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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Amid, Clara; Frankish, Adam; HAVANA; Aken, Bronwen; Ezkurdia, Iakes; Kokocinski, Felix; Gilbert, James; White, Simon; Carninci, Piero; Gingeras, Thomas R.; Guigó Serra, Roderic; Searle, Stephen; Tress, Michael; Harrow, Jennifer; Hubbard, Tim J. (BioMed Central, 2010)
  • Cavazza, Tommaso, 1985-; Peset, Isabel; Vernos, Isabelle, 1959- (Company of Biologists, 2016)
    Bipolar spindle assembly in the vertebrate oocyte relies on a self-organization chromosome-dependent pathway. Upon fertilization, the male gamete provides a centrosome, and the first and subsequent embryonic divisions occur ...
  • Ghose, Ritobrata; Aranguren-Ibáñez, Álvaro; Arecco, Niccolò; Balboa, Diego; Bataller, Marc; Beltran, Sergi; Benisty, Hannah, 1986-; Bénard, Angèle; Bernardo, Edgar; Carbonell Sala, Silvia; Casals, Eloi; Ciampi, Ludovica; Condemi, Livia; Corvò, Alberto; Cosín-Tomás, Marta; Cuenca-Ardura, Mirabai; Duran Serrano, Juan Manuel; Espejo Díaz, María Isabel; Fernández Callejo, Marcos; Gañez-Zapater, Antoni; Garcia-Castellanos, Raquel; Garrido, Romina; Henkin, Gil; Hermoso Pulido, Antonio; Hernandez-Alias, Xavier; Herrero Vicente, Jorge; Ingham, Matthew; Lim, Wei Ming; Llonch, Sílvia; Marmesat Bertoli, Elena; Miguel Escalada, Irene; Montero-Blay, Ariadna; Navarrete Hernández, Cristina; Neguembor, Maria Victoria; Ní Chárthaigh, Róisín-Ana; Pardo-Lorente, Natalia; Pascual-Reguant, Laura, 1990-; Pérez-Lluch, Sílvia; Perza, Reyes; Pesaresi, Martina, 1991-; Picó Amado, Daniel; Pifarré, Paula; Piscia, Davide; Plana-Carmona, Marcos; Ponomarenko, Julia; Radusky, Leandro; Rivero, Ezequiel; Rogalska, Malgorzata; Torcal Garcia, Guillem, 1991-; Wojnacki, José (F1000Research, 2020)
    The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to ...
  • Laurie, Steven, 1973-; Fernández Callejo, Marcos; Marco Sola, Santiago; Trotta, Jean-Remi; Camps-Puchadas, Jordi; Chacón, Alejandro; Espinosa, Antonio; Gut, Marta; Gut, Ivo Glynne; Heath, Simon; Beltran, Sergi (Wiley, 2016)
    As whole genome sequencing becomes cheaper and faster, it will progressively substitute targeted next-generation sequencing as standard practice in research and diagnostics. However, computing cost–performance ratio is not ...
  • Amargant i Riera, Farners, 1990-; García, Désirée; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)
    Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
  • Grau-Bové, Carme; Grau Bové, Xavier; Terra, Ximena; Garcia Vallvé, Santiago; Rodríguez-Gallego, Esther; Beltran-Debón, Raúl; Blay, M. Teresa; Ardévol, Anna; Pinent, Montserrat (Wiley, 2022)
    Bitterness is perceived in humans by 25 subtypes of bitter taste receptors (hTAS2R) that range from broadly tuned to more narrowly tuned receptors. hTAS2R5 is one of the most narrowly tuned bitter taste receptors in humans. ...
