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Browsing Articles (Center for Genomic Regulation (CRG)) by Title

Browsing Articles (Center for Genomic Regulation (CRG)) by Title

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  • Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Gražulevičienė, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Armaos, Alexandros, 1989-; Cirillo, Davide; Tartaglia, Gian Gaetano (Oxford University Press, 2017)
    SUMMARY: Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (> 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction, (ii) pre-compiled ...
  • Cutler, Kevin J.; Stringer, Carsen; Lo, Teresa W.; Rappez, Luca; Stroustrup, Nicholas; Peterson, S. Brook; Wiggins, Paul A.; Mougous, Joseph D. (Nature Research, 2022)
    Advances in microscopy hold great promise for allowing quantitative and precise measurement of morphological and molecular phenomena at the single-cell level in bacteria; however, the potential of this approach is ultimately ...
  • Vidal Ocabo, Enrique; Le Dily, François; Quilez Oliete, Javier; Stadhouders, Ralph; Cuartero, Yasmina; Graf, T. (Thomas); Martí Renom, Marc A.; Beato, Miguel; Filion, Guillaume (Oxford University Press, 2018)
    The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, ...
  • Rodríguez-Nuevo, Aida; Torres-Sanchez, Ariadna; Duran, Juan M.; De Guirior, Cristian; Martínez-Zamora, Maria Angeles; Böke, Elvan (Nature Research, 2022)
    Oocytes form before birth and remain viable for several decades before fertilization1. Although poor oocyte quality accounts for most female fertility problems, little is known about how oocytes maintain cellular fitness, ...
  • Brault, Véronique; Duchon, Arnaud; Romestaing, Caroline; Sahún, Ignasi; Pothion, Stéphanie; Karout, Mona; Borel, Christelle; Dembele, Doulaye; Bizot, Jean-Charles; Messaddeq, Nadia; Sharp, Andrew J.; Roussel, Damien; Antonarakis, Stylianos E.; Dierssen, Mara; Hérault, Yann (Public Library of Science (PLoS), 2015)
    The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or ...
  • Keeble-Gagnère, Gabriel; Câmara Ferreira, Francisco; Appels, Rudi (BioMed Central, 2018)
    Background: Numerous scaffold-level sequences for wheat are now being released and, in this context, we report on a strategy for improving the overall assembly to a level comparable to that of the human genome. Results: ...
  • Willis, Jesse R.; Iraola Guzmán, Susana; Saus Martínez, Ester; Ksiezopolska, Ewa; Cozzuto, Luca; Bejarano, Luis A.; Andreu Somavilla, Núria; Alloza-Trabado, Miriam; Puig, Anna; Blanco, Andrea; Broglio, Elisabetta; Carolis, Carlo; Hecht, Jochen; Ponomarenko, Julia; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis Open Access, 2020)
    Introduction: The oral cavity harbors an abundant and diverse microbial community (i.e. the microbiome), whose composition and roles in health and disease have been the focus of intense research. Down syndrome (DS) is ...
  • Mas, Aina Maria; Goñi, Enrique; Ruiz de Los Mozos, Igor; Arcas Mantas, Aida; Statello, Luisa; González, Jovanna; Blázquez, Lorea; Lee, Wei Ting Chelsea; Gupta, Dipika; Sejas, Álvaro; Hoshina, Shoko; Armaos, Alexandros, 1989-; Tartaglia, Gian Gaetano; Waga, Shou; Ule, Jernej; Rothenberg, Eli; Gómez, María; Huarte, Maite (Nature Research, 2023)
    Cells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in ...
  • de Mendoza, Alex; Sebé-Pedrós, Arnau (Elsevier, 2019)
    Transcription factors (TFs) have a central role in genome regulation directing gene transcription through binding specific DNA sequences. Eukaryotic genomes encode a large diversity of TF classes, each defined by unique ...
  • Gabaldón Estevan, Juan Antonio, 1973-; Pittis, Alexandros, 1982- (Elsevier, 2016)
    A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the ...
  • Grau Bové, Xavier; Ruiz Trillo, Iñaki; Irimia Martínez, Manuel (BioMed Central, 2018)
    Background: Alternative splicing, particularly through intron retention and exon skipping, is a major layer of pre-translational regulation in eukaryotes. While intron retention is believed to be the most prevalent mode ...
  • Ruiz Orera, Jorge, 1988-; Hernández Rodríguez, Jéssica, 1983-; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Kondova, Ivanela; Bontrop, Ronald E.; Marquès i Bonet, Tomàs, 1975-; Albà Soler, Mar (Public Library of Science, 2015)
    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these ...
  • Grau Bové, Xavier; Sebé-Pedrós, Arnau (Oxford University Press, 2021)
    Possvm (Phylogenetic Ortholog Sorting with Species oVerlap and MCL [Markov clustering algorithm]) is a tool that automates the process of identifying clusters of orthologous genes from precomputed phylogenetic trees and ...
  • Cabrera Pérez, Raquel; Monguió Tortajada, Marta; Gámez Valero, Ana; Rojas Márquez, Raquel; Borràs, Francesc Enric; Roura, Santiago; Vives, Joaquim (BioMed Central, 2019)
    Background: Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton’s jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolation ...
  • Sali, Andrej; Martí Renom, Marc A.; Westbrook, John D. (Elsevier, 2015)
    Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical information. We describe here the proceedings and conclusions from the ...
  • Ruiz Mejias, Marcel; Martínez de Lagrán Cabredo, María; Mattia, Maurizio; Castaño Prat, Patricia; Pérez Mendez, Lorena; Ciria Suarez, Laura; Gener, Thomas; Sancristóbal, Belen; García Ojalvo, Jordi; Gruart, Agnès; Delgado García, José María; Sanchez-Vives, Maria V.; Dierssen, Mara (Society for Neuroscience, 2016)
    The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a major candidate of Down syndrome brain alterations and ...
  • Teixeira, Cátia M.; Martín, Eduardo D.; Sahún, Ignasi; Masachs, Nuria; Pujadas, Lluís; Corvelo, André; Bosch, Carles; Rossi, Daniela; Martínez, Albert; Maldonado, Rafael, 1961-; Dierssen, Mara; Soriano, Eduardo (Nature Publishing Group, 2011)
    Despite the impact of schizophrenia and mood disorders, which in extreme cases can lead to death, recent decades have brought little progress in the development of new treatments. Recent studies have shown that Reelin, an ...
  • Viñals Álvarez, Xavier, 1985-; Molas Casacuberta, Susanna, 1985-; Gallego, Xavier; Fernández Montes, Rubén D.; Robledo, Patricia, 1958-; Dierssen, Mara; Maldonado, Rafael, 1961- (Elsevier, 2012)
    Recent studies have revealed that sequence variants in genes encoding the α3/α5/β4 nicotinic acetylcholine receptor subunits are associated with nicotine dependence. In this study, we evaluated two specific aspects of ...
  • Laezza, Chiara; D'Alessandro, Alba; Di Croce, Luciano; Picardi, Paola; Ciaglia, Elena; Pisanti, Simona; Malfitano, Anna Maria; Comegna, Marika; Faraonio, Raffaella; Gazzerro, Patrizia; Bifulco, Maurizio (Nature Publishing Group, 2015)
    The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway ...

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