Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Janiak, Mareike C.; Silva, Felipe E.; Beck, Robin M. D.; de Vries, Dorien; Kuderna, Lukas F.K.; Torosin, Nicole S.; Melin, Amanda D.; Marquès i Bonet, Tomàs, 1975-; Goodhead, Ian B.; Messias, Mariluce; da Silva, Maria N. F.; Sampaio, Iracilda; Farias, Izeni P.; Rossi, Rogerio; de Melo, Fabiano R.; Valsecchi, João; Hrbek, Tomas; Boubli, Jean P. (Wiley, 2022)
    Mitochondrial DNA remains a cornerstone for molecular ecology, especially for study species from which high-quality tissue samples cannot be easily obtained. Methods using mitochondrial markers are usually reliant on ...
  • Sparavier, Aleksandra, 1992-; Di Croce, Luciano (Elsevier, 2022)
    t(9;11)-Induced leukemia is present both in children and adults, and depending on age, can cause predominantly acute lymphoblastic (ALL) or acute myeloid leukemia (AML), respectively. In general, in infants, it is characterized ...
  • Bullich, Gemma; Matalonga, Leslie; Pujadas, Montserrat; Papakonstantinou Ntalis, Anastasios; Piscia, Davide; Tonda, Raúl; González, Juan Ramón; Laurie, Steven, 1973-; Luengo, Cristina; Ovelleiro, David; Parra Farré, Genís; Pérez Jurado, Luis Alberto; Beltran, Sergi; Undiagnosed Rare Disease Program of Catalonia (URD-Cat) Consortium (Elsevier, 2022)
    Many patients experiencing a rare disease remain undiagnosed even after genomic testing. Reanalysis of existing genomic data has shown to increase diagnostic yield, although there are few systematic and comprehensive ...
  • Tierrafría, Víctor H.; Collado Vides, Pedro Julio (Microbiology Society, 2022)
    Genomics has set the basis for a variety of methodologies that produce high-throughput datasets identifying the different players that define gene regulation, particularly regulation of transcription initiation and operon ...
  • Spruce, Thomas; Plass Pórtulas, Mireya, 1982-; Gohr, André; Ray, Debashish; Martínez de Lagrán Cabredo, María; Rot, Gregor; Nóvoa, Ana; Burguera, Demián; Permanyer, Jon; Miret-Cuesta, Marta; Zheng, Hong; Swanson, Maurice S.; Morris, Quaid; Mallo, Moises; Dierssen, Mara; Hughes, Timothy R.; Pernaute, Barbara; Irimia, Manuel (Public Library of Science (PLoS), 2022)
    Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process ...
  • Willis, Jesse R.; Saus Martínez, Ester; Iraola-Guzmán, Susana; Księżopolska, Ewa, 1987-; Cozzuto, Luca; Bejanaro, Luis A.; Andreu Somavilla, Núria; Alloza-Trabado, Miriam; Blanco, Andrea; Puig-Sola, Anna; Broglio, Elisabetta; Carolis, Carlo; Ponomarenko, Julia; Hecht, Jochen; Gabaldón Estevan, Juan Antonio, 1973- (Nature Research, 2022)
    The relevance of the human oral microbiome to our understanding of human health has grown in recent years as microbiome studies continue to develop. Given the links of the oral cavity with the digestive, respiratory and ...
  • Vicencio, Jeremy, 1990-; Sánchez-Bolaños, Carlos; Moreno-Sánchez, Ismael; Brena, David; Vejnar, Charles E.; Kukhtar, Dmytro; Ruiz-López, Miguel; Cots-Ponjoan, Mariona; Rubio, Alejandro; Rodrigo Melero, Natalia; Crespo-Cuadrado, Jesús; Carolis, Carlo; Pérez-Pulido, Antonio J.; Giráldez, Antonio; Kleinstiver, Benjamin P.; Cerón Madrigal, Julián; Moreno Mateos, Miguel Ángel (Nature Research, 2022)
    The requirement for Cas nucleases to recognize a specific PAM is a major restriction for genome editing. SpCas9 variants SpG and SpRY, recognizing NGN and NRN PAMs, respectively, have contributed to increase the number of ...
  • Ruiz-Gartzia, Irune; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Kelley, Joanna L. (Wiley, 2022)
    Natural history museums hold vast collections of biomaterials. The collections in museums, often painstakingly sampled, are largely unexplored treasures that may help us better understand biodiversity on the planet. Museum ...
  • Laurie, Steven, 1973-; Piscia, Davide; Matalonga, Leslie; Corvó, Alberto; Fernández Callejo, Marcos; Garcia-Linares, Carles; Hernandez-Ferrer, Carles, 1987-; Luengo, Cristina; Martínez, Inés; Papakonstantinou Ntalis, Anastasios; Picó-Amador, Daniel; Protasio, Joan; Tonda, Raúl; Bayés, Mònica; Bullich, Gemma; Camps-Puchadas, Jordi; Paramonov, Ida; Trotta, Jean-Remi; Pérez Jurado, Luis Alberto; Rambla de Argila, Jordi; Gut, Ivo Glynne; Lochmüller, Hanns; Beltran, Sergi (Wiley, 2022)
    Rare disease patients are more likely to receive a rapid molecular diagnosis nowadays thanks to the wide adoption of next-generation sequencing. However, many cases remain undiagnosed even after exome or genome analysis, ...
