Browsing Hospital del Mar Research Institute by Title

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  • P-tau235: a novel biomarker for staging preclinical Alzheimer's disease
    Lantero Rodriguez, Juan; Snellman, Anniina; Benedet, Andrea L.; Milà Alomà, Marta; Camporesi, Elena; Montoliu-Gaya, Laia; Ashton, Nicholas J.; Vrillon, Agathe; Karikari, Thomas K.; Domingo Gispert, Juan; Salvadó, Gemma; Shekari, Mahnaz; Toomey, Christina E.; Lashley, Tammaryn L.; Zetterberg, Henrik; Suárez-Calvet, Marc; Brinkmalm, Gunnar; Rosa-Neto, Pedro; Blennow, Kaj (Wiley, 2021)
    Alzheimer's disease (AD) is characterised by a long preclinical phase. Although phosphorylated tau (p-tau) species such as p-tau217 and p-tau231 provide accurate detection of early pathological changes, other biomarkers ...
  • p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes
    Perearnau, Anna; Orlando, Serena; Islam, Abul, 1978-; Gallastegui Calvache, Edurne; Martínez, Jonatan; Jordan Vallès, Albert; Bigas Salvans, Anna; Aligué, Rosa; Pujol, Maria Jesús; Bachs Valldeneu, Oriol (Oxford University Press, 2017)
    The cyclin-dependent kinase inhibitor p27Kip1 (p27) also behaves as a transcriptional repressor. Data showing that the p300/CBP-associated factor (PCAF) acetylates p27 inducing its degradation suggested that PCAF and p27 ...
  • p53 expression in breast cancer predicts tumors with low probability of non-sentinel nodes infiltration.
    Vernet-Tomás, Maria; Baños, Núria; Sabadell Marcadal, Maria Dolores; Corominas Torres, Josep Maria; Mestre-Fusco, Antoni; Suárez-Piñera, Marina; Carreras Collado, Ramón (Wiley, 2015)
    AIM: Several predictive tools of non-sentinel lymph nodes neoplastic involvement when a positive sentinel lymph node is found have been described. However, molecular factors have been rarely evaluated to build these tools. ...
  • p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases
    Rakislova, Natalia; Alemany, Laia; Clavero, Omar; Saco, Adela; Torné, Aureli; Pino, Marta Del; Munmany, Meritxell; Rodrigo Calvo, Maria Teresa; Guerrero, José; Marimon, Lorena; Vega, Naiara; Quirós, Beatriz; Lloveras Rubio, Belen; Ribera-Cortada, Inmaculada; Alejo, María; Pawlita, Michael; Quint, Wim; Sanjosé Llongueras, Silvia de; Ordi, Jaume; Vvap Study Group (MDPI, 2020)
    Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown ...
  • p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
    Solé, Laura; Lobo-Jarne, Teresa; Álvarez-Villanueva, Daniel; Alonso-Marañón, Josune; Guillén, Yolanda; Guix Arnau, Marta, 1974-; Sangrador, Irene; Rozalén, Catalina; Vert, Anna; Lop Gros, Joan; Salido Galeote, Marta; Bellosillo Paricio, Beatriz; García-Romero, Raquel; Garrido, Marta; González, Jessica; López Arribillaga, Erika, 1986-; Iglesias Coma, Mar; Celià-Terrassa, Toni; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Research, 2022)
    Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and ...
  • PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus
    Velasco, Eric R.; Florido Torres, Antonio Luis; Flores de los Heros, África, 1985-; Senabre, Eric; Gómez-Gómez, Àlex; Torres, Antoni; Roca, Antoni; Norrholm, Seth; Newman, Emily L.; Das, Payel; Ross, Rachel A.; Lori, A.; Pozo Mendoza, Óscar J., 1975-; Ressler, Kerry J.; Garcia-Esteve, Lluïsa; Jovanovic, Tanja; Andero, Raül (Nature Research, 2022)
    Exposure to traumatic stress can lead to fear dysregulation, which has been associated with posttraumatic stress disorder (PTSD). Previous work showed that a polymorphism in the PACAP-PAC1R (pituitary adenylate cyclase-activating ...
  • Pacientes con Gripe por Virus Influenza A (H1N1)pdm09 ingresados en UCI. Impacto de las Recomendaciones de la SEMICYUC
    Marin Corral, Judith; Climent Company, María Cristina; Muñoz Bermudez, Rosana; Samper Echevarria, Maria; Dot Jordana, Irene, 1982-; Vilà Vilardell, Clara; Masclans Enviz, Joan Ramon; Rodríguez, Alejandro; Martín Loeches, Ignacio; Álvarez Lerma, Francisco; H1N1 GETGAG/SEMICYUC Study Group (Elsevier, 2018)
    OBJECTIVES: To evaluate the impact of the recommendations of the SEMICYUC (2012) on severe influenza A. DESIGN: A prospective multicenter observational study was carried out. SETTING: ICU. PATIENTS: Patients infected with ...
  • PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses
    Acera Mateos, Pablo; Balboa, Renzo F.; Easteal, Simon; Eyras Jiménez, Eduardo; Patel, Hardip R. (Nature Research, 2021)
    Viral co-infections occur in COVID-19 patients, potentially impacting disease progression and severity. However, there is currently no dedicated method to identify viral co-infections in patient RNA-seq data. We developed ...
  • Pain management during office hysteroscopy: An evidence-based approach
    Buzzaccarini, Giovanni; Pacheco, Luis Alonso; Vitagliano, Amerigo; Haimovich Segal, Sergio Mario; Chiantera, Vito; Török, Péter; Vitale, Salvatore Giovanni; Laganà, Antonio Simone; Carugno, Jose (MDPI, 2022)
    Background and Objectives: Hysteroscopy is a reliable technique which is highly useful for the evaluation and management of intrauterine pathology. Recently, the widespread nature of in-office procedures without the need ...
