• MET Inhibitors in Small Cell Lung Cancer: From the Bench to the Bedside

  Hardy-Werbin, Max; del Rey-Vergara, Raúl; Galindo-Campos, Miguel A.; Moliner Jiménez, Laura; Arriola Aperribay, Edurne (MDPI, 2019)

  Small cell lung cancer (SCLC) is the most aggressive type of lung cancer. The different systemic treatment approaches attempted in the last 35 years have not improved overall survival in the advanced stage. Targeted therapies ...
• Management of metastatic bladder cancer

  Nadal, Rosa; Bellmunt Molins, Joaquim, 1959- (Elsevier, 2019)

  Important advances in the understanding of the biology and mechanisms of tumor progression of urothelial carcinoma (UC) have been achieved over the past decade. The treatment landscape for advanced-stage, unresectable or ...
• Impact of adjuvant chemotherapy on the survival of patients with breast cancer diagnosed by screening

  Zarcos-Pedrinaci, Irene; Redondo, Maximino; Louro, Javier; Rivas Ruiz, Francisco; Téllez, Teresa; Pérez, Diego; Medina Cano, Francisco; Machan, Kenza; Domingo, Laia; Vernet-Tomás, Maria; Padilla-Ruiz, Maria; Castells, Xavier; Rueda, Antonio; Sala Serra, Maria; REDISSEC-CaMISS Group (Wiley, 2019)

  The aim of this study is to determine the survival of patients with breast cancer treated with adjuvant chemotherapy (ACh) after the diagnosis by screening, taking comorbidity into account. This multicenter cohort study ...
• Nivolumab plus ipilimumab combination therapy for the first-line treatment NSCLC: evidence to date

  Taus García, Álvaro; Remon, Jordi; Esteller, Laura; Taus García, Álvaro (Dove Medical Press, 2019)

  Immune checkpoint inhibitors (ICI) as monotherapy in selected patients as well as in combination with chemotherapy have become the standard of care in the first-line treatment strategy of advanced non-small cell lung cancer ...
• Author response to: Comment on: Contralateral surgery in patients scheduled for total thyroidectomy with initial loss or absence of signal during neural monitoring

  Sitges-Serra, Antonio (Wiley, 2019)
• A systematic review and quality assessment of individualised breast cancer risk prediction models

  Louro, Javier; Posso, Margarita; Hilton Boon, Michele; Román, Marta; Domingo, Laia; Castells, Xavier; Sala Serra, Maria (Nature Research, 2019)

  BACKGROUND: Individualised breast cancer risk prediction models may be key for planning risk-based screening approaches. Our aim was to conduct a systematic review and quality assessment of these models addressed to women ...
• Assessment of early therapy discontinuation and health-related quality of life in breast cancer patients treated with aromatase inhibitors: B-ABLE cohort study

  Pineda-Moncusí, Marta; Servitja Tormo, Sonia; Tusquets Trias de Bes, Ignacio; Díez Pérez, Adolfo; Rial, Abora; Cos, Maria Lourdes; Campodarve, Isabel; Rodriguez-Morera, Jaime; Garcia Giralt, Natàlia; Nogués Solan, Francesc Xavier (Springer, 2019)

  PURPOSE: The most frequent adverse effects of aromatase inhibitors (AI) are arthralgia and bone loss induction. These reduce the quality of life of patients and their adherence to the treatment. This study evaluates the ...
• Immune microenvironment of triple-negative breast cancer in African-American and Caucasian women

  O’Meara, Tess; Safonov, Anton; Casadevall Aguilar, David; Qing, Tao; Silber, Andrea; Killelea, Brigid; Hatzis, Christos; Pusztai, Lajos (Springer, 2019)

  PURPOSE: African-American (AA) patients with triple-negative breast cancer (TNBC) are less likely to achieve pathologic complete response from neoadjuvant chemotherapy and have poorer prognosis than Caucasian patients with ...
• Changes in mammographic density over time and the risk of breast cancer: An observational cohort study

  Román, Marta; Sala, Maria; Baré, Marisa; Posso, Margarita; Vidal, Carmen; Louro, Javier; Sánchez, Mar; Peñalva, Lupe; Castells, Xavier; BELE Study Group (Elsevier, 2019)

  BACKGROUND: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. METHODS: We used information from four centres of the Breast Cancer Screening Program in Spain in the ...
• Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients

  Oriolo, Giovanni; Blanco Hinojo, Laura, 1981-; Navinés, Ricard; Mariño, Zoe; Martín-Hernández, David; Cavero, Myriam; Gimenez, Dolors; Caso, Javier; Capuron, Lucile; Forns, Xavier; Pujol Martí, Jesús; Martín Santos, Rocío (Elsevier, 2019)

  BACKGROUND: Sickness behavioral changes elicited by inflammation may become prolonged and dysfunctional in patients with chronic disease, such as chronic hepatitis C (CHC). Neuroimaging studies show that the basal ganglia ...
• Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3

