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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Baeza Centurión, Pablo, 1989-; Miñana Gómez, Belén; Valcárcel, J. (Juan); Lehner, Ben, 1978- (eLife, 2020)
    Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of alternatively spliced exons, consistent with the concept that altered ...
  • Bonilla-Pons, Sergi A.; Nakagawa, Shoma; Garreta Bahima, Elena; Fernández-Blanco, Álvaro; Pesaresi, Martina, 1991-; D'Antin, Justin Christopher; Sebastian-Perez, Ruben; Greco, Daniela; Domínguez-Sala, Eduardo; Gómez-Riera, Raúl; Barraquer Compte, Rafael Ignacio; Dierssen, Mara; Montserrat Pulido, Núria; Cosma, Maria Pia (Elsevier, 2022)
    Background: Visual impairments are a critical medical hurdle to be addressed in modern society. Müller glia (MG) have regenerative potential in the retina in lower vertebrates, but not in mammals. However, in mice, in vivo ...
  • Alburquerque-Bejar, Juan J.; Navajas-Chocarro, Pablo; Saigi, Maria; Ferrero-Andrés, Ana; Morillas, Juan M.; Vilarrubi, Andrea; Gómez, Antonio; Mate, José Luís; Muñoz-Mármol, Ana M.; Romero, Octavio A.; Blecua, Pedro; Davalos, Veronica; Esteller, Manel; Pros, Eva; Llabata, Paula; Torres-Diz, Manuel; Esteve-Codina, Anna; Sánchez Céspedes, Montse (Elsevier, 2023)
    Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to ...
  • Elfmann, Christoph; Zhu, Bingyao; Pedreira, Tiago; Hoßbach, Ben; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Stülke, Jörg (Frontiers, 2022)
    The human pathogen Mycoplasma pneumoniae is viable independently from host cells or organisms, despite its strongly reduced genome with only about 700 protein-coding genes. The investigation of M. pneumoniae can therefore ...
  • Piñero-Lambea, Carlos; García Ramallo, Eva; Martínez, Sira; Delgado Blanco, Javier; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Chemical Society (ACS), 2020)
    Mycoplasma species share a set of features, such as lack of a cell wall, streamlined genomes, simplified metabolism, and the use of a deviant genetic code, that make them attractive approximations of what a chassis strain ...
  • Wodke, Judith A.H.; Alibés, Andreu; Cozzuto, Luca; Hermoso Pulido, Antonio; Yus, Eva; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982-; Roma, Guglielmo (Oxford University Press, 2015)
    MyMpn (http://mympn.crg.eu) is an online resource devoted to studying the human pathogen Mycoplasma pneumoniae, a minimal bacterium causing lower respiratory tract infections. Due to its small size, its ability to grow in ...
  • Bisceglie, Lavinia; Hopp, Ann-Katrin; Gunasekera, Kapila; Wright, Roni H.G.; Le Dily, François; Vidal, Enrique; Dall'Agnese, Alessandra; Caputo, Luca; Nicoletti, Chiara; Puri, Pier Lorenzo; Beato, Miguel; Hottiger, Michael O. (Elsevier, 2021)
    While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts ...
  • Herranz-Itúrbe, Macarena; López-Luque, Judit; Gonzalez-Sanchez, Ester; Caballero-Díaz, Daniel; Crosas-Molist, Eva; Martín-Mur, Beatriz; Gut, Marta; Esteve-Codina, Anna; Jaquet, Vincent; Jiang, Joy X.; Török, Natalie J.; Fabregat, Isabel (Elsevier, 2021)
    Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass. The NADPH oxidase ...
  • Begik, Oguzhan; Diensthuber, Gregor; Liu, Huanle; Delgado-Tejedor, Anna; Kontur, Cassandra; Niazi, Adnan Muhammad; Valen, Eivind; Giraldez, Antonio J.; Beaudoin, Jean-Denis; Mattick, John S.; Novoa, Eva Maria (Nature Research, 2023)
    RNA polyadenylation plays a central role in RNA maturation, fate, and stability. In response to developmental cues, polyA tail lengths can vary, affecting the translation efficiency and stability of mRNAs. Here we develop ...
