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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Sánchez-Herrero, Estela; Serna-Blasco, Roberto; Ivanchuk, Vadym; García-Campelo, Rosario; Dómine Gómez, Manuel; Sánchez, José M.; Massutí, Bartomeu; Reguart, Noemí; Camps, Carlos; Sanz-Moreno, Sandra; Calabuig-Fariñas, Sílvia; Jantus-Lewintre, Eloisa; Arnal, Magdalena; Fernández-Orth, Dietmar; Calvo, Virginia; González-Rumayor, Víctor; Provencio, Mariano; Romero, Atocha (Wiley, 2021)
    Despite impressive and durable responses, nonsmall cell lung cancer (NSCLC) patients treated with anaplastic lymphoma kinase (ALK) inhibitors (ALK-Is) ultimately progress due to development of resistance. Here, we have ...
  • Garrido, Georgina; Vernos, Isabelle, 1959- (Frontiers, 2016)
    Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not ...
  • Lobanov, Michail Yu.; Klus, Petr, 1985-; Sokolovsky, Igor V.; Tartaglia, Gian Gaetano; Galzitskaya, Oxana V. (Nature Publishing Group, 2016)
    The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial ...
  • Hu, Deqing; Gao, Xin; Cao, Kaixiang; Morgan, Marc Alard J.; Mas Martín, Glòria; Smith, Edwin R.; Volk, Andrew G.; Bartom, Elizabeth T.; Crispino, John D.; Di Croce, Luciano; Shilatifard, Ali (Elsevier, 2017)
    The spatiotemporal regulation of gene expression is central for cell-lineage specification during embryonic development and is achieved through the combinatorial action of transcription factors/co-factors and epigenetic ...
  • de Castro-Miró, Marta; Tonda, Raúl; Escudero-Ferruz, Paula; Andrés, Rosa; Mayor-Lorenzo, Andrés; Castro, Joaquín; Ciccioli, Marcela; Hidalgo, Daniel A.; Rodríguez-Ezcurra, Juan José; Farrando, Jorge; Pérez-Santonja, Juan J.; Cormand, Bru; Marfany, Gemma; Gonzàlez-Duarte, Roser (Public Library of Science (PLoS), 2016)
    Background. NGS-based genetic diagnosis has completely revolutionized the human genetics field. In this study, we have aimed to identify new genes and mutations by Whole Exome Sequencing (WES) responsible for inherited ...
  • van der Valk, Ralf J.P.; Guxens Junyent, Mònica; EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium; Bustamante Pineda, Mariona; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (Oxford University Press, 2015)
    Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we ...
  • Gaur, Tarang; Poddutoori, Ramulu; Khare, Leena; Bagal, Bhausaheb; Rashmi, Sonal; Patkar, Nikhil; Tembhare, Prashant; Pg, Subramanian; Shetty, Dhanlaxmi; Dutt, Amit; Zhang, Qi; Konopleva, Marina; Platzbeckar, Uwe; Gupta, Sudeep; Samajdar, Susanta; Ramchandra, Murali; Khattry, Navin; Hasan, Syed K. (BioMed Central, 2023)
    Introduction: The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeutic ...
  • Durán, Mónica; Burballa Tàrrega, Carla, 1988-; Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Malhotra, Vivek; Ariceta, Gema; Sarró, Eduard; Meseguer, Anna (Oxford University Press, 2021)
    Dent disease 1 (DD1) is a rare X-linked renal proximal tubulopathy characterized by low molecular weight proteinuria and variable degree of hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressing to chronic ...
  • Kleinman Ruiz, Daniel; Martínez Cruz, Begoña; Soriano, Laura; Lucena Pérez, María; Cruz, Fernando; Villanueva, Beatriz; Fernández, Jesús María; Godoy, José A. (BioMed Central, 2017)
    BACKGROUND: The Iberian lynx (Lynx pardinus) has been acknowledged as the most endangered felid species in the world. An intense contraction and fragmentation during the twentieth century left less than 100 individuals ...
  • Arlt, Annabelle; Kohlschmidt, Nicolai; Hentschel, Andreas; Bartels, Enrika; Groß, Claudia; Töpf, Ana; Edem, Pinar; Szabo, Nora; Sickmann, Albert; Meyer, Nancy; Schara-Schmidt, Ulrike; Lau, Jarred; Lochmüller, Hanns; Horvath, Rita; Oktay, Yavuz; Roos, Andreas; Hiz, Semra (BioMed Central, 2022)
    Background: Goltz syndrome (GS) is a X-linked disorder defined by defects of mesodermal- and ectodermal-derived structures and caused by PORCN mutations. Features include striated skin-pigmentation, ocular and skeletal ...
  • Vogelezang, Suzanne; Vilor Tejedor, Natàlia, 1988-; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Felix, Janine Frédérique (Public Library of Science (PLoS), 2020)
    The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...
  • Herrando Grabulosa, Mireia; Mulet, Roger; Pujol, Albert; Mas, José Manuel; Navarro, Xavier; Aloy, Patrick, 1972-; Coma Camprodón, Mireia; Casas, Caty (Public Library of Science (PLoS), 2016)
    Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. One of the main difficulties in developing new ...
  • Tarbier, Marcel; Mackowiak, Sebastian D.; Frade, João; Catuara Solarz, Silvina, 1986-; Biryukova, Inna; Gelali, Eleni; Bárcena Menéndez, Diego, 1984-; Zapata Ortiz, Luis, 1985-; Ossowski, Stephan; Bienko, Magda; Gallant, Caroline J.; Friedländer, Marc R. (Nature Research, 2020)
    Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. We apply ...
  • Deniz, Özgen; Flores, Oscar; Aldea, Martí; Soler López, Montserrat; Orozco, Modesto (Nature Publishing Group, 2016)
    Nucleosomes provide additional regulatory mechanisms to transcription and DNA replication by mediating the access of proteins to DNA. During the cell cycle chromatin undergoes several conformational changes, however the ...
  • Buitrago, Diana; Codó, Laia; Illa, Ricard; Jorge, Pau de; Battistini, Federica; Flores, Oscar; Bayarri, Genis; Royo, Romina; Pino, Marc del; Heath, Simon; Hospital, Adam; Gelpí, Josep Lluís; Brun-Heath, Isabelle; Orozco, Modesto (Oxford University Press, 2019)
    We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the ...
  • Ballaré, Cecilia Julia; Castellano, Giancarlo; Gaveglia, Laura; Althammer, Sonja Daniela; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Le Dily, François; Zaurín Quer, Roser; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel (Elsevier, 2013)
    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by ...
  • Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Armaos, Alexandros, 1989-; Cirillo, Davide; Tartaglia, Gian Gaetano (Oxford University Press, 2017)
    SUMMARY: Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (> 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction, (ii) pre-compiled ...
  • Cutler, Kevin J.; Stringer, Carsen; Lo, Teresa W.; Rappez, Luca; Stroustrup, Nicholas; Peterson, S. Brook; Wiggins, Paul A.; Mougous, Joseph D. (Nature Research, 2022)
    Advances in microscopy hold great promise for allowing quantitative and precise measurement of morphological and molecular phenomena at the single-cell level in bacteria; however, the potential of this approach is ultimately ...
  • Vidal Ocabo, Enrique; Le Dily, François; Quilez Oliete, Javier; Stadhouders, Ralph; Cuartero, Yasmina; Graf, T. (Thomas); Martí Renom, Marc A.; Beato, Miguel; Filion, Guillaume (Oxford University Press, 2018)
    The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, ...

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