• Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance

  Suñol, Maria; Martínez-Zalacaín, Ignacio; Picó-Pérez, Maria; López-Solà, Clara; Real, Eva; Fullana Rivas, Miguel Ángel; Pujol Nuez, Jesús; Cardoner, Narcís; Menchón, José M.; Alonso, Pino; Soriano Mas, Carles (Cambridge University Press, 2020)

  Background: Preliminary evidence suggests that hoarding disorder (HD) and obsessive-compulsive disorder (OCD) may show distinct patterns of brain activation during executive performance, although results have been inconclusive ...
• From single drug targets to synergistic network pharmacology in ischemic stroke

  Casas, Ana I.; Hassan, Ahmed; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; López, Manuela G.; Baumbach, Jan; Schmidt, Harald H.H.W. (National Academy of Sciences, 2019)

  Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rather than mechanistic approaches have contributed. We here explore a mechanism-based disease definition for network ...
• Effect of information about the benefits and harms of mammography on women's decision making: the InforMa randomised controlled trial

  Sala Serra, Maria; Pérez-Lacasta, Maria José; Martínez-Alonso, Montserrat; García, Montse; Sala Serra, Maria; Perestelo-Pérez, Lilisbeth; Vidal, Carmen; Codern, Núria; Feijoo-Cid, Maria; Toledo-Chávarri, Ana; Cardona, Àngels; Pons, Anna; Carles, Misericòrdia; Rué, Montserrat; InforMa Group (Public Library of Science (PLoS), 2019)

  Background: In Spain, women invited to breast screening are not usually informed about potential harms of screening. The objective of the InforMa study is to assess the effect of receiving information about the benefits ...
• Early smoking-onset age and risk of cardiovascular disease and mortality

  Fa-Binefa, Manel; Clarà Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)

  Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
• Clinico-pathological discrepancies in the diagnosis of causes of death in adults in Mozambique: a retrospective observational study

  Ordi, Jaume (Public Library of Science (PLoS), 2019)

  Background: Clinico-pathological discrepancies are more frequent in settings in which limited diagnostic techniques are available, but there is little information on their actual impact. Aim: We assessed the accuracy of ...
• Critically ill patients with community-onset intraabdominal infections: influence of healthcare exposure on resistance rates and mortality

  Maseda, Emilio; Ramírez, Sofía; Picatto, Pedro; Peláez-Peláez, Eva; García-Bernedo, Carlos A.; Ojeda-Betancur, Nazario; Aguilar, Gerardo; Forés, Beatriz; Solera-Marín, Jorge; Aliaño-Piña, María; Tamayo Aguirre, Eduardo; Ramasco, Fernando; García-Álvarez, Raquel; González-Lisorge, Ada; Giménez, Maria-José; Suárez-de-la-Rica, Alejandro; HELP Investigators and the Perioperative Infection Research Group (Public Library of Science (PLoS), 2019)

  The concept of healthcare-associated infections (as opposed to hospital-acquired infections) in intraabdominal infections (IAIs) is scarcely supported by data in the literature. The aim of the present study was to analyse ...
• Molecular rescue of Dyrk1A overexpression alterations in mice with Fontup® dietary supplement: role of green tea catechins

  Gu, Yuchen; Moroy, Gautier; Paul, Jean-Louis; Rebillat, Anne-Sophie; Dierssen, Mara; Torre Fornell, Rafael de la; Cieuta-Walti, Cécile; Dairou, Julien; Janel, Nathalie (MDPI, 2020)

  Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have ...
• Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM

  Llauradó Cabot, Gemma; Cano, Albert; Albert, Lara; Ballesta, Silvia; Mazarico, Isabel; Luchtenberg, María-Florencia; González Sastre, Montserrat; Megia, Ana; Simó, Rafael; Vendrell, Joan; González Clemente, José (Public Library of Science (PLoS), 2019)

  Objectives: Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for ...
• Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination

  Hernáez, Álvaro; Soria-Florido, Maria; Schröder, Helmut, 1958-; Ros, Emilio; Pinto, Xavier; Estruch, Ramón; Salas-Salvadó, Jordi; Corella, Dolores; Arós, Fernando; Serra-Majem, Luis; Martínez-González, Miguel A.; Fiol, Miquel; Lapetra, José; Elosua Llanos, Roberto; Lamuela-Raventós, Rosa M.; Fitó Colomer, Montserrat (Public Library of Science (PLoS), 2019)

  Background: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol ...
• Gynecologic and reproductive outcomes in fibrous dysplasia/McCune-Albright Syndrome

  Boyce, Alison M.; Casey, Rachel K.; Ovejero Crespo, Diana; Murdock, Cynthia M.; Estrada, Andrea; Guthrie, Lori C.; Brillante, Beth A.; Gomez-Lobo, Veronica; Nieman, Lynette K.; Collins, Michael T. (BioMed Central, 2019)

  Background: Autonomous ovarian activation with recurrent estrogen-producing cysts is a hallmark feature of the rare bone and endocrine disorder fibrous dysplasia/McCune-Albright syndrome. Precocious puberty in girls with ...
• ScoreInvHap: inversion genotyping for genome-wide association studies

