• Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study

  Moreno, Gerard; Marín Corral, Judith; Loeches, I. M. (Springer, 2018)

  PURPOSE: To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia. METHODS: Secondary analysis of a ...
• Extremely high levels of vancomycin can cause severe renal toxicity

  Barceló-Vidal, Jaime; Rodríguez García, Eva; Grau Cerrato, Santiago (Dove Medical Press, 2018)

  Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both ...
• Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study

  Sureda Gomila, Antoni; Fumadó Ciutat, Lluis; Ferrer Forés, Montserrat; Garín, O.; Bonet, X.; Mir, M.C.; Abascal, J.M.; Vigués, F.; Cecchini, L.; Suárez Novo, José Francisco (BioMed Central, 2019)

  BACKGROUND: The purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical ...
• Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

  Lytras, Theodoros, 1987-; Kogevinas, Manolis; Carsin, Anne-Elie; Antó i Boqué, Josep Maria; García Aymerich, Judith; Zock, Jan-Paul (BMJ Publishing Group, 2018)

  Background: Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using ...
• DNA methylation in childhood asthma: an epigenome-wide meta-analysis

  Xu, Chengjian; Bustamante Pineda, Mariona; García Aymerich, Judith; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Koppelman, Gerard H. (Elsevier, 2018)

  Background: DNA methylation profiles associated with childhood asthma might provide novel insights into disease pathogenesis. We did an epigenome-wide association study to assess methylation profiles associated with childhood ...
• Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

  Tischer, Christina; Dadvand, Payam; Basagaña Flores, Xavier; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria (Elsevier, 2018)

  Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. Methods: This study ...
• Simulations meet machine learning in structural biology

  Pérez, Adrià; Martínez Rosell, Gerard; De Fabritiis, Gianni (Elsevier, 2018)

  Classical molecular dynamics (MD) simulations will be able to reach sampling in the second timescale within five years, producing petabytes of simulation data at current force field accuracy. Notwithstanding this, MD will ...
• Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial

  Galilea-Zabalza, Iñigo; Zomeño Fajardo, Maria Dolores; Muñoz, Miguel Ángel; Fitó Colomer, Montserrat; PREDIMED-PLUS Study Investigators (Public Library of Science (PLoS), 2018)

  We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring ...
• The role impairment associated with mental disorder risk profiles in the WHO World Mental Health International College Student Initiative

  Alonso Caballero, Jordi; Vilagut Saiz, Gemma, 1975-; Mortier, Philippe; Auerbach, Randy P.; Bruffaerts, Ronny; Cuijpers, Pim; Demyttenaere, Koen; Ebert, David D.; Ennis, Edel; Gutiérrez‐García, Raul A.; Green, Jennifer Greif; Hasking, Penelope; Lee, Sue; Bantjes, Jason; Nock, Matthew K.; Pinder-Amaker, Stephanie; Sampson, Nancy A.; Zaslavsky, Alan M.; Kessler, Ronald C.; WHO WMH‐ICS Collaborators (Wiley, 2018)

  OBJECTIVE: The objective of this study is to assess the contribution of mental comorbidity to role impairment among college students. METHODS: Web-based self-report surveys from 14,348 first-year college students (Response ...
• Cross-cultural adaptation and psychometric evaluation of the early childhood oral health impact scale (ECOHIS) in chilean population

  Zaror, Carlos; Atala-Acevedo, Claudia; Espinoza-Espinoza, Gerardo; Muñoz-Millán, Patricia; Muñoz, Sergio; Martínez-Zapata, María José; Ferrer Forés, Montserrat (BioMed Central, 2018)

  BACKGROUND: The Early Childhood Oral Health Impact Scale (ECOHIS) measures the impact of dental diseases on Oral Health-Related Quality of Life both in children and their families. The aim of this study was to develop a ...
• Prevalence of major depressive disorder and association with personal and socio-economic factors. Results for Spain of the European Health Interview Survey 2014-2015

  Arias-de la Torre, Jorge; Vilagut Saiz, Gemma, 1975-; Martín, Vicente; Molina, Antonio J.; Alonso Caballero, Jordi (Elsevier, 2018)

  Background: Depression is a prevalent and most burdensome mental disorder. The objectives of this study are: to assess the prevalence of major depressive disorder in the adult population of Spain; and to analyse its ...
• Psychotic experiences and general medical conditions: a cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys

  Scott, Kate M.; Alonso Caballero, Jordi; McGrath, John J. (Cambridge University Press, 2018)

  Background: Previous work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent ...
• Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene epigenetically regulated

  Martínez-Calle, Nicolás; Pascual, Marien; Ordóñez, Raquel; San José-Enériz, Edurne; Kulis, Marta; Miranda, Estíbaliz; Guruceaga, Elisabeth; Segura, Víctor; Larráyoz, María José; Bellosillo Paricio, Beatriz; Calasanz, María José; Besses Raebel, Carles; Rifón, José; Martín-Subero, José I.; Agirre, Xabier; Prosper, Felipe (2019)

  In this study we have interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpGs corresponding to 10,253 genes between myelofibrosis ...
• The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2

  Riley , Lisa G.; Arenillas Rocha, Leonor; Fleming, Mark D. (2018)

  YARS2 variants have previously been described in patients with myopathy, lactic acidosis and sideroblastic anemia 2 (MLASA2). YARS2 encodes the mitochondrial tyrosyl-tRNA synthetase, which is responsible for conjugating ...
• Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma

  Recasens-Zorzo, Clara; Arenillas Rocha, Leonor; Calvo Gonzalo, Xavier; Colomo Saperas, Luis Alberto; Roué, Gaël (2019)

  Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested ...
• Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

  Solans, Marta; Gracia Lavedan, Esther; Castaño Vinyals, Gemma; Casabonne, Delphine (2018)

  Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed ...
• bigSCale: an analytical framework for big-scale single-cell data

  Iacono, Giovanni; Mereu, Elisabetta; Guillaumet-Adkins, Amy; Corominas, Roser; Cuscó Martí, Ivon, 1973-; Rodríguez Esteban, Gustavo; Gut, Marta; Pérez Jurado, Luis Alberto; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)

  Single-cell RNA sequencing (scRNA-seq) has significantly deepened our insights into complex tissues, with the latest techniques capable of processing tens of thousands of cells simultaneously. Analyzing increasing numbers ...
• How long are long tandem repeats? a challenge for current methods of whole-genome sequence assembly: the case of satellites in caenorhabditis elegans

  Subirana, Juan A.; Messeguer, Xavier (MDPI, 2018)

  Repetitive genome regions have been difficult to sequence, mainly because of the comparatively small size of the fragments used in assembly. Satellites or tandem repeats are very abundant in nematodes and offer an excellent ...
• Efficacy of sofosbuvir and velpatasvir, with and without ribavirin, in patients with hepatitis C virus genotype 3 infection and cirrhosis

  Esteban, Rafael; Carrión Rodríguez, José Antonio; Buti, María (Elsevier, 2018)

  BACKGROUND & AIMS: In phase 3 trials and real-world settings, smaller proportions of patients with genotype 3 hepatitis C virus (HCV) infection and cirrhosis have a sustained virologic response 12 weeks after treatment ...
• Association between air pollution and rhinitis incidence in two European cohorts

  Burte, Emilie; Carsin, Anne-Elie; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Jacquemin Leonard, Bénédicte (Elsevier, 2018)

  Background: The association between air pollution and rhinitis is not well established. Aim: The aim of this longitudinal analysis was to study the association between modeled air pollution at the subjects' home addresses ...

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