  • Puighermanal Puigvert, Emma, 1983-; Castell, Laia; Esteve-Codina, Anna; Melser, Su; Kaganovsky, Konstantin; Zussy, Charleine; Boubaker-Vitre, Jihane; Gut, Marta; Rialle, Stephanie; Kellendonk, Christoph; Sanz, Elisenda; Quintana, Albert; Marsicano, Giovanni; Martin, Miquel; Rubinstein, Marcelo; Girault, Jean-Antoine; Ding, Jun B.; Valjent, Emmanuel (Nature Research, 2020)
    Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly ...
  • Vizán, Pedro; Di Croce, Luciano; Aranda Aragón, Sergio (Frontiers Media, 2021)
    Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of ...
  • Ramilowski, Jordan A.; Borsari, Beatrice, 1992-; Garrido Martín, Diego, 1992-; Muñoz-Aguirre, Manuel; Nurtdinov, Ramil; Guigó Serra, Roderic; Carninci, Piero (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...
  • Bastos, Rafael Wesley; Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973-; Goldman, Gustavo H. (American Society for Microbiology, 2020)
    Aspergillus nidulans is an opportunistic fungal pathogen in patients with immunodeficiency, and virulence of A. nidulans isolates has mainly been studied in the context of chronic granulomatous disease (CGD), with ...
  • Martínez-Torró, Carlos; Torres-Puig, Sergi; Marcos-Silva, Marina; Huguet-Ramón, Marta; Muñoz-Navarro, Carmen; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Querol, Enrique; Piñol, Jaume; Pich, Oscar Q. (Frontiers Media, 2021)
    It is well-established that FtsZ drives peptidoglycan synthesis at the division site in walled bacteria. However, the function and conservation of FtsZ in wall-less prokaryotes such as mycoplasmas are less clear. In the ...
  • Gallego Jiménez, Alicia, 1985-; Melé Messeguer, Marta, 1982-; Balcells, Ingrid; García Ramallo, Eva; Torruella Loran, Ignasi, 1987-; Fernández Bellon, Hugo; Abelló, Teresa; Kondova, Ivanela; Bontrop, Ronald E.; Hvilsom, Christina; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Espinosa Parrilla, Yolanda, 1971- (Public Library of Science, 2016)
    microRNAs are crucial post-transcriptional regulators of gene expression involved in a wide range of biological processes. Although microRNAs are highly conserved among species, the functional implications of existing ...
  • Carbonell Núñez, Caterina, 1987-; Ulsamer, Arnau; Vivori, Claudia, 1989-; Papasaikas, Panagiotis; Böttcher, René; Joaquin i Caudet, Manel; Miñana Gómez, Belén; Tejedor Vaquero, Juan Ramón, 1984-; Nadal Clanchet, Eulàlia de; Valcárcel, J. (Juan); Posas Garriga, Francesc (Elsevier, 2019)
    Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps ...
  • Altarche-Xifro, Wassim; Di Vicino, Umberto; Muñoz-Martin, Maria Isabel; Bortolozzi, Analía; Bové, Jordi; Vila, Miquel; Cosma, Maria Pia (Elsevier, 2016)
    Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. Cellular ...
  • Papasaikas, Panagiotis; Tejedor Vaquero, Juan Ramón, 1984-; Vigevani, Luisa, 1985-; Valcárcel, J. (Juan) (Elsevier, 2015)
    Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the ...
  • Balboa, Diego (Nature Research, 2022)
    Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2020)
    The question of how phenotypic and genomic complexity are inter-related and how they are shaped through evolution is a central question in biology that historically has been approached from the perspective of animals and ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2019)
    The fungal kingdom comprises a hyperdiverse clade of heterotrophic eukaryotes characterized by the presence of a chitinous cell wall, the loss of phagotrophic capabilities and cell organizations that range from completely ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2019)
    Fungi are a highly diverse group of heterotrophic eukaryotes characterized by the absence of phagotrophy and the presence of a chitinous cell wall. While unicellular fungi are far from rare, part of the evolutionary success ...
  • Qamar, Seema; Tartaglia, Gian Gaetano; St George-Hyslop, Peter (Elsevier, 2018)
    Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we ...

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