• Clinical presentations and outcomes related to tuberculosis in children younger than 2 years of age in Catalonia

  Soriano-Arandes, Antoni; López Segura, María Nuria; Caylà i Busqueras, Joan A. (Frontiers, 2019)

  Introduction: Children younger than 2 years have an increased risk of complications associated with tuberculosis (TB) due to the immaturity of the innate and adaptive immune response. We aimed to identify TB clinical ...
• A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis

  Aterido, Adrià; Cañete Crespillo, Juan de Dios; Tornero, Jesús; Blanco, Francisco; Fernández-Gutiérrez, Benjamín; Pérez-García, Carolina; Alperiz, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González-Alvaro, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López Lasanta, María; López Corbeto, Mireia; Palau, Núria; Marsal, Sara; Julià, Antonio (Frontiers, 2019)

  Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show ...
• COPD: preclinical models and emerging therapeutic targets

  Barreiro Portela, Esther; Wang, Xuejie; Tang, Jun (Informa Healthcare, 2019)

  Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In those models, COPD/emphysema has been commonly ...
• Immunotherapy in non-metastatic urothelial cancer: back to the 'future'

  Darling, H. S.; Bellmunt Molins, Joaquim, 1959- (Taylor & Francis, 2019)

  INTRODUCTION: Successful results of immuno-oncological drugs in metastatic urothelial cancer have triggered the interest of researchers to test them in the non-metastatic setting. Conventional treatment modalities in that ...
• Safe use of immune checkpoint inhibitors in the multidisciplinary management of urological cancer: the european association of urology position in 2019

  Grimm, Marc-Oliver; Bex, Axel; De Santis, Maria; Ljunberg, Börje; Catto, James W.F.; Rouprêt, Morgan; Hussain, Syed; Bellmunt Molins, Joaquim, 1959-; Powles, Thomas; Wirth, Manfred; Van Poppel, Hendrik (Elsevier, 2019)

  Immune checkpoint inhibitors (ICIs) are now used routinely to treat advanced or metastatic urothelial and renal cell carcinoma, among other cancers. Furthermore, multiple trials are currently exploring their role in adjuvant, ...
• Plasma androgen receptor and docetaxel for metastatic castration-resistant prostate cancer

  Conteduca, Vincenza; Rodríguez-Vida, Alejo; De Giorgi, Ugo (Elsevier, 2019)

  Plasma androgen receptor (AR) gain identifies metastatic castration-resistant prostate cancer (mCRPC) patients with worse outcome on abiraterone/enzalutamide, but its relevance in the context of taxane chemotherapy is ...
• Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: results of a cluster randomized controlled trial

  Soler-Font, Mercè; Ramada Rodilla, José María, 1961-; van Zon, Sander K.R.; Almansa, Josué; Bültmann, Ute; Serra, Consol (Public Library of Science (PLoS), 2019)

  Background: Nurses and nursing aides are at high risk of developing musculoskeletal pain (MSP). This study aimed to evaluate a multifaceted intervention to prevent and manage MSP in two hospitals. Material and methods: We ...
• The transcription factor NFAT5 limits infection-induced type I interferon responses

  Huerga Encabo, Hector, 1989-; Traveset, Laia; Argilaguet Marqués, Jordi, 1977-; Angulo, Ana; Nistal-Villán, Estanislao; Jaiswal, Rahul; Escalante, Carlos R.; Gekas, Christos; Meyerhans, Andreas; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2020)

  Type I interferon (IFN-I) provides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hematopoietic stem cell (HSC) exhaustion; therefore, IFN-I expression must be tightly controlled. ...
• ERS statement on respiratory muscle testing at rest and during exercise

  Laveneziana, Pierantonio; Barreiro Portela, Esther; Gea Guiral, Joaquim; Verges, Samuel (European Respiratory Society, 2019)

  Assessing respiratory mechanics and muscle function is critical for both clinical practice and research purposes. Several methodological developments over the past two decades have enhanced our understanding of respiratory ...
• The present and future of deep learning in radiology

  Saba, Luca; Biswas, Mainak; Kuppili, Venkatanareshbabu; Cuadrado Godia, Elisa; Suri, Harman S.; Edla, Damodar Reddy; Omerzu, Tomaž; Laird, John R.; Khanna, Narendra N.; Mavrogeni, Sophie; Protogerou, Athanasios; Sfikakis, Petros P.; Viswanathan, Vijay; Kitas, George D.; Nicolaides, Andrew; Gupta, Ajay; Jasjit S. Suri (Elsevier, 2019)

  The advent of Deep Learning (DL) is poised to dramatically change the delivery of healthcare in the near future. Not only has DL profoundly affected the healthcare industry it has also influenced global businesses. Within ...
• Lipid parameter thresholds: the debate continues

  Grau Magaña, Maria (SAGE Publications, 2019)
• Ultra-early continuous cardiac monitoring improves atrial fibrillation detection and prognosis of patients with cryptogenic stroke

  Cuadrado Godia, Elisa; Benito Villabriga, Begoña; Ois Santiago, Angel Javier; Vallés Gras, Ermengol; Rodríguez-Campello, Ana; Giralt-Steinhauer, Eva; Cabrera Gómez, Sandra; Alcalde Rodríguez, Oscar; Jiménez-López, Jesús; Jiménez Conde, Jordi; Martí-Almor, Julio; Roquer, Jaume (Wiley, 2010)

