• Response to comment on "pancreatoduodenectomy: still an open race for a gold standard?"

  Poves Prim, José Ignacio (Lippincott Williams & Wilkins, 2019)
• Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up

  Fradet, Y.; Bellmunt Molins, Joaquim; Bajorin, D.F. (Elsevier, 2019)

  Background: Novel second-line treatments are needed for patients with advanced urothelial cancer (UC). Interim analysis of the phase III KEYNOTE-045 study showed a superior overall survival (OS) benefit of pembrolizumab, ...
• Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: results of the PURIST study

  Schoepke, Nicole; Giménez Arnau, Anna Maria; Maurer, Marcus (Wiley, 2019)

  Background: Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high-affinity receptor (FcεRI) induces mast ...
• Long-term stroke recurrence after transient ischemic attack: implications of etiology

  Ois Santiago, Angel Javier; Cuadrado Godia, Elisa; Giralt-Steinhauer, Eva; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Rodríguez Campello, Ana María; Avellaneda Gómez, Carla; Cascales Lahoz, Diego; Fernández-Pérez, Isabel; Roquer, Jaume (Korean Stroke Society, 2019)

  Background and purpose: To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. Methods: A prospective cohort of 706 TIA patients ...
• Do we really allow patient decision-making in rotator cuff surgery? a prospective randomized study

  Torrens Cánovas, Carlos; Miquel, J.; Santana Pérez, Fernando (BioMed Central, 2019)

  Background: There is a growing patient interest in being involved in the decision-making process. However, little information is provided on how this information should be structured. Does it make a difference, in patient ...
• Evaluation of the effectiveness of hip and knee implant models used in Catalonia: a protocol for a prospective registry-based study

  Arias-de la Torre, Jorge; Domingo Torrell, Laia; Martínez, Olga; Muñoz, Laura; Robles, Noemí; Puigdomènech, Elisa; Pons-Cabrafiga, Miquel; Pallisó, Francesc; Mora, Xavier; Espallargues, Mireia (BioMed Central, 2019)

  Background: Monitoring results regarding the effectiveness of knee and hip arthroplasties may be useful at the clinical, economic and patient level and help reduce the number of prosthesis revisions. In Spain, and specifically ...
• Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation

  Cantacorps, Lídia; Alfonso-Loeches, Silvia; Guerri, Consuelo; Valverde Granados, Olga (SAGE Publications, 2019)

  Background: Alcohol exposure impairs brain development and leads to a range of behavioural and cognitive dysfunctions, termed as foetal alcohol spectrum disorders. Although different mechanisms have been proposed to ...
• Histone deacetylases inhibitor trichostatin A reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice

  Montagud-Romero, Sandra; Cantacorps, Lídia; Valverde Granados, Olga (SAGE Publications, 2019)

  Background: Alcohol exposure during development has detrimental effects, including a wide range of physical, cognitive and neurobehavioural anomalies known as foetal alcohol spectrum disorders. However, alcohol consumption ...
• A critical time window for recovery extends beyond one-year post-stroke

  Rubio Ballester, Belén; Maier Martina; Maier, Martina; Duff, Amin; Cameirão, Mónica; Bermúdez, Sergi; Duarte Oller, Esther; Cuxart, Ampar; Rodriguez, Susana; San Segundo Mozo, Rosa María; Verschure, Paul F. M. J. (American Physiological Society, 2019)

  The impact of rehabilitation on post-stroke motor recovery and its dependency on the patient's chronicity remain unclear. The field has widely accepted the notion of a proportional recovery rule with a "critical window for ...
• Genetic factors contributing to autism spectrum disorder in Williams-Beuren syndrome

  Codina i Solà, Marta, 1988-; Costa-Roger, Mar; Pérez García, Débora, 1985-; Flores Peirats, Raquel; Palacios Verdú, María Gabriela, 1983-; Cuscó Martí, Ivon, 1973-; Pérez Jurado, Luis Alberto (BMJ Publishing Group, 2019)

  Background: The hallmark of the neurobehavioural phenotype of Williams-Beuren syndrome (WBS) is increased sociability and relatively preserved language skills, often described as opposite to autism spectrum disorders (ASD). ...
• GUILDify v2.0: a tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets

  Aguirre Plans, Joaquim; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)

  The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
• The prognostic Role of hepatic venous pressure gradient in cirrhotic patients undergoing elective extrahepatic surgery

  Reverter Enric; Cirera Lorenzo, Isabel; Albillos, Agustín; Debernardi-Venon, Wilma; Abraldes, Juan G.; Llop, Elba; Flores, Alexandra; Martínez-Palli Graciela; Blasi, Annabel; Martínez, Javier; Turon, Fanny; García-Valdecasas, Juan Carlos; Berzigotti, Annalisa; de Lacy, Antoni M.; Fuster, Josep; Hernández-Gea, Virginia; Bosch Colom, Jaume, 1954-; García-Pagán, Joan Carles (Elsevier, 2019)

