Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Melin, Amanda D.; Orkin, Joseph D.; Valenzuela, Alejandro; Gut, Ivo Glynne; Gut, Marta; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Juan, David; Higham, James P. (Wiley, 2021)
    The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their ...
  • Akerman, Ildem; Maestro, Miguel Ángel; De Franco, Elisa; Grau, Vanessa; Flanagan, Sarah; García-Hurtado, Javier; Mittler, Gerhard; Ravassard, Philippe; Piemonti, Lorenzo; Ellard, Sian; Hattersley, Andrew T.; Ferrer, Jorge (Elsevier, 2021)
    Despite the central role of chromosomal context in gene transcription, human noncoding DNA variants are generally studied outside of their genomic location. This limits our understanding of disease-causing regulatory ...
  • Clemente, Florian; Dolgova, Olga; Lao Grueso, Oscar, 1976-; Papageorgopoulou, Christina (Elsevier, 2021)
    The Cycladic, the Minoan, and the Helladic (Mycenaean) cultures define the Bronze Age (BA) of Greece. Urbanism, complex social structures, craft and agricultural specialization, and the earliest forms of writing characterize ...
  • Levy, Shani; Elek, Anamaria; Grau Bové, Xavier; Menéndez-Bravo, Simón; Iglesias, Marta; Tanay, Amos; Mass, Tali; Sebé-Pedrós, Arnau (Elsevier, 2021)
    Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on Earth: coral reefs. Despite their ecological importance, little is known about the cell types and molecular pathways that underpin ...
  • Bradbury, Melissa; Borràs, Eva; Pérez-Benavente, Assumpció; Gil-Moreno, Antonio; Santamaria, Anna; Sabidó Aguadé, Eduard, 1981- (MDPI, 2021)
    High-grade serous ovarian cancer (HGSC) remains the most common and deadly subtype of ovarian cancer. It is characterized by its late diagnosis and frequent relapse despite standardized treatment with cytoreductive surgery ...
  • Lopes Alves, Isadora; Heeman, Fiona; Collij, Lyduine E.; Salvadó, Gemma; Tolboom, Nelleke; Vilor Tejedor, Natàlia, 1988-; Markiewicz, Pawel; Yaqub, Maqsood; Cash, David; Mormino, Elizabeth C.; Insel, Philip S.; Boellaard, Ronald; van Berckel, Bart N. M.; Lammertsma, Adriaan A.; Barkhof, Frederik; Gispert López, Juan Domingo (BioMed Central, 2021)
    Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer's disease (AD). This work aimed ...
  • Llonch, Sílvia; Barragán, Montserrat; Nieto, Paula; Mallol, Anna; Elosua-Bayés, Marc; Lorden, Patricia; Ruiz, Sara; Zambelli, Filippo; Heyn, Holger; Vassena, Rita; Payer, Bernhard, 1975- (Wiley Open Access, 2021)
    Female fertility is inversely correlated with maternal age due to a depletion of the oocyte pool and a reduction in oocyte developmental competence. Few studies have addressed the effect of maternal age on the human mature ...
  • Morató, Xavier; Garcia-Esparcia, Paula; Argerich, Josep; Llorens, Franc; Zerr, Inga; Paslawski, Wojciech; Borrás, Eva; Sabidó Aguadé, Eduard, 1981-; Petäjä-Repo, Ulla E.; Fernández-Dueñas, Víctor; Ferrer, Isidre; Svenningsson, Per; Ciruela, Francisco (BioMed Central, 2021)
    Objective: α-Synuclein has been studied as a potential biomarker for Parkinson's disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD. GPR37 is an ...
  • Rubio Pérez, Carlota; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Moutinho, Catia; Ruiz, Sara; Parra Farré, Genís; Heyn, Holger; Seoane, Joan (Nature Research, 2021)
    Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (ICI) and the degree and phenotype of ...
