• Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

  Benítez-Cano, Adela; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Carazo Cordobés, Jesús; Ramos Delgado, M.; Campillo Ambrós, Núria; Curull Serrano, Víctor; Sánchez-Font, Albert; Vilaplana, Carles; Horcajada Gallego, Juan Pablo; Adalia Bartolomé, Ramón; Bermejo Martínez, Silvia; Samsó Sabé, Enric; Hope, William; Grau Cerrato, Santiago (BioMed Central, 2020)

  Background: Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administered ...
• Immunomodulatory roles of PARP-1 and PARP-2: impact on PARP-centered cancer therapies

  Yelamos López, Jose; Lama, Lucía, 1993-; Jimeno, Jaime; Ali, Syed O. (MDPI, 2020)

  Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-translationally modify proteins through poly(ADP-ribosyl)ation (PARylation)-the transfer of ADP-ribose chains onto amino acid residues-with a resultant ...
• Clinical interest of LMO2 testing for the diagnosis of aggressive large B-Cell lymphomas

  Vazquez de las Heras, Ivonne; Papaleo, Natalia; García, Eugenia; Salido Galeote, Marta; Salar Silvestre, Antonio; Hernández Llodrà, Sílvia; Calvo Gonzalo, Xavier; Colomo Saperas, Luis Alberto (MDPI, 2020)

  MYC rearrangements usually confer aggressive biological behavior to large B-cell lymphomas. In this study, we aimed to evaluate the relevance of LMO2 detection to the clinical approach to these tumors. First, the ability ...
• Narrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy

  Riu Pons, Fausto; Andreu García, Montserrat; Naranjo‐Hans, Dolores; Álvarez-González, Marco Antonio; Seoane, Agustín; Dedeu Cusco, Josep Maria; Barranco Priego, Luis Eugenio; Bessa Caserras, Xavier (BioMed Central, 2020)

  Background: It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not ...
• A prospective study of patient reported urinary incontinence among American, Norwegian and Spanish men 1 year after prostatectomy

  Storås, Anne Holck; Sanda, Martin George; Garin Boronat, Olatz, 1979-; Chang, Peter; Patil, Dattatraya; Crociani, Catrina M.; Suárez, José Francisco; Cvancarova, Milada; Loge, Jon Håvard; Fossà, Sophie Dorothea (Elsevier, 2020)

  Objective: To compare pre- and post-radical prostatectomy (RP) responses in the urinary incontinence domain of Expanded Prostate Cancer Index Composite-26 (EPIC-26) in cohorts from the USA, Norway and Spain. Methods: A ...
• Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results

  Alonso-Molero, Jéssica; Molina, Antonio J.; Jiménez-Moleón, José Juan; Pérez-Gómez, Beatriz; Martín, Vicente; Moreno, Víctor; Amiano, Pilar; Ardanaz Aicua, Eva; Sanjosé Llongueras, Silvia de; Salcedo-Bellido, Inmaculada; Fernández-Tardón, Guillermo; Alguacil, Juan; Salas, Dolores; Marcos-Gragera, Rafael; Chirlaque, María Dolores; Aragonés, Núria; Castaño Vinyals, Gemma; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMJ Publishing Group, 2019)

  Purpose: Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate ...
• Asma leve y exacerbaciones de riesgo vital: ¿es hora de que demos un paso adelante?

  González-García, José Gregorio; Chalela Rengifo, Roberto José, 1985-; Carballo Martínez, Núria; Ausín Herrero, Pilar, 1974- (Elsevier, 2020)
• Molecular characterization of methicillin-resistant staphylococcus aureus clinical strains from the endotracheal tubes of patients with nosocomial pneumonia

  Cabrera Ortega, Roberto; Fernández-Barat, Laia; Motos, Ana; Lopez-Aladid, Ruben; Vázquez, Nil; Panigada, Mauro; Álvarez Lerma, Francisco; Lopez, Yuli; Muñoz, Laura; Castro, Pedro; Vila, Jordi; Torres, Antoni (BioMed Central, 2020)

  Background: Among all cases of nosocomial pneumonia, Staphylococcus aureus is the second most prevalent pathogen (17.8%). In Europe, 29.9% of the isolates are oxacillin-resistant. The changing epidemiology of methicillin-resistant ...
• Improving the resistance and resilience framework for aging and dementia studies

  Arenaza Urquijo, Eider M.; Vemuri, Prashanthi (BioMed Central, 2020)