  • Ronchetti, Domenica; Favasuli, Vanessa; Monti, Paola; Cutrona, Giovanna; Fabris, Sonia; Silvestris, Ilaria; Agnelli, Luca; Colombo, Monica; Menichini, Paola; Matis, Serena; Gentile, Massimo; Nurtdinov, Ramil; Guigó Serra, Roderic; Baldini, Luca; Fronza, Gilberto; Ferrarini, Manlio; Morabito, Fortunato; Neri, Antonino; Taiana, Elisa (MDPI, 2020)
    The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in chronic lymphocytic leukemia (CLL) are still open questions. Herein, we investigated the significance of the lncRNA NEAT1 in CLL. We examined ...
  • Zapata Ortiz, Luis, 1985-; Pich, Oriol; Serrano Pubull, Luis, 1982-; Kondrashov, Fyodor A., 1979-; Ossowski, Stephan; Schaefer, Martin H. (BioMed Central, 2018)
    Background: Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic ...
  • Eibes, Susana; Gallisà-Suñé, Núria; Rosas Salvans, Miquel, 1987-; Martínez-Delgado, Paula; Vernos, Isabelle, 1959-; Roig, Joan (Elsevier, 2018)
    Centrosomes [1, 2] play a central role during spindle assembly in most animal cells [3]. In early mitosis, they organize two symmetrical microtubule arrays that upon separation define the two poles of the forming spindle. ...
  • Akerman, Ildem; Maestro, Miguel Ángel; De Franco, Elisa; Grau, Vanessa; Flanagan, Sarah; García-Hurtado, Javier; Mittler, Gerhard; Ravassard, Philippe; Piemonti, Lorenzo; Ellard, Sian; Hattersley, Andrew T.; Ferrer, Jorge (Elsevier, 2021)
    Despite the central role of chromosomal context in gene transcription, human noncoding DNA variants are generally studied outside of their genomic location. This limits our understanding of disease-causing regulatory ...
  • De Toma, Ilario; Dierssen, Mara (Nature Research, 2021)
    SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID-19 pandemic. Individuals with DS have more risk ...
  • Casas, Caty; Isús Díaz, Laura, 1989-; Herrando Grabulosa, Mireia; Mancuso, Francesco M.; Borrás, Eva; Sabidó Aguadé, Eduard, 1981-; Forés, Joaquim; Aloy, Patrick, 1972- (Nature Publishing Group, 2015)
    Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a ...
  • Klus, Petr, 1985-; Cirillo, Davide; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Nature Publishing Group, 2015)
    It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between ...
  • Cirillo, Davide; Agostini, Federico, 1985-; Klus, Petr, 1985-; Marchese, Domenica, 1986-; Rodríguez, Silvia; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. ...
  • Carriba, Paulina; Lorenzón, Nicola; Dierssen, Mara (University of Münster, 2023)
    Several advances in the field of neurodevelopmental diseases (NDDs) have been reported by 2022. Of course, NDDs comprise a diverse group of disorders, most of which with different aetiologies. However, owing to the development ...
  • Cipriani, Silvia; Phan, Vietxuan; Médard, Jean-Jacques; Horvath, Rita; Lochmüller, Hanns; Chrast, Roman; Roos, Andreas; Spendiff, Sally (MDPI, 2018)
    The neuromuscular junction (NMJ) appears to be a site of pathology in a number of peripheral nerve diseases. Charcot-Marie-Tooth (CMT) 4C is an autosomal recessive, early onset, demyelinating neuropathy. Numerous mutations ...
  • Servello, Francesco A.; Fernandes, Rute; Eder, Matthias; Harris, Nathan; Martin, Olivier M. F., 1991-; Oswal, Natasha; Lindberg, Anders; Derosiers, Nohelly; Sengupta, Piali; Stroustrup, Nicholas; Apfeld, Javier (eLife, 2022)
    Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little ...

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