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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Consortium OPATHY; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2019)
    The incidence of opportunistic yeast infections in humans has been increasing over recent years. These infections are difficult to treat and diagnose, in part due to the large number and broad diversity of species that can ...
  • Kodra, Yllka; Lochmüller, Hanns; Taruscio, Domenica (MDPI, 2018)
    Rare diseases (RD) patient registries are powerful instruments that help develop clinical research, facilitate the planning of appropriate clinical trials, improve patient care, and support healthcare management. They ...
  • Souche, Erika; Beltran, Sergi; Weiss, Marjan M. (Springer Nature, 2022)
    In 2016, guidelines for diagnostic Next Generation Sequencing (NGS) have been published by EuroGentest in order to assist laboratories in the implementation and accreditation of NGS in a diagnostic setting. These guidelines ...
  • López Escardó, David, 1988-; Grau Bové, Xavier; Guillaumet-Adkins, Amy; Gut, Marta; Sieracki, Michael E.; Ruiz Trillo, Iñaki (Royal Society, 2019)
    Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there ...
  • Lladós, Jordi; Guirado, Fernando; Cores, Fernando; Lérida, Josep Lluís; Notredame, Cedric (Springer, 2015)
    Multiple sequence alignment (MSA) is crucial for high-throughput next generation sequencing applications. Large-scale alignments with thousands of sequences are necessary for these applications. However, the quality of the ...
  • Ruiz-Gartzia, Irune; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Kelley, Joanna L. (Wiley, 2022)
    Natural history museums hold vast collections of biomaterials. The collections in museums, often painstakingly sampled, are largely unexplored treasures that may help us better understand biodiversity on the planet. Museum ...
  • Stobbe, Miranda D.; Thun, Gian Andri; Diéguez Docampo, Andrea; Oliva, Meritxell; Whalley, Justin P.; Raineri, Emanuele; Gut, Ivo Glynne (Public Library of Science (PLoS), 2019)
    The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes ...
  • Theka, Ilda, 1984-; Sottile, Francesco, 1988-; Aulicino, Francesco, 1987-; García, Álvaro Castells; Cosma, Maria Pia (Nature Publishing Group, 2017)
    Imprinted genes control several cellular and metabolic processes in embryonic and adult tissues. In particular, paternally expressed gene-3 (Peg3) is active in the adult stem cell population and during muscle and neuronal ...
  • Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2016)
    Many genomes display high levels of heterozygosity (i.e. presence of different alleles at the same loci in homologous chromosomes), being those of hybrid organisms an extreme such case. The assembly of highly heterozygous ...
  • Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Dyke, Stephanie O. M.; De Argila, Jordi Rambla; Flicek, Paul (Nature Research, 2018)
    The Global Alliance for Genomics and Health (GA4GH) proposes a data access policy model-"registered access"-to increase and improve access to data requiring an agreement to basic terms and conditions, such as the use of ...
  • Paronetto, Maria Paola; Bernardis, Isabella; Volpe, Elisabetta; Bechara, Elias; Sebestyén, Endre; Eyras Jiménez, Eduardo; Valcárcel, J. (Juan) (Elsevier, 2014)
    The Ewing sarcoma protein EWS is an RNA and DNA binding protein implicated in transcription, pre-mRNA splicing, and DNA damage response. Using CLIP-seq, we identified EWS RNA binding sites in exonic regions near 5′ splice ...
  • Aranda Aragón, Sergio; Mas, Glòria; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2015)
    The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic ...
  • Teixeira, Vítor; Martínez-Montañés, Fernando; Grippa, Alexandra, 1980-; Buxó, Laura; Idrissi, Fatima-Zahra; Ejsing, Christer S.; Carvalho, Pedro C. (Rockefeller University Press, 2018)
    Storage and consumption of neutral lipids in lipid droplets (LDs) are essential for energy homeostasis and tightly coupled to cellular metabolism. However, how metabolic cues are integrated in the life cycle of LDs is ...
  • Dudin, Omaya; Wielgoss, Sébastien; New, Aaron M.; Ruiz Trillo, Iñaki (Public Library of Science (PLoS), 2022)
    Significant increases in sedimentation rate accompany the evolution of multicellularity. These increases should lead to rapid changes in ecological distribution, thereby affecting the costs and benefits of multicellularity ...
  • Sarkar, Soumyadeep; Ramos-Rodríguez, Mireia; Juan-Mateu, Jonàs; Pasquali, Lorenzo; Nakayasu, Ernesto S. (BioMed Central, 2024)
    Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream ...
  • Vas, Matías G. de; Boulet, Fanny; Joshi, Shweta S.; Garstang, Myles G.; Khan, Tahir N.; Atla, Goutham; Parry, David; Moore, David; Cebola, Inês; Zhang, Shuchen; Cui, Wei, 1970-; Lampe, Anne K.; Lam, Wayne W.; Genomics England Research Consortium; Ferrer, Jorge; Pradeepa, Madapura M.; Atanur, Santosh S. (Life Science Alliance, 2023)
    The genetic aetiology of a major fraction of patients with intellectual disability (ID) remains unknown. De novo mutations (DNMs) in protein-coding genes explain up to 40% of cases, but the potential role of regulatory ...
  • Bravo Ruiz, Gustavo; Sassi, Azza Hadj; Marcet Houben, Marina; Di Pietro, Antonio; Gargouri, Ali Faouzi; Roncero, María Isabel González (Frontiers, 2017)
    Penicillium occitanis is a model system for enzymatic regulation. A mutant strain exhibiting constitutive overproduction of different pectinolytic enzymes both under inducing (pectin) or repressing conditions (glucose) was ...
  • Tierrafría, Víctor H.; Collado Vides, Pedro Julio (Microbiology Society, 2022)
    Genomics has set the basis for a variety of methodologies that produce high-throughput datasets identifying the different players that define gene regulation, particularly regulation of transcription initiation and operon ...
  • Salgado, Heladia; Gelpí, Josep Lluís; Collado Vides, Pedro Julio (Oxford University Press, 2024)
    RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput ...

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