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Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson's disease

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dc.contributor.author Van Hartevelt, Tim J.
dc.contributor.author Cabral, Joana R. B.
dc.contributor.author Deco, Gustavo
dc.contributor.author Møller, Arne
dc.contributor.author Green, Alex L.
dc.contributor.author Aziz, Tipu Z.
dc.contributor.author Kringelbach, Morten L.
dc.date.accessioned 2015-01-26T10:04:06Z
dc.date.available 2015-01-26T10:04:06Z
dc.date.issued 2014
dc.identifier.citation Van Hartevelt TJ, Cabral J, Deco G, Møller A, Green AL, Aziz TZ, Kringelbach ML. Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in parkinson’s disease. PLoS ONE. 2014;9(1):e86496. DOI: 10.1371/journal.pone.0086496
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23068
dc.description.abstract Background: Positive clinical outcomes are now well established for deep brain stimulation, but little is known about the effects of long-term deep brain stimulation on brain structural and functional connectivity. Here, we used the rare opportunity to acquire pre- and postoperative diffusion tensor imaging in a patient undergoing deep brain stimulation in bilateral subthalamic nuclei for Parkinson’s Disease. This allowed us to analyse the differences in structural connectivity before and after deep brain stimulation. Further, a computational model of spontaneous brain activity was used to estimate the changes in functional connectivity arising from the specific changes in structural connectivity./nResults: We found significant localised structural changes as a result of long-term deep brain stimulation. These changes were found in sensory-motor, prefrontal/limbic, and olfactory brain regions which are known to be affected in Parkinson’s Disease. The nature of these changes was an increase of nodal efficiency in most areas and a decrease of nodal efficiency in the precentral sensory-motor area. Importantly, the computational model clearly shows the impact of deep brain stimulation-induced structural alterations on functional brain changes, which is to shift the neural dynamics back towards a healthy regime. The results demonstrate that deep brain stimulation in Parkinson’s Disease leads to a topological reorganisation towards healthy bifurcation of the functional networks measured in controls, which suggests a potential neural mechanism for the alleviation of symptoms./nConclusions: The findings suggest that long-term deep brain stimulation has not only restorative effects on the structural connectivity, but also affects the functional connectivity at a global level. Overall, our results support causal changes in human neural plasticity after long-term deep brain stimulation and may help to identify the underlying mechanisms of deep brain stimulation.
dc.description.sponsorship MLK and TJVH are funded by the TrygFonden Charitable Foundation. TZA is funded by the Medical Research Council, the Norman Collisson Foundation/nand the Charles Wolfson Charitable Trust. ALG is supported by the NIHR Biomedical Research Centre, Oxford. GD and JC were supported by the ERC Advanced/nGrant: DYSTRUCTURE (n. 295129), by the Spanish Research Project SAF2010-16085 and by the CONSOLIDER-INGENIO 2010 Programme CSD2007-00012, the FP7-/nICT BrainScales and by the Brain Network Recovery Group through the James S. McDonnell Foundation.
dc.format.extent 13 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2014;9(1):e86496
dc.rights © 2014 van Hartevelt et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.(http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson's disease
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0086496
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/295129
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/269921
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-16085
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/CSD2007-00012
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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