Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Shirvani Farsani, Zeinab; Maloum, Zahra; Bagheri Hosseinabadi, Zahra; Vilor Tejedor, Natàlia, 1988-; Sadeghi, Iman; Sadeghi, Iman (Elsevier, 2021)
    DNA methylation is a broadly-investigated epigenetic modification that has been considered as a heritable and reversible change. Previous findings have indicated that DNA methylation regulates gene expression in the central ...
  • Liu, Huanle; Begik, Oguzhan; Novoa, Eva Maria (Springer, 2021)
    RNA modifications play pivotal roles in the RNA life cycle and RNA fate, and are now appreciated as a major posttranscriptional regulatory layer in the cell. In the last few years, direct RNA nanopore sequencing (dRNA-seq) ...
  • García Montolío, Marc, 1991-; Ballaré, Cecilia Julia; Blanco, Enrique; Gutiérrez, Arantxa; Aranda Aragón, Sergio; Gómez, Antonio; Kok, Chung H.; Yeung, David T.; Hughes, Timothy P.; Vizán, Pedro; Di Croce, Luciano (Frontiers Media, 2021)
    Polycomb group (PcG) of proteins are a group of highly conserved epigenetic regulators involved in many biological functions, such as embryonic development, cell proliferation, and adult stem cell determination. PHD finger ...
  • Chiva, Cristina; Mendes Maja, Teresa; Panse, Christian; Stejskal, Karel; Douché, Thibaut; Matondo, Mariette; Loew, Darmarys; Helm, Dominic; Rettel, Mandy; Mechtler, Karl; Impens, Francis; Nanni, Paolo; Shevchenko, Anna; Sabidó Aguadé, Eduard, 1981- (EMBO Press, 2021)
    Proteomics research infrastructures and core facilities within the Core for Life alliance advocate for community policies for quality control to ensure high standards in proteomics services.
  • Danko, David; Hecht, Jochen; Mutai, Beth; Ossowski, Stephan; International MetaSUB Consortium (Elsevier, 2021)
    We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an ...
  • Esteve-Codina, Anna; Nadal, Anna; Zagorščak, Maja; Ramšak, Živa; Esteve-Codina, Anna; Gruden, Kristina; Pla, Maria (BioMed Central, 2021)
    Background: Rosaceae species are economically highly relevant crops. Their cultivation systems are constrained by phytopathogens causing severe losses. Plants respond to invading pathogens through signaling mechanisms, a ...
  • Lee, In-Hee; Lin, Yufei; Jefferson Alvarez, William; Hernandez-Ferrer, Carles, 1987-; Mandl, Kenneth D.; Kong, Sek Won (BioMed Central, 2021)
    Background: Whole exome sequencing (WES) is widely adopted in clinical and research settings; however, one of the practical concerns is the potential false negatives due to incomplete breadth and depth of coverage for ...
  • Jiménez, Isabel; Tazón-Vega, Bárbara; Abrisqueta, Pau; Nieto, Juan C.; Bobillo, Sabela; Palacio-García, Carles; Carabia, Júlia; Valdés-Mas, Rafael; Munuera, Magdalena; Puigdefàbregas, Lluís; Parra Farré, Genís; Esteve-Codina, Anna; Franco-Jarava, Clara; Iacoboni, Gloria; Terol, María-José; García-Marco, J. A.; Crespo Barrio, Marta; Bosch, Francesc (BioMed Central, 2021)
    Background: Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a ...
  • Prado Bert, Paula de; Ruiz Arenas, Carlos, 1990-; Vives Usano, Marta, 1990-; Dadvand, Payam; González, Juan Ramón; Maitre, Léa; Nieuwenhuijsen, Mark J.; Pelegrí, Dolors; Sunyer Deu, Jordi; Vrijheid, Martine; Bustamante Pineda, Mariona (Elsevier, 2021)
    The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed ...
  • Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Minguillón, Carolina; Castro de Moura, Manuel; Piñeyro, David; Esteller, Manel; Molinuevo, José Luis; Guigó Serra, Roderic; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; ALFA Study (MDPI, 2021)
    This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and ...
  • Begik, Oguzhan; Lucas, Morghan C.; Pryszcz, Leszek Piotr, 1985-; Ramirez, Jose Miguel; Medina, Rebeca; Milenkovic, Ivan; Cruciani, Sonia; Liu, Huanle; Santos Vieira, Helaine Graziele; Sas Chen, Aldema; Mattick, John S.; Schwartz, Schraga; Novoa, Eva Maria (Nature Research, 2021)
    Nanopore RNA sequencing shows promise as a method for discriminating and identifying different RNA modifications in native RNA. Expanding on the ability of nanopore sequencing to detect N6-methyladenosine, we show that ...
  • Tanay, Amos; Sebé-Pedrós, Arnau (Elsevier, 2021)
    A fundamental characteristic of animal multicellularity is the spatial coexistence of functionally specialized cell types that are all encoded by a single genome sequence. Cell type transcriptional programs are deployed ...
  • Pekmezovic, Marina; Hovhannisyan, Hrant, 1992-; Gresnigt, Mark S.; Iracane, Elise; Oliveira Pacheco, João; Siscar Lewin, Sofía; Seemann, Eric; Qualmann, Britta; Kalkreuter, Till; Müller, Sylvia; Kamradt, Thomas; Mogavero, Selene; Brunke, Sascha; Butler, Geraldine; Gabaldón Estevan, Juan Antonio, 1973-; Hube, Bernhard (Nature Research, 2021)
    Vaginal candidiasis is an extremely common disease predominantly caused by four phylogenetically diverse species: Candida albicans; Candida glabrata; Candida parapsilosis; and Candida tropicalis. Using a time course infection ...
  • Torcal Garcia, Guillem; Graf, T. (Thomas) (Elsevier, 2021)
    Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone ...
  • Aya, Francisco; González Navarro, E. Azucena; Martínez, Clara M.; Carcelero, Esther; Arance, Ana (UNLISTED PUBLISHER, 2021)
    Aim: To evaluate the safety of rechallenge with a different anti-PD-1 antibody after an immune-related adverse event (irAE) that has prompted the discontinuation of anti-PD-1 therapy. Patients & methods: We describe two ...
  • Urbizu, Aintzane; Garrett, Melanie E.; Soldano, Karen; Drechsel, Oliver; Loth, Dorothy; Marcé-Grau, Anna; Mestres Soler, Olga; Poca, María A.; Ossowski, Stephan; Macaya, Alfons; Loth, Francis; Labuda, Rick; Ashley-Koch, Allison (Public Library of Science (PLoS), 2021)
    Chiari Malformation Type 1 (CM-1) is characterized by herniation of the cerebellar tonsils below the foramen magnum and the presence of headaches and other neurologic symptoms. Cranial bone constriction is suspected to be ...
  • Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Milà Alomà, Marta; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Operto, Grégory; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Sala Vila, Aleix; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Molinuevo, José Luis; ALFA study (Elsevier, 2021)
    Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective ...
  • Bevacqua, Romina J.; Dai, Xiaoqing; Lam, Jonathan Y.; Gu, Xueying; Friedlander, Mollie S. H.; Tellez, Krissie; Miguel Escalada, Irene; Bonàs-Guarch, Silvia; Atla, Goutham; Zhao, Weichen; Kim, Seung Hyun; Dominguez, Antonia A.; Qi, Lei S.; Ferrer, Jorge; MacDonald, Patrick E.; Kim, Seung K. (Nature Research, 2021)
    Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly ...
  • Rhie, Arang; Gut, Ivo Glynne; Marquès i Bonet, Tomàs, 1975-; Jarvis, Erich D. (Nature Research, 2021)
    High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. However, such assemblies are available for only a few non-microbial ...

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