• Real-world first-line treatment of patients with BRAFV600E-mutant metastatic colorectal cancer: the CAPSTAN CRC study

  Martinelli, Erika; Cremolini, Chiara; Mazard, Thibault; Vidal Barrull, Joana; Virchow, I.; Tougeron, David; Cuyle, Pieter-Jan; Chibaudel, Benoist; Kim, Stefano; Ghanem, Ismael; Asselain, Bernard; Castagné, Coline; Zkik, A.; Khan, S.; Arnold, Dirk (Elsevier, 2022)

  Background: BRAFV600E mutations occur in 8%-12% of metastatic colorectal cancer (mCRC) cases and are associated with poor survival. European guidelines recommend combination (doublet or triplet) chemotherapy plus bevacizumab ...
• Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients

  Tapia, Javier; Basalo, María; Enjuanes Grau, Cristina; Calero Molina, Esther; José, Nuria; Ruíz, Marta; Calvo, Elena; Garcimartín Cerezo, Paloma; Moliner Borja, Pedro; Hidalgo, Encarnacion; Yun, Sergi; Garay, Alberto; Jiménez-Marrero, Santiago; Pons, Alexandra; Corbella, Xavier; Comín Colet, Josep (Wiley, 2022)

  Aims: There is little information about the influence of gender on quality of life (QoL) in heart failure. The purpose of this study was to evaluate whether the health-related QoL gap between men and women can be explained ...
• Carbon dioxide (CO2) emissions and adherence to Mediterranean diet in an adult population: the Mediterranean diet index as a pollution level index

  García, Silvia; Goday Arno, Alberto; Cabanes, Robert; Castañer, Olga; Ciurana, Ramon; Tur, Josep A. (BioMed Central, 2023)

  Background: Research related to sustainable diets is is highly relevant to provide better understanding of the impact of dietary intake on the health and the environment. Aim: To assess the association between the adherence ...
• Individual blood concentrations of persistent organic pollutants and chemical elements, and COVID-19: A prospective cohort study in Barcelona

  Porta Serra, Miquel; Pumarega Rodríguez, José Antonio; Gasull Panadès, Magda; Aguilar, Ruth; Henríquez Hernández, Luis Alberto; Basagaña Flores, Xavier; Zumbado, Manuel; Villar García, Judit; Rius, Cristina; Mehta, Sneha; Vidal, Marta; Jiménez, Alfons; Campi, Laura; Lop Gros, Joan; Pérez Luzardo, Octavio L.; Dobaño, Carlota; Moncunill, Gemma (Elsevier, 2023)

  Background: There is wide, largely unexplained heterogeneity in immunological and clinical responses to SARS-CoV-2 infection. Numerous environmental chemicals, such as persistent organic pollutants (POPs) and chemical ...
• Genomic predictors of good outcome, recurrence, or progression in high-grade T1 non-muscle-invasive bladder cancer

  Bellmunt Molins, Joaquim, 1959-; Perera Bel, Júlia; Orsola, Anna; Rodriguez-Vida, Alejo; Juanpere, Nuria; Lloreta Trull, Josep, 1958-; Hernández, Silvia; Kwiatkowski, David J. (American Association for Cancer Research (AACR), 2020)

  High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non-muscle-invasive bladder cancer with unpredictable outcome and poorly understood risk factors. Here, we examined the association of somatic mutation ...
• Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk

  Yuan, Fangcheng; Porta Serra, Miquel; Real, Francisco X.; Stolzenberg-Solomon, Rachael Z. (American Association for Cancer Research (AACR), 2020)

  Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic ...
• The ARIA approach of Value-Added Medicines: as-needed treatment in allergic rhinitis

  Bousquet, Jean; Antó i Boqué, Josep Maria; Zuberbier, Torsten (Elsevier, 2022)

  Drug repurposing is a major field of value-added medicine. It involves investigating and evaluating existing drugs for new therapeutic purposes that address unmet healthcare needs. Several unmet needs in allergic rhinitis ...
• Academic productivity of young people with allergic rhinitis: a MASK-air study

  Vieira, Rafael José; Antó i Boqué, Josep Maria; MASK study group (Elsevier, 2022)

  Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available. Objective: To use RWD to assess the impact of allergic ...
• Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

  Akin, Leyla; Pérez Jurado, Luis Alberto; Dattani, Mehul T. (Elsevier, 2022)

  Purpose: We aimed to investigate the molecular basis underlying a novel phenotype including hypopituitarism associated with primary ovarian insufficiency. Methods: We used next-generation sequencing to identify variants ...
• Modeling SARS-CoV-2 proteins in the CASP-commons experiment

  Kryshtafovych, Andriy; Moult, John; Billings, Wendy M.; Della Corte, Dennis; Fidelis, Krzysztof; Kwon, Sohee; Olechnovič, Kliment; Seok, Chaok; Venclovas, Česlovas; Won, Jonghun; CASP-COVID participants (Wiley, 2021)

  Critical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute ...
• Perceived helpfulness of bipolar disorder treatment: Findings from the World Health Organization World Mental Health Surveys

  Nierenberg, Andrew A.; Alonso Caballero, Jordi; WHO World Mental Health Survey collaborators (Wiley, 2021)

  Objectives: To examine patterns and predictors of perceived treatment helpfulness for mania/hypomania and associated depression in the WHO World Mental Health Surveys. Methods: Face-to-face interviews with community samples ...
• Comparative bioavailability study of a novel multi-day patch formulation of rivastigmine (twice weekly) with Exelon® transdermal patch (daily)- a randomized clinical trial

