• A critical time window for recovery extends beyond one-year post-stroke

  Rubio Ballester, Belén; Maier Martina; Maier, Martina; Duff, Amin; Cameirão, Mónica; Bermúdez, Sergi; Duarte Oller, Esther; Cuxart, Ampar; Rodriguez, Susana; San Segundo Mozo, Rosa María; Verschure, Paul F. M. J. (American Physiological Society, 2019)

  The impact of rehabilitation on post-stroke motor recovery and its dependency on the patient's chronicity remain unclear. The field has widely accepted the notion of a proportional recovery rule with a "critical window for ...
• Genetic factors contributing to autism spectrum disorder in Williams-Beuren syndrome

  Codina i Solà, Marta, 1988-; Costa-Roger, Mar; Pérez García, Débora, 1985-; Flores Peirats, Raquel; Palacios Verdú, María Gabriela, 1983-; Cuscó Martí, Ivon, 1973-; Pérez Jurado, Luis Alberto (BMJ Publishing Group, 2019)

  Background: The hallmark of the neurobehavioural phenotype of Williams-Beuren syndrome (WBS) is increased sociability and relatively preserved language skills, often described as opposite to autism spectrum disorders (ASD). ...
• GUILDify v2.0: a tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets

  Aguirre Plans, Joaquim; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)

  The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
• The prognostic Role of hepatic venous pressure gradient in cirrhotic patients undergoing elective extrahepatic surgery

  Reverter Enric; Cirera Lorenzo, Isabel; Albillos, Agustín; Debernardi-Venon, Wilma; Abraldes, Juan G.; Llop, Elba; Flores, Alexandra; Martínez-Palli Graciela; Blasi, Annabel; Martínez, Javier; Turon, Fanny; García-Valdecasas, Juan Carlos; Berzigotti, Annalisa; de Lacy, Antoni M.; Fuster, Josep; Hernández-Gea, Virginia; Bosch Colom, Jaume, 1954-; García-Pagán, Joan Carles (Elsevier, 2019)

  Background & aims: Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal ...
• Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C previously treated with DAAs

  Llaneras, Jordi; Carrión Rodríguez, José Antonio; Buti, María (Elsevier, 2019)

  Background & aims: Around 5% of patients with chronic hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents do not achieve sustained virological response (SVR). The currently approved retreatment ...
• Impact of a riverside accessibility intervention on use, physical activity, and wellbeing: A mixed methods pre-post evaluation

  Vert, Cristina; Carrasco Turigas, Glòria; Zijlema, Wilma; Espinosa Díaz, Ana; Cano-Riu, Lia; Elliott, Lewis R.; Litt, Jill; Nieuwenhuijsen, Mark J.; Gascon Merlos, Mireia, 1984- (Elsevier, 2019)

  Introduction: Access to natural outdoor environments can promote physical activity, social cohesion, and improved psychological well-being. In 2016, an urban riverside regeneration project to facilitate access to the ...
• Colistin for the treatment of urinary tract infections caused by Extremely Drug-resistant pseudomonas aeruginosa: dose is critical

  Sorli Redó, M. Luisa; Luque Pardos, Sònia; Li, Jian; Campillo Ambrós, Núria; Danés, Marc; Montero, Maria Milagro; Montero, Maria Milagro; Segura, Concepción; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Objectives: Optimal dosage regimens of colistin for the treatment of urinary tract infections (UTI) are unknown. Colistimethate sodium (CMS), the inactive prodrug of colistin, is mainly excreted in urine and converts to ...
• Colistin plus meropenem combination is synergistic in vitro Aagainst extensively drug-resistant pseudomonas aeruginosa, including high-risk clones

  Montero, Maria Milagro; Domene Ochoa, Sandra; López-Causapé, Carla; VanScoy, Brian; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Campillo Ambrós, Núria; Padilla, Eduardo; Prim, Núria; Segura, Concepción; Pomar, Virginia; Rivera, Alba; Grau Cerrato, Santiago; Ambrose, Paul G.; Oliver, Antonio; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Background: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (P. aeruginosa) and particularly P. aeruginosa high-risk clones, are of growing concern because treatment options are limited. For years, colistin monotherapy ...
• Parametric finite element model of medial patellofemoral ligament reconstruction model development and clinical validation

  Sanchis-Alfonso, Vicente; Alastruey-López, Diego; Ginovart, Gerard; Montesinos-Berry, Erik; García-Castro, Fabio; Ramirez-Fuentes, Cristina; Monllau García, Juan Carlos; Alberich-Bayarri, Angel; Pérez, María Angeles (Springer, 2019)

  Background: Currently, there is uncertainty regarding the long-term outcome of medial patellofemoral ligament reconstructions (MPFLr). Our objectives were: (1) to develop a parametric model of the patellofemoral joint (PFJ) ...
• Biplane opening wedge high tibial osteotomy with a distal tuberosity osteotomy, radiological and clinical analysis with minimum follow-up of 2 Years

