Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek

Home
→
Recerca: articles, congressos, llibres
→
Center for Genomic Regulation (CRG)
→
Articles (Center for Genomic Regulation (CRG))
→
View Item

Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network

Document Type: Article

Version: Published version

Date: 2012

This document is associated with a Creative Common license

© Blume, Julia von et al., 2012. This article is distributed under a/nCreative Commons License Attribution–Noncommercial–Share Alike 3.0 Unported.

Name: malhotra_joucell.pdf

Size: 2.132Mb

Format: PDF

View/Open

Citation: von Blume J, Alleaume AM, Kienzle C, Carreras-Sureda A, Valverde M, Malhotra V. Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network. J Cell Biol. 2012;199(7):1057-66. DOI: 10.1083/jcb.201207180

Permanent link: http://hdl.handle.net/10230/22475

Abstract:

Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca(2+) import into the TGN; it binds secretory cargo in a Ca(2+)-dependent reaction and is required for its sorting at the TGN.