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Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks

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dc.contributor.author Kiel, Christina
dc.contributor.author Serrano Pubull, Luis, 1982-
dc.date.accessioned 2015-02-11T09:31:36Z
dc.date.available 2015-02-11T09:31:36Z
dc.date.issued 2012
dc.identifier.citation Kiel C, Serrano L. Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks. Structure. 2012;20(11):1806-13. DOI: 10.1016/j.str.2012.10.002
dc.identifier.issn 0969-2126
dc.identifier.uri http://hdl.handle.net/10230/23121
dc.description.abstract In recent years, high-throughput discovery of macromolecular protein structures and complexes has played a major role in advancing a more systems-oriented view of protein interaction and signaling networks. The design of biological systems often employs structural information or structure-based protein design to successfully implement synthetic signaling circuits or for rewiring signaling flows. Here, we summarize the latest advances in using structural information for studying protein interaction and signaling networks, and in synthetic biology approaches. We then provide a perspective of how combining structural biology with engineered cell signaling modules--using additional information from quantitative biochemistry and proteomics, gene evolution, and mathematical modeling--can provide insight into signaling modules and the general design principles of cell signaling. Ultimately, this will improve our understanding of cell- and tissue-type-specific signal transduction. Integrating the quantitative effects of disease mutations into these systems may provide a basis for elucidating the molecular mechanisms of diseases.
dc.description.sponsorship The work was supported by the EU (PROSPECTS, grant agreement number 201648, and PRIMES, grant agreement number 278568)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Structure. 2012;20(11):1806-13
dc.rights © Elsevier http://dx.doi.org/10.1016/j.str.2012.10.002 Article published under an Elsevier user license, protected by copyright and may be used for non-commercial purposes. Users may access, download, copy, translate, text mine and data mine the article.
dc.rights.uri http://www.elsevier.com/open-access/userlicense/1.0/
dc.subject.other Proteïnes
dc.subject.other Transducció de senyal cel·lular
dc.title Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.str.2012.10.002
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201648
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/278568
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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