  Erquicia, Juan Ignacio; Gelber, Pablo-Eduardo; Perelli, Simone; Ibañez, Federico; Ibañez, Maximiliano; Pelfort López, Javier; Monllau García, Juan Carlos (Springer, 2019)

  Background: High tibial osteotomy is an established and helpful treatment for unicompatimental osteoarthritis associated with varus deformity. However, asupratubercle high tibial osteotomy leads to a decrease in patellar ...
• Broad consensus on the optimal sequence for the systemic treatment of metastatic breast cancer: results from a survey of spanish medical oncologists

  Sánchez-Rovira, Pedro; Zamora, Pilar; Salvador-Bofill, Javier; Morales, Serafín; Martínez-Jáñez, Noelia; Martínez-de-Dueñas, Eduardo; Lluch, Ana; Illarramendi, José Juan; Gómez-Pardo, Patricia; Gavilá Gregori, Joaquín; García-Palomo, Andrés; García-Mata, Jesús; Fernández, Yolanda; del Barco, Sonia; de Juan, Ana; Ciruelos, Eva; Chacón, José Ignacio; Calvo, Lourdes; Barnadas, A.; Albanell Mestres, Joan (Taylor & Francis, 2019)

  Objective: The aim of this survey conducted by 20 leading Spanish oncologists was to analyze the concurrence between Spanish clinical practice and the recently published definition of the optimal sequence for the systemic ...
• What can public health do for the welfare state? Occupational health could be an answer

  Benavides, Fernando G. (Fernando García); Serra, Consol; Delclos, George L. (BMJ Publishing Group, 2019)

  Background: The welfare state has a long history of uncertain future. Nonetheless, health indicators of people living in countries with a more universal and generous welfare state remain better than those living under less ...
• Real-life data on the effectiveness and safety of omalizumab in monotherapy or combined for chronic spontaneous urticaria: a retrospective cohort study

  Salman, Andac; Ergun, Tulin (Informa Healthcare, 2020)

  Background: The real-life data on the effectiveness and safety of omalizumab in chronic spontaneous urticaria (CSU) with validated methods are scarce. There is also a lack of information on the use of combination ...
• Binimetinib, encorafenib, and cetuximab triplet therapy for patients with BRAF V600E-mutant metastatic colorectal cancer: safety lead-in results from the phase III BEACON colorectal cancer study

  Van Cutsem, Eric; Montagut Viladot, Clara; Tabernero Cartula, Josep (American Society of Clinical Oncology, 2019)

  Purpose: To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastatic colorectal cancer (mCRC) in the safety lead-in phase of the open-label, randomized, ...
• Long daytime napping is associated with increased adiposity and type 2 diabetes in an elderly population with metabolic syndrome

  Papandreou, Christopher; Fitó Colomer, Montserrat; Schröder, Helmut, 1958-; Goday Arno, Alberto; Castañer, Olga; Salas-Salvadó, Jordi (MDPI, 2019)

  Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals ...
• Independent multiple factor association analysis for multiblock data in imaging genetics

  Vilor Tejedor, Natàlia, 1988-; Ikram, Mohammad Arfan; Roshchupkin, Gennady V.; Cáceres, Alejandro; Alemany, Silvia; Vernooij, Meike W.; Niessen, Wiro J.; Duijn, Cornelia M. van; Sunyer Deu, Jordi; Adams, Hieab H.; González Ruiz, Juan Ramón (Springer, 2019)

  Multivariate methods have the potential to better capture complex relationships that may exist between different biological levels. Multiple Factor Analysis (MFA) is one of the most popular methods to obtain factor scores ...
• Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients

  Masana, Luís; Zamora, Alberto; Plana, Nuria; Comas Cufí, Marc; Garcıa-Gil, Maria; Martí, Ruth; Ponjoan, Anna; Alves-Cabratosa, Lia; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; Dégano, Irene R.; Ramos, Rafel (MDPI, 2019)

  In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with ...
• Dynamics of phenotypic heterogeneity associated with EMT and stemness during cancer progression

  Jolly, Mohit Kumar; Celià-Terrassa, Toni (MDPI, 2019)

  Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to genetic heterogeneity, a consequence of mutational ...
• EGFR and KRAS mutations in the non-tumoral lung. Prognosis in patients with adenocarcinoma

  Chalela Rengifo, Roberto José; Bellosillo Paricio, Beatriz; Curull Serrano, Víctor; Longarón Rozalen, Raquel; Pascual Guàrdia, Sergi, 1979-; Badenes Bonet, Diana; Arriola Aperribay, Edurne; Sánchez-Font, Albert; Pijuan Andujar, Lara; Gea Guiral, Joaquim (MDPI, 2019)

  Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout ...
• The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms

  Benito, Natividad; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo (MDPI, 2019)

  The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was ...

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