• Octadecylpropyl sulfamide reduces neurodegeneration and restores the memory deficits induced by hypoxia-ischemia in mice

  Kossatz, Elk; Silva Peña, Daniel; Suárez, Juan; de Fonseca, Fernando R.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Frontiers, 2018)

  The PPAR-α agonist, oleoylethanolamide (OEA) has neuroprotective properties in stroke models. However, its rapid degradation represents a limitation for an effective therapeutic approach. In this study, we evaluated the ...
• Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets

  Karube, Kennosuke; Rubio Pérez, Carlota; Tamborero Noguera, David; Salar Silvestre, Antonio; Colomo Saperas, Luis Alberto; López Bigas, Núria; Miyoshi, Hiroaki (Nature Publishing Group, 2018)

  Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical significance of these alterations is still not well defined. In ...
• Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

  Felix, Janine Frédérique; Kogevinas, Manolis; Sunyer Deu, Jordi; Vrijheid, Martine; London, Stephanie J. (Oxford University Press, 2018)
• L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

  van der Putten, Louis J.M.; Mancebo Moreno, Gemma; Alameda Quitllet, Fransesc; Pijnenborg, Johanna M.A. (Nature Publishing Group, 2016)

  BACKGROUND: Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic ...
• A birth cohort study in the Middle East: the Qatari birth cohort study (QBiC) phase I

  Sadoun, Eman; Leventakou, Vasiliki; Casas Sanahuja, Maribel; Ahmed, Heba Fawzy; Kogevinas, Manolis; Fthenou, Eleni (BioMed Central, 2017)

  BACKGROUND: The latest scientific reports raise concerns about the rapidly increasing burden of chronic diseases in the state of Qatar. Pregnant Qatari women often confront complications during pregnancy including gestational ...
• Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder: results of a randomized, double-blind clinical trial

  Pérez Solá, Victor; Salavert, Ariana; Espadaler, Jordi; Tusón, Miquel; Saiz-Ruiz, Jerónimo; Sáez-Navarro, Cristina; Bobes, Julio; Baca-García, Enrique; Baca-García, Enrique; Olivares, José M.; Rodriguez-Jimenez, Roberto; Villagrán, José M.; Gascón, Josep; Cañete-Crespillo, Josep; Solé, Montse; Saiz, Pilar A.; Ibáñez, Ángela; Diego-Adeliño, Javier de; AB-GEN Collaborative Group; Menchón, José M. (BioMed Central, 2017)

  BACKGROUND: A 12-week, double-blind, parallel, multi-center randomized controlled trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate the effectiveness of pharmacogenetic (PGx) testing ...
• Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function

  Collado Nieto, Silvia; Coll, Elisabeth; Nicolau, Carlos; Azqueta, Manel; Pons, Mercedes; Cruzado, Josep M.; Torre, Bernat de la; Deulofeu, Ramón; Mojal, Sergio; Pascual Santos, Julio; Cases, Aleix (BioMed Central, 2017)

  BACKGROUND: To assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients. METHODS: Multicenter, observational, prospective study ...
• The renin-angiotensin system: a possible new target for depression

  Vian, João; Pereira, Círia; Chavarría Romero, Víctor; Köhler, Cristiano; Stubbs, Brendon; Quevedo, João; Kim, Sung-Wan; Carvalho, André F.; Berk, Michael; Fernandes, Brisa S. (BioMed Central, 2017)

  Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways ...
• The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis

  Alonso-Molero, Jéssica; Castaño Vinyals, Gemma; Kogevinas, Manolis; Martín Sánchez, Vicente (BioMed Central, 2017)

  BACKGROUND: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. METHODS: We examined 1087 cases of ...
• Transcultural adaptation and validation of the patient empowerment in long-term conditions questionnaire

  Garcimartín Cerezo, Paloma; Comín Colet, Josep; Delgado-Hito, Pilar; Badosa Marcé, Neus; Linas Alonso, Ana Maria (BioMed Central, 2017)

  BACKGROUND: Patient empowerment is a key element to improve the results in health, increase satisfaction amongst users and obtain higher treatment compliance. The main objective of this study is to validate the Spanish ...
• Effectiveness and safety of dipeptidyl peptidase 4 inhibitors in the management of type 2 diabetes in older adults: a systematic review and development of recommendations to reduce inappropriate prescribing

  Schott, Gisela; Martinez, Yolanda V.; Ediriweera de Silva, R. Erandie; Renom-Guiteras, Anna; Vögele; Anna; Reeves, David; Kunnamo, Ilkka; Marttila-Vaara, Minna; Sönnichsen, Andreas (BioMed Central, 2017)

  BACKGROUND: Preventable drug-related hospital admissions can be associated with drugs used in diabetes and the benefits of strict diabetes control may not outweigh the risks, especially in older populations. The aim of ...
• Effectiveness and safety of beta blockers in the management of hypertension in older adults: a systematic review to help reduce inappropriate prescribing

