• Arterial stiffness is highly correlated with the scores obtained from the steno type 1 risk engine in subjects with T1DM

  Llauradó Cabot, Gemma; Cano, Albert; Albert, Lara; Ballesta, Silvia; Mazarico, Isabel; Luchtenberg, María-Florencia; González Sastre, Montserrat; Megia, Ana; Simó, Rafael; Vendrell, Joan; González Clemente, José (Public Library of Science (PLoS), 2019)

  Objectives: Currently used risk scores for type 2 diabetes mellitus (T2DM) clearly underestimate cardiovascular risk in type 1 diabetes (T1DM). Hence, there is a need to develop novel and specific risk-estimation tools for ...
• Role of HDL function and LDL atherogenicity on cardiovascular risk: a comprehensive examination

  Hernáez, Álvaro; Soria-Florido, Maria; Schröder, Helmut, 1958-; Ros, Emilio; Pinto, Xavier; Estruch, Ramón; Salas-Salvadó, Jordi; Corella, Dolores; Arós, Fernando; Serra-Majem, Luis; Martínez-González, Miguel A.; Fiol, Miquel; Lapetra, José; Elosua Llanos, Roberto; Lamuela-Raventós, Rosa M.; Fitó Colomer, Montserrat (Public Library of Science (PLoS), 2019)

  Background: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol ...
• Gynecologic and reproductive outcomes in fibrous dysplasia/McCune-Albright Syndrome

  Boyce, Alison M.; Casey, Rachel K.; Ovejero Crespo, Diana; Murdock, Cynthia M.; Estrada, Andrea; Guthrie, Lori C.; Brillante, Beth A.; Gomez-Lobo, Veronica; Nieman, Lynette K.; Collins, Michael T. (BioMed Central, 2019)

  Background: Autonomous ovarian activation with recurrent estrogen-producing cysts is a hallmark feature of the rare bone and endocrine disorder fibrous dysplasia/McCune-Albright syndrome. Precocious puberty in girls with ...
• ScoreInvHap: inversion genotyping for genome-wide association studies

  Ruiz-Arenas, Carlos; Cáceres, Alejandro; López Sánchez, Marcos, 1986-; Tolosana, Ignacio; Pérez Jurado, Luis Alberto; González Ruiz, Juan Ramón (Public Library of Science (PLoS), 2019)

  Polymorphic inversions contribute to adaptation and phenotypic variation. However, large multi-centric association studies of inversions remain challenging. We present scoreInvHap, a method to genotype inversions from SNP ...
• Contribution of trastuzumab to the prognostic improvement of HER2-positive early breast cancer in Spain: an estimation of life years and disease-free life years gained since its approval

  Ciruelos, Eva; Alba, Emilio; López, Rafael; Lluch, Ana; Martín, Miguel; Arroyo, Isabel; Navarro, Beatriz; Carcedo, David; Colomer, Ramon; Albanell Mestres, Joan (Impact Journals, 2019)

  Introduction: Trastuzumab has become the standard treatment for both HER2-positive early and metastatic breast cancer (HER2+ eBC or mBC) since its approval. The objective of the study is to estimate the benefit of adjuvant ...
• Gender differences in cancer risk after kidney transplantation

  Buxeda, Anna; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Bartolomé, Álvaro; Mir Fontana, M. Luisa; Pascual-Dapena, Ana; Sans, Anna; Duran Jordà, Xavier, 1974-; Crespo Barrio, Marta; Pascual Santos, Julio (Impact Journals, 2019)

  Kidney transplant (KT) recipients are at greater risk of developing some cancers than the general population. Moreover, cancer is the only cause of death that is currently increasing after kidney transplantation. We analyzed ...
• Conventional and molecular cytogenetic studies to characterize 32 complex variant philadelphia translocations in patients with chronic myeloid leukemia

  Costa, Dolors; Grau, Javier; Espinet Solà, Blanca; Arias, Amparo; Gómez, Cándida; López-Guerra, Mónica; Nomdedeu, Meritxell; Cervantes, Francisco (Spandidos Publications, Ltd., 2019)

  BCR/ABL1 gene fusion is the hallmark of chronic myeloid leukemia (CML), and is generated in 5-10% of patients by a variant translocation involving 9q34, 22q11.2 and one or more additional genomic regions. The objective of ...
• LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells

  Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra-Bardenys, Gemma; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, R. A.; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yelamos López, Jose; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)

  Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
• Changes in central 24-h ambulatory blood pressure and hemodynamics 12 months after bariatric surgery: the BARIHTA study

  Oliveras, Anna; Goday Arno, Alberto; Sans Atxer, Laia; Vázquez, Susana; Benaiges Foix, David; Ramón Moros, José Manuel; Pascual Santos, Julio (Springer, 2020)

  Background: Weight loss is associated to blood pressure (BP) reduction in obese patients. There is no information on central 24-h BP changes after bariatric surgery (BS). Methods and results: In this study, we analyzed ...
• Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer

  Hardy-Werbin, Max; Rocha, Pedro P.; Arpí Llucià, Oriol; Taus García, Álvaro; Nonell Mazelón, Lara; Duran Jordà, Xavier, 1974-; Villanueva, Xavier; Joseph-Pietras, Deborah; Nolan, Luke; Danson, Sarah; Griffiths, Richard; López-Botet, M. (Miguel); Rovira Guerín, Ana; Albanell Mestres, Joan; Ottensmeier, Christian; Arriola Aperribay, Edurne (Taylor & Francis, 2019)

