Browsing Hospital del Mar Research Institute by Title

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  • Moral breakdowns and ethical dilemmas of perioperative nurses during COVID-19: COREQ-Compliant study
    Sillero-Sillero, Amalia; Ayuso Margañón, Raquel; Gil Poisa, Maria; Buil, Neus; Padrosa Sayeras, Eva, 1993-; Insa-Calderón, Esther; Marqués Sulé, Elena; Alcover Van De Walle, Carlota (MDPI, 2023)
    (1) Background: The COVID-19 pandemic has led to an increase in the complexity of caregiving, resulting in challenging situations for perioperative nurses. These situations have prompted nurses to assess their personal and ...
  • Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis
    Micó, Víctor; Fitó Colomer, Montserrat; Schröder, Helmut, 1958-; Martínez, José Alfredo (Frontiers, 2022)
    Metabolic syndrome (MetS) is one of the most important medical problems around the world. Identification of patient´s singular characteristic could help to reduce the clinical impact and facilitate individualized management. ...
  • Morphological changes of the pancreas after pancreaticoduodenectomy
    Quesada Diez, Rita; Simón, Clara; Radosevic, Aleksandar, 1974-; Poves Prim, José Ignacio; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Research, 2019)
    The aim of this retrospective study was thus to evaluate postoperative morphological changes in the remnant pancreas after pancreaticoduodenectomy (PD) associated with postoperative pancreatic fistula (POPF). Fifty-one ...
  • Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study
    Suárez Novo, José Francisco; Zamora, Víctor; Garin Boronat, Olatz, 1979-; Gutiérrez, Cristina; Pont Acuña, Àngels; Pardo Cladellas, Yolanda; Goñi, Alai; Mariño, Alfonso; Hervás, Asunción; Herruzo, Ismael; Cabrera Roldán, Patricia; Sancho-Pardo, Gemma; Ponce de León, Javier; Macías, Víctor; Guedea, Ferrán; Vigués, Francesc; Castells, Manuel; Ferrer Forés, Maria Montserrat; Multicentric Spanish Group of Clinically Localized Prostate Cancer (Nature Research, 2022)
    To compare the effectiveness at ten years of follow-up of radical prostatectomy, brachytherapy and external radiotherapy, in terms of overall survival, prostate cancer-specific mortality and biochemical recurrence. Cohort ...
  • Mortality due to cryptococcus neoformans and cryptococcus gattii in low-income settings: an autopsy study
    Hurtado, Juan Carlos; Letang Jiménez de Anta, Emilio Ángel; Martínez, Miguel J. (Nature Research, 2019)
    Cryptococcosis is a major opportunistic infection and is one of the leading causes of death in adults living with HIV in sub-Saharan Africa. Recent estimates indicate that more than 130,000 people may die annually of ...
  • Mortality in hemodialysis patients with COVID-19, the effect of paricalcitol or calcimimetics
    Arenas Jiménez, María Dolores; Riera Oliva, Marta; Cao Baduell, Higinio; Collado Nieto, Silvia; Barbosa Puig, Francisco; Nogués Solan, Francesc Xavier; Crespo, Marta; Pascual Santos, Julio (MDPI, 2021)
    Background: In COVID-19 patients, low serum vitamin D (VD) levels have been associated with severe acute respiratory failure and poor prognosis. In regular hemodialysis (HD) patients, there is VD deficiency and markedly ...
  • Mortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study
    Sánchez-Rodríguez, María Dolores; Locquet, Médéa; Reginster, Jean-Yves; Cavalier, Etienne; Bruyère, Olivier; Beaudart, Charlotte (Wiley, 2020)
    Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently launched by consensus of the major nutrition societies. GLIM criteria are partly constructed on the previous definition of ...
  • Mortality risk estimation in acute calculous cholecystitis: beyond the Tokyo Guidelines
    González Castillo, Ana María; Sancho Insenser, Juan; Miguel Palacio, Maite de; Morera Casaponsa, Josep Ricard; Membrilla Fernández, Estela; Pons Fragero, María José; Pera Roman, Miguel; Grande Posa, Luís (BioMed Central, 2021)
    Background: Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is the early laparoscopic cholecystectomy; however, the Tokyo Guidelines ...
  • Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators
    Codina, Pau; Zamora, Elisabet; Levy, Wayne C.; Revuelta-López, Elena; Borrellas, Andrea; Spitaleri, Giosafat; Cediel, German; Ruiz-Cueto, María; Cañedo, Elena; Santiago-Vacas, Evelyn; Domingo, Mar; Buchaca, David; Subirana Cachinero, Isaac; Santesmases, Javier; de la Espriella, Rafael; Núñez, Julio; Lupón, Josep; Bayes-Genis, Antoni (Frontiers, 2022)
    Objectives: heart failure (HF) management has significantly improved over the past two decades, leading to better survival. This study aimed to assess changes in predicted mortality risk after 12 months of management in a ...
  • Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort.
    Garriga, César; Garcia de Olalla, Patricia; Miró, José María; Ocaña, Inma; Knobel Freud, Hernando; Barberà, María Jesús; Humet, Victoria; Domingo, Pere; Gatell, Josep M.; Ribera, Esteve; Gurguí, Mercè; Marco, Andrés; Caylà i Busqueras, Joan A.; Barcelona HIV/AIDS working group (Public Library of Science, 2015)
    INTRODUCTION: Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their ...
