Welcome to the UPF Digital Repository

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Sort by: Order: Results:

  • Stobbe, Miranda D.; Thun, Gian Andri; Diéguez Docampo, Andrea; Oliva, Meritxell; Whalley, Justin P.; Raineri, Emanuele; Gut, Ivo Glynne (Public Library of Science (PLoS), 2019)
    The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes ...
  • Theka, Ilda, 1984-; Sottile, Francesco, 1988-; Aulicino, Francesco, 1987-; García, Álvaro Castells; Cosma, Maria Pia (Nature Publishing Group, 2017)
    Imprinted genes control several cellular and metabolic processes in embryonic and adult tissues. In particular, paternally expressed gene-3 (Peg3) is active in the adult stem cell population and during muscle and neuronal ...
  • Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2016)
    Many genomes display high levels of heterozygosity (i.e. presence of different alleles at the same loci in homologous chromosomes), being those of hybrid organisms an extreme such case. The assembly of highly heterozygous ...
  • Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Dyke, Stephanie O. M.; De Argila, Jordi Rambla; Flicek, Paul (Nature Research, 2018)
    The Global Alliance for Genomics and Health (GA4GH) proposes a data access policy model-"registered access"-to increase and improve access to data requiring an agreement to basic terms and conditions, such as the use of ...
  • Paronetto, Maria Paola; Bernardis, Isabella; Volpe, Elisabetta; Bechara, Elias; Sebestyén, Endre; Eyras Jiménez, Eduardo; Valcárcel, J. (Juan) (Elsevier, 2014)
    The Ewing sarcoma protein EWS is an RNA and DNA binding protein implicated in transcription, pre-mRNA splicing, and DNA damage response. Using CLIP-seq, we identified EWS RNA binding sites in exonic regions near 5′ splice ...
  • Aranda Aragón, Sergio; Mas, Glòria; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2015)
    The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic ...
  • Teixeira, Vítor; Martínez-Montañés, Fernando; Grippa, Alexandra, 1980-; Buxó, Laura; Idrissi, Fatima-Zahra; Ejsing, Christer S.; Carvalho, Pedro C. (Rockefeller University Press, 2018)
    Storage and consumption of neutral lipids in lipid droplets (LDs) are essential for energy homeostasis and tightly coupled to cellular metabolism. However, how metabolic cues are integrated in the life cycle of LDs is ...
  • Dudin, Omaya; Wielgoss, Sébastien; New, Aaron M.; Ruiz Trillo, Iñaki (Public Library of Science (PLoS), 2022)
    Significant increases in sedimentation rate accompany the evolution of multicellularity. These increases should lead to rapid changes in ecological distribution, thereby affecting the costs and benefits of multicellularity ...
  • Vas, Matías G. de; Boulet, Fanny; Joshi, Shweta S.; Garstang, Myles G.; Khan, Tahir N.; Atla, Goutham; Parry, David; Moore, David; Cebola, Inês; Zhang, Shuchen; Cui, Wei, 1970-; Lampe, Anne K.; Lam, Wayne W.; Genomics England Research Consortium; Ferrer, Jorge; Pradeepa, Madapura M.; Atanur, Santosh S. (Life Science Alliance, 2023)
    The genetic aetiology of a major fraction of patients with intellectual disability (ID) remains unknown. De novo mutations (DNMs) in protein-coding genes explain up to 40% of cases, but the potential role of regulatory ...
  • Bravo Ruiz, Gustavo; Sassi, Azza Hadj; Marcet Houben, Marina; Di Pietro, Antonio; Gargouri, Ali Faouzi; Roncero, María Isabel González (Frontiers, 2017)
    Penicillium occitanis is a model system for enzymatic regulation. A mutant strain exhibiting constitutive overproduction of different pectinolytic enzymes both under inducing (pectin) or repressing conditions (glucose) was ...
  • Tierrafría, Víctor H.; Collado Vides, Pedro Julio (Microbiology Society, 2022)
    Genomics has set the basis for a variety of methodologies that produce high-throughput datasets identifying the different players that define gene regulation, particularly regulation of transcription initiation and operon ...
  • Salgado, Heladia; Gelpí, Josep Lluís; Collado Vides, Pedro Julio (Oxford University Press, 2024)
    RegulonDB is a database that contains the most comprehensive corpus of knowledge of the regulation of transcription initiation of Escherichia coli K-12, including data from both classical molecular biology and high-throughput ...
  • Almouzni, Geneviève; Estivill, Xavier, 1955-; Ossowski, Stephan; Widschwendter, Martin (BioMed Central, 2014)
    Understanding the links between genetic, epigenetic and non-genetic factors throughout the lifespan and across generations and their role in disease susceptibility and disease progression offer entirely new avenues and ...
  • Iannone, Camilla, 1984-; Pohl, Andy, 1979-; Papasaikas, Panagiotis; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press, 2015)
    Splicing of mRNA precursors can occur cotranscriptionally and it has been proposed that chromatin structure influences splice site recognition and regulation. Here we have systematically explored potential links between ...
  • Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2018)
    The origin of eukaryotes stands as a major open question in biology. Central to this question is the nature and timing of the origin of the mitochondrion, an ubiquitous eukaryotic organelle originated by the endosymbiosis ...
  • Cruz-Garcia, David; Curwin, Amy; Popoff, Jean-François; Bruns, Caroline, 1984-; Duran, Juan M.; Malhotra, Vivek (Rockefeller University Press, 2014)
    Upon starvation, Grh1, a peripheral membrane protein located at endoplasmic reticulum (ER) exit sites and early Golgi in Saccharomyces cerevisiae under growth conditions, relocates to a compartment called compartment for ...
  • Corvò, Alberto; Matalonga, Leslie; Laurie, Steven, 1973-; Picó-Amador, Daniel; Fernández Callejo, Marcos; Paramonov, Ida; Gut, Ivo Glynne; Piscia, Davide; Beltran, Sergi (Elsevier, 2023)
    The Solve-RD project objectives include solving undiagnosed rare diseases (RD) through collaborative research on shared genome-phenome datasets. The RD-Connect Genome-Phenome Analysis Platform (GPAP), for data collation ...
  • Marigorta, Urko M.; Rodríguez, Juan Antonio; Gibson, Greg; Navarro i Cuartiellas, Arcadi, 1969- (Elsevier, 2018)
    Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark study a decade ago, genome-wide association studies (GWAS) have led to the discovery of thousands of risk variants involved in disease ...
  • Pool, Fran M.; Kiel, Christina; Serrano Pubull, Luis, 1982-; Luthert, Philip J. (Nature Research, 2020)
    Age-related macular degeneration (AMD) is one of the commonest causes of sight loss in the elderly population and to date there is no intervention that slows or prevents early AMD disease progressing to blinding ...

Search DSpace


Advanced Search

Browse

My Account

In collaboration with Compliant to Partaking