• The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients

  Cabrera-Aguilera, Ignacio; Falcones, Bryan; Calvo-Fernández, Alicia; Benito Villabriga, Begoña; Barreiro Portela, Esther; Gea Guiral, Joaquim; Farré, Ramon; Almendros, Isaac; Farré López, Núria (Public Library of Science (PLoS), 2020)

  Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease. The isoproterenol-induced ...
• A randomized trial of deep brain stimulation to the subcallosal cingulate and nucleus accumbens in patients with treatment-refractory, chronic, and severe anorexia nervosa: initial results at 6 months of follow up

  Villalba Martínez, Gloria; Justicia Díaz, Azucena; Salgado Serrano, Purificación; Ginés Miranda, José María; Guardiola, Rocío; Cedrón Castro, Carlos; Polo, María; Delgado-Martínez, Ignacio; Medrano-Martorell, Santiago; Manero, Rosa María; Conesa Bertran, Gerardo; Faus, Gustavo; Grau, Antoni; Elices, Matilde; Pérez Solá, Victor (MDPI, 2020)

  Background: The main objective of this study was to assess the safety and efficacy of deep brain stimulation (DBS) in patients with severe anorexia nervosa (AN). Methods: Eight participants received active DBS to the ...
• Proximal tibiofibular dislocation in a closing-wedge high tibial osteotomy causes lateral radiological gapping of the knee: a prospective randomized study

  Torres Claramunt, Raúl; Sánchez Soler, Juan; Hinarejos Gómez, Pedro Angel; Sala-Pujals, Aleix; Leal Blanquet, Joan; Monllau García, Juan Carlos (MDPI, 2020)

  Background: To determine whether a proximal tibiofibular joint dislocation (TFJD) increases lateral compartment gapping more than a fibular head osteotomy (FHO) during a closing-wedge high tibial osteotomy (CWHTO). The ...
• Insights into the multi-dimensional dynamic landscape of epithelial-mesenchymal plasticity through inter-disciplinary approaches

  Jolly, Mohit Kumar; Celià-Terrassa, Toni (MDPI, 2020)

  Epithelial-mesenchymal transition (EMT), first described by Dr. Elizabeth (Betty) Hay in the 1980s during vertebrate embryonic development [1], has important implications in cancer aggressiveness.
• Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: the REGICOR Study

  Dégano, Irene R.; Camps-Vilaró, Anna; Subirana Cachinero, Isaac; García-Mateo, Nadia; Cidad, Pilar; Muñoz Aguayo, Daniel; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Vila, Joan; Crepaldi, Felipe M.; Gonzalo-Calvo, David de; Llorente-Cortés, Vicenta; Pérez García, María Teresa; Elosua Llanos, Roberto; Fitó Colomer, Montserrat; Marrugat de la Iglesia, Jaume (MDPI, 2020)

  Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine ...
• How do molecular dynamics data complement static structural data of GPCRs

  Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Aranda García, David; Morales Pastor, Adrián; Medel Lacruz, Brian; Selent, Jana (MDPI, 2020)

  G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron ...
• Sources of stress and their associations with mental disorders among college students: results of the World Health Organization World Mental Health Surveys International College Student Initiative

  Karyotaki, Eirini; Cuijpers, Pim; Albor, Yesica; Alonso Caballero, Jordi; Auerbach, Randy P.; Bantjes, Jason; Bruffaerts, Ronny; Ebert, David Daniel; Hasking, Penelope; Kiekens, Glenn; Lee, Sue; McLafferty, Margaret; Mak, Arthur; Mortier, Philippe; Sampson, Nancy A.; Stein, Dan J.; Vilagut Saiz, Gemma, 1975-; Kessler, Ronald C.; WHO World Mental Health Survey Collaborators (Frontiers, 2020)

  The college years are stressful for many students. Identifying the sources of stress and their relative importance in leading to clinically significant emotional problems may assist in the development of targeted stress ...
• Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries

  McGrath, John J.; Alonso Caballero, Jordi; de Jonge, P. (Cambridge University Press, 2020)

  Aims: Epidemiological studies indicate that individuals with one type of mental disorder have an increased risk of subsequently developing other types of mental disorders. This study aimed to undertake a comprehensive ...
• Association between the 2018 WCRF/AICR and the low-risk lifestyle scores with colorectal cancer risk in the Predimed Study

  Barrubés, Laura; Babio, Nancy; Hernández-Alonso, Pablo; Toledo, Estefania; Estruch, Ramón; Ros, Emilio; Fitó Colomer, Montserrat; Alonso-Gómez, Ángel; Fiol, Miquel; Lapetra, José; Serra-Majem, Luis; Pintó Sala, Xavier; Ruiz-Canela, Miguel; Corella, Dolores; Castañer, Olga; Macías-González, Manuel; Salas-Salvadó, Jordi (MDPI, 2020)

  Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other ...
• Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD

  Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Qin, Liyun; Mateu Jiménez, Mercè, 1990-; Duran Jordà, Xavier, 1974-; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)

  Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by ...
• The hippo pathway transducers YAP1/TEAD induce acquired resistance to trastuzumab in HER2-Positive breast cancer

  González-Alonso, Paula; Arpí Llucià, Oriol; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (MDPI, 2020)

  Trastuzumab is the first-line targeted therapeutic drug for HER2-positive breast cancer, leading to improved overall survival. However, acquired resistance inevitably occurs. We aimed to identify, quantify, and assess the ...
• Ethnic disparities in hospitalisation for COVID-19 in England: The role of socioeconomic factors, mental health, and inflammatory and pro-inflammatory factors in a community-based cohort study

  Lassale, Camille; Gaye, Bamba; Hamer, Mark; Gale, Catharine R.; Batty, G. David (Elsevier, 2020)

  Background: Differentials in COVID-19 hospitalisations and mortality according to ethnicity have been reported but their origin is uncertain. We examined the role of socioeconomic, mental health, and pro-inflammatory factors ...
• Health inequity in workers of Latin America and the Caribbean

  Silva Peñaherrera, Michael; López Ruiz, María, 1982-; Merino Salazar, Pamela Alexandra, 1978-; Gómez García, Antonio Ramón; Benavides, Fernando G. (Fernando García) (BioMed Central, 2020)

  Background: Latin America and the Caribbean (LAC) is the world's most inequitable region in terms of wealth distribution. The full scale of social inequalities in health has been hidden by the lack of reliable data. This ...
• A demonstration project of Global Alliance against Chronic Respiratory Diseases: Prediction of interactions between air pollution and allergen exposure-the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach

  Sofiev, Mikhail; Bédard, Annabelle, 1986-; Basagaña Flores, Xavier; Antó i Boqué, Josep Maria; Bousquet, Jean (Wolters Kluwer (LWW), 2020)

  This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers. For decades, information available for the patients and allergologists consisted of pollen counts, which ...
• Catalonia Suicide Risk Code Epidemiology (CSRC-Epi) study: protocol for a population-representative nested case-control study of suicide attempts in Catalonia, Spain

  Mortier, Philippe; Vilagut Saiz, Gemma, 1975-; Puértolas Gracia, Beatriz; De Inés Trujillo, Ana; Alayo, Itxaso; Ballester, Laura; Blasco Cubedo, Maria Jesús; Elices, Matilde; Gómez Sánchez, Javier; Martín Sánchez, Mario; Pérez Solá, Victor; Alonso Caballero, Jordi; CODIRISC Epidemiology Study Group (BMJ Publishing Group, 2020)

  Introduction: Suicide attempts represent an important public health burden. Centralised electronic health record (EHR) systems have high potential to provide suicide attempt surveillance, to inform public health action ...
• Chronic pain after groin hernia repair: pain characteristics and impact on quality of life

  Bande, David; Moltó, Luis; Pereira Rodríguez, José Antonio; Montes Pérez, Antonio (BioMed Central, 2020)

  Background: Chronic postsurgical pain (CPSP) after hernia repair research has mainly relied on unconfirmed self-reporting. We aimed to describe confirmed CPSP incidence, management, and quality of life (QoL) in a 2-year ...
• The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

  Krebs, Alice; Pastor Maeso, Manuel; Leist, Marcel (Springer, 2020)

  Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is ...
• Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality

  Scott, Kate M.; Alonso Caballero, Jordi; de Jonge, P.; World Mental Health Surveys collaborators (Cambridge University Press, 2020)

  Aims: Intermittent explosive disorder (IED) is characterised by impulsive anger attacks that vary greatly across individuals in severity and consequence. Understanding IED subtypes has been limited by lack of large, general ...
• The LifeCycle Project-EU child cohort network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

  Jaddoe, Vincent W. V.; Sunyer Deu, Jordi; Duijts, Liesbeth; LifeCycle Project Group (SpringerOpen, 2020)

  Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, ...
• Omalizumab updosing in chronic spontaneous urticaria: an overview of Real-World Evidence

  Metz, Martin; Vadasz, Zahava; Kocatürk, Emek; Giménez Arnau, Anna Maria (SpringerOpen, 2020)

  Chronic spontaneous urticaria (CSU) is defined as the spontaneous development of itchy hives and/or angioedema due to known or unknown causes that last for at least 6 weeks. At any given time, CSU is believed to affect ...

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