  • Mosaic loss of chromosome Y is associated with common variation near TCL1A
    Zhou, W.; Real, Francisco X.; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Chanock, Stephen J. (Nature Publishing Group, 2016)
    Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts ...
  • Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
    Rodríguez Santiago, Benjamín; Malats i Riera, Núria; Rothman, Nathaniel; Armengol i Dulcet, Lluís; García Closas, Montserrat; Kogevinas, Manolis; Villa, Olaya; Hutchinson, Amy; Earl, Julie; Marenne, Gaëlle; Jacobs, Kevin; Rico, Daniel; Tardón, Adonina; Carrato, Alfredo; Thomas, Gilles; Valencia, Alfonso; Silverman, Debra T.; Real, Francisco X.; Chanock, Stephen J.; Pérez Jurado, Luis Alberto (Elsevier, 2010)
    Mosaicism is defined as the coexistence of cells with different genetic composition within an individual, caused by postzygotic somatic mutation. Although somatic mosaicism for chromosomal abnormalities is a well-established ...
  • MRI evaluation of the peripheral attachments of the lateral meniscal body: the menisco-tibio-popliteus-fibular complex
    Morales Avalos, Rodolfo; Masferrer-Pino, Àngel; Ruiz-Chapa, Eustorgio; Padilla-Medina, José Ramón; Vilchez-Cavazos, Félix; Peña Martínez, Víctor M.; Elizondo Omaña, Rodrigo E.; Perelli, Simone; Guzmán-López, Santos; García-Quintanilla, Juan Francisco; Monllau García, Juan Carlos (Springer, 2022)
    Purpose: To determine, identify and measure the structures of the menisco-tibio-popliteus-fibular complex (MTPFC) with magnetic resonance imaging (MRI) in knees without structural abnormalities or a history of knee surgery. ...
  • MRI radiomic signature of white matter hyperintensities is associated with clinical phenotypes
    Bretzner, Martin; Jimenez-Conde, Jordi; Rost, Natalia (Frontiers, 2021)
    Objective: Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing ...
  • mTOR inhibition and T-DM1 in HER2-positive breast cancer
    Casadevall Aguilar, David; Hernández Prat, Anna, 1984-; García-Alonso, Sara; Arpí Llucià, Oriol; Menéndez, Silvia; Qin, Mengjuan; Guardia Valenzuela, Cristina, 1990-; Morancho Armisen, Beatriz; Sánchez-Martín, Francisco Javier; Zazo, Sandra; Gavilán, Elena; Sabbaghi Mehrjardi, Mohammad Ali; Eroles, Pilar; Cejalvo, Juan M.; Lluch, Ana; Rojo, Federico; Pandiella, Atanasio; Rovira, Ana; Albanell Mestres, Joan (American Association for Cancer Research (AACR), 2022)
    In patients with trastuzumab-resistant HER2-positive breast cancer, the combination of everolimus (mTORC1 inhibitor) with trastuzumab failed to show a clinically significant benefit. However, the combination of mTOR ...
  • mTOR intersects antibody-inducing signals from TACI in marginal zone B cells
    Sintes, Jordi; Serrano Figueras, Sergi; Lloreta, Josep, 1958-; Cerutti, Andrea, 1965- (Nature Publishing Group, 2017)
    Mechanistic target of rapamycin (mTOR) enhances immunity in addition to orchestrating metabolism. Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte ...
  • Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
    Paternoster, Lavinia; Gonzalez, Juan Ramon; Bustamante Pineda, Mariona; Tejedor, Elisabeth; Sunyer Deu, Jordi; Weidinger, Stephan (Nature Research, 2015)
    Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, ...
  • Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer.
    Solassol, Jérome; Bellosillo Paricio, Beatriz; Montagut Viladot, Clara; Sillekens, Peter (Public Library of Science (PLoS) , 2016)
    Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent ...
  • Multi-center evaluation of the novel fully-automated PCR-based Idylla™ BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma.
    Melchior, Linea; Grauslund, Morten; Bellosillo Paricio, Beatriz; Montagut Viladot, Clara; Torres, Erica; Moragón, Ester; Micalessi, Isabel; Frans, Johan; Noten, Veerle; Bourgain, Claire; Vriesema, Renske; van der Geize, Robert; Cokelaere, Kristof; Vercooren, Nancy; Crul, Katrien; Rüdiger, Thomas; Buchmüller, Diana; Reijans, Martin; Jans, Caroline (Elsevier, 2015)
    The advent of BRAF-targeted therapies led to increased survival in patients with metastatic melanomas harboring a BRAF V600 mutation (implicated in 46–48% of malignant melanomas). The Idylla™ System (Idylla™), i.e., the ...
  • Multi-omics signatures of the human early life exposome
    Maitre, Léa; Bustamante Pineda, Mariona; Hernández Ferrer, Carles; Vives Usano, Marta, 1990-; Ruiz-Arenas, Carlos; Pelegrí-Sisó, Dolors; Casas Sanahuja, Maribel; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; González, Juan Ramón; Vrijheid, Martine (Nature Research, 2022)
    Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) ...

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