Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Faure, Andre J.; Domingo, Júlia; Schmiedel, Jörn M.; Hidalgo-Carcedo, Cristina; Diss, Guillaume; Lehner, Ben, 1978- (2022)
    Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development1-6. An important reason for this is ...
  • Mas, Glòria; Santoro, Fabio; Blanco, Enrique; Gamarra Figueroa, Gianni Paolo; Le Dily, François; Frigè, Gianmaria; Vidal, Enrique; Mugianesi, Francesca; Ballaré, Cecilia Julia; Gutiérrez, Arantxa; Sparavier, Aleksandra; Marti-Renom, Marc A.; Minucci, Saverio; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Genome organization plays a pivotal role in transcription, but how transcription factors (TFs) rewire the structure of the genome to initiate and maintain the programs that lead to oncogenic transformation remains poorly ...
  • Baldassarri, Margherita; Gut, Marta; GEN-COVID Multicenter Study (Elsevier, 2021)
    Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino ...
  • Brown, Peter; Raote, Ishier; RELISH Consortium; Zhou, Yaoqi (Oxford University Press, 2019)
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that ...
  • Anguera, Montserrat; Payer, Bernhard, 1975-; Morey, Céline (Frontiers, 2020)
  • Palmada-Flores, Marc; Orkin, Joseph D.; Haase, Bettina; Mountcastle, Jacquelyn; Bertelsen, Mads F.; Fedrigo, Olivier; Kuderna, Lukas F.K.; Jarvis, Erich D.; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2022)
    Background: The ring-tailed lemur (Lemur catta) is a charismatic strepsirrhine primate endemic to Madagascar. These lemurs are of particular interest, given their status as a flagship species and widespread publicity in ...
  • Vonesch, Sibylle C.; Li, Shengdi; Szu-Tu, Chelsea; Henning, Bianca P.; Dobrev, Nikolay; Steinmetz, Lars M. (Oxford University Press, 2021)
    Through the increase in the capacity of sequencing machines massively parallel sequencing of thousands of samples in a single run is now possible. With the improved throughput and resulting drop in the price of sequencing, ...
  • Ndondo, Alvin Pumelele; Eley, Brian; Wilmshurst , Jo Madeleine; Kakooza-Mwesige, Angelina; Giannoccaro, Maria Pia; Willison, Hugh J.; Rodríguez Cruz, Pedro M.; Heckmann, Jeannine M.; Bateman, Kathleen; Vincent, Angela (Frontiers Media, 2022)
    The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they involve the central (CNS) or peripheral nervous system (PNS). The historical understanding ...
  • Della Marina, Adela; Wibbeler, Eva; Abicht, Angela; Kölbel, Heike; Lochmüller, Hanns; Roos, Andreas; Schara-Schmidt, Ulrike (Frontiers Media, 2020)
    Introduction: Congenital myasthenic syndromes (CMS) refer to a heterogenic group of neuromuscular transmission disorders. CMS-subtypes are diverse regarding exercise intolerance and muscular weakness, varying from mild ...
  • Belbin, Olivia; Lehmann, Sylvain; Sabidó Aguadé, Eduard, 1981-; Hirtz, Christophe (Frontiers Media, 2020)
  • Ghose, Ritobrata; Aranguren-Ibáñez, Álvaro; Arecco, Niccolò; Balboa, Diego; Bataller, Marc; Beltran, Sergi; Benisty, Hannah, 1986-; Bénard, Angèle; Bernardo, Edgar; Carbonell Sala, Silvia; Casals, Eloi; Ciampi, Ludovica; Condemi, Livia; Corvó, Alberto; Cosín-Tomás, Marta; Cuenca-Ardura, Mirabai; Duran Serrano, Juan Manuel; Espejo Díaz, María Isabel; Fernández Callejo, Marcos; Gañez-Zapater, Antoni; Garcia-Castellanos, Raquel; Garrido, Romina; Henkin, Gil; Hermoso Pulido, Antonio; Hernandez-Alias, Xavier; Herrero Vicente, Jorge; Ingham, Matthew; Lim, Wei Ming; Llonch, Sílvia; Marmesat Bertoli, Elena; Miguel Escalada, Irene; Montero-Blay, Ariadna; Navarrete Hernández, Cristina; Neguembor, Maria Victoria; Ní Chárthaigh, Róisín-Ana; Pardo-Lorente, Natalia; Pascual-Reguant, Laura, 1990-; Pérez-Lluch, Sílvia; Perza, Reyes; Pesaresi, Martina, 1991-; Picó Amado, Daniel; Pifarré, Paula; Piscia, Davide; Plana-Carmona, Marcos; Ponomarenko, Julia; Radusky, Leandro; Rivero, Ezequiel; Rogalska, Malgorzata; Torcal Garcia, Guillem, 1991-; Wojnacki, José (F1000Research, 2020)
    The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to ...
