• Methylphenidate attenuates the cognitive and mood alterations observed in mbnl2 knockout mice and reduces mcroglia overexpression

  Ramon-Duaso, Carla; Gener, Thomas; Consegal, Marta; Fernández-Avilés, Cristina; Gallego, Juan José; Castarlenas, Laura; Swanson, Maurice S.; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Puig Velasco, María Victoria; Robledo, Patricia, 1958- (Oxford University Press, 2018)

  Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting muscle and central nervous system (CNS) function. The cellular mechanisms underlying CNS alterations are poorly understood and no useful treatments exist ...
• PharmaTrek: a semantic web explorer for open innovation in multitarget drug discovery

  Carrascosa Baena, María Carmen, 1972-; Massaguer, Oriol L.; Mestres i López, Jordi (Wiley-VCH Verlag, 2012)
• Evolución de la DMO durante el tratamiento con inhibidores de aromatasa y su relación con el gen CYP11A1: estudio prospectivo de la cohorte B-ABLE

  Rodríguez Sanz, Maria, 1984-; Prieto-Alhambra, Daniel; Servitja Tormo, Sonia; Garcia Giralt, Natàlia; Garrigos, L.; Albanell Mestres, Joan; Martinez-García, Maria; González, I.; Martos, Tamara; Díez Pérez, Adolfo; Tusquets Trias de Bes, Ignacio; Nogués Solán, Xavier (Sociedad Española de Investigación Ósea y del Metabolismo Mineral, 2015)

  Objetivos: El objetivo del estudio fue analizar los cambios en la densidad mineral ósea (DMO) a lo largo del tratamiento con inhibidores de aromatasa (IA) en la práctica clínica y evaluar la asociación entre el gen CYP11A1 ...
• Estudio del patrón de expresión de microRNAs en el hueso osteoporótico

  Garcia Giralt, Natàlia; Ugarte Corbalán, Laura de, 1988-; Yoskovitz, Guy; Güerri Fernández, Roberto; Grinberg, Daniel; Nogués Solán, Xavier; Mellibovsky, Leonardo; Balcells, Susana; Díez Pérez, Adolfo (Sociedad Española de Investigación Ósea y del Metabolismo Mineral (SEIOMM), 2016)

  Objetivos: Identificar microRNAs (miRNAs) diferencialmente expresados en muestras óseas con fractura osteoporótica respecto a huesos sanos. Material y métodos: Se extrajo RNA total a partir de hueso trabecular fresco del ...
• The effect of information about the benefits and harms of mammography on women's decision-making: study protocol for a randomized controlled trial

  Carles, Misericòrdia; Martínez-Alonso, Montserrat; Pons, Anna; Pérez-Lacasta, Maria José; Perestelo-Pérez, Lilisbeth; Sala Serra, Maria; Vidal, Carmen; García, Montse; Toledo-Chávarri, Ana; Codern, Núria; Feijoo-Cid, Maria; Romero, Anabel; Pla, Roger; Soler-González, Jorge; Castells, Xavier; Rué, Montserrat; InforMa Group (BioMed Central, 2017)

  BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ...
• Civilians in World War II and DSM-IV mental disorders: results from the World Mental Health Survey Initiative

  Frounfelker, Rochelle; Gilman, Stephen E.; Betancourt, Theresa S.; Aguilar Gaxiola, Sergio; Alonso Caballero, Jordi; Bromet, Evelyn J.; Bruffaerts, Ronny; De Girolamo, Giovanni; Gluzman, Semyon; Gureje, Oye; Karam, Elie G.; Lee, Sing; Lépine, Jean-Pierre; Ono, Yutaka; Pennell, Beth-Ellen; Popovici, Daniela G.; ten Have, Margreet; Kessler, Ronald C.; WHO World Mental Health Survey Collaborators (Springer, 2018)

  PURPOSE: Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected ...
• Role of CRF1 receptor in post-incisional plasma extravasation and nociceptive responses in mice

  Romero, Asunción; García-Carmona, Juan-Antonio; Laorden, María-Luisa; Puig, Margarita M. (Elsevier, 2017)

  The corticotropin-releasing factor (CRF) is involved in a number of physiological functions including pain perception. The purpose of this study was to evaluate the role of CRF1 receptor in the long-lasting post-surgical ...
• Reference values for oxygen saturation from sea level to the highest human habitation in the Andes in acclimatised persons

  Rojas-Camayo, Jose; Mejia, Christian Richard; Callacondo, David; Dawson, Jennifer A.; Posso, Margarita; Galvan, Cesar Alberto; Davila-Arango, Nadia; Bravo, Erick Anibal; Loescher, Viky Yanina; Padilla-Deza, Magaly Milagros; Rojas-Valero, Nora; Velasquez-Chavez, Gary; Clemente, Jose; Alva-Lozada, Guisela; Quispe-Mauricio, Angel; Bardalez, Silvana; Subhi, Rami (BMJ Publishing Group, 2018)

  Oxygen saturation, measured by pulse oximetry (SpO2), is a vital clinical measure. Our descriptive, cross-sectional study describes SpO2 measurements from 6289 healthy subjects from age 1 to 80 years at 15 locations from ...
• Prevalence of asthma-like symptoms with ageing

  Jarvis, Debbie; Antó i Boqué, Josep Maria; Zock, Jan-Paul; Burney, Peter (BMJ Publishing Group, 2016)

  BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy. METHODS: The European Community Respiratory Health Survey ...
• Results of arthroscopic treatment of chondral delamination in femoroacetabular impingement with bone marrow stimulation and BST-CarGel®

