• Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors

  Antolín Hernández, Albert, 1984-; Mestres i López, Jordi (Impact Journals, 2014)

  PARP inhibitors hold promise as a novel class of targeted anticancer drugs. However, their true mechanism of action is still not well understood following recent reports that show marked differences in cellular effects. ...
• Alteraciones del olfato en la COVID-19, revisión de la evidencia e implicaciones en el manejo de la pandèmia

  Lop Gros, Joan; Iglesias Coma, Mar; González-Farré, Mónica; Serra, Consol (Elsevier, 2020)

  Existe debate sobre si las alteraciones en el olfato deberían considerarse un síntoma de la COVID-19. Se realizó una revisión sistemática bibliográfica de los artículos indexados en PubMed sobre alteraciones del olfato en ...
• Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

  Kos, Zuzana; Comerma Blesa, Laura, 1983-; Salgado, Roberto; International Immuno-Oncology Biomarker Working Group (Nature Research, 2020)

  Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible ...
• Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model: a development and validation study

  Reijnen, Casper; Mancebo Moreno, Gemma; Pijnenborg, Johanna M.A. (Public Library of Science (PLoS), 2020)

  Background: Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical ...
• Tenosynovial giant cell tumor mimicking an ankle monoarthritis

  Vílchez-Oya, Francisco; Pros Simón, Ana (AVES, 2020)
• COVID-19 in elderly kidney transplant recipients

  Crespo Barrio, Marta; Pérez-Sáez, María José; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Montero, Maria Milagro; Villar García, Judit; Arias Cabrales, Carlos Enrique; Burballa Tarrega, Carla Cristina; Vázquez, Susana; Mir, Marisa; Sierra Ochoa, Adriana; Collado Nieto, Silvia; Barrios Barrera, Clara; Rodriguez García, Eva; Sans Atxer, Laia; Barbosa Puig, Francisco; Cao Baduell, Higinio; Arenas Jiménez, María Dolores; Güerri Fernández, Roberto; Horcajada Gallego, Juan Pablo; Pascual Santos, Julio (Wiley, 2020)

  The SARS-Cov-2 infection disease (COVID-19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March 12 until April 4, 2020, we diagnosed COVID-19 in 16 of our 324 ...
• Adaptación lingüística y cultural al español del cuestionario para el cribaje deartritis psoriásica ‘cuestionario PURE-4’

  Belinchón, I.; Queiro, R.; Salgado-Boquete, L.; López-Ferrer, Anna; Ferran Farrés, Marta; Coto-Segura, P.; Rivera, R.; Vidal, David; Rodríguez, L.; Cueva, Pablo de la; Guinea, G.; Martín Vázquez, V. (Elsevier, 2020)

  Resumen. Antecedentes y objetivo: El cuestionario 4-item Psoriatic arthritis UnclutteRed screening Evaluation (PURE-4) puede considerarse una herramienta útil para identificar pacientes con posible artritis psoriásica y ...
• Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population

  Khamlaoui, Wided; Mehri, Sounira; Hammami, Sonia; Elosua Llanos, Roberto; Hammami, Mohamed (SAGE Publications, 2020)

  Objective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched ...
• Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

  Rovida, Costanza; Pastor Maeso, Manuel; Hartung, Thomas (ALTEX, 2020)

  Read-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case studies to probe general applicability of RAx, ...
• Cirugía de la pared abdominal después del SARS-CoV-2: ¿es hora de restablecer los procedimientos no esenciales pospuestos?

  López Cano, Manuel; Saludes Serra, Judit; Rosselló Jiménez, Daniel; Pereira Rodríguez, José Antonio; Rodrigues Gonçalves, Victor; García Alamino, Josep M. (Elsevier, 2020)

  La pandemia por el COVID-19 nos ha encontrado desprotegidos ante la dificultad para dar una respuesta sanitaria adecuada y rápida. La red de hospitales del sistema sanitario público ha dispuesto la mayoría de los recursos ...
• RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis

  Sánchez Molina, Sara; Figuerola, Elisabeth; Blanco, Enrique; Sánchez Jiménez, María; Táboas, Pablo; Gómez, Soledad; Ballaré, Cecilia Julia; García-Domínguez, Daniel J.; Prada, Estela; Hontecillas-Prieto, Lourdes; Carcaboso, Angel M.; Tirado, Oscar M.; Hernández Muñoz, Inmaculada; Alava, Enrique de; Lavarino, Cinzia; Di Croce, Luciano; Mora, Jaume (American Association for the Advancement of Science (AAAS), 2020)

  Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of ...
• Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

  Vogelezang, Suzanne; Vilor Tejedor, Natàlia, 1988-; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Felix, Janine Frédérique (Public Library of Science (PLoS), 2020)

  The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...
• Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children

  Aguilar Lacasaña, Sofía; Vilor Tejedor, Natàlia, 1988-; Jansen, Philip R.; López Vicente, Mònica, 1988-; Bustamante Pineda, Mariona; Burgaleta Díaz, Miguel, 1981-; Sunyer Deu, Jordi; Alemany, Silvia (Cambridge University Press, 2020)

  Background: Attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim ...
• COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms

  Ostaszewski, Marek; Furlong, Laura I., 1971-; Schneider, Reinhard (Nature Research, 2020)

  Researchers around the world join forces to reconstruct the molecular processes of the virus-host interactions aiming to combat the cause of the ongoing pandemic.
• Situación de la infección por SARS-CoV-2 en pacientes en tratamiento renal sustitutivo. Informe del Registro COVID-19 de la Sociedad Española de Nefrología (SEN)

  Sánchez-Álvarez, Emilio; Pérez-Fontán, Miguel; Jiménez Martín, Carlos; Blasco Pelícano, Miquel; Cabezas Reina, Carlos Jesús; Sevillano Prieto, Ángel M.; Melilli, Edoardo; Crespo Barrio, Marta; Macía-Heras, Manuel; Pino-Pino, María Dolores (SpringerOpen, 2020)

  Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due ...
• Mortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study

  Sánchez-Rodríguez, María Dolores; Locquet, Médéa; Reginster, Jean-Yves; Cavalier, Etienne; Bruyère, Olivier; Beaudart, Charlotte (Wiley, 2020)

  Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently launched by consensus of the major nutrition societies. GLIM criteria are partly constructed on the previous definition of ...
• Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

  Trebicka, Jonel; Cañete Hidalgo, Nuria; Bañares, Rafael; International Variceal Bleeding Observational Study Group and Baveno Cooperation (Elsevier, 2020)

  Background & aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, ...
• Manejo de la epidemia por coronavirus SARS-CoV-2 (COVID-19) en unidades de hemodiálisis

  Arenas Jiménez, María Dolores; Villar García, Judit; González Juanes, Cristina; Cao Baduell, Higinio; Collado Nieto, Silvia; Crespo Barrio, Marta; Horcajada Gallego, Juan Pablo; Pascual Santos, Julio (Elsevier, 2020)

  La epidemia de SARS-CoV-2 representa un riesgo especial para los pacientes renales por su condición de personas con comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas. ...
• Climate change, air pollution, and allergic respiratory diseases: a call to action for health professionals

  Deng, Shi-Zhou; Jalaludin, Bin B.; Antó i Boqué, Josep Maria; Hess Jeremy J.; Huang, Cun-Rui (Wolters Kluwer (LWW), 2020)

  Rising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air quality. The increased prevalence of allergic airway disease worldwide can be partially ...
• Quality of life benefits of urban rooftop gardening for people with intellectual disabilities or mental health disorders

  Triguero Mas, Margarita, 1985-; Anguelovski, Isabelle; Cirac-Claveras, Judith; Connolly, James; Vázquez, Ana; Urgell Plaza, Ferran; Cardona Giralt, Núria; Sanyé Mengual, Esther; Alonso Caballero, Jordi; Cole, Helen (Centers for Disease Control and Prevention, 2020)

  Background: The number of urban community gardens, including those on rooftops, is increasing. However, few studies have explored the benefits of these gardens for people with intellectual disabilities or mental health ...

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