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Patterns and rates of intron divergence between humans and chimpanzees

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dc.contributor.author Gazave, Elodie
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Fernando, Olga
dc.contributor.author Charlesworth, Brian
dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
dc.date.accessioned 2014-12-22T12:59:12Z
dc.date.available 2014-12-22T12:59:12Z
dc.date.issued 2007
dc.identifier.citation Gazave E, Marqués-Bonet T, Fernando O, Charlesworth B, Navarro A. Patterns and rates of intron divergence between humans and chimpanzees. Genome Biology. 2007 Feb;8(2):R21. DOI: 10.1186/gb-2007-8-2-r21
dc.identifier.issn 1465-6906
dc.identifier.uri http://hdl.handle.net/10230/23020
dc.description.abstract We present the first analysis of human-chimpanzee intron divergence, in which differences in the number of substitutions per intronic site (Ki) can be interpreted as the footprint of different intensities and directions of the pressures of natural selection. Our main findings are as follows: there was a strong positive correlation between intron length and divergence; there was a strong negative correlation between intron length and GC content; and divergence rates vary along introns and depending on their ordinal position within genes (for instance, first introns are more GC rich, longer and more divergent, and divergence is lower at the 3' and 5' ends of all types of introns).We show that the higher divergence of first introns is related to their larger size. Also, the lower divergence of short introns suggests that they may harbor a relatively greater proportion of regulatory elements than long introns. Moreover, our results are consistent with the presence of functionally relevant sequences near the 5' and 3' ends of introns. Finally, our findings suggest that other parts of introns may also be under selective constraints.Introns are neither neutrally evolving sequences nor junk DNA, as they were once considered to be. Increasing amounts of evidence show that they harbor a variety of untranslated RNAs, including microRNAs, small nucleolar RNAs, and guide RNAs for RNA editing [1]. Introns are also important for mRNA processing and transport [2]. Moreover, microarray tiling experiments [3] have shown that a substantial part of the cell's transcriptional activity involves polyadenylated RNA that appears to be derived from intergenic regions, antisense sequences of known transcripts, and introns. Also, recent studies [4,5] show that almost all small nucleolar RNAs and a large proportion of microRNAs in animals are encoded in introns. Finally, novel intronic transcripts are continually being reported (for instance, see the report by Kampa and coworkers [6]), even tho
dc.description.sponsorship This research was supported by grants to AN from the Ministerio de Ciencia y Tecnologia (Spain; BOS2003-0870 and BFU2006-15413-C02-01) and the Genome Canada-Genoma España Joint R+D+I Projects in Human Health (JLI/038). OF was supported by a PhD fellowship (SFRH/BD/15856//n2005) from the Fundação para a Ciência e a Tecnologia (Portugal).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Genome Biology. 2007 Feb;8(2):R21
dc.rights © 2007 Gazave et al.; licensee BioMed Central Ltd./nThis is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other Ximpanzés
dc.subject.other Humans
dc.subject.other ADN
dc.title Patterns and rates of intron divergence between humans and chimpanzees
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/gb-2007-8-2-r21
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2006-15413
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PN/BOS2003-0870
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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