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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Martínez de Lagrán Cabredo, María; Elizalde-Torrent, Aleix; Paredes, Roger; Clotet, Bonaventura; Dierssen, Mara (Wiley, 2022)
    An elevated activity of retrotransposons is increasingly recognized to be implicated in a wide range of neurodegenerative and neurodevelopmental diseases. Down syndrome (DS) is the most common genetic disorder associated ...
  • Djebali, Sarah; Merkel, Angelika; Tanzer, Andrea; Lagarde, Julien; Röder, Maik; Curado, Joao; Derrien, Thomas; Ferreira, Pedro G.; González, David; Johnson, Rory; Kingswood, Colin; Ribeca, Paolo; Sammeth, Michael; Skancke, Jorgen; Tilgner, Hagen, 1980-; Guigó Serra, Roderic; Gingeras, Thomas R. (Nature Publishing Group, 2012)
    Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic ...
  • Tukiainen, Taru; Guigó Serra, Roderic; MacArthur, Daniel G.; Genotype-Tissue Expression (GTEx) Consortium (Nature Publishing Group, 2017)
    X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to ...
  • Brown, Peter; Raote, Ishier; RELISH Consortium; Zhou, Yaoqi (Oxford University Press, 2019)
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that ...
  • Sebestyén, Endre; Singh, Babita, 1986-; Miñana Gómez, Belén; Pagès Pinós, Amadís; Mateo, Francesc; Pujana, Miguel Angel; Valcárcel, J. (Juan); Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press), 2016)
    Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in human disease, and particularly in cancer, is only starting ...
  • Pittis, Alexandros, 1982-; Gabaldón Estevan, Juan Antonio, 1973- (Nature Publishing Group, 2016)
    The origin of eukaryotes stands as a major conundrum in biology. Current evidence indicates that the last eukaryotic common ancestor already possessed many eukaryotic hallmarks, including a complex subcellular organization. ...
  • Pérez-Núñez, Iván; Rozalén, Catalina; Palomeque, José Ángel; Sangrador, Irene; Dalmau, Mariona; Comerma Blesa, Laura, 1983-; Hernández Prat, Anna, 1984-; Casadevall Aguilar, David; Menendez Romero, Silvia; Liu, Daniel Dan; Berenguer De Felipe, Jordi; Peña Arranz, Raúl, 1976-; Montañés, José Carlos; Albà Soler, Mar; Bonnin, Sarah; Ponomarenko, Julia; Servitja Tormo, Sonia; Arribas, Joaquín; Albanell Mestres, Joan; Celià-Terrassa, Toni (Nature Research, 2022)
    Ligand-dependent corepressor (LCOR) mediates normal and malignant breast stem cell differentiation. Cancer stem cells (CSCs) generate phenotypic heterogeneity and drive therapy resistance, yet their role in immunotherapy ...
  • Saunders, Gary; Beltran, Sergi; Gut, Ivo Glynne; Navarro i Cuartiellas, Arcadi, 1969-; Rambla de Argila, Jordi; Scollen, Serena (Nature Research, 2019)
    Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the ...
  • Alamancos, Gael P.; Pagès Pinós, Amadís; Trincado Alonso, Juan Luis, 1987-; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo (Cambridge University Press, 2015)
    Alternative splicing plays an essential role in many cellular processes and bears major relevance in the understanding of multiple diseases, including cancer. High-throughput RNA sequencing allows genome-wide analyses of ...
  • Rajewsky, Nicolaus; Bertero, Michela G.; Martí Renom, Marc A.; LifeTime Community (Nature Research, 2020)
    LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development ...
  • Martínez Jiménez, Francisco; Martí Renom, Marc A. (Public Library of Science (PLoS), 2015)
    Target identification is essential for drug design, drug-drug interaction prediction, dosage adjustment and side effect anticipation. Specifically, the knowledge of structural details is essential for understanding the ...
  • Abe, Jun; Ozga, Aleksandra J.; Swoger, Jim; Sharpe, James; Ripoll, Jorge; Stein, Jens V. (Elsevier, 2016)
    Reactive lymph nodes (LNs) are sites where pMHC-loaded dendritic cells (DCs) interact with rare cognate T cells, leading to their clonal expansion. While DC interactions with T cell subsets critically shape the ensuing ...
  • Cañada, Andrés; Capella Gutiérrez, Salvador Jesús, 1985-; Rabal, Obdulia; Oyarzábal, Julen; Valencia, Alfonso; Krallinger, Martin (Oxford University Press, 2017)
    A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in ...
  • de Vienne, Damien M.; Giraud, Tatiana; Gouyon, Pierre-Henri (Public Library of Science (PLoS), 2013)
  • Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina, 1991-; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Hebbara, Sarita; Khandelwal, Avinash; Khandelwal, Avinash, 1987-; Jayashreeb, Rangareddy; Hindlec, Samantha J.; Chiangd, Yin Ning; Yewe, Joanne Y.; Sweeneyc, Sean T.; Schwudke, Dominik (American Society for Cell Biology, 2017)
    Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegenerative diseases, including lysosomal storage disorders (LSD). Detailed characterization of lipid metabolic changes ...
  • Trinidad, Eva María; Vidal, Enrique; Coronado, Esther; Esteve-Codina, Anna; Castel, Victoria; Cañete, Adela; Gut, Marta; Heath, Simon; Font de Mora, Jaime (Oxford University Press, 2023)
    Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping and prognosis. However, its application is frequently hampered by the ...
  • Díaz-Rodríguez, Martín; Lithgow-Serrano, Oscar; Guadarrama-García, Francisco; Tierrafría, Víctor H.; Gama-Castro, Socorro; Solano-Lira, Hilda; Salgado, Heladia; Rinaldi, Fabio; Méndez-Cruz, Carlos-Francisco; Collado Vides, Pedro Julio (Elsevier, 2021)
    The number of published papers in biomedical research makes it rather impossible for a researcher to keep up to date. This is where manually curated databases contribute facilitating the access to knowledge. However, the ...
  • Basu, Srinjan; Blanco, Enrique; Laue, Ernest D. (Nature Research, 2023)
    To understand how the nucleosome remodeling and deacetylase (NuRD) complex regulates enhancers and enhancer-promoter interactions, we have developed an approach to segment and extract key biophysical parameters from live-cell ...
  • Mas Ponte, David; Carlevaro-Fita, Joana; Palumbo, Emilio; Hermoso Pulido, Antonio; Guigó Serra, Roderic; Johnson, Rory (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The subcellular localization of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localization of newly discovered lncRNAs involves time-consuming and costly experimental ...

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