  • Mendieta-Esteban, Julen; Di Stefano, Marco; Castillo Andreo, David; Farabella, Irene; Marti-Renom, Marc A. (Oxford University Press, 2021)
    Chromosome conformation capture (3C) technologies measure the interaction frequency between pairs of chromatin regions within the nucleus in a cell or a population of cells. Some of these 3C technologies retrieve interactions ...
  • Harjivan, Shrika G.; Charneira, Catarina; Martins, Inês L.; Pereira, Sofia A.; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Beland, Frederick A.; Marques, M. Matilde; Antunes, Alexandra M. M. (MDPI, 2021)
    Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission of the human immunodeficiency virus type 1, is associated with ...
  • Olivella, Roger; Chiva, Cristina; Serret, Marc; Mancera, Daniel; Cozzuto, Luca; Hermoso Pulido, Antonio; Borràs, Eva; Espadas, Guadalupe; Morales Sanfrutos, Julia; Pastor, Olga; Solé, Amanda; Ponomarenko, Julia; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2021)
    QCloud is a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, and automated data processing. Since its release, QCloud has facilitated automated ...
  • Manta, Alexander; Spendiff, Sally; Lochmüller, Hanns; Thompson, Rachel (IOS Press, 2021)
    Background: Metabolic myopathies are a heterogenous group of muscle diseases typically characterized by exercise intolerance, myalgia and progressive muscle weakness. Effective treatments for some of these diseases are ...
  • Laquerrière, Annie; Gut, Ivo Glynne; Melki, Judith (BMJ Publishing Group, 2021)
    Background: Arthrogryposis multiplex congenita (AMC) is characterised by congenital joint contractures in two or more body areas. AMC exhibits wide phenotypic and genetic heterogeneity. Our goals were to improve the genetic ...
  • Gungor, Serdal; Aranguren-Ibáñez, Álvaro; Laurie, Steven, 1973-; Beltran, Sergi; Vernos, Isabelle, 1959-; Horvath, Rita (Cell Press, 2020)
    Microtubules help building the cytoskeleton of neurons and other cells. Several components of the gamma-tubulin (γ-tubulin) complex have been previously reported in human neurodevelopmental diseases. We describe two siblings ...
  • García-Castro, Helena; Kenny, Nathan J.; Iglesias, Marta; Álvarez Campos, Patricia; Mason, Vincent; Elek, Anamaria; Schönauer, Anna; Sleight, Victoria A.; Neiro, Jakke; Aboobaker, Aziz; Permanyer, Jon; Irimia, Manuel; Sebé-Pedrós, Arnau; Solana, Jordi (BioMed Central, 2021)
    Single-cell sequencing technologies are revolutionizing biology, but they are limited by the need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation approach for single-cell transcriptomics ...
  • Maceda Porto, Iago, 1986-; Martín Álvarez, Miguel; Athanasiadis, Georgios; Tonda, Raúl; Camps, Jordi; Beltran, Sergi; Camps, Agustí; Fàbrega, Jordi; Felisart, Josefina; Grané, Joan; Remón, José Luis; Serra, Jordi; Moral, Pedro; Lao Grueso, Oscar, 1976- (Springer Nature, 2021)
    The area of the Spanish Pyrenees is particularly interesting for studying the demographic dynamics of European rural areas given its orography, the main traditional rural condition of its population and the reported higher ...
  • Choi, Jinmi; Lysakovskaia, Kseniia; Sitk, Gregoire; Demel, Carina; Söding, Johannes; Tian, Tian V.; Graf, T. (Thomas); Cramer, Patrick (eLife Sciences Publications, 2021)
    Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation during transdifferentiation of human ...
  • Thomy, Julie; Sanchez, Frederic; Gut, Marta; Cruz, Fernando; Alioto, Tyler; Piganeau, Gwenael; Grimsley, Nigel; Yau, Sheree (MDPI, 2021)
    Ostreococcus tauri is a simple unicellular green alga representing an ecologically important group of phytoplankton in oceans worldwide. Modern molecular techniques must be developed in order to understand the mechanisms ...
  • Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (Cell Press, 2021)
    Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting ...

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