  Background & aims: Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal ...
• Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C previously treated with DAAs

  Llaneras, Jordi; Carrión Rodríguez, José Antonio; Buti, María (Elsevier, 2019)

  Background & aims: Around 5% of patients with chronic hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents do not achieve sustained virological response (SVR). The currently approved retreatment ...
• Impact of a riverside accessibility intervention on use, physical activity, and wellbeing: A mixed methods pre-post evaluation

  Vert, Cristina; Carrasco Turigas, Glòria; Zijlema, Wilma; Espinosa Díaz, Ana; Cano-Riu, Lia; Elliott, Lewis R.; Litt, Jill; Nieuwenhuijsen, Mark J.; Gascon Merlos, Mireia, 1984- (Elsevier, 2019)

  Introduction: Access to natural outdoor environments can promote physical activity, social cohesion, and improved psychological well-being. In 2016, an urban riverside regeneration project to facilitate access to the ...
• Colistin for the treatment of urinary tract infections caused by Extremely Drug-resistant pseudomonas aeruginosa: dose is critical

  Sorli Redó, M. Luisa; Luque Pardos, Sònia; Li, Jian; Campillo Ambrós, Núria; Danés, Marc; Montero, Maria Milagro; Montero, Maria Milagro; Segura, Concepción; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Objectives: Optimal dosage regimens of colistin for the treatment of urinary tract infections (UTI) are unknown. Colistimethate sodium (CMS), the inactive prodrug of colistin, is mainly excreted in urine and converts to ...
• Colistin plus meropenem combination is synergistic in vitro Aagainst extensively drug-resistant pseudomonas aeruginosa, including high-risk clones

  Montero, Maria Milagro; Domene Ochoa, Sandra; López-Causapé, Carla; VanScoy, Brian; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Campillo Ambrós, Núria; Padilla, Eduardo; Prim, Núria; Segura, Concepción; Pomar, Virginia; Rivera, Alba; Grau Cerrato, Santiago; Ambrose, Paul G.; Oliver, Antonio; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Background: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (P. aeruginosa) and particularly P. aeruginosa high-risk clones, are of growing concern because treatment options are limited. For years, colistin monotherapy ...
• Parametric finite element model of medial patellofemoral ligament reconstruction model development and clinical validation

  Sanchis-Alfonso, Vicente; Alastruey-López, Diego; Ginovart, Gerard; Montesinos-Berry, Erik; García-Castro, Fabio; Ramirez-Fuentes, Cristina; Monllau García, Juan Carlos; Alberich-Bayarri, Angel; Pérez, María Angeles (Springer, 2019)

  Background: Currently, there is uncertainty regarding the long-term outcome of medial patellofemoral ligament reconstructions (MPFLr). Our objectives were: (1) to develop a parametric model of the patellofemoral joint (PFJ) ...
• Biplane opening wedge high tibial osteotomy with a distal tuberosity osteotomy, radiological and clinical analysis with minimum follow-up of 2 Years

  Erquicia, Juan Ignacio; Gelber, Pablo-Eduardo; Perelli, Simone; Ibañez, Federico; Ibañez, Maximiliano; Pelfort López, Javier; Monllau García, Juan Carlos (Springer, 2019)

  Background: High tibial osteotomy is an established and helpful treatment for unicompatimental osteoarthritis associated with varus deformity. However, asupratubercle high tibial osteotomy leads to a decrease in patellar ...
• Broad consensus on the optimal sequence for the systemic treatment of metastatic breast cancer: results from a survey of spanish medical oncologists

  Sánchez-Rovira, Pedro; Zamora, Pilar; Salvador-Bofill, Javier; Morales, Serafín; Martínez-Jáñez, Noelia; Martínez-de-Dueñas, Eduardo; Lluch, Ana; Illarramendi, José Juan; Gómez-Pardo, Patricia; Gavilá Gregori, Joaquín; García-Palomo, Andrés; García-Mata, Jesús; Fernández, Yolanda; del Barco, Sonia; de Juan, Ana; Ciruelos, Eva; Chacón, José Ignacio; Calvo, Lourdes; Barnadas, A.; Albanell Mestres, Joan (Taylor & Francis, 2019)

  Objective: The aim of this survey conducted by 20 leading Spanish oncologists was to analyze the concurrence between Spanish clinical practice and the recently published definition of the optimal sequence for the systemic ...
• What can public health do for the welfare state? Occupational health could be an answer

  Benavides, Fernando G. (Fernando García); Serra, Consol; Delclos, George L. (BMJ Publishing Group, 2019)

  Background: The welfare state has a long history of uncertain future. Nonetheless, health indicators of people living in countries with a more universal and generous welfare state remain better than those living under less ...

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