• White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

  Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)

  White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...
• Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

  Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)

  Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
• Incapacidad permanente y mortalidad prematura en una cohorte de afiliados a la Seguridad Social en España, 2004-2015

  Serra Saurina, Laura; Ubalde López, Mònica, 1972-; Benavides, Fernando G. (Fernando García) (Elsevier, 2020)

  Objetivo: Describir un sistema de vigilancia y monitorización basado en el análisis de la tasa de incidencia de la incapacidad permanente (IP) y la mortalidad prematura (MP) en una muestra de afiliados/as a la Seguridad ...
• Elección informada en el cribado del cáncer de mama: el papel del nivel educativo

  Pons, Anna; Martínez-Alonso, Montserrat; Perestelo-Pérez, Lilisbeth; García, Montse; Sala Serra, Maria; Rué, Montserrat; InforMa Group (Elsevier, 2020)

  Objetivo: Evaluar el efecto de recibir información sobre los beneficios y los efectos adversos del cribado del cáncer de mama en la elección informada, en función del nivel educativo. Método: Análisis Secundario de un ...
• Therapeutic use of LSD in psychiatry: a systematic review of randomized-controlled clinical trials

  Fuentes Valenzuela, Juan José; Fonseca Casals, Francina, 1972-; Elices, Matilde; Farré Albaladejo, Magí; Torrens, Marta (Frontiers, 2020)

  Lysergic acid diethylamide (LSD) was studied from the 1950s to the 1970s to evaluate behavioral and personality changes, as well as remission of psychiatric symptoms in various disorders. LSD was used in the treatment of ...
• Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

  Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus, 1982-; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BioMed Central, 2020)

  Background: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
• Family features of social withdrawal syndrome (Hikikomori)

  Malagón, Angeles; Martín López, Luis Miguel; Córcoles, David; Gonzalez Fresnedo, Ana María; Bellsolà González, Magdalena; Teo, Alan R.; Bulbena Vilarrasa, Antonio; Pérez Solá, Victor; Bergé, Daniel (Frontiers, 2020)

  Background: Family may play an important role in the origin, maintenance, and treatment of people with social withdrawal. The aim of this study is to analyze family factors related to social withdrawal syndrome. Methods: ...
• A multicenter phase II RCT to compare the effectiveness of EMDR versus TAU in patients with a first-episode psychosis and psychological trauma: a protocol design

  Valiente Gómez, Alicia; Pujol, Nuria; Moreno Alcázar, Ana; Radua, Joaquim; Monteagudo-Gimeno, Eila; Gardoki-Souto, Itxaso; Hogg, Bridget; Álvarez, Maria José; Safont, Gemma; Lupo, Walter; Pérez Solá, Victor; Amann, Benedikt Lorenz; FEP-EMDR Research Group (Frontiers, 2020)

  Background: Patients with a first episode psychosis (FEP) who are admitted for the first time to a psychiatric hospital frequently have experienced prior psychological trauma. Additionally, 40-80% develop posttraumatic ...
• Chronic sleep fragmentation mimicking sleep apnea does not worsen left-ventricular function in healthy and heart failure mice

  Cabrera-Aguilera, Ignacio; Benito Villabriga, Begoña; Tajes Orduña, Marta; Farré, Ramon; Gozal, David; Almendros, Isaac; Farré López, Núria (Frontiers, 2020)

  Aims: Obstructive sleep apnea (OSA) has been associated with heart failure (HF). Sleep fragmentation (SF), one of the main hallmarks of OSA, induces systemic inflammation, oxidative stress and sympathetic activation, hence ...
• Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis

  Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, M. (Miguel); Martínez Rodríguez, Jose E. (BioMed Central, 2020)

  Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
• Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

  Yeung, Edwina H.; Guan, Weihua; Zeng, Xuehuo; Salas Díaz, Lucas Andrés, 1980-; Mumford, Sunni L.; Prado Bert, Paula de; van Meel, Evelien R.; Malmberg, Anni; Sunyer Deu, Jordi; Duijts, Liesbeth; Felix, Janine Frédérique; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B.; Räikkönen, Katri; Lahti, Jari; London, Stephanie J.; Silver, Robert M.; Schisterman, Enrique F. (BioMed Central, 2020)

