Browsing Hospital del Mar Research Institute by Title

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  • C-edge loops of arrestin function as a membrane anchor
    Lally, Ciara C.M.; Bauer, Brain; Selent, Jana; Sommer, Martha E. (Nature Publishing Group, 2017)
    G-protein-coupled receptors are membrane proteins that are regulated by a small family of arrestin proteins. During formation of the arrestin–receptor complex, arrestin first interacts with the phosphorylated receptor C ...
  • C-reactive protein may misdiagnose prosthetic joint infections, particularly chronic and low-grade infections
    Pérez-Prieto, Daniel; Portillo, María Eugenia; Puig Verdié, Luís; Alier Fabrego, Albert; Martínez Díaz, Santos; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo; Monllau García, Juan Carlos (Springer, 2017)
    BACKGROUND: Periprosthetic tissue cultures, sonication and synovial fluid cultures remain the gold standard for prosthetic joint infection (PJI) diagnosis. However, some 15-20% culture-negative PJI are still reported. ...
  • Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
    Bousquet, Jean; Antó i Boqué, Josep Maria; Czarlewski, Wienczyslawa; Haahtela, Tari; Fonseca, Susana C.; Iaccarino, Guido; Blain, Hubert; Vidal, Alain; Sheikh, Aziz; Akdis, Cezmi A.; Zuberbier, Torsten; ARIA group (Wiley, 2020)
    Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of ...
  • Caecal volvulus and jejunostomy: challenging diagnostic
    Morera-Grau, Álex; Membrilla Fernández, Estela; González Castillo, Ana María; Pelegrina Manzano, Amalia; Guerrero-Ortiz, M. A.; Téllez-Marquès, C.; Pons Fragero, María José; Guzmán-Ahumada, J.; Pera Roman, Miguel; Sancho Insenser, Juan (Oxford University Press, 2021)
    Caecal volvulus represent the 20-40% of colonic volvulus, being the second most frequent localization. It causes intestinal occlusion symptomatology (nausea, vomiting, abdominal distension). We present a case of 45-year-old ...
  • Caesarean deliveries in the Mother-Child (Rhea) cohort in Crete, Greece: almost as frequent as vaginal births and even more common in first-time mothers
    Vassilaki, Maria; Chatzi, Leda; Rasidaki, M.; Bagkeris, Emmanouil; Kritsotakis, G.; Roumeliotaki, Theano; Koutis, Antonis; Philalithis, A.; Kogevinas, Manolis (Hippokratio General Hospital of Thessalonki, 2015)
    BACKGROUND: Caesarean deliveries are on the increase in Greece and around the world. The objective of the present study was to assess the frequency of planned and emergency caesarean deliveries and their socio-demographic ...
  • Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
    Gutiérrez Martos, Miriam, 1989-; Girard, Benoît; Mendonça Netto, Sueli; Perroy, Julie; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Wiley-Blackwell, 2018)
    High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the ...
  • Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts
    Bazal, P.; Gea, Alfredo; Navarro, A. M.; Salas Salvadó, Jordi; Corella, Dolores; Alonso-Gómez, Ángel; Fitó Colomer, Montserrat; Muñoz-Bravo, Carlos; Estruch, Ramón; Fiol, Miquel; Lapetra, José; Serra Majem, Lluís; Ros, Emilio; Rekondo, Javier; Muñoz, Miguel Ángel; Basora, Josep; Sorlí, José Vicente; Toledo, Estefania; Martínez-González, Miguel Ángel, 1957-; Ruiz-Canela, Miguel (Oxford University Press, 2021)
    Aims: The association between caffeinated coffee consumption and atrial fibrillation remains unclear. Recent studies suggest an inverse association only between a moderate caffeinated coffee consumption and atrial fibrillation, ...
  • Calcifediol treatment and COVID-19-related outcomes
    Nogués Solan, Francesc Xavier; Ovejero Crespo, Diana; Pineda-Moncusí, Marta; Bouillon, Roger; Arenas Jiménez, María Dolores; Pascual Santos, Julio; Ribes, Anna; Guerri-Fernandez, Robert; Villar García, Judit; Rial, Abora; Gimenez-Argente, Carme; Cos, Maria Lourdes; Rodriguez-Morera, Jaime; Campodarve, Isabel; Quesada-Gómez, J.M.; García-Giralt, Natalia (Oxford University Press, 2021)
    Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims ...
  • Calcifying aponeurotic fibroma: A multimodal imaging description of an unusual case involving soft tissues adjacent to the clavicle
    Sanmiguel, Javier; Santiago-Díaz, Pablo; Marsico, Salvatore; Lloreta, Josep, 1958-; Solano-López, Alberto (Elsevier, 2022)
    Calcifying aponeurotic fibromas (CAFs) are rare benign tumors that typically develop in the soft tissue of the extremities. We report a case of 64-year-old woman with a CAF in the soft tissue surrounding her left clavicle. ...
  • Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients.
    Latorre, Irene; Esteve-Solé, Ana; Redondo Pachón, María Dolores; Giest, Sandra; Argilaguet Marqués, Jordi, 1977-; Álvarez, Sara; Peligero Cruz, Cristina, 1986-; Forstmann, Isabelle; Crespo Barrio, Marta; Pascual Santos, Julio; Meyerhans, Andreas (Elsevier, 2016)
    BACKGROUND: Regulatory B (Breg) and T (Treg) cells represent a biomarker for tolerance in transplant patients. Despite the importance of Treg and Breg in transplantation and the suggested crosstalk between both suppressive ...
  • Cam Femoroacetabular Impingement as a Possible Explanation of Recalcitrant Anterior Knee Pain.
    Sanchis-Alfonso, Vicente; Tey Pons, Marcos; Monllau García, Juan Carlos (Hindawi Publishing Corporation, 2016)
    We present a case of a patient with chronic anterior knee pain (AKP) recalcitrant to conservative treatment who returned to our office for severe hip pain secondary to Cam femoroacetabular impingement (Cam FAI) at 10 months ...
  • Cambios en las tendencias de la prescripción y causas de la interrupción en los tratamientos biológicos indicados en la psoriasis durante los primeros 10 años. Datos obtenidos del registro español Biobadaderm
    Ruiz-Genao, D.P.; Ferran Farrés, Marta; García-Doval, Ignacio; Biobadaderm Study Group (Elsevier, 2020)
    antecedentes y objetivos: Las guías sobre el tratamiento de la psoriasis habitualmente no incluyen las recomendaciones acerca de cuál debe ser la primera línea de tratamiento sistémico o biológico. Los objetivos de este ...
  • Can Healthy Cities be made really healthy?
    Cole, Helen; Shokry, Galia; Connolly, James; Pérez-del-Pulgar, Carmen; Alonso Caballero, Jordi; Anguelovski, Isabelle (Elsevier, 2017)
  • Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
    Kapla, Jon; Rodríguez Espigares, Ismael, 1990-; Ballante, Flavio; Selent, Jana; Carlsson, Jens (Public Library of Science (PLoS), 2021)
    The determination of G protein-coupled receptor (GPCR) structures at atomic resolution has improved understanding of cellular signaling and will accelerate the development of new drug candidates. However, experimental ...
  • Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
    Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2018)
    While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a ...
  • Cancer LncRNA census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
    Carlevaro-Fita, Joana; Lanzós, Andrés; Feuerbach, Lars; Hong, Chen; Mas Ponte, David; Pedersen, Jackob S.; PCAWG Drivers and Functional Interpretation Working Group; Johnson, Rory; PCAWG Consortium (Nature Research, 2020)
    Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive ...
  • Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
    Loomis, Dana; Guha, Neela; Kogevinas, Manolis; Fontana, Vincenzo; Gennaro, Valerio; Kolstad, Henrik A.; McElvenny, Damien Martin; Sallmén, Markku; Saracci, Rodolfo (BMJ Publishing Group, 2019)
    Objective: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. Methods: Mortality from cancers of prior interest was ...
  • Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
    Almanza-Aguilera, Enrique; Hernáez, Álvaro; Corella, Dolores; Sanllorente Melenchón, Albert; Ros, Emilio; Portolés, Olga; Valussi, Julieta; Estruch, Ramón; Coltell, Oscar; Subirana Cachinero, Isaac; Canudas i Puig, Sílvia; Razquin, Cristina; Blanchart, Gemma; Nonell Mazelon, Lara, 1972-; Fitó Colomer, Montserrat; Castañer, Olga (MDPI, 2020)
    We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis ...
  • Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
    Celià-Terrassa, Toni; Jolly, Mohit Kumar (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to initiate heterogeneous tumors. It is also relevant in metastasis and can explain how metastatic tumors mirror the heterogeneity ...
  • Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
    Herrera, Mercedes; Herrera, Alberto; Domínguez, Gemma; Silva, Javier; García, Vanesa; García, Jose M.; Gómez, Irene; Soldevilla, Beatriz; Muñoz, Concepción; Provencio, Mariano; Campos Martin, Yolanda; García de Herreros, Antonio; Casal, José Ignacio; Bonilla, Félix; Peña, Cristina (Japanese Cancer Association, 2013)
    Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts ...

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