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Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

 

Recent Submissions

  • Chadban, Steven J.; Ahn, Curie; Axelrod, David A.; Foster, Bethany J.; Kasiske, Bertram L.; Kher, Vijah; Kumar, Deepali; Oberbauer, Rainer; Pascual Santos, Julio; Pilmore, Helen L.; Rodrigue, James R.; Segev, Dorry L.; Sheerin, Neil S.; Tinckam, Kathryn J.; Tinckam, Kathryn J.; Wong, Germaine; Knoll, Gregory A. (Wolters Kluwer (LWW), 2020)
    The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who ...
  • Bertran-Recasens, Bernat; Martinez-Llorens, Juana María; Rodríguez-Sevilla, Juan José; Rubio Pérez, Miguel Angel (Wiley, 2020)
  • Parra, Eduardo; Arenas Jiménez, María Dolores; Fernández-Reyes Luis, María José; Blasco Forcén, Angel; Álvarez-Ude, Fernando; Aguarón Joven, Juan; Altuzarra Casas, Alfredo; Moreno-Jiménez, José María (BioMed Central, 2020)
    Background: Evaluation of renal replacement therapy with haemodialysis is essential for its improvement. Remarkably, outcomes vary across centres. In addition, the methods used have important epistemological limitations, ...
  • Cabañero Ferri, David; Maldonado, Rafael, 1961- (Wiley, 2021)
    Background: The use of paracetamol or nefopam for postoperative pain control is limited by the need of high doses associated with unwanted effects. Previous works suggest positive interactions between both compounds that ...
  • Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Yélamos López, José; Duran Jordà, Xavier, 1974-; Faura, Anna; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (MDPI, 2020)
    Classical immunosuppression based on steroids, calcineurin inhibitors, and mycophenolate results in several unwanted effects and unsatisfactory long-term outcomes in kidney transplantation (KT). New immunosuppressors search ...
  • Hollanda, Ana de; Goday Arno, Alberto; Castañer, Olga; Rebollo, Ángel (MDPI, 2020)
    Almost one third of patients do not achieve type 2 diabetes remission after bariatric surgery or are unable to sustain this effect long term. Our objective was to delve further into the dynamic responses of diabetes after ...
  • López, Verónica; Crespo Barrio, Marta; Díaz-Corte, Carmen; Hernández, Domingo; Grupo Español de Actualizaciones en Trasplante (GREAT) (Elsevier, 2020)
    La pandemia por coronavirus SARS-CoV-2 (Covid-19) está evolucionando de manera muy rápida y representa un riesgo especial en pacientes inmunodeprimidos y con comorbilidades añadidas. El conocimiento sobre esta infección ...
  • Chalouni, Mathieu; Rodríguez-Centeno, Javier; Samri, Assia; Blanco, Julian; Stella-Ascariz, Natalia; Wallet, Cedrick; Knobel Freud, Hernando; Zucman, David; Alejos Ferreras, Belen; Autran, Brigitte; Thiebaut, Rodolphe; Raffi, François; Arribas, José Ramón; NEAT 001/ANRS 143 Trial Study Group (Public Library of Science (PLoS), 2020)
    In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = ...
  • Maurer, Marcus; Giménez Arnau, Anna Maria; Castaldo, Anthony (Wiley-Blackwell, 2020)
  • Carrillo-Reixach, Juan; Arnal, Magdalena; Nonell Mazelón, Lara; Armengol, Carolina (Elsevier, 2020)
    Background & aims: Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the ...
  • Martínez, Evelyn; Garin Boronat, Olatz, 1979-; Pardo Cladellas, Yolanda; Fernández, Pablo; Guix, Benjamin; Gutiérrez, Cristina; Boladeras, Ana; Ferrer, Ferran; Hernández, Tania; Ayala, Adriana; Egiguren, Mikel; Fernández, Gema; Muñoz, Víctor; Macías, Víctor; Pera, Joan; Pont Acuña, Àngels; Ferrer, Montserrat; Guedea, Ferrán (Termedia Publishing, 2021)
    Introduction: Brachytherapy (BT) and external beam radiation therapy (EBRT) are effective treatments for high-risk prostate cancer (PCa). However, the impact of these treatments on health-related quality of life (HRQL) ...
  • Ågren, Richard; Stepniewski, Tomasz Maciej, 1988-; Zeberg, Hugo; Selent, Jana; Sahlholm, Kristoffer (MDPI, 2021)
    The forward (kon) and reverse (koff) rate constants of drug-target interactions have important implications for therapeutic efficacy. Hence, time-resolved assays capable of measuring these binding rate constants may be ...
