Inici
→
Recerca: articles, congressos, llibres
→
Hospital del Mar Research Institute
→
Articles (Hospital del Mar Research Institute)
→
Visualitza Articles (Hospital del Mar Research Institute) per autoria

Visualitza Articles (Hospital del Mar Research Institute) per autoria "Muñoz Cánoves, Pura, 1962-"

Ara mostrant els elements 1-5 de 5

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch

López Arribillaga, Erika, 1986-; Rodilla, Verónica; Pellegrinet, Luca; Guiu Sagarra, Jordi, 1983-; Iglesias Coma, Mar; Roman, Angel Carlos; Gutarra, Susana; González, Susana; Muñoz Cánoves, Pura, 1962-; Fernández-Salguero, Pedro; Radtke, Freddy; Bigas Salvans, Anna; Espinosa Blay, Lluís (Company of Biologists, 2015)

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation ...
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Greco, Carolina M.; Welz, Patrick-Simon; Kumar, Arun; Vaca-Dempere, Mireia; Deryagian, Oleg; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo (American Association for the Advancement of Science (AAAS), 2021)

The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of the lack of ...
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Smith, Jacob G.; Kumar, Arun; Deryagin, Oleg; Vaca Dempere, Mireia, 1994-; Sica, Valentina; Welz, Patrick-Simon; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo (Elsevier, 2023)

Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions ...
The central clock suffices to drive the majority of circulatory metabolic rhythms

Petrus, Paul; Smith, Jacob G.; Koronowski, Kevin B.; Chen, Siwei; Sato, Tomoki; Greco, Carolina M.; Mortimer, Thomas; Welz, Patrick-Simon; Zinna, Valentina M.; Shimaji, Kohei; Cervantes, Marlene; Punzo, Daniela; Baldi, Pierre; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo; Aznar Benitah, Salvador (American Association for the Advancement of Science (AAAS), 2022)

Life on Earth anticipates recurring 24-hour environmental cycles via genetically encoded molecular clocks active in all mammalian organs. Communication between these clocks controls circadian homeostasis. Intertissue ...
Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells

Muñoz Cánoves, Pura, 1962-; Neves, Joana; Sousa-Victor, Pedro (Wiley-Blackwell, 2019)

Aging is characterized by the progressive dysfunction of most tissues and organs, which has been linked to the regenerative decline of their resident stem cells over time. Skeletal muscle provides a stark example of this ...