  Ruiz-Arenas, Carlos; Cáceres, Alejandro; López Sánchez, Marcos, 1986-; Tolosana, Ignacio; Pérez Jurado, Luis Alberto; González Ruiz, Juan Ramón (Public Library of Science (PLoS), 2019)

  Polymorphic inversions contribute to adaptation and phenotypic variation. However, large multi-centric association studies of inversions remain challenging. We present scoreInvHap, a method to genotype inversions from SNP ...
• Contribution of trastuzumab to the prognostic improvement of HER2-positive early breast cancer in Spain: an estimation of life years and disease-free life years gained since its approval

  Ciruelos, Eva; Alba, Emilio; López, Rafael; Lluch, Ana; Martín, Miguel; Arroyo, Isabel; Navarro, Beatriz; Carcedo, David; Colomer, Ramon; Albanell Mestres, Joan (Impact Journals, 2019)

  Introduction: Trastuzumab has become the standard treatment for both HER2-positive early and metastatic breast cancer (HER2+ eBC or mBC) since its approval. The objective of the study is to estimate the benefit of adjuvant ...
• Gender differences in cancer risk after kidney transplantation

  Buxeda, Anna; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Bartolomé, Álvaro; Mir Fontana, M. Luisa; Pascual-Dapena, Ana; Sans, Anna; Duran Jordà, Xavier, 1974-; Crespo Barrio, Marta; Pascual Santos, Julio (Impact Journals, 2019)

  Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed ...
• Conventional and molecular cytogenetic studies to characterize 32 complex variant philadelphia translocations in patients with chronic myeloid leukemia

  Costa, Dolors; Grau, Javier; Espinet Solà, Blanca; Arias, Amparo; Gómez, Cándida; López-Guerra, Mónica; Nomdedeu, Meritxell; Cervantes, Francisco (Spandidos Publications, Ltd., 2019)

  BCR/ABL1 gene fusion is the hallmark of chronic myeloid leukemia (CML), and is generated in 5-10% of patients by a variant translocation involving 9q34, 22q11.2 and one or more additional genomic regions. The objective of ...
• LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells

  Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra-Bardenys, Gemma; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, R. A.; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yelamos López, Jose; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)

  Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
• Changes in central 24-h ambulatory blood pressure and hemodynamics 12 months after bariatric surgery: the BARIHTA study

  Oliveras, Anna; Goday Arno, Alberto; Sans Atxer, Laia; Vázquez, Susana; Benaiges Foix, David; Ramón Moros, José Manuel; Pascual Santos, Julio (Springer, 2020)

  Background: Weight loss is associated to blood pressure (BP) reduction in obese patients. There is no information on central 24-h BP changes after bariatric surgery (BS). Methods and results: In this study, we analyzed ...
• Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer

  Hardy-Werbin, Max; Rocha, Pedro P.; Arpí Llucià, Oriol; Taus García, Álvaro; Nonell Mazelón, Lara; Duran Jordà, Xavier, 1974-; Villanueva, Xavier; Joseph-Pietras, Deborah; Nolan, Luke; Danson, Sarah; Griffiths, Richard; López-Botet, M. (Miguel); Rovira Guerín, Ana; Albanell Mestres, Joan; Ottensmeier, Christian; Arriola Aperribay, Edurne (Taylor & Francis, 2019)

  Background. Immunotherapy has shown efficacy in small cell lung cancer (SCLC), but only a subset of patients benefits. Surrogate biomarkers are urgently needed. Our aim was to evaluate serum Th1, Th2, and proinflammatory ...
• Flow sorting enrichment and nanopore sequencing of chromosome 1 from a Chinese individual

  Kuderna, Lukas F.K.; Solís Moruno, Manuel; Batlle Masó, Laura; Julià, Eva; Lizano, Esther; Anglada Busquets, Roger; Ramírez Bautista, Eva; Bote, Alex; Tormo, Marc; Marquès i Bonet, Tomàs, 1975-; Fornas Carreño, Oscar; Casals López, Ferran (Frontiers Media, 2020)

  Sorting of individual chromosomes by Flow Cytometry (flow-sorting) is an enrichment method to potentially simplify genome assembly by isolating chromosomes from the context of the genome. We have recently developed a ...
• Mediterranean alcohol-drinking pattern, low to moderate alcohol intake and risk of atrial fibrillation in the PREDIMED study

  Bazal, P.; Gea, Alfredo; Martínez-González, Miguel Ángel; Salas-Salvadó, Jordi; Asensio, E. M.; Muñoz-Bravo, Carlos; Fiol, Miquel; Muñoz, Miguel Ángel; Lapetra, José; Serra-Majem, Luis; Pinto, Xavier; González, José I.; Becerra-Tomás, Nerea; Fitó Colomer, Montserrat; Ros, Emilio; Alonso-Gómez, Ángel; Ruiz-Canela, Miguel (Elsevier, 2019)

  Background and aims: There is ongoing controversy about the effect of a low to moderate alcohol consumption on atrial fibrillation (AF). Our aim is to assess the association between adherence to a Mediterranean alcohol ...
• Flavonoids and the risk of gastric cancer: an exploratory Case-Control study in the MCC-Spain study

  Vitelli Storelli, Facundo; Kogevinas, Manolis; Martín, Vicente (MDPI, 2019)

  Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the ...

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