  Background and purpose: Subclinical atrial fibrillation (AF) is known to underlie a number of cases of cryptogenic stroke (CrS). However, there is need to define the most effective strategy for AF detection. The diagnostic ...
• Acute heart failure and adverse events associated with the presence of renal dysfunction and hyperkalaemia. EAHFE- renal dysfunction and hyperkalaemia

  Jacob, Javier; Llauger, Lluis; Herrero-Puente, Pablo; Martín-Sánchez, Francisco J.; Llorens, Pere; Roset, Alex; Gil, Víctor; Fuentes, Marta; Lucas-Imbernón, Francisco Javier; Miró, Òscar; ICA-SEMES Research Group (Elsevier, 2019)

  Objective: To study the outcomes of patients with acute heart failure (AHF) presenting renal dysfunction (RD) or hyperkalaemia (Hk) alone or in combination. Method: We analysed the data of the EAHFE registry, a multicentre, ...
• Departments involved during the first episode of acute heart failure and subsequent emergency department revisits and rehospitalisations: an outlook through the NOVICA cohort

  Miró, Òscar; Aguirre Tejedo, Alfons; Alquézar, Aitor; ICA-SEMES Research Group (Wiley, 2019)

  Objectives: We investigated the natural history of patients after a first episode of acute heart failure (FEAHF) requiring emergency department (ED) consultation, focusing on: the frequency of ED visits and hospitalisations, ...
• Development and validation of the EspaiJove.net Mental Health Literacy (EMHL) test for spanish adolescents

  Castellvi Obiols, Pere; Casañas, Rocío; Arfuch, Victoria-Mailen; Gil Moreno, Juan José; Torres Torres, María; García Forero, Carlos; Ruiz-Castañeda, Dyanne; Alonso Caballero, Jordi; Lalucat-Jo, Lluís (MDPI, 2019)

  There is evidence of the effectiveness of implementing mental health literacy (MHL) programs. However, there are substantial limitations in the instruments available for measuring MHL. This study aimed to develop and ...
• Anthracycline-induced cardiotoxicity in diffuse large B-cell lymphoma: NT-proBNP and cardiovascular score for risk stratification

  Gimeno Vázquez, Eva; Subirana Cachinero, Isaac; Gómez Pérez, Miguel Angel; Díaz, Javier; Sanchez Gonzalez, Blanca; García-Pallarols, Francesc; Martínez, Laia; Ble, Mireia; Molina Ferragut, Luis; Belarte Tornero, Laia Carla; Abella Monreal, Eugenia; Elosua Llanos, Roberto; Comín Colet, Josep; Salar Silvestre, Antonio (Wiley, 2019)

  OBJECTIVE: To evaluate the role of N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and a cardiovascular (CV) risk score named FRESCO for predicting anthracycline-induced cardiotoxicity (AIC) in diffuse large ...
• Unmet therapeutic, educational and scientific needs in parathyroid disorders: Consensus Statement from the first European Society of Endocrinology Workshop (PARAT)

  Bollerslev, Jens; Schalin-Jäntti, Camilla; Rejnmark, Lars; Siggelkow, Heide; Morreau, Hans; Thakker, Rajesh; Sitges-Serra, Antonio; Cetani, Filomena; Marcocci, Claudio; PARAT Workshop Group (BioScientifica, 2019)

  PARAT, a new European Society of Endocrinology program, aims to identify unmet scientific and educational needs of parathyroid disorders, such as primary hyperparathyroidism (PHPT), including parathyroid cancer (PC), and ...
• Auricular transcutaneous vagus nerve stimulation improves memory persistence in naïve mice and in an intellectual disability mouse model

  Vázquez-Oliver, Anna; Brambilla Pisoni, Cecilia; Domingo-Gainza, Mikel; Maldonado, Rafael, 1961-; Ivorra Cano, Antoni, 1974-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)

  Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous ...
• Extended-pulsed fidaxomicin versus vancomycin in patients 60 years and older with Clostridium difficile infection: cost-effectiveness analysis in Spain

  Rubio-Terrés, Carlos; Aguado, José María; Almirante, Benito; Cobo, Javier; Grau Cerrato, Santiago; Salavert, M.; González Antona Sánchez, Elena; López Gutiérrez, Cristina; Rubio-Rodríguez, Darío (SpringerOpen, 2019)

  The cost of treating Clostridium difficile infection (CDI) in Spain is substantial. Findings from the randomised, controlled, open-label, phase 3b/4 EXTEND study showed that an extended-pulsed fidaxomicin (EPFX) regimen ...
• Efficacy of a nurse-led lipid-lowering secondary prevention intervention in patients hospitalized for ischemic heart disease: A pilot randomized controlled trial

  Ruiz-Bustillo, Sonia; Ivern Díaz, Consol; Badosa Marcé, Neus; Farré López, Núria; Marco Navarro, Ester; Bruguera-Cortada, Jordi; Cladellas Capdevila, M.Mercedes; Enjuanes Grau, Cristina; Cainzos-Achirica, Miguel; Marti-Almor, Julio; Comín Colet, Josep (SAGE Publications, 2019)

  Background and aims: Lack of achievement of secondary prevention objectives in patients with ischaemic heart disease remains an unmet need in this patient population. We aimed at evaluating the six-month efficacy of an ...

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