Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Begik, Oguzhan; Mattick, John S.; Novoa, Eva Maria (Cold Spring Harbor Laboratory Press (CSHL Press), 2022)
    Chemical RNA modifications, collectively referred to as the "epitranscriptome," are essential players in fine-tuning gene expression. Our ability to analyze RNA modifications has improved rapidly in recent years, largely ...
  • Bosch-Camós, Laia; Alonso, Uxía; Esteve-Codina, Anna; Chang, Chia-Yu; Martín-Mur, Beatriz; Accensi, Francesc; Muñoz, Marta; Navas, María J.; Dabad, Marc; Vidal, Enric; Pina-Pedrero, Sonia; Pleguezuelos, Patricia; Caratù, Ginevra; Salas, María L.; Liu, Lihong; Bataklieva, Stanimira; Gavrilov, Boris; Rodríguez, Fernando; Argilaguet Marqués, Jordi, 1977- (Public Library of Science (PLoS), 2022)
    African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease in wild boars and ...
  • Ramos-Romero, Sara; Ponomarenko, Julia; Amézqueta, Susana; Hereu, Mercè; Miralles-Pérez, Bernat; Romeu, Marta; Méndez, Lucía; Medina, Isabel; Torres, Josep Lluís (MDPI, 2022)
    The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard ...
  • Chandra, Vikash; Ibrahim, Hazem; Halliez, Clémentine; Prasad, Rashmi B.; Vecchio, Federica; Dwivedi, Om Prakash; Kvist, Jouni; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam; Barsby, Tom; Lithovius, Väinö; Artner, Isabella; Gopalakrishnan, Swetha; Groop, Leif; Mallone, Roberto; Eizirik, Décio L.; Otonkoski, Timo (Nature Research, 2022)
    Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which encodes a Janus kinase with critical roles in ...
  • Zadra, Ivan, 1991-; Jiménez-Delgado, Senda; Anglada-Girotto, Miquel; Segura-Morales, Carolina; Compton, Zachary J.; Janke, Carsten; Serrano Pubull, Luis, 1982-; Ruprecht, Verena; Vernos, Isabelle, 1959- (Nature Research, 2022)
    Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is ...
  • Seuma, Mireia; Lehner, Ben, 1978-; Bolognesi, Benedetta (Nature Research, 2022)
    Multiplexed assays of variant effects (MAVEs) guide clinical variant interpretation and reveal disease mechanisms. To date, MAVEs have focussed on a single mutation type-amino acid (AA) substitutions-despite the diversity ...
  • Escobedo, Albert; Piccirillo, Jonathan; Aranda, Juan; Diercks, Tammo; Mateos, Borja; Garcia-Cabau, Carla; Sánchez-Navarro, Macarena; Topal, Busra; Biesaga, Mateusz; Staby, Lasse; Kragelund, Birthe B.; García, Jesús; Millet, Oscar; Orozco, Modesto; Coles, Murray; Crehuet, Ramon; Salvatella, Xavier (Nature Research, 2022)
    The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules ...
  • Uszczynska-Ratajczak, Barbara; Sugunan, Sreedevi; Kwiatkowska, Monika; Migdal, Maciej; Carbonell Sala, Silvia; Sokol, Anna; Winata, Cecilia L.; Chacinska, Agnieszka (UNLISTED PUBLISHER, 2022)
    Most mitochondrial proteins are encoded by nuclear genes, synthetized in the cytosol and targeted into the organelle. To characterize the spatial organization of mitochondrial gene products in zebrafish (Danio rerio), we ...
  • Dias, Felipe M. S.; Pantoja, Raoní K.; Gomez, José Gregório C.; Silva, Luiziana F. (Springer, 2022)
    Gallic acid is a powerful antioxidant with multiple therapeutic applications, usually obtained from the acidic hydrolysis of tannins produced by many plants. As this process generates a considerable amount of toxic waste, ...
  • Bianchi, Agostina; Scherer, Michael; Zaurín Quer, Roser; Quililan, Kimberly; Velten, Lars; Beekman, Renée (BioMed Central, 2022)
    Single-cell DNA methylation profiling currently suffers from excessive noise and/or limited cellular throughput. We developed scTAM-seq, a targeted bisulfite-free method for profiling up to 650 CpGs in up to 10,000 cells ...
