Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Martínez-Riaño, Ana; Bovolenta, Elena R.; Boccasavia, Viola L.; Ponomarenko, Julia; Abia, David; Oeste, Clara L.; Fresno, Manuel; van Santen, Hisse M.; Alarcon, Balbino (Rockefeller University Press, 2019)
    Signal strength controls the outcome of αβ T cell selection in the thymus, resulting in death if the affinity of the rearranged TCR is below the threshold for positive selection, or if the affinity of the TCR is above the ...
  • Pérez-Pérez, Martin; Pérez-Rodríguez, Gael; Blanco-Míguez, Aitor; Fdez-Riverola, Florentino; Valencia, Alfonso; Krallinger, Martin; Lourenço, Anália (Springer, 2019)
    Background: Shared tasks and community challenges represent key instruments to promote research, collaboration and determine the state of the art of biomedical and chemical text mining technologies. Traditionally, such ...
  • Castilla-Vallmanya, Laura; Gürsoy, Semra; Bozkaya, Özlem Giray; Prats-Planas, Aina; Bullich, Gemma; Matalonga, Leslie; Centeno-Pla, Mónica; Rabionet Janssen, Raquel; Grinberg, Daniel; Balcells, Susana; Urreizti, Roser (MDPI, 2021)
    We present a Turkish family with two cousins (OC15 and OC15b) affected with syndromic developmental delay, microcephaly, and trigonocephaly but with some phenotypic traits distinct between them. OC15 showed asymmetrical ...
  • Mateo, Lidia; Duran-Frigola, Miquel, 1985-; Gris-Oliver, Albert; Palafox, Marta; Scaltriti, Maurizio; Razavi, Pedram; Chandarlapaty, Sarat; Arribas, Joaquín; Bellet, Meritxell; Serra, Violeta; Aloy, Patrick, 1972- (BioMed Central, 2020)
  • Baud, Amelie; Casale, Francesco Paolo; Barkley-Levenson, Amanda M.; Farhadi, Nilgoun; Montillot, Charlotte; Yalcin, Binnaz; Nicod, Jerome; Palmer, Abraham A.; Stegle, Oliver (BioMed Central, 2021)
  • Lao Grueso, Oscar, 1976-; Lao Grueso, Oscar, 1976- (MDPI, 2018)
  • Faure, Andre J.; Domingo, Júlia; Schmiedel, Jörn M.; Hidalgo-Carcedo, Cristina; Diss, Guillaume; Lehner, Ben, 1978- (2022)
    Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development1-6. An important reason for this is ...
  • Mas, Glòria; Santoro, Fabio; Blanco, Enrique; Gamarra Figueroa, Gianni Paolo; Le Dily, François; Frigè, Gianmaria; Vidal, Enrique; Mugianesi, Francesca; Ballaré, Cecilia Julia; Gutiérrez, Arantxa; Sparavier, Aleksandra; Marti-Renom, Marc A.; Minucci, Saverio; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Genome organization plays a pivotal role in transcription, but how transcription factors (TFs) rewire the structure of the genome to initiate and maintain the programs that lead to oncogenic transformation remains poorly ...
  • Baldassarri, Margherita; Gut, Marta; GEN-COVID Multicenter Study (Elsevier, 2021)
    Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino ...
  • Brown, Peter; Raote, Ishier; RELISH Consortium; Zhou, Yaoqi (Oxford University Press, 2019)
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that ...
  • Anguera, Montserrat; Payer, Bernhard, 1975-; Morey, Céline (Frontiers, 2020)
  • Palmada-Flores, Marc; Orkin, Joseph D.; Haase, Bettina; Mountcastle, Jacquelyn; Bertelsen, Mads F.; Fedrigo, Olivier; Kuderna, Lukas F.K.; Jarvis, Erich D.; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2022)
    Background: The ring-tailed lemur (Lemur catta) is a charismatic strepsirrhine primate endemic to Madagascar. These lemurs are of particular interest, given their status as a flagship species and widespread publicity in ...
  • Vonesch, Sibylle C.; Li, Shengdi; Szu-Tu, Chelsea; Henning, Bianca P.; Dobrev, Nikolay; Steinmetz, Lars M. (Oxford University Press, 2021)
    Through the increase in the capacity of sequencing machines massively parallel sequencing of thousands of samples in a single run is now possible. With the improved throughput and resulting drop in the price of sequencing, ...
