Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Ip, Hill F.; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Sunyer Deu, Jordi; Boomsma, Dorret I. (Nature Research, 2021)
    Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from ...
  • Pearman, Peter B.; Alioto, Tyler; Trotta, Jean-Remi; Columbus, J. Travis (Wiley, 2021)
    The resolution of cryptic diversity is essential for understanding the evolutionary diversification of lineages and establishing conservation priorities. We examine relationships in Eriogoneae (Polygonaceae), a diverse ...
  • Ortega, Natalia; Ribes, Marta; Vidal, Marta; Rubio, Rocío; Aguilar, Ruth; Williams, Sarah; Barrios, Diana; Alonso, Selena; Mitchell, Robert A.; Jairoce, Chenjerai; Cruz, Angeline; Jimenez, Alfons; Santano, Rebeca; Méndez, Susana; Lamoglia, Montserrat; Rosell, Neus; Llupià, Anna; Puyol, Laura; Chi, Jordi; Rodrigo Melero, Natalia; Mayor, Alfredo; Vilella, Anna; Trilla, Antoni; Carolis, Carlo; Izquierdo, Luis; García-Basteiro, Alberto L.; Moncunill, Gemma; Dobaño, Carlota (Nature Research, 2021)
    Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and the individual characteristics influencing it, including the impact of pre-existing antibodies to human coronaviruses causing common cold (HCoVs), is essential ...
  • Blanco, Enrique; Di Croce, Luciano; Aranda Aragón, Sergio (Oxford University Press, 2021)
    In order to evaluate cell- and disease-specific changes in the interacting strength of chromatin targets, ChIP-seq signal across multiple conditions must undergo robust normalization. However, this is not possible using ...
  • Mieth, Bettina; Rozier, Alexandre; Rodriguez, Juan Antonio; Höhne, Marina M.C.; Görnitz, Nico; Müller, Klaus-Robert (Oxford University Press, 2021)
    Deep learning has revolutionized data science in many fields by greatly improving prediction performances in comparison to conventional approaches. Recently, explainable artificial intelligence has emerged as an area of ...
  • Sánchez-Barreiro, Fátima; Gopalakrishnan, Shyam; Ramos-Madrigal, Jazmín; Westbury, Michael V.; Manuel Montero, Marc de, 1991-; Margaryan, Ashot; Ciucani, Marta M.; Vieira, Filipe Garrett; Patramanis, Yannis; Kalthoff, Daniela C.; Timmons, Zena; Sicheritz-Ponten, Thomas; Dalén, Love; Ryder, Oliver A.; Zhang, Guojie; Marquès i Bonet, Tomàs, 1975-; Moodley, Yoshan; Gilbert, M Thomas (Wiley, 2021)
    Large vertebrates are extremely sensitive to anthropogenic pressure, and their populations are declining fast. The white rhinoceros (Ceratotherium simum) is a paradigmatic case: this African megaherbivore has suffered a ...
  • Farré, Xavier; Molina, Ruben; Barteri, Fabio; Timmers, Paul R.H.J.; Joshi, Peter K.; Oliva Miguel, Baldomero; Acosta, Sandra; Esteve Altava, Borja; Navarro i Cuartiellas, Arcadi, 1969-; Muntané, Gerard (Oxford University Press, 2021)
    The enormous mammal's lifespan variation is the result of each species' adaptations to their own biological trade-offs and ecological conditions. Comparative genomics have demonstrated that genomic factors underlying both, ...
  • Grau Bové, Xavier; Sebé-Pedrós, Arnau (Oxford University Press, 2021)
    Possvm (Phylogenetic Ortholog Sorting with Species oVerlap and MCL [Markov clustering algorithm]) is a tool that automates the process of identifying clusters of orthologous genes from precomputed phylogenetic trees and ...
  • Ramsheh, Mohammadali Yavari; Esteve-Codina, Anna; Heath, Simon; Gut, Ivo Glynne; Brightling, Christopher E. (Elsevier, 2021)
    Background: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the airway microbiome and bronchial gene expression in COPD is poorly ...
  • Vandelli, Andrea; Cid Samper, Fernando, 1991-; Torrent Burgas, Marc; Sánchez de Groot, Natalia; Tartaglia, Gian Gaetano (Elsevier, 2021)
    Condensation, or liquid-like phase separation, is a phenomenon indispensable for the spatiotemporal regulation of molecules within the cell. Recent studies indicate that the composition and molecular organization of ...