  • Salgado, David; Beltran, Sergi; Furlong, Laura I., 1971-; Gut, Ivo Glynne; Laurie, Steven, 1973-; Marquès i Bonet, Tomàs, 1975-; Piñero González, Janet, 1977-; Sanz, Ferran; Béroud, Christophe (F1000Research, 2020)
    Copy number variations (CNVs) are major causative contributors both in the genesis of genetic diseases and human neoplasias. While "High-Throughput" sequencing technologies are increasingly becoming the primary choice for ...
  • Dehasque, Marianne; Ávila Arcos, María C.; Díez-Del-Molino, David; Fumagalli, Matteo; Guschanski, Katerina; Lorenzen, Eline D.; Malaspinas, Anna-Sapfo; Marquès i Bonet, Tomàs, 1975-; Martin, Michael D.; Murray, Gemma G. R.; Papadopulos, Alexander S. T.; Overgaard Therkildsen, Nina; Wegmann, Daniel; Dalén, Love; Foote, Andrew D. (Wiley Open Access, 2020)
    Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral ...
  • James, Maddie E.; Wilkinson, Melanie J.; Bernal, Diana M.; Liu, Huanle; North, Henry L.; Engelstädter, Jan; Ortiz-Barrientos, Daniel (Wiley, 2021)
    The independent and repeated adaptation of populations to similar environments often results in the evolution of similar forms. This phenomenon creates a strong correlation between phenotype and environment and is referred ...
  • López-Méndez, Blanca; Carolis, Carlo; Rodrigo, Natalia; Wu, Di (Springer, 2021)
    Microscale thermophoresis (MST), and the closely related Temperature Related Intensity Change (TRIC), are synonyms for a recently developed measurement technique in the field of biophysics to quantify biomolecular interactions, ...
  • Di Croce, Luciano; Fico, Annalisa; Di Croce, Luciano; Matarazzo, Maria R. (MDPI, 2020)
    The epigenome refers to the entirety of DNA methylations, histone modifications, nucleosome occupancy, and coding and non-coding RNAs (and their modifications) in different cell types [...].
  • Jhanwar, Shalu, 1986-; Deogade, Ajinkya, 1989- (MDPI, 2019)
    In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality ...
  • Scherer, Michael; Gasparoni, Gilles; Rahmouni, Souad; Shashkova, Tatiana; Arnoux, Marion; Louis, Edouard; Nostaeva, Arina; Avalos, Diana; Dermitzakis, Emmanuouil T.; Aulchenko, Yurii S.; Lengauer, Thomas; Lyons, Paul A.; Georges, Michel; Walter, Jörn (BioMed Central, 2021)
    Background: Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for ...
  • Beltran Marqués, Antoni; Pahita, Elena; Ghosh, Subhanita; Lenhard, Boris; Sarkies, Peter (EMBO Press, 2021)
    Piwi-interacting RNAs (piRNAs) play key roles in germline development and genome defence in metazoans. In C. elegans, piRNAs are transcribed from > 15,000 discrete genomic loci by RNA polymerase II (Pol II), resulting in ...
  • Ruiz-Arenas, Carlos; Hernandez-Ferrer, Carles, 1987-; Vives Usano, Marta, 1990-; Marí, Sergi; Casas Sanahuja, Maribel; Vafeiadi, Marina, 1983-; Vrijheid, Martine; González Ruiz, Juan Ramón; Bustamante Pineda, Mariona (eLife Sciences Publications, 2022)
    Background: The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide ...

View more