Browsing Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)) by Author "Abad, Antonio"

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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia

Robles-Valero, Javier; Lorenzo-Martín, L. Francisco; Menacho Márquez, Mauricio; Fernández-Pisonero, Isabel; Abad, Antonio; Camós, Mireia; Toribio, María Luisa; Espinosa Blay, Lluís; Bigas Salvans, Anna; Bustelo, Xose R. (Elsevier, 2017)

Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their ...
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model

Robles-Valero, Javier; Fernández-Nevado, Lucía; Cuadrado, Myriam; Lorenzo-Martín, L. Francisco; Fernández-Pisonero, Isabel; Abad, Antonio; Redín, Esther; Montuenga, Luis; Martín-Zanca, Dionisio; Bigas Salvans, Anna; Mallo, Moises; Dosil, Mercedes; Bustelo, Xose R. (Wiley, 2022)

Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall-cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene-edited ...

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