  • Martín Sánchez, Ana; Piñero González, Janet, 1977-; Nonell Mazelón, Lara; Arnal, Magdalena; Ribe, Elena; Nevado-Holgado, Alejo J.; Lovestone, Simon; Sanz, Ferran; Furlong, Laura I., 1971-; Valverde, Olga (BioMed Central, 2021)
    Background: Major depression (MD) is the most prevalent psychiatric disease in the population and is considered a prodromal stage of the Alzheimer's disease (AD). Despite both diseases having a robust genetic component, ...
  • Chadban, Steven J.; Pascual Santos, Julio; Knoll, Gregory A. (Wolters Kluwer (LWW), 2020)
    The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who ...
  • Silvestre Salvador, Juan Francisco; Heras-Mendaza, Felipe; Hervella Garcés, Marcos; Palacios-Martínez, D.; Sánchez Camacho, R.; Senan Sanz, R.; Apellaniz González, A.; Giménez Arnau, Anna Maria (Elsevier, 2020)
    El eccema de manos es una patología frecuente con un fuerte impacto en la calidad de vida de los pacientes y un alto coste social y laboral. Su manejo por los médicos de atención primaria y de medicina del trabajo es ...
  • Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Blennow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; ALFA study (Oxford University Press, 2020)
    Gray matter networks (GMn) provide essential information on the intrinsic organization of the brain and appear to be disrupted in Alzheimer's disease (AD). Apolipoprotein E (APOE)-ε4 represents the major genetic risk factor ...
  • Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • Gómez-Martín, Ignacio; Collgros, Helena; Ferguson, Peter M.; Barreiro, Alicia; Guitera, Pascale; Andrades, Evelyn; Puig, Susana; Pujol Vallverdú, Ramon Maria; Barranco Sanz, Luis Carlos; Alòs, Llúcia; Segura Tigell, Sonia (Elsevier, 2020)
    Background: Pigmented labial macules (PLMs) are clinical, dermoscopic, and histopathologic challenges. Objective: To describe and evaluate the utility of reflectance confocal microscopy (RCM) in PLMs and to establish a ...
  • Porcheri, Cristina; Golan, Ohad; Calero-Nieto, Fernando J.; Thambyrajah, Roshana; Ruiz-Herguido, Cristina; Wang, Xiaonan; Catto, Francesca; Guillén, Yolanda; Sinha, Roshani; González, Jessica; Kinston, Sarah J.; Mariani, Samanta A.; Maglitto, Antonio; Vink, Chris S.; Dzierzak, Elaine; Charbord, Pierre; Göttgens, Bertie; Espinosa Blay, Lluís; Sprinzak, David; Bigas Salvans, Anna (Wiley-Blackwell, 2020)
    Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is known about the molecular characteristics of the developing ...
  • Leisman, Daniel E.; Barreiro Portela, Esther; Maslove, David M.; Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involves estimating the relationship between patient factors and outcomes, it is distinct from casual inference. Prediction modeling thus requires unique considerations for development, validation, and updating. This document represents an effort from editors at 31 respiratory, sleep, and critical care medicine journals to consolidate contemporary best practices and recommendations related to prediction study design, conduct, and reporting. Herein, we address issues commonly encountered in submissions to our various journals. Key topics include considerations for selecting predictor variables, operationalizing variables, dealing with missing data, the importance of appropriate validation, model performance measures and their interpretation, and good reporting practices. Supplemental discussion covers emerging topics such as model fairness, competing risks, pitfalls of "modifiable risk factors", measurement error, and risk for bias. This guidance is not meant to be overly prescriptive; we acknowledge that every study is different, and no set of rules will fit all cases. Additional best practices can be found in the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) guidelines, to which we refer readers for further details. (Wolters Kluwer (LWW), 2020)

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