  • Liedtke, H. Christoph; Cruz, Fernando; Gómez Garrido, Jèssica; Fuentes Palacios, Diego; Marcet Houben, Marina; Gut, Marta; Alioto, Tyler; Gabaldón Estevan, Juan Antonio, 1973-; Gomez-Mestre, Ivan (Oxford University Press, 2022)
    Genomic resources for amphibians are still hugely under-represented in vertebrate genomic research, despite being a group of major interest for ecology, evolution and conservation. Amphibians constitute a highly threatened ...
  • Souche, Erika; Beltran, Sergi; Weiss, Marjan M. (Springer Nature, 2022)
    In 2016, guidelines for diagnostic Next Generation Sequencing (NGS) have been published by EuroGentest in order to assist laboratories in the implementation and accreditation of NGS in a diagnostic setting. These guidelines ...
  • Severino, Jacqueline, 1990-; Bauer, Moritz, 1987-; Mattimoe, Tom; Arecco, Niccolò; Cozzuto, Luca; Lorden, Patricia; Hamada, Norio; Nosaka, Yoshiaki; Nagaoka, So I.; Audergon, Pauline; Tarruell Pellegrin, Antonio,1990-; Heyn, Holger; Hayashi, Katsuhiko; Saitou, Mitinori; Payer, Bernhard, 1975- (EMBO Press, 2022)
    The mammalian germline is characterized by extensive epigenetic reprogramming during its development into functional eggs and sperm. Specifically, the epigenome requires resetting before parental marks can be established ...
  • Carreras-Gallo, Natàlia; Cáceres, Alejandro; Balagué-Dobón, Laura; Ruiz-Arenas, Carlos; Casas Sanahuja, Maribel; Maitre, Léa; Nieuwenhuijsen, Mark J.; Stratakis, Nikos; Urquiza, José M.; Bustamante Pineda, Mariona; Vrijheid, Martine; Pérez Jurado, Luis Alberto; Gonzalez, Juan Ramon (Nature Research, 2022)
    Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three ...
  • Matute-Blanch, Clara; Brito, Verónica; Midaglia, Luciana; Villar, Luisa Maria; Garcia-Diaz Barriga, Gerardo; Guzman de la Fuente, Alerie; Borrás, Eva; Fernández-García, Sara; Calvo-Barreiro, Laura; Miguez, Andrés; Costa-Frossard, Lucienne; Pinteac, Rucsanda; Sabidó Aguadé, Eduard, 1981-; Alberch, Jordi; Fitzgerald, Denise C.; Montalbán Gairín, Xavier; Comabella López, Manuel (Wiley Open Access, 2022)
  • Arnan Ros, Carme; Ullrich, Sebastian, 1984-; Pulido-Quetglas, Carlos; Nurtdinov, Ramil; Esteban, Alexandre; Blanco-Fernandez, Joan; Aparicio-Prat, Estel; Johnson, Rory; Pérez-Lluch, Sílvia; Guigó Serra, Roderic (BioMed Central, 2022)
    CRISPR-Cas9 screening libraries have arisen as a powerful tool to identify protein-coding (pc) and non-coding genes playing a role along different processes. In particular, the usage of a nuclease active Cas9 coupled to a ...
  • Wu, Dong-Dong; Qi, Xiao-Guang; Yu, Li; Li, Ming; Liu, Zhi-Jin; Yoder, Anne D.; Roos, Christian; Hayakawa, Takashi; Rogers, Jeffrey; Marquès i Bonet, Tomàs, 1975-; Su, Bing; Yao, Yong-Gang; Zhang, Ya-Ping; Zhang, Guojie (Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences, 2022)
  • Thorogood, Adrian; Rehm, Heidi L.; Goodhand, Peter; Page, Angela J. H.; Joly, Yann; Baudis, Michael; Rambla de Argila, Jordi; Navarro i Cuartiellas, Arcadi, 1969-; Nyronen, Tommi H.; Linden, Mikael; Dove, Edward S.; Fiume, Marc; Brudno, Michael; Cline, Melissa S.; Bimey, Ewan (Elsevier, 2021)
    We promote a shared vision and guide for how and when to federate genomic and health-related data sharing, enabling connections and insights across independent, secure databases. The GA4GH encourages a federated approach ...
  • Lerner, Jonathan; Gómez García, Pablo; McCarthy, Ryan L.; Liu, Zhe; Lakadamyali, Melike; Zaret, Kenneth S. (Elsevier, 2020)
    This protocol provides a two-parameter analysis of single-molecule tracking (SMT) trajectories of Halo-tagged histones in living adherent cell lines and unveils a chromatin mobility landscape composed of five chromatin ...
  • Gimenez, Neus; Tripathi, Rupal; Giró, Ariadna; Rosich, Laia; López-Guerra, Mónica; López-Oreja, Irene; Playa-Albinyana, Heribert; Arenas, Fabián; Mas, José Manuel; Pérez-Galán, Patricia; Delgado González, Julio; Campo, Elias; Farrés, Judith; Colomer, Dolors (Nature Research, 2020)
    Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL ...
  • Mays, Suzanne G.; Stec, Józef; Liu, Xu; D'Agostino, Emma H.; Whitby, Richard J.; Ortlund, Eric A. (Nature Research, 2020)
    Chirality is an important consideration in drug development: it can influence recognition of the intended target, pharmacokinetics, and off-target effects. Here, we investigate how chirality affects the activity and mechanism ...

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