  Background. Immunotherapy has shown efficacy in small cell lung cancer (SCLC), but only a subset of patients benefits. Surrogate biomarkers are urgently needed. Our aim was to evaluate serum Th1, Th2, and proinflammatory ...
• Flow sorting enrichment and nanopore sequencing of chromosome 1 from a Chinese individual

  Kuderna, Lukas F.K.; Solís Moruno, Manuel; Batlle Masó, Laura; Julià, Eva; Lizano, Esther; Anglada Busquets, Roger; Ramírez Bautista, Eva; Bote, Alex; Tormo, Marc; Marquès i Bonet, Tomàs, 1975-; Fornas Carreño, Oscar; Casals López, Ferran (Frontiers Media, 2020)

  Sorting of individual chromosomes by Flow Cytometry (flow-sorting) is an enrichment method to potentially simplify genome assembly by isolating chromosomes from the context of the genome. We have recently developed a ...
• Mediterranean alcohol-drinking pattern, low to moderate alcohol intake and risk of atrial fibrillation in the PREDIMED study

  Bazal, P.; Gea, Alfredo; Martínez-González, Miguel Ángel; Salas-Salvadó, Jordi; Asensio, E. M.; Muñoz-Bravo, Carlos; Fiol, Miquel; Muñoz, Miguel Ángel; Lapetra, José; Serra-Majem, Luis; Pinto, Xavier; González, José I.; Becerra-Tomás, Nerea; Fitó Colomer, Montserrat; Ros, Emilio; Alonso-Gómez, Ángel; Ruiz-Canela, Miguel (Elsevier, 2019)

  Background and aims: There is ongoing controversy about the effect of a low to moderate alcohol consumption on atrial fibrillation (AF). Our aim is to assess the association between adherence to a Mediterranean alcohol ...
• Flavonoids and the risk of gastric cancer: an exploratory Case-Control study in the MCC-Spain study

  Vitelli Storelli, Facundo; Kogevinas, Manolis; Martín, Vicente (MDPI, 2019)

  Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the ...
• Role of leptin in the association between body adiposity and persistent asthma: a longitudinal study

  Li, Zhen; Leynaert, Bénédicte; Dumas, Orianne; Díaz Gil, Oscar; García Aymerich, Judith; Fitó Colomer, Montserrat; Le Moual, Nicole; Pison, Christophe; Romieu, Isabelle; Siroux, Valérie; Camargo, Carlos A.; Varraso, Raphaëlle; Nadif, Rachel (Wiley, 2019)

  Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived ...
• Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats

  Vázquez, Alejandra; Sánchez-Rodriguez, Estefanía; Vargas, Félix; Montoro-Molina, Sebastián; Romero-Cuevas, Miguel; Espejo, Juan-Antonio; Vilchez, Pedro; Jaramillo, Sara; Olmo-García, Lucía; Carrasco-Pancorbo, Alegría; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Martínez de Victoria, Emilio; Mesa, Maria-Dolores (MDPI, 2019)

  Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), ...
• Association of adherence to the mediterranean diet with urinary factors favoring renal lithiasis: cross-sectional study of overweight individuals with metabolic síndrome

  Prieto, Rafael M.; Rodríguez, Adrian; Sanchís, Pilar; Morey, Marga; Fiol, Miquel; Grases, Félix; Castañer, Olga; Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Romaguera, Dora (MDPI, 2019)

  Our purpose was to study the relationship of adherence to the Mediterranean diet (MedDiet) with urinary factors that favor the formation of renal calcium and uric acid stones in overweight and obese participants who had ...
• Agreement among mediterranean diet pattern adherence indexes: MCC-Spain Study

  Olmedo-Requena, Rocío; Castaño Vinyals, Gemma; Kogevinas, Manolis; Martín Sánchez, Vicente (MDPI, 2019)

  There are many different methods used to measure the degree of adherence to a Mediterranean diet (MD), limiting comparison and interpretation of their results. The concordance between different methodologies has been ...
• Plasma metabolites associated with coffee consumption: a metabolomic approach within the PREDIMED Study

  Papandreou, Christopher; Fitó Colomer, Montserrat; Salas Salvadó, Jordi (MDPI, 2019)

  Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, ...
• Sleep duration is inversely associated with serum uric acid concentrations and uric acid to creatinine ratio in an elderly mediterranean population at high cardiovascular risk

  Papandreou, Christopher; Schröder, Helmut, 1958-; Quifer, Mireia; Torras, Laura; Castañer, Olga; Salas Salvadó, Jordi (MDPI, 2019)

  The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly ...
• Dose and time effects of solar-simulated ultraviolet radiation on the in vivo human skin transcriptome

  Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Tewari, Angela; Sarria-Trujillo, Yaris; Harrison, Graham I.; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Kang, W.; Friedländer, Marc R.; Estivill, Xavier, 1955-; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Young, Antony R. (Wiley, 2019)

  BACKGROUND: Terrestrial ultraviolet (UV) radiation causes erythema, oxidative stress, DNA mutations and skin cancer. Skin can adapt to these adverse effects by DNA repair, apoptosis, keratinization and tanning. OBJECTIVES: ...

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