  • Monti, Michele; Armaos, Alexandros, 1989-; Fantini, Marco; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2021)
    Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution ...
  • Illouz, Tomer; Biragyn, Arya; Iulita, Maria Florencia; Flores-Aguilar, Lisi; Dierssen, Mara; De Toma, Ilario; Antonarakis, Stylianos E.; Yu, Eugene; Herault, Yann; Potier, Marie-Claude; Botté, Alexandra; Roper, Randall; Sredni, Benjamin; London, Jacqueline; Mobley, William; Strydom, Andre; Okun, Eitan (Frontiers, 2021)
    The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i.e., hypertension, diabetes, cardiovascular ...
  • Lara-Chica, Maribel; Correa-Sáez, Alejandro; Jiménez-Izquierdo, Rafael; Garrido-Rodríguez, Martín; Ponce, Francisco J.; Moreno, Rita; Morrison, Kimberley; Di Vona, Chiara, 1981-; Arató, Krisztina, 1981-; Jiménez-Jiménez, Carla; Morrugares, Rosario; Schmitz, M. Lienhard; Luna, Susana de la; Vega, Laureano de la; Calzado, Marco A. (Nature Research, 2021)
    The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin-Cyclin-dependent kinase complexes, with an emergent role in the DNA damage ...
  • Gallego-Paüls, Marta; Hernández-Ferrer, Carles; Bustamante Pineda, Mariona; Basagaña Flores, Xavier; Barrera Gómez, Jose; Vives Usano, Marta, 1990-; Ruiz Arenas, Carlos, 1990-; Casas Sanahuja, Maribel; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; Urquiza, José M.; González, Juan Ramón; Vrijheid, Martine; Maitre, Léa (BioMed Central, 2021)
    Background: Multiple omics technologies are increasingly applied to detect early, subtle molecular responses to environmental stressors for future disease risk prevention. However, there is an urgent need for further ...
  • Herman, Emily K.; Najle, Sebastián R.; Dacks, Joel B. (BioMed Central, 2021)
    Background: The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material ...
  • Pryszcz, Leszek Piotr, 1985-; Novoa, Eva Maria (Oxford University Press, 2021)
    Motivation: DNA and RNA modifications can now be identified using Nanopore sequencing. However, we currently lack a flexible software to efficiently encode, store, analyze and visualize DNA and RNA modification data. ...
  • Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; Operto, Grégory; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA study (BioMed Central, 2021)
    Background: Understanding the changes that occur in the transitional stage between absent and overt amyloid-β (Aβ) pathology within the Alzheimer's continuum is crucial to develop therapeutic and preventive strategies. The ...
  • Vara, Covadonga; Paytuví Gallart, Andreu; Cuartero, Yasmina; Álvarez-González, Lucía; Marín-Gual, Laia; Garcia, Francisca; Florit-Sabater, Beatriu; Capilla, Laia; Sanchéz-Guillén, Rosa Ana; Sarrate, Zaida; Cigliano, Riccardo Aiese; Sanseverino, Walter; Searle, Jeremy B.; Ventura, Jacint; Martí Renom, Marc A.; Le Dily, François; Ruiz Herrera, Aurora (Nature Research, 2021)
    The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation ...
  • Buitrago, Diana; Labrador, Mireia; Arcon, Juan Pablo; Lema, Rafael; Flores, Oscar; Esteve-Codina, Anna; Blanc, Julie; Villegas, Núria; Bellido, David; Gut, Marta; Dans, Pablo D.; Heath, Simon; Gut, Ivo Glynne; Brun-Heath, Isabelle; Orozco, Modesto (Nature Research, 2021)
    Determining the effect of DNA methylation on chromatin structure and function in higher organisms is challenging due to the extreme complexity of epigenetic regulation. We studied a simpler model system, budding yeast, ...
  • Willis, Jesse R.; Saus Martínez, Ester; Iraola Guzman, Susana; Cabello-Yeves, Elena; Ksiezopolska, Ewa; Cozzuto, Luca; Bejarano, Luis A.; Andreu Somavilla, Núria; Alloza-Trabado, Miriam; Blanco, Andrea; Puig-Sola, Anna; Broglio, Elisabetta; Carolis, Carlo; Ponomarenko, Julia; Hecht, Jochen; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis, 2021)
    Introduction: Cystic fibrosis (CF) is an autosomal genetic disease, associated with the production of excessively thick mucosa and with life-threatening chronic lung infections. The microbiota of the oral cavity can act ...

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