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Advancing cell biology through proteomics in space and time (PROSPECTS)

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dc.contributor.author Lamond, Angus I.
dc.contributor.author Uhlen, Mathias
dc.contributor.author Horning, Stevan
dc.contributor.author Makarov, Alexander
dc.contributor.author Robinson, Carol V.
dc.contributor.author Serrano Pubull, Luis, 1982-
dc.contributor.author Hartl, F. Ulrich
dc.contributor.author Baumeister, Wolfgang
dc.contributor.author Werenskiold, Anne Katrin
dc.contributor.author Andersen, Jens S.
dc.contributor.author Vorm, Ole
dc.contributor.author Linial, Michal
dc.contributor.author Aebersold, Ruedi
dc.contributor.author Mann, Matthias
dc.date.accessioned 2015-02-11T09:31:30Z
dc.date.available 2015-02-11T09:31:30Z
dc.date.issued 2012
dc.identifier.citation Lamond AI, Uhlen M, Horning S, Makarov A, Robinson CV, Serrano L et al. Advancing cell biology through proteomics in space and time (PROSPECTS). Mol Cell Proteomics. 2012; 11(3): O112.017731. DOI: 10.1074/mcp.O112.017731
dc.identifier.issn 1535-9476
dc.identifier.uri http://hdl.handle.net/10230/23119
dc.description.abstract The term "proteomics" encompasses the large-scale detection and analysis of proteins and their post-translational modifications. Driven by major improvements in mass spectrometric instrumentation, methodology, and data analysis, the proteomics field has burgeoned in recent years. It now provides a range of sensitive and quantitative approaches for measuring protein structures and dynamics that promise to revolutionize our understanding of cell biology and molecular mechanisms in both human cells and model organisms. The Proteomics Specification in Time and Space (PROSPECTS) Network is a unique EU-funded project that brings together leading European research groups, spanning from instrumentation to biomedicine, in a collaborative five year initiative to develop new methods and applications for the functional analysis of cellular proteins. This special issue of Molecular and Cellular Proteomics presents 16 research papers reporting major recent progress by the PROSPECTS groups, including improvements to the resolution and sensitivity of the Orbitrap family of mass spectrometers, systematic detection of proteins using highly characterized antibody collections, and new methods for absolute as well as relative quantification of protein levels. Manuscripts in this issue exemplify approaches for performing quantitative measurements of cell proteomes and for studying their dynamic responses to perturbation, both during normal cellular responses and in disease mechanisms. Here we present a perspective on how the proteomics field is moving beyond simply identifying proteins with high sensitivity toward providing a powerful and versatile set of assay systems for characterizing proteome dynamics and thereby creating a new "third generation" proteomics strategy that offers an indispensible tool for cell biology and molecular medicine.
dc.description.sponsorship This work was funded in part by the EU FP7 PROSPECTS network (Grant#: HEALTH-F4-2008-201648)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Society for Biochemistry and Molecular Biology (ASBMB)
dc.rights © The Authors. This article is distributed under the terms of a Creative Commons Attribution- NonCommercial License http://dx.doi.org/10.1074/mcp.O112.017731
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Citologia
dc.subject.other Espectrometria de masses
dc.subject.other Proteòmica
dc.title Advancing cell biology through proteomics in space and time (PROSPECTS)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1074/mcp.O112.017731
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201648
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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