  Tahoun, Mahmoud; Shehata, Tamer Aly; Ormazabal, Inmaculada; Mas, Jesús; Sanz, Javier; Tey Pons, Marcos (EDP Sciences, 2017)

  OBJECTIVES: The purpose of this study is to show the preliminary results of using chitosan-based scaffold (BST-CarGel®) with microfracture for treatment of acetabular chondral delamination associated with femoroacetabular ...
• Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis

  Losada-Grande, Eladio; Hawley, Samuel; Soldevila, Berta; Martinez-Laguna, Daniel; Nogués Solan, Francesc Xavier; Díez Pérez, Adolfo; Puig-Domingo, Manel; Mauricio, Dídac; Prieto-Alhambra, Daniel (Nature Publishing Group, 2017)

  Despite normal to high bone mineral density, patients with type 2 diabetes (T2DM) have an increased fracture risk. T2DM medications could partially account for this excess risk. The aim of this study was to assess the ...
• Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia

  Sintas, Cèlia; Carreño, Oriel; Fernández Castillo, Noelia; Corominas, Roser; Vila Pueyo, Marta; Toma, Claudio; Cuenca-León, Ester; Barroeta, Isabel; Roig, Carles; Volpini, Victor; Macaya, Alfons; Cormand, Bru (Nature Publishing Group, 2017)

  Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it ...
• The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index

  Dégano, Irene R.; Marrugat de la Iglesia, Jaume; Grau Magaña, Maria; Salvador-González, Betlem; Ramos, Rafael; Zamora, Alberto; Martí, Ruth; Elosua Llanos, Roberto (Nature Publishing Group, 2017)

  Education and cardiovascular disease (CVD) are inversely associated but the mediating factors have not been totally elucidated. Our aim was to analyze the mediating role of modifiable risk factors. Cohort study using the ...
• Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

  Aiello, Sistiana; Rocchetta, Federica; Longaretti, Lorena; Faravelli, Silvia; Todeschini, Marta; Cassis, Linda, 1977-; Pezzuto, Francesca; Tomasoni, Susanna; Azzollini, Nadi; Mister, Marilena; Mele, Caterina; Conti, Sara; Breno, Matte; Remuzzi, Giuseppe; Noris, Marina; Benigni, Ariela (Nature Publishing Group, 2017)

  We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4+CD25- regulatory T cells (dnIKK2-Treg). ...
• Short and Long-Term Outcomes After Surgical Procedures Lasting for More Than Six Hours

  Cornellà, Natalia; Sancho Insenser, Juan; Sitges-Serra, Antonio (Nature Publishing Group, 2017)

  Long-term all-cause mortality and dependency after complex surgical procedures have not been assessed in the framework of value-based medicine. The aim of this study was to investigate the postoperative and long-term ...
• Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study

  Gómez-Acebo, Inés; Dierssen Sotos, Trinidad; Fernández-Navarro, Pablo; Palazuelos, Camilo; Moreno, Víctor; Aragonés, Núria; Castaño Vinyals, Gemma; Jiménez-Monleón, Jose J.; Ruiz-Cerdá, Jose Luis; Pérez-Gómez, Beatriz; Ruiz Dominguez, José Manuel; Alonso Molero, Jessica; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (Nature Publishing Group, 2017)

  Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors ...
• Defining quantification methods and optimizing protocols for microarray hybridization of circulating microRNAs

  Garcia-Elias Heras, Anna; Alloza, Leonor; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Tajes Orduña, Marta; Curado, Joao; Enjuanes Grau, Cristina; Díaz, Oscar; Bruguera-Cortada, Jordi; Martí-Almor, Julio; Comín Colet, Josep; Benito Villabriga, Begoña (Nature Publishing Group, 2017)

  MicroRNAs (miRNAs) have emerged as promising biomarkers of disease. Their potential use in clinical practice requires standardized protocols with very low miRNA concentrations, particularly in plasma samples. Here we tested ...
• Prognostic impact of CD133 expression in Endometrial Cancer Patients

  Mancebo Moreno, Gemma; Sole-Sedeno, J.M.; Pino, O.; Miralpeix, E.; Mojal, Sergio; Garrigos, L.; Lloveras Rubio, Belen; Navarro Medrano, Pilar; Gibert, Joan; Lorenzo Perez, Marta; Aran, Iris; Carreras Collado, Ramón; Alameda Quitllet, Fransesc (Nature Publishing Group, 2017)

  To assess the impact of CD133 expression on the prognosis of endometrioid endometrial carcinoma (EEC). We retrospectively assessed CD133 expression in tissue microarray of 116 surgically treated FIGO I-III EEC. Tumors with ...
• El tatuaje endoscópico en las neoplasias colorrectales intervenidas vía laparoscópica: una propuesta de marcaje selectivo

  Alonso Gonçalves, Sandra; Pérez Farré, Silvia; Argudo Aguirre, Nuria; Latorraca, José Isaac; Pascual Damieta, Marta; Álvarez González, Marco Antonio; Seoane, Agustín; Barranco Priego, Luis Eugenio; Grande Posa, Luís; Pera Roman, Miguel (Sociedad Española de Patología Digestiva (SEPD), 2018)
• Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia

  Climent Biescas, Elisenda; Pérez-Calahorra, Sofía; Marco-Benedí, Victoria; Plana, Nuria; Sánchez, Rosa; Ros, Emilio; Ascaso Gimilio, Juan Francisco; Puzo, Jose; Almagro, Fátima; Lahoz, Carlos; Civeira, F.; Pedro-Botet, Juan Carlos (Nature Publishing Group, 2017)

  Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess ...

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