• A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

  García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)

  The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
• A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)

  We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
• Power and sample size calculations for longitudinal studies comparing rates of change with a time-varying exposure

  Basagaña Flores, Xavier; Liao, Xiaomei; Spiegelman, Donna (Wiley-VCH Verlag, 2010)

  Existing study design formulas for longitudinal studies assume that the exposure is time invariant or that it varies in a manner that is controlled by design. However, in observational studies, the investigator does not ...
• Power and sample size calculations for longitudinal studies estimating a main effect of a time-varying exposure

  Basagaña Flores, Xavier; Spiegelman, Donna (SAGE Publications, 2011)

  Existing study design formulas for longitudinal studies have assumed that the exposure is time-invariant. We derived sample size formulas for studies comparing rates of change by exposure when the exposure varies with time ...
• Diagnostic accuracy of non-melanocytic pink flat skin lesions on the legs: dermoscopic and reflectance confocal microscopy evaluation

  Gómez Martín, Ignacio; Moreno, Sara; Duran Jordà, Xavier; Pujol Vallverdú, Ramon Maria; Segura Tigell, Sonia (Society for Publication of Acta Dermato-Venereologica, 2019)

  Pink flat skin lesions on the legs in elderly people represent a diagnostic challenge due to the paucity of clinical and dermoscopic evidence. A prospective study of 114 pink flat lesions on the legs of 85 elderly patients ...
• A myxoid fibrotic reaction pattern is associated with metastatic risk in cutaneous squamous cell carcinoma

  Hernández-Ruiz, Eugenia; Hernández Muñoz, Inmaculada; Masferrer, Emili; Ferrandiz-Pulido, Carla; Andrades, Evelyn; Gimeno Beltran, Javier; Duran, Xavier; García-Patos, Vicenç; Pujol Vallverdú, Ramon Maria; Toll Abelló, Agustín (Society for Publication of Acta Dermato-Venereologica, 2019)

  Although desmoplasia has been associated with poor prognoses in cutaneous squamous cell carcinoma, little attention has been paid to the patterns of fibrosis. This study aimed to examine the different stromal fibrotic ...
• The effects of co-morbidity in defining major depression subtypes associated with long-term course and severity

  Wardenaar, Klaas J.; Alonso Caballero, Jordi; Kessler, Ronald C. (Cambridge University Press, 2014)

  BACKGROUND: Although variation in the long-term course of major depressive disorder (MDD) is not strongly predicted by existing symptom subtype distinctions, recent research suggests that prediction can be improved by using ...
• Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

  Bousquet, Jean; Antó i Boqué, Josep Maria; Pinart, Mariona; Gergen, Peter J. (Elsevier, 2014)

  Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. More than 130 birth cohorts focusing on asthma and allergy have been initiated ...
• Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys

  McLaughlin, Katie A.; Alonso Caballero, Jordi; Kessler, Ronald C. (Elsevier, 2015)

  BACKGROUND: Although only a few people exposed to a traumatic event (TE) develop posttraumatic stress disorder (PTSD), symptoms that do not meet full PTSD criteria are common and often clinically significant. Individuals ...
• Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

  van der Valk, Ralf J.P.; Cáceres, Alejandro; Sunyer Deu, Jordi; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Elsevier, 2014)

  BACKGROUND: The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood ...
• DSM-5 and ICD-11 definitions of posttraumatic stress disorder: investigating "narrow" and "broad" approaches

  Stein, Dan J.; Alonso Caballero, Jordi; Kessler, Ronald C. (Wiley-VCH Verlag, 2014)

  BACKGROUND: The development of the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and ICD-11 has led to reconsideration of diagnostic criteria for posttraumatic stress disorder (PTSD). The World ...
• Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment

  Curto-Barredo, Laia; Riba Archilla, Laura; Roura Vives, Guillem; Pujol Vallverdú, Ramon Maria; Giménez Arnau, Anna Maria (Society for Publication of Acta Dermato-Venereologica, 2018)

  Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU ...
• Combining Ensemble Learning with a Fragment-Based Topological Approach To Generate New Molecular Diversity in Drug Discovery: In Silico Design of Hsp90 Inhibitors

  Speck-Planche, Alejandro (American Chemical Society (ACS), 2018)

  Machine learning methods have revolutionized modern science, providing fast and accurate solutions to multiple problems. However, they are commonly treated as "black boxes". Therefore, in important scientific fields such ...
• Dual Inhibitors of PARPs and ROCKs

  Antolín Hernández, Albert, 1984-; Mestres i López, Jordi (American Chemical Society (ACS), 2018)

  Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ...
• Cross-pharmacology analysis of G protein-coupled receptors

  Briansó, Ferran; Carrascosa Baena, María Carmen, 1972-; Oprea, Tudor I.; Mestres i López, Jordi (Bentham Science Publishers, 2011)

  The degree of applicability of chemogenomic approaches to protein families depends on the accuracy and completeness of pharmacological data and the corresponding level of pharmacological similarity observed among their ...
• Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain

  Yubero Lahoz, Samanta, 1985-; Ayestas, Mario A.; Blough, Bruce E.; Partilla, John S.; Rothman, Richard B.; Torre Fornell, Rafael de la; Baumann, Michael H. (Elsevier, 2012)

  (±)-3,4-Methylenedioxymethamphetamine (MDMA) is an illicit drug that evokes transporter-mediated release of serotonin (5-HT) in the brain. 5-HT transporter (SERT) proteins are also expressed in non-neural tissues (e.g., ...
• The prevalence and correlates of binge eating disorder in the WHO World Mental Health Surveys

  Kessler, Ronald C.; Alonso Caballero, Jordi; Xavier, Miguel (Elsevier, 2013)

  Background: Little population-based data exist outside the United States on the epidemiology of binge eating disorder (BED). Cross-national BED data are presented here and compared with bulimia nervosa (BN) data in the ...
• Comorbidity of common mental disorders with cancer and their treatment gap: findings from the World Mental Health Surveys

  Nakash, Ora; Alonso Caballero, Jordi; Scott, Kate M. (Wiley-VCH Verlag, 2014)

  OBJECTIVE: This study aimed to study the comorbidity of common mental disorders (CMDs) and cancer, and the mental health treatment gap among community residents with active cancer, cancer survivors and cancer-free respondents ...
• Barriers to mental health treatment: results from the WHO World Mental Health surveys

  Andrade, Laura Helena; Alonso Caballero, Jordi; Kessler, Ronald C. (Cambridge University Press, 2014)

  BACKGROUND: To examine barriers to initiation and continuation of mental health treatment among individuals with common mental disorders. METHOD: Data were from the World Health Organization (WHO) World Mental Health (WMH) ...
• A comparative analysis of role attainment and impairment in binge-eating disorder and bulimia nervosa: results from the WHO World Mental Health Surveys

  Kessler, Ronald C.; Alonso Caballero, Jordi; Xavier, Miguel (Cambridge University Press, 2014)

  BACKGROUND: Cross-national population data from the WHO World Mental Health surveys are used to compare role attainments and role impairments associated with binge-eating disorder (BED) and bulimia nervosa (BN). METHODS: ...

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