  • Painful hemorrhage of vestibular papillae: A probably underreported complication of vestibular papillomatosis
    López Trujillo, Emilio; Segura Tigell, Sonia; Sánchez-Schmidt, Julia Maria (Mattioli 1885, 2024)
  • PAKistan Study of prEmature coronary atHerosclerosis in young AdulTs (PAK-SEHAT): a prospective longitudinal study protocol investigating the prevalence, severity and determinants of atherosclerotic cardiovascular disease in the young adult Pakistani population
    Hanif, Bashir; Sheikh, Sana; Peerwani, Ghazal; Cainzos-Achirica, Miguel; Javed, Wajiha; Baqar, Jaffer Bin; Samad, Zainab; Bashir, Faiza; Virani, Salim S.; Nasir, Khurram; Aijaz, Saba (BMJ Publishing Group, 2023)
    Introduction: Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity, mortality and health expenditures worldwide. Despite having higher ASCVD in the Pakistani population, data on subclinical coronary ...
  • Palbociclib and ribociclib in breast cancer: consensus workshop on the management of concomitant medication
    Bellet, Meritxell; Ruiz, Ada; de la Peña, Lorena (SAGE Publications, 2019)
    Drug-drug interactions are of significant concern in clinical practice in oncology, particularly in patients receiving Cyclin-dependent kinase (CDK) 4/6 inhibitors, which are typically exposed to long-term regimens. This ...
  • Palbociclib combined with endocrine therapy in heavily pretreated HR +/HER2 - advanced breast cancer patients: results from the compassionate use program in Spain (PALBOCOMP)
    Manso, Luis; Servitja Tormo, Sonia; Moreno, Fernando (Elsevier, 2020)
    Background: This study evaluated efficacy and safety of palbociclib, a CDK4/6 inhibitor, in heavily-pretreated hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast ...
  • Palbociclib rechallenge for hormone receptor-positive/HER-negative advanced breast cancer: findings from the phase II BioPER trial
    Albanell Mestres, Joan; Comerma Blesa, Laura, 1983-; Gibert, Joan; Bellosillo Paricio, Beatriz; Menéndez, Silvia; Llombart-Cussac, Antonio (American Association for Cancer Research (AACR), 2023)
    Purpose: to assess the efficacy and exploratory biomarkers of continuing palbociclib plus endocrine therapy (ET) beyond progression on prior palbociclib-based regimen in patients with hormone receptor-positive/HER2-negative ...
  • Palbociclib with fulvestrant or letrozole in endocrine-sensitive patients with HR-Positive/HER2-Negative advanced breast cancer: A detailed safety analysis of the randomized PARSIFAL trial
    Di Cosmo, Serena; Albanell Mestres, Joan; Llombart-Cussac, Antonio (Oxford University Press, 2023)
    Background: Palbociclib has gained a central role in the treatment of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). Despite its manageable toxicity ...
  • Palliative oncological patients with insomnia: concerns of the patients and their relatives' perception
    Font Guiteras, Antoni; Villar Abelló, Helena; Planas Domingo, Josep; Farriols, Cristina; Ruiz Ripoll, Ada; Berger, Rita (MDPI, 2021)
    Insomnia is one of the most frequent symptoms and usually generates significant stress in 60% of patients with advanced cancer. Worries from the patients' and relatives' perspective are crucial to improve the patients' ...
  • Pan-cancer analysis of whole genomes
    ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; Demidov, German, 1990-; Drechsel, Oliver; Ossowski, Stephan; Estivill, Xavier, 1955-; Escaramís, Geòrgia; Bosio, Mattia; Holik, Aliaksei Z.; Sušak, Hana, 1985-; Rabionet, Raquel; Stobbe, Miranda D.; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Gut, Ivo Glynne; Beltran, Sergi; Gut, Marta; Trotta, Jean-Remi; Whalley, Justin P.; Heath, Simon; Prasad, Aparna; Heredia Genestar, José María, 1985-; Sabarinathan, Radhakrishnan; Pich, Oriol; Gonzalez-Perez, Abel; Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Mularoni, Loris; Deu-Pons, Jordi; Muiños, Ferran; Muyas Remolar, Francesc, 1992- (Nature Research, 2020)
    Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale . Here we report the integrative analysis of 2,658 ...
  • Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination
    Sisteré-Oró, Marta; Du, Juan; Wortmann, Diana D. J.; Filippi, Marina D.; Cañas-Ruano, Esperanza; Arrieta Aldea, Itziar; Marcos-Blanco, Agustín; Castells, Xavier; Grau Cerrato, Santiago; García-Giralt, Natalia; Perez-Zsolt, Daniel; Boreika, Rytis; Izquierdo-Useros, Nuria; Güerri Fernández, Roberto; Meyerhans, Andreas (Wiley, 2024)
    People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a ...
  • Pancreatectomy with concomitant portal vein resection in the current neoadjuvant era
    Ielpo, Benedetto; Burdío Pinilla, Fernando; Martinez-Solá, Ana; Sánchez Velázquez, Patrícia (AME Publishing Company, 2022)
  • Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
    Cáceres, Marta; Quesada Diez, Rita; Iglesias, Mar; Real, Francisco X.; Villamonte, Maria; Martínez de Villarreal, Jaime; Pérez, Mónica; Andaluz, Anna; Moll, Xavier; Berjano, Enrique J.; Dorcaratto, Dimitri; Sánchez Velázquez, Patricia, 1985-; Grande Posa, Luís; Burdío Pinilla, Fernando (Nature Research, 2020)
    Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This study describes ...

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