  • Duro-Sánchez, Santiago; Nadal-Serrano, Mercedes; Lalinde-Gutiérrez, Marta; Arenas, Enrique J.; Bernadó Morales, Cristina; Morancho Armisen, Beatriz; Escorihuela, Marta; Pérez-Ramos, Sandra; Escrivá-de-Romaní, Santiago; Gandullo-Sánchez, Lucía; Pandiella, Atanasio; Esteve-Codina, Anna; Rodilla, Verónica; Dijcks,Fred A.; Dokter, Wim H.A.; Cortés, Javier; Saura, Cristina; Arribas, Joaquín (American Association for Cancer Research (AACR), 2022)
    Antibody-drug conjugates (ADC) are antineoplastic agents recently introduced into the antitumor arsenal. T-DM1, a trastuzumab-based ADC that relies on lysosomal processing to release the payload, is approved for HER2-positive ...
  • Fontseré Alemany, Clàudia, 1992-; Kuhlwilm, Martin; Morcillo Suárez, Carlos, 1969-; Alvarez-Estape, Marina; Hecht, Jochen; Marquès i Bonet, Tomàs, 1975- (Elsevier, 2022)
    Knowledge on the population history of endangered species is critical for conservation, but whole-genome data on chimpanzees (Pan troglodytes) is geographically sparse. Here, we produced the first non-invasive geolocalized ...
  • Brasó-Vives, Marina, 1990-; Marlétaz, Ferdinand; Echchiki, Amina; Mantica, Federica; Acemel, Rafael D.; Gómez Skarmeta, José Luis; Hartasánchez Frenk, Diego Andrés, 1982-; Le Targa, Lorlane; Pontarotti, Pierre; Tena, Juan J.; Maeso, Ignacio; Escriva, Hector; Irimia, Manuel; Robinson-Rechavi, Marc (BioMed Central, 2022)
    Background: Amphioxus are non-vertebrate chordates characterized by a slow morphological and molecular evolution. They share the basic chordate body-plan and genome organization with vertebrates but lack their 2R whole-genome ...
  • Oldoni, Emanuela; Saunders, Gary; Bietrix, Florence; Garcia Bermejo, Maria Laura; Niehues, Anna; Hoen, Peter A. C.; Nordlund, Jessica; Hajduch, Marian; Scherer, Andreas; Kivinen, Katja; Pitkänen, Esa; Mäkela, Tomi Pekka; Gut, Ivo Glynne; Scollen, Serena; Kozera, Łukasz; Esteller, Manel; Shi, Leming; Ussi, Anton; Andreu, Antonio L.; Gool, Alian J. van (Frontiers, 2022)
    Personalised medicine (PM) presents a great opportunity to improve the future of individualised healthcare. Recent advances in -omics technologies have led to unprecedented efforts characterising the biology and molecular ...
  • Jablonszky, Mónika; Canal, David; Hegyi, Gergely; Herényi, Márton; Laczi, Miklós; Lao Grueso, Oscar, 1976-; Markó, Gábor; Nagy, Gergely; Rosivall, Balázs; Szász, Eszter; Török, János; Zsebők, Sándor; Garamszegi, László Zsolt (Frontiers, 2022)
    Heritable genetic variation is a prerequisite for adaptive evolution; however, our knowledge about the heritability of plastic traits, such as behaviors, is scarce, especially in wild populations. In this study, we ...
  • Servello, Francesco A.; Fernandes, Rute; Eder, Matthias; Harris, Nathan; Martin, Olivier M. F., 1991-; Oswal, Natasha; Lindberg, Anders; Derosiers, Nohelly; Sengupta, Piali; Stroustrup, Nicholas; Apfeld, Javier (eLife, 2022)
    Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little ...
  • Baltzis, Athanasios; Mansouri, Leila; Jin, Suzanne; Langer, Björn E.; Erb, Ionas; Notredame, Cedric (Oxford University Press, 2022)
    Motivation: Protein sequence alignments are essential to structural, evolutionary and functional analysis, but their accuracy is often limited by sequence similarity unless molecular structures are available. Protein ...
  • Cuypers, Bart; Meysman, Pieter; Erb, Ionas; Bittremieux, Wout; Valkenborg, Dirk; Baggerman, Geert; Mertens, Inge; Sundar, Shyam; Khanal, Basudha; Notredame, Cedric; Dujardin, Jean-Claude; Domagalska, Malgorzata A.; Laukens, Kris (Public Library of Science (PLoS), 2022)
    Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually ...
  • Stobbe, Miranda D.; González-Pérez, Abel; López Bigas, Núria; Gut, Ivo Glynne (Public Library of Science (PLoS), 2022)
  • Oswal, Natasha; Martin, Olivier M. F., 1991-; Stroustrup, Sofia; Bruckner, Monika Anna Matusiak; Stroustrup, Nicholas (Public Library of Science (PLoS), 2022)
    Aging involves a transition from youthful vigor to geriatric infirmity and death. Individuals who remain vigorous longer tend to live longer, and within isogenic populations of C. elegans the timing of age-associated ...

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