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Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

Articles (Institut Hospital del Mar d'Investigacions Mèdiques (IMIM))

 

Recent Submissions

  • Principe, Alessandro; Ley Nacher, Miguel; Conesa Bertran, Gerardo; Rocamora Zúñiga, Rodrigo Alberto (Elsevier, 2019)
    Several models have been proposed to explain brain regional and interregional communication, the majority of them using methods that tap the frequency domain, like spectral coherence. Considering brain interareal communication ...
  • Trebaul, Lena; Rocamora Zúñiga, Rodrigo Alberto; David, Olivier (Elsevier, 2018)
    In patients with pharmaco-resistant focal epilepsies investigated with intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in ...
  • Portolés, José; Pérez-Saez, María José; Pascual Santos, Julio (Elsevier, 2019)
    INTRODUCTION: Many European countries have transplant programmes with controlled donors after cardiac death (cDCD). Twenty-two centres are part of GEODAS group. We analysed clinical results from a nephrological perspective. ...
  • Ortiz, Alberto; Sanchez-Niño, Maria Dolores; Crespo Barrio, Marta; De-Sequera-Ortiz, Patricia; Fernández-Giráldez, Elvira; García-Maset, Rafael; Macía-Heras, Manuel; Pérez-Fontán, Miguel; Rodríguez-Portillo, Mariano; Salgueira-Lazo, Mercedes; Sánchez-Álvarez, Emilio; Santamaría-Olmo, Rafael; Simal-Blanco, Fernando; Pino-Pino, María Dolores (Elsevier, 2019)
    The Global Burden of Disease (GBD) study measures the health of populations worldwide and by country on an annual basis and aims at helping guide public policy on health issues. The GBD estimates for Spain in 2016 and ...
  • Del Toro, N.; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Porras, P.; IMEx Consortium Curators (Nature Research, 2019)
    The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct ...
  • Arias Cabrales, Carlos Enrique; Pérez-Sáez, María José; Redondo Pachón, María Dolores; Buxeda, Anna; Burballa Tarrega, Carla Cristina; Bermejo García, Sheila; Sierra Ochoa, Adriana; Mir Fontana, M. Luisa; Buron Pust, Andrea; Zapatero, Ana; Crespo Barrio, Marta; Pascual Santos, Julio (Elsevier, 2018)
    INTRODUCTION: Kidney donor shortage requires expanding donor selection criteria, as well as use of objective tools to minimize the percentage of discarded organs. Some donor pre-transplant variables such as age, standard/expanded ...
  • Jiang, Xia; Kogevinas, Manolis; Koutros, Stella; Lindström, Sara (Nature Research, 2019)
    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total ...
  • Haworth, S.; Vrijheid, Martine; Guxens Junyent, Mònica; Sunyer Deu, Jordi; St. Pourcain, Beate (Nature Research, 2019)
    Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the ...
  • Matejcic, Marco; Kogevinas, Manolis; Haiman, Christopher A. (Nature Research, 2018)
    Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
  • López Arribillaga, Erika; Rodilla, Verónica; Colomer Montañá, Carlota; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)
    Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
  • Dadaev, Tokhir; Kogevinas, Manolis; Castaño Vinyals, Gemma; Kote-Jarai, Zsofia (Nature Research, 2018)
    Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable ...
  • Farinello, Diego; Bascones, Sabrina; Lligé, David; Brendolan, Andrea (Nature Research, 2018)
    In chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival, and expansion. However, the nature of the stromal cells ...
  • Celià-Terrassa, Toni; Bastian, Caleb; Liu, Daniel; Ell, Brian; Aiello, Nicole M.; Wei, Yong; Zamalloa, Jose; Blanco, Andres M.; Hang, Xiang; Kunisky, Dmitriy; Li, Wenyang; Williams, Elizabeth D.; Rabitz, Herschel; Kang, Yibin (Nature Research, 2018)
    Epithelial-mesenchymal transition (EMT) have been extensively characterized in development and cancer, and its dynamics have been modeled as a non-linear process. However, less is known about how such dynamics may affect ...
  • Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (Nature Research, 2018)
    Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted ...
  • Celià-Terrassa, Toni; Kang, Yibin (Nature Research, 2018)
    Metastasis is an inefficient process, especially during colonization at a distant organ. This bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of metastases. Here, we classify the common ...
  • Esteban, Carlos; Rodríguez, Patricia; Escudero, José Román; Clarà Velasco, Alberto; Fernández, Álvaro; Fernández, Sebastián; Agúndez, Ignacio (Elsevier, 2019)
    Antecedentes y objetivos: En los pacientes con enfermedad arterial periférica que requieren intervenciones quirúrgicas la anemia se ha comprobado que puede ser un factor independiente de mal pronóstico tanto a corto como ...
  • Pineda-Moncusí, Marta; García-Pérez, Miguel Angel; Rial, Abora; Casamayor, Guillem; Cos, Maria Lourdes; Servitja Tormo, Sonia; Tusquets, Ignasi; Díez Pérez, Adolfo; Cano, Antonio; Garcia Giralt, Natàlia; Nogués Solan, Francesc Xavier (Elsevier, 2018)
    To evaluate the vitamin D status of postmenopausal women with early estrogen-receptor-positive breast cancer and to compare it with that of healthy postmenopausal women from the same Mediterranean region. STUDY DESIGN AND ...
  • Millares, Laura; Barreiro Portela, Esther; Cortes, Roldan; Martínez-Romero, Anabel; Balcells, Cristina; Cascante, Marta; Enguita, Ana Belen; Álvarez, Carlos; Rami-Porta, Ramón; Sánchez de Cos, Julio; Seijo, Luis; Monsó, Eduard; Grupo Colaborativo en Cáncer de Pulmón CIBERES-CIBERONC-SEPAR-Plataforma Biobanco Pulmonar (Elsevier, 2018)
    INTRODUCTION: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help ...
  • Birgegård, Gunnar; Folkvaljon, Folke; Garmo, Hans; Holmberg, Lars; Besses Raebel, Carles; Griesshammer, Martin; Gugliotta, Luigi; Wuh, Jingyang; Achenbach, Heinrich; Kiladjian, Jean-Jacques; Harrison, Claire N. (Elsevier, 2018)
    EXELS, a post-marketing observational study, is the largest prospective study of high-risk essential thrombocythemia (ET) patients, with an observation time of 5 years. EXELS found higher event rates of acute leukemia ...
  • Rack, K. A.; van den Berg-de-Ruiter, Eva; Haferlach, C.; Beverloo, H. B.; Costa, Delfina; Espinet Solà, Blanca; Foot, N.; Jeffries, S.; Martin, K.; O’Connor, S.; Schoumans, Jacqueline; Talley, P.; Telford, N.; Stioui, S.; Zemanova, Zuzana; Hastings, Rosalind J. (Frontiers, 2019)
    Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray analyses have become increasingly important in the clinical management ...

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