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dc.contributor.author Djebali, Sarah
dc.contributor.author Merkel, Angelika
dc.contributor.author Tanzer, Andrea
dc.contributor.author Lagarde, Julien
dc.contributor.author Röder, Maik
dc.contributor.author Curado, Joao
dc.contributor.author Derrien, Thomas
dc.contributor.author Ferreira, Pedro G.
dc.contributor.author González, David
dc.contributor.author Johnson, Rory
dc.contributor.author Kingswood, Colin
dc.contributor.author Ribeca, Paolo
dc.contributor.author Sammeth, Michael
dc.contributor.author Skancke, Jorgen
dc.contributor.author Tilgner, Hagen, 1980-
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Gingeras, Thomas R.
dc.date.accessioned 2015-01-27T08:29:27Z
dc.date.available 2015-01-27T08:29:27Z
dc.date.issued 2012
dc.identifier.citation Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A et al. Landscape of transcription in human cells. Nature. 2012; 489(7414): 101-8. DOI: 10.1038/nature11233
dc.identifier.issn 0028-0836
dc.identifier.uri http://hdl.handle.net/10230/23073
dc.description.abstract Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.
dc.description.sponsorship This work was supported by the National Human Genome Research Institute (NHGRI) production grants U54HG004557, U54HG004555, U54HG004576 and U54HG004558, and by the NHGRI pilot grant R01HG003700. It was also supported by the NHGRI ARRA stimulus grant 1RC2HG005591, the National Science Foundation (SNF) grant 127375, the European Research Council (ERC) grant/n249968, a research grant for the RIKEN Omics Science Center from the Japanese Ministry of Education, Culture, Sports, Science and Technology, and grants BIO2011-26205, CSD2007-00050 and INB GNV-1 from the Spanish Ministry of Science
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.rights http://dx.doi.org/10.1038/nature11247. This article is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject.other Genètica
dc.subject.other Genoma humà
dc.title Landscape of transcription in human cells
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/nature11233
dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/249968
dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/127375
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-26205
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00050
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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