• Embracing the dark side: computational approaches to unveil the functionality of genes lacking biological annotation in drug-induced liver injury

  Souza, Terezinha; Panuwat, Trairatphisan; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Saez-Rodriguez, Julio; Kleinjans, Jos; Jennen, Danyel (Frontiers, 2018)

  In toxicogenomics, functional annotation is an important step to gain additional insights into genes with aberrant expression that drive pathophysiological mechanisms. Nevertheless, there exists a gap on annotation of these ...
• Long-term efficacy and effectiveness of a behavioural and community-based exercise intervention (Urban Training) to increase physical activity in patients with COPD: a randomised controlled trial

  Arbillaga-Etxarri, Ane; Gimeno Santos, Elena, 1980-; Balcells Vilarnau, Eva, 1967-; Benet, Marta; Delgado Llobet, Anna; Rodríguez, Diego; Torrent-Pallicer, Jaume; García Aymerich, Judith (European Respiratory Society, 2018)

  There is a need to increase and maintain physical activity in patients with chronic obstructive pulmonary disease (COPD). We assessed 12-month efficacy and effectiveness of the Urban Training intervention on physical ...
• Rectal, central venous, gastric and bladder pressures versus esophageal pressure for the measurement of cough strength: a prospective clinical comparison

  Aguilera, Lluís G.; Gallart Gallego, Lluís; Álvarez, Juan C.; Vallès, Jordi; Gea Guiral, Joaquim (BioMed Central, 2018)

  Background: Cough pressure, an expression of expiratory muscle strength, is usually measured with esophageal or gastric balloons, but these invasive catheters can be uncomfortable for the patient or their placement ...
• Drivers of international variation in prevalence of disabling low back pain: Findings from the Cultural and Psychosocial Influences on Disability study

  Coggon, D.; Vargas-Prada Figueroa, Sergio, 1976 -; Harcombe, H. (Wiley, 2019)

  BACKGROUND: Wide international variation in the prevalence of disabling low back pain (LBP) among working populations is not explained by known risk factors. It would be useful to know whether the drivers of this variation ...
• The Global State of the Genetic Counseling Profession

  Abacan, MaryAnn; Serra Juhé, Clara, 1984-; Wicklund, Catherine (Nature Research, 2019)

  The profession of genetic counseling (also called genetic counselling in many countries) began nearly 50 years ago in the United States, and has grown internationally in the past 30 years. While there have been many papers ...
• Serum albumin is a strong predictor of sepsis outcome in elderly patients

  Arnau-Barrés, Isabel; Güerri Fernández, Roberto; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Vázquez Ibar, Olga; Miralles Basseda, Ramon (Elsevier, 2019)

  The incidence of sepsis is disproportionately higher in elderly adults, and age is an independent predictor of mortality. Retrospective analysis was conducted among patients admitted to the emergency department in a tertiary ...
• Optimising the use of cetuximab in the continuum of care for patients with metastatic colorectal cancer

  Goldberg, Richard M.; Montagut Viladot, Clara; Wainberg, Zev A.; Ronga, Philippe; Audhuy, François; Taieb, Julien; Stintzing, Sebastian; Siena, Salvatore; Santini, Daniele (BMJ Publishing Group, 2018)

  The anti-epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in combination with chemotherapy is a standard of care in the first-line treatment of RAS wild-type (wt) metastatic colorectal cancer (mCRC) ...
• Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort

  Gasull Panadès, Magda; Pumarega Rodríguez, José Antonio; Iglesias Coma, Mar; Kühn, Tilman; Porta Serra, Miquel (Elsevier, 2019)

  BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex ...
• Traffic-related air pollution, APOEε4 status, and neurodevelopmental outcomes among school children enrolled in the BREATHE project (Catalonia, Spain)

  Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; García Esteban, Raquel; Bustamante Pineda, Mariona; Dadvand, Payam; Esnaola, Mikel; Mortamais, Marion; Forns i Guzman, Joan, 1981-; van Drooge, Barend L.; Álvarez Pedrerol, Mar; Grimalt Obrador, Joan; Rivas, Ioar; Querol, Xavier; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of ...
• Evaluation of the impact of ambient temperatures on occupational injuries in Spain

  Martínez Solanas, Èrica, 1982-; López Ruiz, María, 1982-; Wellenius, Gregory A.; Gasparrini, Antoni; Sunyer Deu, Jordi; Benavides, Fernando G.(Fernando García); Basagaña Flores, Xavier (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Extreme cold and heat have been linked to an increased risk of occupational injuries. However, the evidence is still limited to a small number of studies of people with relatively few injuries and with a limited ...
• Evaluating the association between artificial light-at-night exposure and breast and prostate cancer risk in Spain (MCC-Spain study).