  Vögele, Anna; Johansson, Tim; Renom-Guiteras, Anna; Reeves, David; Rieckert, Anja; Schlender, Lisa; Teichmann, Anne-Lisa; Sönnichsen, Andreas; Martinez, Yolanda V. (BioMed Central, 2017)

  BACKGROUND: The benefit from a blood pressure lowering therapy with beta blockers may not outweigh its risks, especially in older populations. The aim of this study was to look for evidence on risks and benefits of beta ...
• Thiazides in the management of hypertension in older adults - a systematic review

  Sommerauer, Christina; Kaushik, Neha; Woodham, Adrine; Renom-Guiteras, Anna; Martinez, Yolanda V.; Reeves, David; Kunnamo, Ilkka; Al Qur 'An, Thekraiat; Hübner, Steffen; Sönnichsen, Andreas (BioMed Central, 2017)

  BACKGROUND: Thiazides are commonly prescribed to older people for the management of hypertension. The objective of this study was to identify the evidence on the risks and benefits of their use among adults aged ≥65 years ...
• Acute pharmacological effects of 2C-B in humans: An observational study

  Papaseit Fontanet, Esther; Farré Albaladejo, Magí; Pérez Mañá, Clara; Torrens, Marta; Ventura, Mireia; Pujadas, Mitona; Torre Fornell, Rafael de la; González, Débora (Frontiers, 2018)

  2,5-dimethoxy-4-bromophenethylamine (2C-B) is a psychedelic phenylethylamine derivative, structurally similar to mescaline. It is a serotonin 5-hydroxytryptamine-2A (5-HT2A), 5-hydroxytryptamine-2B (5-HT2B), and ...
• Effectiveness and safety of vitamin K antagonists and new anticoagulants in the prevention of thromboembolism in atrial fibrillation in older adults - a systematic review of reviews and the development of recommendations to reduce inappropriate prescribing

  Sommerauer, Christina; Schlender, Lisa; Krause, Mark; Weißbach, Sabine; Rieckert, Anja; Martinez, Yolanda V.; Reeves, David; Renom-Guiteras, Anna; Kunnamo, Ilkka; Sönnichsen, Andreas (BioMed Central, 2017)

  Background: Oral anticoagulants are used for stroke prevention in patients with atrial fibrillation, the most common cardiac arrhythmia in older adults. The aim of our study was to identify the evidence on the risks and ...
• Efficacy and safety of metformin in the management of type 2 diabetes mellitus in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing

  Schlender, Lisa; Martinez, Yolanda V.; Adeniji, Charles; Reeves, David; Faller, Barbara; Sommerauer, Christina; Al Qur’an, Thekraiat; Woodham, Adrine; Kunnamo, Ilkka; Sönnichsen, Andreas; Renom-Guiteras, Anna (BioMed Central, 2017)

  BACKGROUND: Metformin is usually prescribed as first line therapy for type 2 diabetes mellitus (DM2). However, the benefits and risks of metformin may be different for older people. This systematic review examined the ...
• Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults - a systematic review

  Meinshausen, Maren; Rieckert, Anja; Renom-Guiteras, Anna; Kröger, Moritz; Sommerauer, Christina; Kunnamo, Ilkka; Martinez, Yolanda V.; Esmail, Aneez; Sönnichsen, Andreas (BioMed Central, 2017)

  BACKGROUND: Platelet aggregation inhibitors (PAI) are among the most frequently prescribed drugs in older people, though evidence about risks and benefits of their use in older adults is scarce. The objectives of this ...
• A set of systematic reviews to help reduce inappropriate prescribing to older people: study protocol

  Martinez, Yolanda V.; Renom-Guiteras, Anna; Reeves, David; Erandie Ediriweera de Silva, R.; Esmail, Aneez; Kunnamo, Ilkka; Rieckert, Anja; Sommerauer, Christina; Sönnichsen, Andreas (BioMed Central, 2017)

  BACKGROUND: Multimorbidity and polypharmacy are common in older people. Assessment tools or lists of criteria aimed at supporting prescription decisions for older people exist, but have often been based on expert opinion ...
• Surface ECG interatrial block-guided treatment for stroke prevention: rationale for an attractive hypothesis

  Bayés-De-Luna, Antoni; Martínez-Sellés, Manuel; Bayés-Genís, Antoni; Elosua Llanos, Roberto; Baranchuk, Adrian (BioMed Central, 2017)

  Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with stroke, cognitive impairment, and cardiovascular death. Some predisposing factors - as aging, diabetes, hypertension - induce and ...
• Short-term exposure to traffic-related air pollution and ischemic stroke onset in Barcelona, Spain

  Vivanco Hidalgo, Rosa María; Wellenius, Gregory A.; Basagaña Flores, Xavier; Cirach, Marta; González, Alejandra Gómez; Ceballos, Pablo de; Zabalza, Ana; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Alastuey, Andrés; Querol, Xavier; Sunyer Deu, Jordi; Roquer, Jaume (Elsevier, 2018)

  OBJECTIVE: To assess the relationship between short-term exposure to outdoor ambient air pollutants (fine particulate matter [PM2.5] and black carbon [BC]), ischemic stroke (IS) and its different subtypes, and the potential ...

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