  Background: The "resistance vs resilience" to Alzheimer's disease (AD) framework (coping vs avoiding) has gained interest in the field in the last year. In this viewpoint, our effort is (i) to provide clarity to the usage ...
• Factors associated with readmissions in women participating in screening programs and treated for breast cancer: a retrospective cohort study

  Miret, Carme; Domingo, Laia; Louro, Javier; Barata, Teresa; Baré, Marisa; Ferrer, Joana; Carmona-Garcia, Maria Carmen; Castells, Xavier; Sala, Maria (BioMed Central, 2019)

  Background: We aimed to identify the risk factors associated with early, late and long-term readmissions in women diagnosed with breast cancer participating in screening programs. Methods: We performed a multicenter cohort ...
• Inicio y progresión en el consumo de sustancias en la población general de Cataluña, España

  Sánchez Niubò, Albert; Sordo, Luis; Barrio, Gregorio; Indave, Blanca; Domingo-Salvany, Antònia (Socidrogalcohol, 2020)

  Este estudio tuvo como finalidad realizar un análisis retrospectivo de la secuencia de inicio y progresión de las vías más comunes del inicio del consumo de sustancias en una muestra de la población general española. ...
• Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

  Gómez-Acebo, Inés; Domingo, Laia; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (SpringerOpen, 2020)

  Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as ...
• Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation

  Skouras, Stavros; Torner, Jordi; Andersson, Patrik; Koush, Yury; Falcon, Carles; Minguillón, Carolina; Fauria, Karine; Alpiste, Francesc; Blenow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Oxford University Press, 2020)

  Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In this study, we aimed to ...
• Barbed sutures in total knee arthroplasty: are they really useful? a randomized controlled trial

  Gamba, Carlo; Hinarejos Gómez, Pedro Angel; Serrano-Chinchilla, Paula; Leal Blanquet, Joan; Torres Claramunt, Raúl; Sánchez Soler, Juan; Monllau García, Juan Carlos (Thieme Medical, 2019)

  Bidirectional barbed sutures (BBSs) have recently been investigated in total knee arthroplasty (TKA). The contrasting results from the scarce literature suggest that BBSs are safe, save time and money, and give results ...
• Changes in Individual and Contextual Socio-Economic Level Influence on Reproductive Behavior in Spanish Women in the MCC-Spain Study

  Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Sala Serra, Maria; Kogevinas, Manolis; Llorca, Javier (BioMed Central, 2020)

  Background: The association between socioeconomic level and reproductive factors has been widely studied. For example, it is well known that women with lower socioeconomic status (SES) tend to have more children, the age ...
• Adaptation and validation of the PEDSQL™ Oral Health Scale for toddlers in chilean population

  Atala-Acevedo, Claudia; Zaror, Carlos; Espinoza-Espinoza, Gerardo; Muñoz-Millán, Patricia; Muñoz, Sergio; Martínez-Zapata, María José; Ferrer Forés, Maria Montserrat (BioMed Central, 2020)

  Background: The Pediatric Quality of Life Inventory™ (PedsQL™) Oral Health Scale was developed to measure oral health-related quality of life (OHRQoL). The aim of this study was to cross-culturally adapt the parent-reported ...
• The ISCB Student Council Internship Program: expanding computational biology capacity worldwide

  Anupama, Jigisha; Francescatto, Margherita; Rahman, Farzana; Fatima, Nazeefa; DeBlasio, Dan; Shanmugam, Avinash Kumar; Satagopam, Venkata; Santos, Alberto; Kolekar, Pandurang; Michaut, Magali; Guney, Emre (Public Library of Science (PLoS), 2018)

  Education and training are two essential ingredients for a successful career. On one hand, universities provide students a curriculum for specializing in one's field of study, and on the other, internships complement ...
• Identifying human diamine sensors for death related putrescine and cadaverine molecules

  Izquierdo, Cristina; Gómez-Tamayo, José C.; Nebel, Jean-Christophe; Pardo Carrasco, Leonardo; Gonzalez, Angel (Public Library of Science (PLoS), 2018)

  Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules ...
• The McCAVE Trial: vanucizumab plus mFOLFOX-6 versus bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal carcinoma (mCRC)

  Bendell, Johanna C.; Montagut Viladot, Clara; Hurwitz, Herbert; McCAVE Study Group (Wiley, 2020)

  Background: Bevacizumab, a VEGF-A inhibitor, in combination with chemotherapy, has proven to increase progression-free survival (PFS) and overall survival in multiple lines of therapy of metastatic colorectal cancer (mCRC). ...
• Reply to Veronese and Smith: Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-Analysis of observational studies

  Lassale, Camille; Batty, G. David; Akbaraly, Tasnime (Nature Research, 2019)

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