• Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations

  Barrios Barrera, Clara; Otero, Sol; Rodríguez García, Eva; Pedro-Botet, Juan Carlos; Pascual Santos, Julio; Menni, Cristina (Nature Research, 2018)

  Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent ...
• Weighted multi-marker genetic risk scores for incident coronary heart disease among individuals of african, latino and east-asian ancestry

  Iribarren, Carlos; Lu, Meng; Jorgenson, Eric; Martínez, Manuel; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Eduardo; Elosua Llanos, Roberto (Nature Research, 2018)

  We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. ...
• Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study

  Maldonado-Araque, Cristina; Goday Arno, Alberto; Rojo-Martínez, Gemma (Nature Research, 2018)

  Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free ...
• Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density

  Martínez-Gil, Núria; Roca Ayats, Neus; Monistrol-Mula, Anna; García-Giralt, Natalia; Diez Pérez, Adolfo; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)

  Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, ...
• Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos

  Pizzagalli, Diego Ulisse; Sintes, Jordi; Fernández González, Santiago (Nature Research, 2018)

  Recent advances in intravital video microscopy have allowed the visualization of leukocyte behavior in vivo, revealing unprecedented spatiotemporal dynamics of immune cell interaction. However, state-of-the-art software ...
• Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period

  Ferránzez Quirante, Olivia; Grau Cerrato, Santiago; Urbina, Olatz; Mojal, Sergio; Riu Camps, Marta; Salas Sanchez, Esther (Elsevier, 2018)

  OBJECTIVE: Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number ...
• VIH en España 2017: políticas para una nueva gestión de la cronicidad más allá del control virológico

  del Amo, Julia; Roman Degano, Irene; Marrugat de la Iglesia, Jaume; Gol-Montserrat, Jordi (Ministerio de Sanidad, Consumo y Bienestar Social, 2018)

  El análisis de las bases de datos disponibles relacionadas con VIH/SIDA confirma un cambio de paradigma en la esperanza de vida del paciente: ahora el VIH se ha convertido en una enfermedad crónica, con la que los pacientes ...
• Infectious postoperative endophthalmitis after cataract surgery performed over 7 years. The role of azithromycin versus ciprofloxacin eye drops

  Tuñí-Picado, Josep; Martínez-Palmer, A.R.; Fernández-Sala, Xènia; Barceló-Vidal, Jaime; Cartagena Guardado, Yasmin; Grau Cerrato, Santiago (Sociedad Española de Quimioterapia, 2018)

  Introduction. Although topical antibiotics have been used as antimicrobial prophylaxis after ocular surgery, recent studies have determined that intracameral cefuroxime at the end of surgery significantly reduce the risk ...
• Association between EBRT dose volume histograms and quality of life in prostate cancer patients

  Boladeras, Ana; Ferrer, Ferran; Navarro, Valentin; Blas, Rodolfo de; Cunillera, Oriol; Mateo, David; Gutiérrez, Cristina; Martínez, Evelyn; Villà, Salvador; Pera, Joan; Boladeras, Ana; Guedea, Ferrán (Elsevier, 2018)

  AIM: To evaluate the association between dose-volume histogram (DVH) values in organs at risk (OAR) and patient-reported HRQoL outcomes. BACKGROUND: Data on the association between DVHs and health-related quality of life ...
• Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies

  Vrotsou, Kalliopi; Ávila Pacheco, Mónica Marcela, 1984-; Machón, Mónica; Mateo-Abad, Maider; Pardo Cladellas, Yolanda; Garin Boronat, Olatz, 1979-; Zaror, Carlos; González, Nerea; Escobar, Antonio; Cuéllar, Ricardo (SpringerOpen, 2018)

  PURPOSE: The objective of this study was to evaluate the psychometric properties of the Constant-Murley Score (CMS) in various shoulder pathologies, based on a systematic review and expert standardized evaluations. METHODS: ...
• Validity of the EQ-5D-5L and reference norms for the Spanish population

  Hernandez, Gimena; Garin Boronat, Olatz, 1979-; Pardo, Yolanda; Vilagut Saiz, Gemma, 1975-; Pont Acuña, Àngels; Suárez, Mónica; Neira, Montse; Rajmil Rajmil, Luis Alberto; Gorostiza, Inigo; Ramallo-Fariña, Yolanda; Cabases, Juan; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (Springer, 2018)

  BACKGROUND AND OBJECTIVE: The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version ...
• Change in functioning outcomes as a predictor of the course of depression: a 12-month longitudinal study

  Forero, Carlos G.; Olariu, Elena, 1984-; Álvarez López, Pilar; Castro-Rodriguez, José-Ignacio; Blasco Cubedo, Maria Jesus; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; INSAyD Investigators (Springer, 2018)

  PURPOSE: Functioning is a necessary diagnostic criterion for depression, and thus routinely assessed in depressive patients. While it is highly informative of disorder severity, its change has not been tested for prognostic ...
• Genetic or other causation should not change the clinical diagnosis of cerebral palsy

  MacLennan, Alastair H.; Pérez Jurado, Luis Alberto; Gecz, Jozef (SAGE Publications, 2019)

  High throughput sequencing is discovering many likely causative genetic variants in individuals with cerebral palsy. Some investigators have suggested that this changes the clinical diagnosis of cerebral palsy and that ...
• The contribution of brain imaging to the understanding of psychopathy

  Pujol Martí, Jesús (Cambridge Medical Publications, 2019)

  Psychopathy is a personality type characterized by both callous emotional dysfunction and deviant behavior that affects society in the form of actions that harm others. Historically, researchers have been concerned with ...
• Acceptance and present-moment awareness in psychiatric disorders: is mindfulness mood dependent?

  Elices, Matilde; Tejedor, Rosa; Pascual, Juan C.; Carmona, Cristina; Soriano, José; Soler, Joaquim (Elsevier, 2019)

  The aim of the present study was to determine 1) whether deficits in two mindfulness dimensions (present-centered awareness and acceptance) were present in individuals with different psychiatric conditions and 2) whether ...
• Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine: A substudy of the NEAT001/ANRS143 randomised trial

  Bernardino, Jose I.; Mocroft, Amanda; Wallet, Cedrick; de Wit, Stéphane; Katlama, Christine; Reiss, Peter; Mallon, Patrick W.; Richert, Laura; Molina, Jean-Michel; Knobel Freud, Hernando; Morlat, Philippe; Babiker, Abdel; Pozniac, Anton; Raffi, Francois; Arribas, José Ramón; NEAT001/ANRS143 Trial Study Group (Public Library of Science (PLoS), 2019)

  BACKGROUND: Comparison of changes in body composition, adipokines and inflammatory markers after initial therapy with a nucleos(t)ide reverse transcriptase inhibitor (N(t)RTI)- sparing or containing regimen are scarce. ...
• Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer

  Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets, Ignasi; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)

  NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
• Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

  Nieuwenhuijsen, Mark J.; Martinez Murciano, David; Grellier, James; Bennett, James; Best, Nicky; Iszatt, Nina; Vrijheid, Martine; Toledano, Mireille B. (National Institute of Environmental Health Sciences (NIEHS), 2009)

  OBJECTIVES: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide ...
• Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis

  Vrijheid, Martine; Martinez Murciano, David; Manzanares, Sandra; Dadvand, Payam; Schembari, Anna, 1982-; Rankin, Judith; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2011)

  OBJECTIVE: We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. DATA SOURCES AND EXTRACTION: ...
• European birth cohorts for environmental health research

  Vrijheid, Martine; Casas Sanahuja, Maribel; Kogevinas, Manolis; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2012)

  BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, ...

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