Here, we ...
  • Gallo, Maria; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)
    The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...
  • Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Ballestín, Raúl; Alegre Zurano, Laia; Ferrer-Pérez, Carmen; Cantacorps, Lídia; Miñarro, José; Valverde Granados, Olga; Rodríguez-Arias, Marta (Elsevier, 2021)
    Using the social defeat (SD) model, numerous studies have shown that stressed mice display an enhanced response to the motivational effects of cocaine in the self-administration (SA) and conditioned-place preference (CPP) ...
  • Castro-Barquero, Sara; Lassale, Camille; Hernáez, Álvaro (MDPI, 2020)
    Our aim is to assess whether following a Mediterranean Diet (MedDiet) decreases the risk of initiating antithrombotic therapies and the cardiovascular risk associated with its use in older individuals at high cardiovascular ...
  • Velázquez, Ana Magdalena; Roglans, Núria; Bentanachs, Roger; Gené, Maria; Sala Vila, Aleix; Lázaro, Iolanda; Rodríguez-Morató, Jose, 1987-; Sánchez, Rosa María; Laguna, Juan Carlos; Alegret, Marta (MDPI, 2020)
    Non-alcoholic fatty liver disease is a highly prevalent condition without specific pharmacological treatment, characterized in the initial stages by hepatic steatosis. It was suggested that lipid infiltration in the liver ...
  • Bouzas, Cristina; Schröder, Helmut, 1958-; Castañer, Olga; Zomeño Fajardo, Maria Dolores; Goday Arno, Alberto; Tur, J. Antoni (MDPI, 2020)
    One-year dietary quality change according to the preceding maximum weight in a lifestyle intervention program (PREDIMED-Plus trial, 55-75-year-old overweight or obese adults; n = 5695) was assessed. A validated food frequency ...
  • Ramírez López, Angela; Pastor, Antonio; Torre Fornell, Rafael de la; La Porta, Carmen, 1985-; Ozaita Mintegui, Andrés, 1969-; Cabañero Ferri, David; Maldonado, Rafael, 1961- (Wiley, 2021)
    Background: Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an ...
  • Rubín-García, María; Vitelli Storelli, Facundo; Molina, Antonio J.; Zamora-Ros, Raúl; Aragonés, Núria; Ardanaz Aicua, Eva; Castaño Vinyals, Gemma; Obón-Santacana Mireia; Gómez-Acebo, Inés; Molina-Barceló, Ana; Fernández-Tardón, Guillermo; Jiménez-Moleón, José Juan; Alguacil Ojeda, Juan; Chirlaque, María Dolores; Toledo, Estefania; Pérez-Gómez, Beatriz; Pollan, Marina; Kogevinas, Manolis; Martín, Vicente (MDPI, 2020)
    Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric ...
  • Fuentes, B.; Amaro, S.; Alonso de Leciñana, M.; Arenillas, J.F.; Ayo-Martín, O.; Castellanos, M.; Freijo, M.M.; García Pastor, A.; Gomis,M.; Gómez Choco, M.; López-Cancio Martínez, E.; Martínez Sánchez, P.; Morales, A.; Palacio-Portilla, E.J.; Rodríguez-Yáñez, M.; Roquer, Jaume; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, J.; Spanish Society of Neurology's Cerebrovascular Disease Study Group (Elsevier, 2021)
    Objetivo: actualizar las recomendaciones de la Sociedad Española de Neurología para la prevención del ictus en pacientes con DM-2 o prediabetes, analizando las evidencias disponibles sobre el efecto del control metabólico ...
  • Rodríguez-Yáñez, M.; Gómez Choco, M.; López-Cancio Martínez, E.; Amaro, S.; Alonso de Leciñana, M.; Arenillas, J.F.; Ayo-Martín, O.; Castellanos, M.; Freijo, M.M.; García Pastor, A.; Gomis, M.; Martínez Sánchez, P.; Morales, A.; Palacio-Portilla, E.J.; Roquer, Jaume; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, J.; Fuentes, B.; Spanish Society of Neurology's Cerebrovascular Disease Study Group (Elsevier, 2021)
    Objective: To update the recommendations of the Spanish Society of Neurology on primary and secondary stroke prevention in patients with arterial hypertension. Development: We proposed several questions to identify practical ...
  • García Pastor, A.; López-Cancio Martínez, E.; Rodríguez-Yáñez, M.; Alonso de Leciñana, M.; Amaro, S.; Arenillas, J.F.; Ayo-Martín, O.; Castellanos, M.; Fuentes, B.; Freijo, M.M.; Gomis, M.; Gómez Choco, M.; Martínez Sánchez, P.; Morales, A.; Palacio-Portilla, E.J.; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, J.; Roquer, Jaume; Spanish Society of Neurology's Cerebrovascular Disease Study Group (Elsevier, 2021)
    Objective: to update the recommendations of the Spanish Society of Neurology regarding lifestyle interventions for stroke prevention. Development: We reviewed the most recent studies related to lifestyle and stroke risk, ...
  • Martín Sánchez, Ana; García Baos, Alba; Castro Zavala, Adriana, 1988-; Alegre Zurano, Laia; Valverde Granados, Olga (Elsevier, 2021)
    Early-life stress induces an abnormal brain development and increases the risk of psychiatric diseases, including depression, anxiety and substance use disorders. We have developed a reliable model for maternal neglect, ...
  • Tejedor Vaquero, Sonia, 1988-; Campos Mata, Leire de, 1991-; Ramada Rodilla, José María, 1961-; Díaz, Pilar; Navarro-Barriuso, Juan; Ribas-Llauradó, Clara; Rodrigo Melero, Natalia; Carolis, Carlo; Cerutti, Andrea, 1965-; Gimeno Martínez, Ramón; Magri, Giuliana, 1978- (Frontiers Media, 2021)
    mRNA-based vaccines effectively induce protective neutralizing antibodies against SARS-CoV-2, the etiological agent of COVID-19. Yet, the kinetics and compositional patterns of vaccine-induced antibody responses to the ...

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