• Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial

  Boronat Rigol, Anna; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz Aguayo, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)

  Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 ...
• Accuracy of online survey assessment of mental disorders and suicidal thoughts and behaviors in Spanish university students. Results of the WHO World Mental Health- International College Student initiative

  Ballester, Laura; Alayo, Itxaso; Vilagut Saiz, Gemma, 1975-; Blasco Cubedo, Maria Jesús; Mortier, Philippe; Alonso Caballero, Jordi; UNIVERSAL study group (Public Library of Science (PLoS), 2019)

  Objective: To assess the accuracy of WMH-ICS online screening scales for evaluating four common mental disorders (Major Depressive Episode[MDE], Mania/Hypomania[M/H], Panic Disorder[PD], Generalized Anxiety Disorder[GAD]) ...
• Generation of the antioxidant hydroxytyrosol from tyrosol present in beer and red wine in a randomized clinical trial

  Soldevila-Domenech, Natalia; Boronat Rigol, Anna; Mateus Rodriguez, Julian Andrés; Diaz-Pellicer, Patricia; Matilla, Iris; Pérez-Otero, Marta; Aldea-Perona, Ana; Torre Fornell, Rafael de la (MDPI, 2019)

  Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. We investigated in humans ...
• N-of-1 clinical trials in nutritional interventions directed at improving cognitive function

  Soldevila-Domenech, Natalia; Boronat Rigol, Anna; Langohr, Klaus; Torre Fornell, Rafael de la (Frontiers, 2019)

  Longer life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent ...
• Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children

  Mortamais, Marion; Pujol Martí, Jesús, 1981-; Martínez-Vilavella, Gerard; Fenoll, Raquel; Reynes, Christelle; Sabatier, Robert; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cirach, Marta; Alvarez-Pedrerol, Mar; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi (Elsevier, 2019)

  Objective: Air pollution (AP) may affect neurodevelopment, but studies about the effects of AP on the growing human brain are still scarce. We aimed to investigate the effects of prenatal exposure to AP on lateral ventricles ...
• Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms

  Ghosh, Eshan; Dwivedi, Hemlata; Baidya, Mithu; Srivastava, Ashish; Kumari, Punita; Stepniewski, Tomek; Kim, Hee Ryung; Lee, Mi-Hye; van Gastel, Jaana; Chaturvedi, Madhu; Roy, Debarati; Pandey, Shubhi; Maharana, Jagannath; Guixà González, Ramon, 1978-; Luttrell, Louis M.; Chung, Ka Young; Dutta, Somnath; Selent, Jana; Shukla, Arun K. (Elsevier, 2019)

  Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high ...
• Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)

  Navarro Mateu, Fernando; Quesada, Mari Paz; Escámez, Teresa; Alcaráz, Mª José; Seiquer de la Peña, Catherine; Salmerón, Diego; Huerta, José María; Vilagut Saiz, Gemma, 1975-; Chirlaque, María Dolores; Navarro, Carmen; Husky, Mathilde M.; Kessler, Ronald C.; Alonso Caballero, Jordi; Martínez, Salvador (BMJ Publishing Group, 2019)

  Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. Design Retrospective case-control study. Setting Cases ...
• Three-dimensional genomic structure and cohesin occupancy correlate with transcriptional activity during spermatogenesis

  Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Le Dily, François; Garcia, Francisca; Salvà-Castro, Judit; Gómez-H, Laura; Julià, Eva; Moutinho, Catia; Aiese Cigliano, Riccardo; Sanseverino, Walter; Fornas Carreño, Oscar; Pendás, Alberto M.; Heyn, Holger; Waters, Paul D.; Marti-Renom, Marc A.; Ruiz Herrera, Aurora (Elsevier, 2019)

  Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas ...
• Impact of socio-economic inequities on tuberculosis in a Southern European city: what is the effect of the recession?

  Prats Uribe, Albert; Orcau, Angels; Millet, Joan-Pau; Caylà i Busqueras, Joan A. (International Union Against Tuberculosis and Lung Disease, 2019)

  INTRODUCTION: Economic crises affect a population's health, particularly among the most deprived. The increase in health inequalities in the latest recession may have influenced the incidence of tuberculosis (TB). We ...
• Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker's yeast

  Blevins, William R.; Tavella, Teresa; Moro, Simone G.; Blasco Moreno, Bernat, 1986-; Closa-Mosquera, Adrià; Díez Antón, Juana, 1962-; Carey, Lucas; Albà Soler, Mar (Nature Research, 2019)

  Cells responds to diverse stimuli by changing the levels of specific effector proteins. These changes are usually examined using high throughput RNA sequencing data (RNA-Seq); transcriptional regulation is generally assumed ...
• Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

