Visualitza Articles (Hospital del Mar Research Institute) per autoria "Eckhart, Leopold"

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Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.

Manils, Joan; Gómez, Diana; Salla-Martret, Mercè; Fischer, Heinz; Fye, Jason M.; Marzo, Elena; Marruecos, Laura; Serrano, Inma; Salgado, Rocío; Rodrigo, Juan P.; Garcia-Pedrero, Juana M.; Serafin, Anna M.; Cañas, Xavier; Benito, María del Carmen; Toll Abelló, Agustín; Forcales Fernàndez, Sonia-Vanina; Perrino, Fred W.; Eckhart, Leopold; Soler, Concepció (Impact Journals, 2015)

TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic ...