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Comparative genomics of emerging pathogens in the Candida glabrata clade

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dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.contributor.author Martin, Tiphaine
dc.contributor.author Marcet Houben, Marina
dc.contributor.author Durrens, Pascal
dc.contributor.author Bolotin Fukuhara, Monique
dc.contributor.author Lespinet, Olivier
dc.contributor.author Arnaise, Sylvie
dc.contributor.author Boisnard, Stéphanie
dc.contributor.author Aguileta, Gabriela
dc.contributor.author Atanasova, Ralitsa
dc.contributor.author Bouchier, Christiane
dc.contributor.author Couloux, Arnaud
dc.contributor.author Creno, Sophie
dc.contributor.author Almeida Cruz, José
dc.contributor.author Devillers, Hugo
dc.contributor.author Enache-Angoulvant, Aadela
dc.contributor.author Guitard, Juliette
dc.contributor.author Jaouen, Laure
dc.contributor.author Ma, Laurence
dc.contributor.author Marck, Christian
dc.contributor.author Neuvéglise, Cécile
dc.contributor.author Pelletier, Eric
dc.contributor.author Pinard, Amélie
dc.contributor.author Poulain, Julie
dc.contributor.author Recoquillay, Julien
dc.contributor.author Westhof, Eric
dc.contributor.author Wincker, Patrick
dc.contributor.author Dujon, Bernard
dc.contributor.author Hennequin, Christophe
dc.contributor.author Fairhead, Cécile
dc.date.accessioned 2014-05-14T07:34:15Z
dc.date.available 2014-05-14T07:34:15Z
dc.date.issued 2013
dc.identifier.citation Gabaldón T, Martin T, Marcet-Houben M, Durrens P, Bolotin-Fukuhara M, Lespinet O et al. Comparative genomics of emerging pathogens in the Candida glabrata clade. BMC Genomics. 2013;14:623. DOI: 10.1186/1471-2164-14-623
dc.identifier.issn 1471-2164
dc.identifier.uri http://hdl.handle.net/10230/22483
dc.description.abstract BACKGROUND: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C. glabrata being part of the Nakaseomyces, a group more closely related to Saccharomyces cerevisiae. Although C. glabrata was thought to be the only pathogenic Nakaseomyces, two new pathogens have recently been described within this group: C. nivariensis and C. bracarensis. To gain insight into the genomic changes underlying the emergence of virulence, we sequenced the genomes of these two, and three other non-pathogenic Nakaseomyces, and compared them to other sequenced yeasts. RESULTS: Our results indicate that the two new pathogens are more closely related to the non-pathogenic N. delphensis than to C. glabrata. We uncover duplications and accelerated evolution that specifically affected genes in the lineage preceding the group containing N. delphensis and the three pathogens, which may provide clues to the higher propensity of this group to infect humans. Finally, the number of Epa-like adhesins is specifically enriched in the pathogens, particularly in C. glabrata. CONCLUSIONS: Remarkably, some features thought to be the result of adaptation of C. glabrata to a pathogenic lifestyle, are present throughout the Nakaseomyces, indicating these are rather ancient adaptations to other environments. Phylogeny suggests that human pathogenesis evolved several times, independently within the clade. The expansion of the EPA gene family in pathogens establishes an evolutionary link between adhesion and virulence phenotypes. Our analyses thus shed light onto the relationships between virulence and the recent genomic changes that occurred within the Nakaseomyces.
dc.description.sponsorship This work was supported by funding from the European Research Council/nunder the European Union’s Seventh Framework Programme (FP/2007- 2013)/ERC Grant Agreement n.310325, a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and by a grant from the Spanish Ministry of Economy and Competitiveness (BIO2012-37161). CF’s research is/nfunded in part by an “Attractivité” grant from the University Paris Sud. GA is/na recipient of a Marie Curie grant (FP7-PEOPLE-2010-IEF-No.274223). SB, HD and RA are recipients of, respectively, a shared post-doctoral grant and a Ph. D. grant, from the Région Ile-de-France’s DIM Malinf program. JAC was supported by the Ph.D. Program in Computational Biology of the Instituto Gulbenkian de Ciência, Portugal (sponsored by Fundação Calouste Gulbenkian, Siemens SA, and Fundação para a Ciência e Tecnologia; SFRH/BD/33528/2008)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Genomics. 2013;14:623
dc.rights © 2013 Toni Gabaldón et al. This article is distributed under a Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Genòmica
dc.subject.other Llevats -- Genètica
dc.subject.other Càndida
dc.title Comparative genomics of emerging pathogens in the Candida glabrata clade
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1471-2164-14-623
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/274223
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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