  Chauhan, Ganesh; Jiménez-Conde, Jordi; Debette, Stéphanie (Lippincott Williams & Wilkins, 2019)

  OBJECTIVE: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. METHODS: We performed meta-analyses of genome-wide association studies (GWAS) and examined ...
• Multicenter study of parenteral nutrition in non-critically ill elderly patients compared to younger patients - Study IAIOS-PN (Incidence and Assessment of Iatrogenesis in Older Subjects receiving Parenteral Nutrition)

  Mateu de Antonio, Francisco Javier; Berlana, David; Pons-Busom, Montserrat; Badia-Tahull, Maria B.; Miana-Mena, María Teresa; Martínez-Castro, Beatriz; Sunyer-Esquerrà, Neus; Sanmartin-Suñer, Mónica; González-Valdivieso, Juan; Leiva-Badosa, Elisabet; Martínez-Bernabé, Eva; Murgadella-Sancho, Anna; Mirerachs-Aranda, Nuria; Vila-Bundó, Anna; Fernández-Morató, Jordi; Vitales-Farrero, María Teresa (Arán Ediciones, 2018)

  OBJECTIVE: this study assessed the incidence of hyperglycemia, hypertriglyceridemia, and liver function test (LFT) alterations among patients older and younger than 65 years receiving parenteral nutrition (PN). A secondary ...
• Trajectories of sickness absence among salaried workers: evidence from the WORKss cohort in Catalonia (Spain), 2012-2014

  Ubalde López, Mònica, 1972-; Hernando-Rodriguez, Julio C.; Benavides, Fernando G. (Fernando García); Serra Saurina, Laura (BMJ Publishing Group, 2019)

  Objectives: Sickness absence (SA) is a widely studied integrated measure of health status. To better understand how SA behaves over time (SA trajectory) a longitudinal and individual-centred approach will allow identifying ...
• Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients

  Millares, Laura; Pascual Guàrdia, Sergi, 1979-; Montón, Concepción; García-Nuñez, Marian; Lalmolda, Cristina; Faner, Rosa; Casadevall Fusté, Carme; Setó, Laia; Capilla, Silvia; Moreno, Amàlia; Castro-Acosta, Ady Angélica; Alvarez-Martinez, Carlos José; Sibila, Oriol; Peces-Barba, Germán; Cosio, Borja G.; Agustí, Alvar; Gea Guiral, Joaquim; Monsó, Eduard (BioMed Central, 2019)

  Background: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating ...
• The role of socioeconomic status in the association of lung function and air pollution-A pooled analysis of three adult ESCAPE cohorts

  Keidel, Dirk; Antó i Boqué, Josep Maria; Basagaña Flores, Xavier; Burte, Marthe-Emilie, 1989-; Carsin, Anne-Elie; Sunyer Deu, Jordi; Jacquemin Leonard, Bénédicte; Probst-Hensch, Nicole (MDPI, 2019)

  Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution ...
• Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

  Carsin, Anne-Elie; Fuertes, Elaine; Antó i Boqué, Josep Maria; Guerra, Stefano; García Aymerich, Judith (Elsevier, 2019)

  Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with ...
• Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial

  Sánchez-Rodriguez, Estefanía; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Calleja, Miguel Angel; Espejo-Calvo, Juan A.; Gil-Extremera, Blas; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Vilchez, Pedro; Alche, Juan de Dios; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (MDPI, 2019)

  A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of ...
• Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis

  Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)

  BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
• Urine metabolic signatures of multiple environmental pollutants in pregnant women: an exposome approach

  Maitre, Léa; Robinson, Oliver; Martínez, David; Toledano, Mireille B.; Ibarluzea, Jesús; Marina, Loreto Santa; Sunyer Deu, Jordi; Villanueva, Cristina M.; Keun, Hector C.; Vrijheid, Martine; Coen, Muireann (American Chemical Society (ACS), 2018)

  Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. ...
• Long-term exposure to residential green and blue spaces and anxiety and depression in adults: A cross-sectional study

  Gascon Merlos, Mireia, 1984-; Sánchez Benavides, Gonzalo; Dadvand, Payam; Martínez, David; Gramunt Fombuena, Nina; Gotsens, Xavier; Cirach, Marta; Vert, Cristina; Molinuevo, José Luis; Crous-Bou, Marta; Nieuwenhuijsen, Mark J. (Elsevier, 2018)

  Background: Although exposure to natural outdoor environments has been consistently associated with improved perceived general health, available evidence on a protective association between this exposure and specific mental ...

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