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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • X-inactivation: quantitative predictions of protein interactions in the Xist network
    Agostini, Federico, 1985-; Cirillo, Davide; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Oxford University Press, 2013)
    The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of ...
  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
    Asano, Takaki; Gut, Marta; Casanova, Jean-Laurent (American Association for the Advancement of Science, 2021)
    Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants ...
  • XTACC3-XMAP215 association reveals an asymmetric interaction promoting microtubule elongation
    Mortuza, Gulnahar; Cavazza, Tommaso, 1985-; García Mayoral, María Flor; Hermida, Dario; Peset, Isabel; Pedrero, Juan G.; Merino, Nekane; Blanco, Francisco; Lyngsø, Jeppe; Bruix, Marta; Pedersen, Jan Skov; Vernos, Isabelle, 1959-; Montoya, Guillermo (Nature Research, 2014)
    chTOG is a conserved microtubule polymerase that catalyses the addition of tubulin dimers to promote microtubule growth. chTOG interacts with TACC3, a member of the transforming acidic coiled-coil (TACC) family. Here we ...
  • Y chromosome sequence and epigenomic reconstruction across human populations
    Esteller Cucala, Paula; Palmada Flores, Marc; Kuderna, Lukas, 1989-; Fontseré Alemany, Clàudia, 1992-; Serres Armero, Aitor, 1992-; Dabad, Marc; Torralvo, María; Faella, Armida; Ferrández Peral, Luis, 1991-; Llovera Nadal, Laia; Fornas Carreño, Oscar; Julià, Eva; Ramírez, Erika; González, Irene; Hecht, Jochen; Lizano González, Esther, 1974-; Juan, David; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2023)
    Recent advances in long-read sequencing technologies have allowed the generation and curation of more complete genome assemblies, enabling the analysis of traditionally neglected chromosomes, such as the human Y chromosome ...
  • ya||a: GPU-Powered spheroid models for mesenchyme and epithelium
    Germann, Philipp; Marin-Riera, Miquel; Sharpe, James (Elsevier, 2019)
    Simulating morphogenesis of both mesenchyme and epithelium has typically required complex and computationally expensive models. To meet this challenge, we developed ya||a-yet another parallel agent-based model. Our model ...
  • YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
    Bowness, Joseph S.; Almeida, Mafalda; Nesterova, Tatyana B.; Brockdorff, Neil (Nature Research, 2024)
    X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis to silence genes on a single X chromosome in XX female cells, thereby equalising levels of X-linked gene expression relative to XY ...
  • Zerone: a ChIP-seq discretizer for multiple replicates with built-in quality control
    Cuscó Pons, Pol, 1987-; Filion, Guillaume (Oxford University Press, 2016)
    Motivation: Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the standard method to investigate chromatin protein composition. As the number of community-available ChIP-seq profiles ...
  • Zooming in on protein-RNA interactions: a multi-level workflow to identify interaction partners
    Colantoni, Alessio; Rupert, Jakob; Vandelli, Andrea; Tartaglia, Gian Gaetano; Zacco, Elsa (Portland Press, 2020)
    Interactions between proteins and RNA are at the base of numerous cellular regulatory and functional phenomena. The investigation of the biological relevance of non-coding RNAs has led to the identification of numerous ...
  • Zrf1 is required to establish and maintain neural progenitor identity
    Aloia, Luigi; Di Stefano, Bruno, 1984-; Sessa, Alessandro; Morey, Lluis; Santanach, Alexandra; Gutierrez, Arantxa; Cozzuto, Luca; Aznar Benitah, Salvador; Graf, T. (Thomas); Broccoli, Vania; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2014)
    The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is ...
  • ZRF1: a novel epigenetic regulator of stem cell identity and cancer
    Aloia, Luigi; Demajo Meseguer, Santiago, 1985-; Di Croce, Luciano (Taylor & Francis (Routledge), 2015)
    The Zuotin-related factor 1, ZRF1, has recently been identified as an epigenetic regulator of gene transcription in stem cells and cancer. During differentiation of human teratocarcinoma cells, ZRF1 promotes transcriptional ...
  • β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
    García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)
    Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...
  • β-catenin fluctuates in mouse ESCs and is essential for Nanog-mediated/nreprogramming of somatic cells to pluripotency
    Marucci, Lucia; Pedone, Elisa, 1985-; Vicino, Umberto di; Sanuy-Escribano, Blanca; Isalan, Mark; Cosma, Maria Pia, 1970- (Elsevier, 2014)
    The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to ...
  • β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus
    Zhang, Meng; Arumugam, Karthik; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Esteban, Miguel A. (American Association for the Advancement of Science (AAAS), 2020)
    Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3) inhibitors (2i) more closely resemble the inner cell mass of preimplantation blastocysts than ...
  • ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
    Keyes, William M., 1973-; Pecoraro, Matteo, 1984-; Aranda, Victoria; Vernersson Lindahl, Emma; Li, Wangzhi; Vogel, Hannes; Guo, Xuecui; Garcia, Elvin L.; Michurina, Tatyana V.; Enikolopov, Grigori; Muthuswamy, Senthil K.; Mills, Alea A. (Elsevier, 2011)
    The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism of cellular senescence, causing a striking absence of stratified ...
  • ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
    Di Giacomo, Valeria, 1983-; Tian, Tian V.; Mas Malavila, Alba; Pecoraro, Matteo, 1984-; Batlle Morera, Laura; Noya Ferreiro, Lourdes; Martín Caballero, Juan; Ruberte, Jesús; Keyes, William M., 1973- (Springer, 2017)
    ΔNp63α is a critical mediator of epithelial development and stem cell function in a variety of tissues including the skin and breast, while overexpression of ΔNp63α acts as an oncogene to drive tumor formation and cancer ...

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