  Roca Ayats, Neus; Martínez-Gil, Núria; Cozar, Mónica; Gerousi, Marina; Garcia Giralt, Natàlia; Ovejero, Diana; Mellibovsky, Leonardo; Nogués Solan, Francesc Xavier; Díez Pérez, Adolfo; Grinberg, Daniel; Balcells, Susana (Elsevier, 2019)

  Genome-wide association studies (GWAS) have repeatedly identified genetic variants associated with bone mineral density (BMD) and osteoporotic fracture in non-coding regions of C7ORF76, a poorly studied gene of unknown ...
• Brain activity during traditional textbook and audiovisual-3D learning

  Pujol Martí, Jesús; Blanco Hinojo, Laura, 1981-; Martínez-Vilavella, Gerard; Canu-Martín, Lucila; Pujol, Anna; Pérez Solá, Victor; Deus, Joan (Wiley, 2019)

  INTRODUCTION: Audiovisual educational tools have increasingly been used during the past years to complement and compete with traditional textbooks. However, little is known as to how the brain processes didactic information ...
• Sexually transmitted infections in young people and factors associated with HIV coinfection: an observational study in a large city

  Sentís, Alexis; Martin-Sánchez, Mario; Arando, Maider; Vall, Martí; Barbera, María Jesús; Ocaña, Inma; González Cordón, Ana; Alsina, Mercè; Martin-Ezquerra, Gemma; Knobel Freud, Hernando; Gurguí, Mercè; Vives, Alvaro; Coll, Josep; Caylà i Busqueras, Joan A.; Garcia de Olalla, Patricia; STI-HIV groupo Barcelona (BMJ Publishing Group, 2019)

  OBJECTIVES: Young people are a critical target group for sexually transmitted infections (STI) surveillance due to their particular behavioural and social related vulnerability. The aim of this study was to describe the ...
• Persistence with dual antiplatelet therapy after percutaneous coronary intervention for ST-segment elevation acute coronary syndrome: a population-based cohort study in Catalonia (Spain)

  Ribera, Aida; Tizón-Marcos, Helena; Garcia Dorado, David; VESA Study; Codi IAM Investigators (BMJ Publishing Group, 2019)

  OBJECTIVES: Guidelines recommending 12-month dual antiplatelet therapy (DAPT) in patients with ST-elevation acute coronary syndrome (STEACS) undergoing percutaneous coronary intervention (PCI) were published in year 2012. ...
• Organisational and financial consequences of the early discharge of patients treated for acute bacterial skin and skin structure infection and osteomyelitis in infectious disease departments in Greece, Italy and Spain: a scenario analysis

  Restelli, Umberto; Bonfanti, Marzia; Croce, Davide; Grau Cerrato, Santiago; Metallidis, Symeon; Pacelli, Valeria; Rizzardini, Giuliano; Soro, Marco; Vozikis, Athanasios; Gray, Alastair (BMJ Publishing Group, 2019)

  OBJECTIVE: The aim of the analysis is to assess the organisational and economic consequences of adopting an early discharge strategy for the treatment of acute bacterial skin and skin structure infection (ABSSSI) and ...
• Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget’s disease of bone

  Cronin, Owen (BMJ Publishing Group, 2019)

  INTRODUCTION: Paget's disease of bone (PDB) is characterised by increased and disorganised bone remodelling affecting one or more skeletal sites. Complications include bone pain, deformity, deafness and pathological ...
• Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

  Albasanz-Puig, Adaia; Montero, Maria Milagro; Carratalà, Jordi; IRONIC study group (BMJ Publishing Group, 2019)

  INTRODUCTION: Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) ...
• The role of the laparoscopic approach in the surgical management of acute adhesive small bowel obstruction

  Sebastian-Valverde, Enric; Poves Prim, José Ignacio; Membrilla-Fernández, Estela; Pons-Fragero, María José; Grande Posa, Luís (BioMed Central, 2019)

  BACKGROUND: Postoperative adhesions represent 75% of all acute small bowel obstructions. Although open surgery is considered the standard approach for adhesiolysis, laparoscopic approach is gaining popularity. METHODS: A ...
• Incisional hernia recurrence after open elective repair: expertise in abdominal wall surgery matters

  Pereira Rodríguez, José Antonio; Bravo-Salva, Alejandro; Montcusí Ventura, Blanca; Pérez-Farre, Silvia; Fresno de Prado, L.; López-Cano, Manuel (BioMed Central, 2019)

  BACKGROUND: Recurrence after incisional hernia repair is one of the major problems related with this operation. Our objective is to analyze the influence of abdominal wall surgery expertise in the results of the open ...
• Prevention and management of musculoskeletal pain in nursing staff by a multifaceted intervention in the workplace: design of a cluster randomized controlled trial with effectiveness, process and economic evaluation (INTEVAL_Spain)

  Serra, Consol; Soler-Font, Mercè; García, Ana María; Peña, Pilar; Vargas-Prada Figueroa, Sergio, 1976 -; Ramada Rodilla, José María, 1961- (BioMed Central, 2019)

  BACKGROUND: Musculoskeletal pain (MSP) is the leading cause of years lived with disability. In consequence, to reduce MSP and its associated sickness absence is a major challenge. Previous interventions have been developed ...

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