  • Ndondo, Alvin Pumelele; Eley, Brian; Wilmshurst , Jo Madeleine; Kakooza-Mwesige, Angelina; Giannoccaro, Maria Pia; Willison, Hugh J.; Rodríguez Cruz, Pedro M.; Heckmann, Jeannine M.; Bateman, Kathleen; Vincent, Angela (Frontiers Media, 2022)
    The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they involve the central (CNS) or peripheral nervous system (PNS). The historical understanding ...
  • Della Marina, Adela; Wibbeler, Eva; Abicht, Angela; Kölbel, Heike; Lochmüller, Hanns; Roos, Andreas; Schara-Schmidt, Ulrike (Frontiers Media, 2020)
    Introduction: Congenital myasthenic syndromes (CMS) refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild ...
  • Belbin, Olivia; Lehmann, Sylvain; Sabidó Aguadé, Eduard, 1981-; Hirtz, Christophe (Frontiers Media, 2020)
  • Ghose, Ritobrata; Aranguren-Ibáñez, Álvaro; Arecco, Niccolò; Balboa, Diego; Bataller, Marc; Beltran, Sergi; Benisty, Hannah, 1986-; Bénard, Angèle; Bernardo, Edgar; Carbonell Sala, Silvia; Casals, Eloi; Ciampi, Ludovica; Condemi, Livia; Corvó, Alberto; Cosín-Tomás, Marta; Cuenca-Ardura, Mirabai; Duran Serrano, Juan Manuel; Espejo Díaz, María Isabel; Fernández Callejo, Marcos; Gañez-Zapater, Antoni; Garcia-Castellanos, Raquel; Garrido, Romina; Henkin, Gil; Hermoso Pulido, Antonio; Hernandez-Alias, Xavier; Herrero Vicente, Jorge; Ingham, Matthew; Lim, Wei Ming; Llonch, Sílvia; Marmesat Bertoli, Elena; Miguel Escalada, Irene; Montero-Blay, Ariadna; Navarrete Hernández, Cristina; Neguembor, Maria Victoria; Ní Chárthaigh, Róisín-Ana; Pardo-Lorente, Natalia; Pascual-Reguant, Laura, 1990-; Pérez-Lluch, Sílvia; Perza, Reyes; Pesaresi, Martina, 1991-; Picó Amado, Daniel; Pifarré, Paula; Piscia, Davide; Plana-Carmona, Marcos; Ponomarenko, Julia; Radusky, Leandro; Rivero, Ezequiel; Rogalska, Malgorzata; Torcal Garcia, Guillem, 1991-; Wojnacki, José (F1000Research, 2020)
    The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to ...
  • Salgado, David; Beltran, Sergi; Furlong, Laura I., 1971-; Gut, Ivo Glynne; Laurie, Steven, 1973-; Marquès i Bonet, Tomàs, 1975-; Piñero González, Janet, 1977-; Sanz, Ferran; Béroud, Christophe (F1000Research, 2020)
    Copy number variations (CNVs) are major causative contributors both in the genesis of genetic diseases and human neoplasias. While "High-Throughput" sequencing technologies are increasingly becoming the primary choice for ...
  • Dehasque, Marianne; Ávila Arcos, María C.; Díez-Del-Molino, David; Fumagalli, Matteo; Guschanski, Katerina; Lorenzen, Eline D.; Malaspinas, Anna-Sapfo; Marquès i Bonet, Tomàs, 1975-; Martin, Michael D.; Murray, Gemma G. R.; Papadopulos, Alexander S. T.; Overgaard Therkildsen, Nina; Wegmann, Daniel; Dalén, Love; Foote, Andrew D. (Wiley Open Access, 2020)
    Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral ...
  • James, Maddie E.; Wilkinson, Melanie J.; Bernal, Diana M.; Liu, Huanle; North, Henry L.; Engelstädter, Jan; Ortiz-Barrientos, Daniel (Wiley, 2021)
    The independent and repeated adaptation of populations to similar environments often results in the evolution of similar forms. This phenomenon creates a strong correlation between phenotype and environment and is referred ...

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