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Now showing items 5087-5095 of 5095

YAP activation is associated with a worse prognosis of poorly cohesive gastric cancer

Bencivenga, Maria; Torroni, Lorena; Dal Cero, Mariagiulia; Quinzii, Alberto; Zecchetto, Camilla; Merz, Valeria; Casalino, Simona; Taus, Francesco; Pietrobono, Silvia; Mangiameli, Domenico; Filippini, Federica; Alloggio, Mariella; Castelli, Claudia; Iglesias Coma, Mar; Pera Roman, Manuel Ramón; Melisi, Davide (MDPI, 2023)

Poorly cohesive (PC) gastric cancer (GC) is extremely aggressive in progression, and there is an urgent need to identify the molecular pathways involved. We hypothesized the essential role of the RhoA-YAP axis in these ...
Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial

Martínez-González, Miguel Ángel, 1957-; Hernáez, Álvaro; Castañer, Olga; Salas Salvadó, Jordi (BioMed Central, 2023)

Background: Several large observational prospective studies have reported a protection by the traditional Mediterranean diet against type 2 diabetes, but none of them used yearly repeated measures of dietary intake. Repeated ...
Yield of clinically reportable genetic variants in unselected cerebral palsy by whole genome sequencing

van Eyk, Clare L.; Webber, Dani L.; Minoche, André E.; Pérez Jurado, Luis Alberto; Corbett, Mark A.; Gardner, Alison E.; Berry, Jesia G.; Harper, Kelly; MacLennan, Alastair H.; Gecz, Jozef (Nature Research, 2021)

Cerebral palsy (CP) is the most common cause of childhood physical disability, with incidence between 1/500 and 1/700 births in the developed world. Despite increasing evidence for a major contribution of genetics to CP ...
ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells

Riso, Vincenzo; Cammisa, Marco; Kukreja, Harpreet; Anvar, Zahra; Verde, Gaetano; Sparago, Angela; Acurzio, Basilia; Lad, Shraddha; Lonardo, Enza; Sankar, Aditya; Helin, Kristian; Feil, Robert; Fico, Annalisa; Angelini, Claudia; Grimaldi, Giovanna; Riccio, Andrea (Oxford University Press, 2016)

ZFP57 is necessary for maintaining repressive epigenetic modifications at Imprinting control regions (ICRs). In mouse embryonic stem cells (ESCs), ZFP57 binds ICRs (ICRBS) and many other loci (non-ICRBS). To address the ...
Zinc-finger domains in metazoans: evolution gone wild

Albà Soler, Mar (BioMed Central, 2017)
Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget’s disease of bone

Cronin, Owen; Blanch-Rubió, Josep; Ralston, Stuart H. (BMJ Publishing Group, 2019)

INTRODUCTION: Paget's disease of bone (PDB) is characterised by increased and disorganised bone remodelling affecting one or more skeletal sites. Complications include bone pain, deformity, deafness and pathological ...
Zoledronic acid as compared with observation in multiple myeloma patients at biochemical relapse: results of the randomized AZABACHE Spanish trial.

García-Sanz, Ramón; Albert, Oriol; Moreno, María J.; Rubia, Javier de la; Payer, Angel R.; Hernández, Miguel T.; Palomera, Luis; Teruel, Ana I.; Blanchard, María J.; Gironella, Mercedes; Ribas, Paz; Bargay, Joan; Abella Monreal, Eugenia; Granell, Miquel; Ocio, Enrique M.; Ribera, Josep Maria; San Miguel, Jesús F.; Mateos, María V.; Spanish Myeloma Group (GEM/PETHEMA). (Ferrata Storti Foundation, 2015)

This study analyzed the anti-myeloma effect of zoledronic acid monotherapy by investigating patients at the time of asymptomatic biochemical relapse. One hundred patients were randomized to receive either zoledronic acid ...
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia

García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)

Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...
β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.

Gekas, Christos; Teresa, D'Altri 1984-; Aligué, Rosa; González, Jessica; Espinosa Blay, Lluís; Bigas Salvans, Anna (Nature Publishing Group, 2016)

Notch activation is instrumental in the development of most T-cell acute lymphoblastic leukemia (T-ALL) cases, yet Notch mutations alone are not sufficient to recapitulate the full human disease in animal models. We here ...

Now showing items 5087-5095 of 5095

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