  Background: Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical ...
• Closing the gap between therapeutic use and mode of action in remedial herbs

  Olivés Farrés, Joaquim, 1987-; Mestres i López, Jordi (Frontiers, 2019)

  The ancient tradition of taking parts of a plant or preparing plant extracts for treating certain discomforts and maladies has long been lacking a scientific rationale to support its preparation and still widespread use ...
• Management of heart failure with reduced ejection fraction after ESC 2016 heart failure guidelines: the Linx Registry

  de Frutos, Fernando; Mirabet, Sonia; Ortega-Paz, Luis; Buera, Irene; Darnés, Sara; Farré López, Núria; Pérez, Bernardo; Adeliño, Raquel; Bascompte, Ramón; Pérez-Rodón, Jordi; Aparicio, Xavier; Sutil-Vega, Mario; Soto, Adriana; Faraudo, Mercedes; Cainzos-Achirica, Miguel; Manito Lorite, Nicolás (Wiley, 2020)

  Aims: In May 2016, a new version of the European Society of Cardiology (ESC) Guidelines for the management of heart failure (HF) was released. The aim of this study was to describe the management of HF with reduced ejection ...
• Weaving notions of justice into urban ecosystem services research and practice

  Langemeyer, Johannes; Connolly, James (Elsevier, 2020)

  In a rising urban age planning for cities around the globe is increasingly based on assessments of ecosystemservices, making enhanced considerations of ecosystem service justice critically important. Yet, justice remains ...
• Trihalomethanes in drinking water and bladder cancer burden in the European Union

  Evlampidou, Iro; Font-Ribera, Laia; Kogevinas, Manolis; Villanueva Belmonte, Cristina (National Institute of Environmental Health Sciences (NIEHS), 2020)

  Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM ...
• A decade of structural variants: description, history and methods to detect structural variation

  Escaramís, Geòrgia; Docampo, Elisa; Rabionet, Raquel (Oxford University Press, 2015)

  In the past decade, the view on genomic structural variation (SV) has been changed completely. SVs, previously considered rare events, are now recognized as the largest source of interindividual genetic variation affecting ...
• Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study

  Castelló, Adela; Castaño Vinyals, Gemma; O'Callaghan Gordo, Cristina; Kogevinas, Manolis; García-Pérez, Javier (Elsevier, 2020)

  Background: Self-reported data about environmental exposures can lead to measurement error. Objectives: To validate the self-reported perception of proximity to industrial facilities. Methods: MCC-Spain is a population-based ...
• Deep brain stimulation in treatment resistant schizophrenia: a pilot randomized cross-over clinical trial

  Corripio, Iluminada; Roldán, Alexandra; Sarró, Salvador; McKenna, Peter; Alonso-Solís, Anna; Rabella, Mireia; Díaz, Anna; Puigdemont, Dolors; Pérez Solá, Victor; Álvarez, Enric; Arévalo, Antonio; Padilla, Pedro P.; Ruiz-Idiago, Jesús; Rodríguez, Rodrigo; Molet, Joan; Pomarol-Clotet, Edith; Portella, Maria J. (Elsevier, 2020)

  Background: Up to 30% of patients with schizophrenia are resistant to antipsychotic drug treatment, with 60% of such cases also failing to respond to clozapine. Deep brain stimulation (DBS) has been used in treatment ...
• Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

  Benítez-Cano, Adela; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Carazo Cordobés, Jesús; Ramos Delgado, M.; Campillo Ambrós, Núria; Curull Serrano, Víctor; Sánchez-Font, Albert; Vilaplana, Carles; Horcajada Gallego, Juan Pablo; Adalia Bartolomé, Ramón; Bermejo Martínez, Silvia; Samsó Sabé, Enric; Hope, William; Grau Cerrato, Santiago (BioMed Central, 2020)

  Background: Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administered ...
• Immunomodulatory roles of PARP-1 and PARP-2: impact on PARP-centered cancer therapies

  Yelamos López, Jose; Lama, Lucía, 1993-; Jimeno, Jaime; Ali, Syed O. (MDPI, 2020)

  Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)-the transfer of ADP-ribose chains onto amino acid residues-with a resultant ...

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