Visualitza Articles (Hospital del Mar Research Institute) per autoria "Jacoby, Edgar"

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Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.

Digles, Daniela; Queralt Rosinach, Núria; Furlong, Laura I., 1971-; Jacoby, Edgar (Royal Society of Chemistry, 2016)

Phenotypic screening is in a renaissance phase and is expected by many academic and industry leaders to accelerate the discovery of new drugs for new biology. Given that phenotypic screening is per definition target agnostic, ...
Scientific competency questions as the basis for semantically enriched open pharmacological space development

Azzaoui, Kamal; Jacoby, Edgar; Senger, Stefan; Cuadrado Rodríguez, Emiliano; Loza, Mabel; Zdrazil, Barbara; Pinto, Marta; Williams, Antony J.; Torre, Victor de la; Mestres i López, Jordi; Pastor Maeso, Manuel; Taboureau, Olivier; Rarey, Matthias; Chichester, Christine; Pettifer, Steve; Blomberg, Niklas; Harland, Lee; Williams-Jones, Bryn; Ecker, Gerhard F. (Elsevier, 2013)

Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline ...