• Gene expression study and pathway analysis of histological subtypes of intestinal metaplasia that progress to gastric cancer

  Companioni, Osmel; Sanz-Anquela, José Miguel; Pardo, María Luisa; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; García, Nadia; Parra Blanco, Verónica; López, Consuelo; Andreu, Victoria; Cuatrecasas, Miriam; Garmendia, Maddi; Gisbert, Javier P.; González Svatetz, Carlos Alberto; Sala, Núria (Public Library of Science (PLoS), 2017)

  BACKGROUND: Intestinal metaplasia (IM) is a precursor lesion that precedes gastric cancer (GC). There are two IM histological subtypes, complete (CIM) and incomplete (IIM), the latter having higher progression rates to ...
• Evaluation of machine learning algorithms and structural features for optimal MRI-based diagnostic prediction in psychosis

  Salvador, Raymond; Radua, Joaquim; Canales-Rodrıguez, Erick J.; Solanes, Aleix; Sarro, Salvador; Goikolea, J.M.; Valiente Gómez, Alicia; Monte, Gemma; Natividad, Marıa del Carmen; Guerrero-Pedraza, Amalia; Moro, Noemí; Fernandez-Corcuera, Paloma; Amann, Benedikt Lorenz; Maristany, Teresa; Vieta, Eduard; McKenna, Peter J.; Pomarol-Clotet, Edith (Public Library of Science (PLoS), 2017)

  A relatively large number of studies have investigated the power of structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few of them have also ...
• Evolution of acute hepatitis C virus infection in a large European city: Trends and new patterns

  Garriga, César; Manzanares-Laya, Sandra; García de Olalla, Patrícia; Gorrindo, Pilar; Lens, Sabela; Solà Lamoglia, Ricard; Martínez-Rebollar, María; Laguno, Montserrat; Navarro, Jordi; Torras, Xavier; Gurguí, Mercé; Barberá, María Jesús; Quer Sivila, Josep; Masdeu, Eva; Simón, Pere; Ros, Miriam; Andrés, Anna de; Caylà i Busqueras, Joan A. (Public Library of Science (PLoS), 2017)

  The aims of this study were to describe the evolution of acute hepatitis C virus (HCV) infections since 2004 and to determine its associated factors. Acute HCV infections diagnosed in Barcelona from 2004 to 2015 were ...
• Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses

  Sultana, Janet; Calabro, Marco; Garcia-Serna, Ricard; Ferrajolo, Carmen; Crisafulli, Concetta; Mestres i López, Jordi; Trifiró, Gianluca (Public Library of Science (PLoS), 2017)

  INTRODUCTION: Antipsychotic (AP) safety has been widely investigated. However, mechanisms underlying AP-associated pneumonia are not well-defined. AIM: The aim of this study was to investigate the known mechanisms of ...
• Development and validation of a protocol for optimizing the use of paraffin blocks in molecular epidemiological studies: The example from the HPV-AHEAD study

  Mena, Marisa; Lloveras Rubio, Belen; Tous, Sara; Bogers, Johannes; Maffini, Fausto; Gangane, Nitin; Kumar, Rekha Vijay; Somanathan, Thara; Lucas, Eric; Anantharaman, Devasena; Gheit, Tarik; Castellsagué, Xavier; Pawlita, Michael; Sanjosé Llongueras, Silvia de; Alemany, Laia; Tommasino, Massimo; HPV-AHEAD study group (Public Library of Science (PLoS), 2017)

  Worldwide use of formalin-fixed paraffin-embedded blocks (FFPE) is extensive in diagnosis and research. Yet, there is a lack of optimized/standardized protocols to process the blocks and verify the quality and presence of ...
• Improving the therapeutic relationship in inpatient psychiatric care: Assessment of the therapeutic alliance and empathy after implementing evidence-based practices resulting from participatory action research

  Moreno-Poyato, Antonio Rafael; Delgado-Hito, Pilar; Suárez-Pérez, Raquel; Lluch-Canut, Teresa; Roldán-Merino, Juan F.; Montesó-Curto, Pilar (Wiley, 2018)

  PURPOSE: To examine how evidence about the therapeutic alliance gleaned from participatory action project affected the level of this alliance and the degree of empathy of psychiatric nurses. DESIGN AND METHODS: Quasi-experimental ...
• Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGFα) as a potential biomarker of consumption and dual diagnosis

  Maza-Quiroga, Rosa; García-Marchena, Nuria; Romero-Sanchiz, Pablo; Barrios, Vicente; Pedraz, María; Serrano, Antonia; Nogueira-Arjona, Raquel; Ruiz, Juan Jesus; Soria, Maribel; Campos Cloute, Rafael; Chowen, Julie A.; Argente, Jesús; Torrens, Marta; López-Gallardo, Meritxell; Marco, Eva María; Rodríguez de Fonseca, Fernando; Pavón, Francisco Javier; Araos, Pedro Fernando (PeerJ open, 2017)

  BACKGROUND: Cocaine use disorder (CUD) is a complex health condition, especially when it is accompanied by comorbid psychiatric disorders (dual diagnosis). Dual diagnosis is associated with difficulties in the stratification ...
• Dietary flavonoids of Spanish youth: intakes, sources, and association with the Mediterranean diet

  Bawaked, Rowaedh Ahmed; Schröder, Helmut, 1958-; Ribas Barba, Lourdes; Cárdenas, Gabriela; Peña-Quintana, Luis; Pérez Rodrigo, Carmen; Fitó Colomer, Montserrat; Serra Majem, Lluís (PeerJ open, 2017)

  BACKGROUND: Plant-based diets have been linked to high diet quality and reduced risk of cardiovascular diseases. The health impact of plant-based diets might be partially explained by the concomitant intake of flavonoids. ...
• Brain imaging of pain sensitization in patients with knee osteoarthritis

  Pujol Martí, Jesús; Martínez-Vilavella, Gerard; Llorente-Onaindia, J.; Harrison, Ben J.; López-Solà, Marina; Blanco-Hinojo, L.; Benito Ruiz, Pedro; Deus, Joan; Monfort Faure, Jorge (Elsevier, 2017)

  A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional magnetic resonance ...
• Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence

  Guasch Ferré, Marta; Merino, Jorsi; Sun, Qi; Fitó Colomer, Montserrat; Salas-Salvadó, Jordi (Hindawi, 2017)

  Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as ...
• Spanish consensus on treat to target for osteoporosis

  Nogués Solan, Francesc Xavier; Nolla, J.M.; Casado, E.; Jódar, E.; Muñoz-Torres, M.; Quesada-Gómez, J.M.; Canals, L.; Balcells, M.; Lizán, L. (Springer, 2018)

  To reach a Spanish expert consensus on a treat-to-target strategy in osteoporosis, a Delphi Consensus Study has been developed. Most of the experts (59.8%) were rheumatologist with a mean clinical experience of 21.3 years ...
• Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

  Puiggros Metje, Anna Maria; Salido Galeote, Marta; Ferrer Del Alamo, Ana; Gimeno Vázquez, Eva; Abella Monreal, Eugenia; Espinet, Blanca (Impact Journals, 2017)

  Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex ...
• Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

  Pérez Martínez, Pablo; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Schröder, H.; Torre Fornell, Rafael de la; López Miranda, José (Oxford University Press, 2017)

  The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the ...
• Limitations in predicting PAM50 intrinsic subtype and risk of relapse score with Ki67 in estrogen receptor-positive HER2-negative breast cancer

  Fernández-Martínez, Aranzazu; Albanell Mestres, Joan; Martin, Miguel (Impact Journals, 2017)

  PAM50/Prosigna gene expression-based assay identifies three categorical risk of relapse groups (ROR-low, ROR-intermediate and ROR-high) in post-menopausal patients with estrogen receptor estrogen receptor-positive (ER+)/ ...
• The PREDIMED trial, Mediterranean diet and health outcomes: How strong is the evidence?

  Guasch Ferré, Marta; Salas-Salvadó, Jordi; Ros, Emilio; Estruch, Ramón; Corella, Dolores; Fitó Colomer, Montserrat; Martínez-González, Miguel A.; PREDIMED Investigators (Elsevier, 2017)

  AIMS: To address potential controversies on the health benefits of the Mediterranean diet (MedDiet) after PREDIMED, a randomized trial of MedDiet for primary cardiovascular prevention. We have focused on: a) the PREDIMED ...
• Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism

  Goday Arno, Alberto; Farré Albaladejo, Magí; Rodríguez-Morató, Jose, 1987-; Ramón Moros, José Manuel; Pérez Mañá, Clara; Papaseit Fontanet, Esther; Civit, Ester; Langohr, Klaus; Carbó Banús, Marcel·lí; Benaiges Boix, David; Castañer, Olga; Flores-Le-Roux, Juana Antonia; Pera Roman, Manuel Ramón; Grande Posa, Luís; Torre Fornell, Rafael de la (Springer, 2017)

  PURPOSE: The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver ...
• Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial

  Papandreou, Christopher; Bulló, Mònica; Tinahones, Francisco José; Martínez-González, Miguel A.; Corella, Dolores; Fragkiadakis ,Georgios A.; López-Miranda, José; Estruch, Ramón; Fitó Colomer, Montserrat; Salas-Salvadó, Jordi (BioMed Central, 2017)

  BACKGROUND: Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in ...
• Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk

  Bargallo, Nuria; Gilabert, Rosa; Romero-Mamani, Edwin-Saúl; Cofán, Montserrat; Calder, Philip C.; Fitó Colomer, Montserrat; Corella, Dolores; Salas-Salvadó, Jordi; Ruiz-Canela, Miguel; Estruch, Ramón; Ros, Emilio; Sala Vila, Aleix (MDPI, 2017)

  Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta ...
• Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)

  Guo, Xiaohui; Tresserra-Rimbau, Anna; Estruch, Ramón; Martínez-González, Miguel A.; Medina-Remón, Alexander; Fitó Colomer, Montserrat; Corella, Dolores; Salas-Salvadó, Jordi; Puy Portillo, Maria; Moreno, Juan J.; Pi-Sunyer, Xavier; Lamuela-Raventós, Rosa M. (MDPI, 2017)

  Overweight and obesity have been steadily increasing in recent years and currently represent a serious threat to public health. Few human studies have investigated the relationship between polyphenol intake and body weight. ...
• The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery

  García-Layana, Alfredo; Gianfranco, Ciufo; Toledo, Estefania; Martínez-González, Miguel A.; Corella, Dolores; Fitó Colomer, Montserrat; Estruch, Ramón; Gómez-Gracia, Enrique; Fiol, Miquel; Lapetra, José; Serra-Majem, Luis; Pinto, Xavier; Portillo, María P.; Sorlí, J.V.; Bulló, Mònica; Vinyoles, Ernest; Sala Vila, Aleix; Ros, Emilio; Salas-Salvadó, Jordi; Arós, Fernando (MDPI, 2017)

  BACKGROUND: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the ...

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