  Garcia-Saenz, Ariadna; Espinosa Díaz, Ana; Valentín, Antònia; Castaño Vinyals, Gemma; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time ...
• Common variants at 12q15 and 12q24 are associated with infant head circumference

  Taal, H. Rob; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Estivill, Xavier, 1955-; Jaddoe, Vincent W. V. (Nature Research, 2012)

  To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy ...
• Microorganisms resistant to conventional antimicrobials in acute exacerbations of chronic obstructive pulmonary disease

  Estirado Vera, Cristina; Ceccato, Adrian; Guerrero, Monica; Huerta, Arturo; Cilloniz, Catia; Vilaró, Olivia; Gabarrús, Albert; Gea Guiral, Joaquim; Crisafulli, Ernesto; Soler, Nestor; Torres, Antoni (BioMed Central, 2018)

  Background: Antimicrobial treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains controversial. In some cases AECOPD are caused by microorganisms that are resistant to treatments ...
• Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

  Peremiquel-Trillas, Paula; Tusquets Trias de Bes, Ignacio; Castaño Vinyals, Gemma; Kogevinas, Manolis; Costas, Laura (Elsevier, 2019)

  BACKGROUND: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the ...
• Green and blue spaces and physical functioning in older adults: Longitudinal analyses of the Whitehall II study

  de Keijzer, Carmen; Tonne, Cathryn; Sabia, Severine; Basagaña Flores, Xavier; Valentín, Antònia; Singh-Manoux, Archana; Antó i Boqué, Josep Maria; Alonso Caballero, Jordi; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Dadvand, Payam (Elsevier, 2019)

  There is increasing evidence of the health benefits of exposure to natural environments, including green and blue spaces. The association with physical functioning and its decline at older age remains to be explored. The ...
• Weather and gastrointestinal disease in Spain: A retrospective time series regression study

  Morral, Clara; Martínez Solanas, Èrica, 1982-; Villanueva Belmonte, Cristina; Basagaña Flores, Xavier (Elsevier, 2018)

  BACKGROUND: A few studies in high-income countries have investigated the relationship between ambient temperature and/or precipitation and the occurrence of gastroenteritis. In most of the cases, hot temperatures and heavy ...
• Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly

  Valassi, Elena; García-Giralt, Natalia; Malouf Sierra, Jorge; Crespo, Iris; Llauger, Jaume; Diez Pérez, Adolfo; Webb, Susan M. (BioScientifica, 2019)

  Background Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the ...
• Whole blood storage in CPDA1 blood bags alters erythrocyte membrane proteome

  Al-Thani, Amna Mohamed; Voss, Sven Christian; Al-Menhali, Afnan Saleh; Barcaru, Andrei; Horvatovich, Peter; Al Jaber, Hind; Nikolovski, Zoran; Latiff, Aishah; Georgakopoulos, Costas; Merenkov, Zeyd; Segura Noguera, Jordi; Alsayrafi, Mohammed; Jaganjac, Morana (Hindawi, 2018)

  Autologous blood transfusion (ABT) has been frequently abused in endurance sport and is prohibited since the mid-1980s by the International Olympic Committee. Apart from any significant performance-enhancing effects, the ...
• Response to growth hormone in patients with RNPC3 mutations

  Martos Moreno, Gabriel A.; Travieso-Suárez, Lourdes; Pozo-Román, Jesús; Muñoz-Calvo, María T.; Chowen, Julie A.; Frilander, Mikko J.; Pérez Jurado, Luis Alberto; Hawkins, Federico G.; Argente, Jesús (Wiley-Blackwell, 2018)
• Endovascular treatment of thoracic aortic pseudoaneurysm through a subclavian approach in patient with aortoiliac occlusive disease: a case report

  Paredes-Mariñas, Ezequiel; Llort-Pont, Carme; Castro-Bolance, Francisca; Riambau-Alonso, Vicente (Elsevier, 2018)

  INTRODUCTION: Thoracic endovascular aortic repair (TEVAR) has become the preferred option for treatment of thoracic aortic pathology, but lack of vascular access options is a common contraindication to TEVAR. CASE REPORT: ...

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