• Genetic and epigenetic regulation of YKL-40 in childhood

  Guerra, Stefano; Sunyer Deu, Jordi; Lavi, Iris; Benet, Marta; Bustamante Pineda, Mariona; Carsin, Anne-Elie; Dobaño, Carlota; Guxens Junyent, Mònica; Tischer, Christina; Vrijheid, Martine; Antó i Boqué, Josep Maria; Koppelman, Gerard H. (Elsevier, 2018)

  Background: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients with several diseases, including ...
• The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model

  Ramon, Maria Antonia; Ter Riet, Gerben; Carsin, Anne-Elie; Gimeno Santos, Elena, 1980-; Agustí, Alvar; Antó i Boqué, Josep Maria; Donaire González, David; Ferrer, Jaume; Rodríguez, Esther; Rodríguez Roisin, Robert; Puhan, Milo A.; García Aymerich, Judith (European Respiratory Society, 2018)

  The vicious circle of dyspnoea-inactivity has been proposed, but never validated empirically, to explain the clinical course of chronic obstructive pulmonary disease (COPD). We aimed to develop and validate externally a ...
• Epigenome-wide meta-analysis of DNA methylation and childhood asthma

  Reese, Sarah E.; Ruiz Arenas, Carlos, 1990-; Antó i Boqué, Josep Maria; London, Stephanie J. (Elsevier, 2019)

  Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. OBJECTIVE: We sought to identify differential ...
• Screen-detected and interval colorectal cancers in England: Associations with lifestyle and other factors in women in a large UK prospective cohort

  Blanks, Roger; Buron Pust, Andrea; Alison, Rupert; He, Emily; Barnes, Isobel; Patnick, Julietta; Reeves, Gillian K.; Floud, Sarah; Beral, Valerie; Green, Jane (Wiley, 2019)

  Faecal occult blood (FOB) - based screening programmes for colorectal cancer detect about half of all cancers. Little is known about individual health behavioural characteristics which may be associated with screen-detected ...
• Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

  Bueno, Clara; Calero-Nieto, Fernando J.; Wang, Xiaonan; Valdés-Mas, Rafael; Gutiérrez-Agüera, Francisco; Roca-Ho, Heleia; Ayllon, Veronica; Real, Pedro J.; Arambilet, David; Espinosa Blay, Lluís; Torres-Ruiz, Raul; Agraz-Doblas, Antonio; Varela, Ignacio; de Boer, Jasper; Bigas Salvans, Anna; Gottgens, Bertie; Marschalek, Rolf; Menéndez, Pablo (Ferrata Storti Foundation, 2019)

  The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the ...
• Análisis de los problemas relacionados con los medicamentos en un hospital de tercer nivel de Barcelona

  Ferránzez Quirante, Olivia; Casañ, Borja; Grau Cerrato, Santiago; Louro, Javier; Salas Sanchez, Esther; Castells, Xavier; Sala Serra, Maria (Elsevier, 2019)

  OBJECTIVE: To describe drug-related problems identified in hospitalized patients and to assess physicians' acceptance rate of pharmacists' recommendations. METHODS: Retrospective observational study that included all ...
• Narrow band imaging and white light endoscopy in the characterization of a polypectomy scar: A single-blind observational study

  Riu Pons, Fausto; Andreu García, Montserrat; Gimeno Beltran, Javier; Álvarez-González, Marco Antonio; Seoane, Agustín; Dedeu Cusco, Josep Maria; Barranco Priego, Luis Eugenio; Bessa Caserras, Xavier (Baishideng Publishing Group, 2018)

  AIM: To assess the incremental benefit of narrow band imaging (NBI) and white light endoscopy (WLE), randomizing the initial technique for the detection of residual neoplasia at the polypectomy scar after an endoscopic ...
• Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study

  Maurer, Marcus; Houghton, K.; Costa, C.; Dabove, F.; Ensina, L.F.; Giménez Arnau, Anna Maria; Guillet, G.; Konstantinou, G.N.; Labrador-Horrillo, M.; Lapeere, H.; Meshkova, R.; Pastorello, E.A.; Velásquez-Lopera, M.; Tamayo Quijano, L.M.; Tamayo Quijano, L.M.; Vestergaard, C.; Chapman-Rothe, N. (Elsevier, 2018)

  BACKGROUND: Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America ...
• Assessing green gentrification in historically disenfranchised neighborhoods: a longitudinal and spatial analysis of Barcelona

  Anguelovski, Isabelle; Connolly, James; Masip, Laia; Pearsall, Hamil (Taylor & Francis, 2018)

  To date, little is known about the extent to which the creation of municipal green spaces over an entire city addresses social or racial inequalities in the distribution of environmental amenities – or whether such an ...
• Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial

  Carot, Laura; Castells, Antoni; Hernández Rodríguez, Cristina; Alvarez-Urturi, Ana Cristina; Balaguer, Francesc; Lanas, Angel; Cubiella, Joaquı́n; Tasende, Jose D.; Jover, Rodrigo; Hernandez, Vicent; Carballo, Fernando; Bujanda, Luis; Quintero, Enrique; Andreu García, Montserrat; Bessa Caserras, Xavier; ColonPrev study (SAGE Publications, 2018)

  BACKGROUND: The diagnostic yield of the faecal immunochemical test and sigmoidoscopy in detecting proximal serrated polyps in a colorectal cancer screening programme has not been fully assessed. AIM: We determined the ...
• Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study

  Knolle, Franziska; Ermakova, Anna O.; Justicia Díaz, Azucena; Fletcher, Paul C.; Bunzeck, Nico; Düzel, Emrah; Murray, Graham K. (Nature Research, 2018)

  Abnormal salience processing has been suggested to contribute to the formation of positive psychotic symptoms in schizophrenia and related conditions. Previous research utilising reward learning or anticipation paradigms ...
• Changes in the lipid profile 5 years after bariatric surgery: laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy

  Climent Biescas, Elisenda; Benaiges Foix, David; Flores-Le-Roux, Juana Antonia; Ramón Moros, José Manuel; Pedro-Botet, Juan Carlos; Goday Arno, Alberto (Elsevier, 2018)

  BACKGROUND: Few studies have compared mid-term results of laparoscopic Roux-en-Y gastric bypass (LRYGB) versus laparoscopic sleeve gastrectomy (LSG), and none have focused on lipid profile. OBJECTIVES: To compare LRYGB ...
• Prospective study of shoulder strength, shoulder range of motion, and lymphedema in breast cancer patients from pre-surgery to 5 years after ALND or SLNB

  Belmonte Martinez, Roser; Messaggi-Sartor, Monique, 1984-; Ferrer Forés, Maria Montserrat; Pont Acuña, Àngels; Escalada, Ferran (Springer, 2018)

  OBJECTIVE: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) METHOD: ...
• Synthesis of steroid bisglucuronide and sulfate glucuronide reference materials: Unearthing neglected treasures of steroid metabolism

  Pranata, Andy; Fitzgerald, Christopher C.; Khymenets, Olha, 1974-; Westley, Erin; Anderson, Natasha J.; Ma, Paul; Pozo Mendoza, Óscar J., 1975-; McLeod, Malcolm D. (Elsevier, 2019)

  Doubly or bisconjugated steroid metabolites have long been known as minor components of the steroid profile that have traditionally been studied by laborious and indirect fractionation, hydrolysis and gas chromatography-mass ...
• Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations

  Barrios Barrera, Clara; Otero, Sol; Rodríguez García, Eva; Pedro-Botet, Juan Carlos; Pascual Santos, Julio; Menni, Cristina (Nature Research, 2018)

  Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent ...
• Weighted multi-marker genetic risk scores for incident coronary heart disease among individuals of african, latino and east-asian ancestry

  Iribarren, Carlos; Lu, Meng; Jorgenson, Eric; Martínez, Manuel; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Eduardo; Elosua Llanos, Roberto (Nature Research, 2018)

  We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. ...
• Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study

  Maldonado-Araque, Cristina; Goday Arno, Alberto; Rojo-Martínez, Gemma (Nature Research, 2018)

  Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free ...
• Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density

  Martínez-Gil, Núria; Roca Ayats, Neus; Monistrol-Mula, Anna; García-Giralt, Natalia; Diez Pérez, Adolfo; Nogués Solan, Francesc Xavier; Mellibovsky, Leonardo; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)

  Numerous GWAS and candidate gene studies have highlighted the role of the Wnt pathway in bone biology. Our objective has been to study in detail the allelic architecture of three Wnt pathway genes: WNT16, DKK1 and SOST, ...
• Leukocyte Tracking Database, a collection of immune cell tracks from intravital 2-photon microscopy videos

  Pizzagalli, Diego Ulisse; Sintes, Jordi; Fernández González, Santiago (Nature Research, 2018)

  Recent advances in intravital video microscopy have allowed the visualization of leukocyte behavior in vivo, revealing unprecedented spatiotemporal dynamics of immune cell interaction. However, state-of-the-art software ...
• Validation of a score to identify inpatients at risk of a drug-related problem during a 4-year period

  Ferránzez Quirante, Olivia; Grau Cerrato, Santiago; Urbina, Olatz; Mojal, Sergio; Riu Camps, Marta; Salas Sanchez, Esther (Elsevier, 2018)

  OBJECTIVE: Drug-related problems (DRP) produce high morbidity and mortality. It is therefore essential to identify patients at higher risk of these events. This study aimed to validate a DRP risk score in a large number ...

View more