  Schurad, Bjoern; Koch, Cornelius; Schug, Barbara; Morte, Adelaida; Vaqué, Anna; Torre Fornell, Rafael de la; Iniesta, Marc (Bentham Science Publishers, 2022)

  Background: Rivastigmine, a reversible AChEI for symptomatic treatment of mild to moderately severe Alzheimer's dementia, is administered once daily transdermal patches, enabling an easier and continuous drug delivery. A ...
• Toward measuring effective treatment coverage: critical bottlenecks in quality- and user-adjusted coverage for major depressive disorder

  Vigo, Daniel V.; Alonso Caballero, Jordi; Kessler, Ronald C. (Cambridge University Press, 2020)

  Background: Major depressive disorder (MDD) is a leading cause of morbidity and mortality. Shortfalls in treatment quantity and quality are well-established, but the specific gaps in pharmacotherapy and psychotherapy are ...
• Childhood adversities and mental disorders in first-year college students: results from the World Mental Health International College Student Initiative

  Husky, Mathilde M.; Sadikova, Ekaterina; Lee, Sue; Alonso Caballero, Jordi; Auerbach, Randy P.; Bantjes, Jason; Bruffaerts, Ronny; Cuijpers, Pim; Ebert, David Daniel; Gutiérrez Garcia, Raùl; Hasking, Penelope; Mak, Arthur; McLafferty, Margaret; Sampson, Nancy A.; Stein, Dan J.; Kessler, Ronald C.; WHO WMH‐ICS Collaborators (Cambridge University Press, 2022)

  Background: This study investigates associations of several dimensions of childhood adversities (CAs) with lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. Methods: ...
• Clinical guideline on perioperative management of patients with advanced chronic liver disease

  Canillas, Lidia; Pelegrina-Manzano, A.; Álvarez, Juan C.; Colominas-González, Elena; Salar, Antonio; Aguilera, Lluís G.; Burdío Pinilla, Fernando; Montes, Antonio; Grau, Santiago; Grande, Luís; Carrión, José A. (MDPI, 2023)

  (1) Background: Patients with advanced chronic liver disease (ACLD) are living longer with more comorbidities because of improved medical and surgical management. However, patients with ACLD are at increased risk of ...
• Predictors of preeclampsia in the first trimester in normotensive and chronic hypertensive pregnant women

  Vázquez, Susana; Pascual, Julio (Pascual Santos); Durán-Jordà, Xavier; Hernández, Jose Luís; Crespo, Marta; Oliveras, Anna (MDPI, 2023)

  Preeclampsia (PE) is characterized by the new onset of hypertension (HT) and proteinuria beyond the 20th week of gestation. We aimed to find the best predictor of PE and find out if it is different in women with or without ...
• Variation in nicotine metabolization according to biological factors and type of nicotine consumer

  Pérez-Martín, Hipólito; Lidón-Moyano, Cristina; González-Marrón, Adrián; Fu, Marcela; Pérez-Ortuño, Raúl; Ballbè, Montse; Martín-Sánchez, Juan Carlos; Pascual Esteban, José A.; Fernández, Esteve; Martínez-Sánchez, Jose M. (MDPI, 2023)

  This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult ...
• Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age

  Jiménez-Balado, Joan; Giralt-Steinhauer, Eva; Fernández-Pérez, Isabel; Rey, Lucía; Cuadrado-Godia, Elisa; Ois, Ángel; Rodríguez-Campello, Ana; Soriano-Tárraga, Carolina; Lazcano, Uxue; Macias-Gómez, Adrià; Suárez-Pérez, Antoni; Revert, Anna; Estragués-Gázquez, Isabel; Beltrán Mármol, Marlyn Briggith; Medrano-Martorell, Santiago; Capellades, Jaume; Roquer, Jaume; Jiménez-Conde, Jordi (MDPI, 2023)

  In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both ...
• The P4-ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast

  Pazos, Irene; Puig-Tintó, Marta; Betancur, Laura; Cordero, Jorge; Jiménez-Menéndez, Nereida; Abella, Marc; Hernández, Altair C.; Duran, Ana G.; Adachi-Fernández, Emi; Belmonte Mateos, Carla, 1992-; Sabido-Bozo, Susana; Tosi, Sebastien; Nezu, Akiko; Oliva Miguel, Baldomero; Colombelli, Julien; Graham, Todd R.; Yoshimori, Tamotsu; Muñiz, Manuel; Hamasaki, Maho; Gallego, Oriol (EMBO Press, 2023)

  Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that tether vesicles at the acceptor membrane. Interactions with other components of the trafficking machinery regulate MTCs through mechanisms ...
• Socioeconomic and gender inequalities in mental disorders among adolescents and young adults

  Mar, Javier; Larrañaga, Igor; Ibarrondo, Oliver; González-Pinto, Ana; Hayas, Carlota las; Fullaondo, Ane; Izco‑Basurko, Irantzu; Alonso Caballero, Jordi; Mateo-Abad, Maider; Manuel Keenoy, Esteban de (Elsevier, 2022)

  Background: Socioeconomic status (SES) and gender play a key role in mental health. The objective of this study was to assess socioeconomic and gender mental health inequalities in adolescents and young adults using a ...

View more