Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Gebauer, Fátima; Schwarzl, Thomas; Valcárcel, J. (Juan); Hentze, Matthias W. (Nature Research, 2020)
    RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks ...
  • Benisty, Hannah, 1986-; Weber, Marc; Hernandez-Alias, Xavier; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2020)
    It is well known that in cancer gene families some members are more frequently mutated in tumor samples than their family counterparts. A paradigmatic case of this phenomenon is KRAS from the RAS family. Different explanations ...
  • Espejo, Isabel; Di Croce, Luciano; Aranda Aragón, Sergio (Wiley-VCH Verlag, 2020)
    Chromatin-bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the ...
  • Llambrich, Sergi; Wouters, Jens; Himmelreich, Uwe; Dierssen, Mara; Sharpe, James; Gsell, Willy; Martínez Abadías, Neus; Velde, Greetje Vande (Nature Research, 2020)
    Up to 40% of congenital diseases present disturbances of brain and craniofacial development resulting in simultaneous alterations of both systems. Currently, the best available method to preclinically visualize the brain ...
  • Irimia, Manuel; Vellutini, Bruno C.; Marlétaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau Bové, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gómez Skarmeta, José Luis; Irimia, Manuel; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas (Nature Research, 2020)
    The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ...
  • Zoonomia Consortium; Serres Armero, Aitor, 1992-; Juan, David; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2020)
    The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe ...
  • Gerdol, Marco; Cruz, Fernando; Gómez-Garrido, Jèssica; Vlasova, Anna; Naranjo Ortiz, Miguel Ángel, 1989-; Corvelo, André; Frias, Leonor; Gut, Marta; Gabaldón Estevan, Juan Antonio, 1973-; Alioto, Tyler; Figueras, Antonio (BioMed Central, 2020)
    Background: The Mediterranean mussel Mytilus galloprovincialis is an ecologically and economically relevant edible marine bivalve, highly invasive and resilient to biotic and abiotic stressors causing recurrent massive ...
  • Ruiz de Porras, Vicenç; Indacochea Cusirramos, Alberto; Aytes, Alvaro (Elsevier, 2020)
    Background: Taxanes are the most active chemotherapy agents in metastatic castration-resistant prostate cancer (mCRPC) patients; yet, resistance occurs almost invariably, representing an important clinical challenge. ...
  • Raote, Ishier; Chabanon, Morgan; Walani, Nikhil; Arroyo, Marino; Garcia-Parajo, Maria F.; Malhotra, Vivek; Campelo, Felix (eLife, 2020)
    The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) ...
  • Marti-Renom, Marc A.; Paulsen, Jonas; Jost, Daniel; Marti-Renom, Marc A. (Elsevier, 2020)
    The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in regulating DNA transcription, replication, and damage-repair among other nuclear functions. With this increased awareness, reinforced ...
  • Binenbaum, Ilona; Atamni, Hanifa Abu-Toamih; Fotakis, Georgios; Kontogianni, Georgia; Koutsandreas, Theodoros; Pilalis, Eleftherios; Mott, Richard; Himmelbauer, Heinz; Iraqi, Fuad A.; Chatziioannou, Aristotelis A. (BioMed Central, 2020)
    Background: The Collaborative Cross (CC) mouse population is a valuable resource to study the genetic basis of complex traits, such as obesity. Although the development of obesity is influenced by environmental factors, ...
  • Telford, Marco, 1984-; Hughes, David; Juan, David; Stoneking, Mark; Navarro i Cuartiellas, Arcadi, 1969-; Santpere Baró, Gabriel, 1981- (MDPI, 2020)
    The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation ...
  • Santpere Baró, Gabriel, 1981-; Telford, Marco, 1984-; Andrés Benito, Pol; Navarro i Cuartiellas, Arcadi, 1969-; Ferrer, Isidre (MDPI, 2020)
    The human herpesvirus 6 (HHV-6) -A and -B are two dsDNA beta-herpesviruses infectingalmost the entire worldwide population. These viruses have been implicated in multipleneurological conditions in individuals of various ...
  • Pohl, Andy, 1979-; Beato, Miguel (Oxford University Press, 2014)
    BigWig files are a compressed, indexed, binary format for genome-wide signal data for calculations (e.g. GC percent) or experiments (e.g. ChIP-seq/RNA-seq read depth). bwtool is a tool designed to read bigWig files rapidly ...
  • Keyes, William M., 1973-; Pecoraro, Matteo, 1984-; Aranda, Victoria; Vernersson Lindahl, Emma; Li, Wangzhi; Vogel, Hannes; Guo, Xuecui; Garcia, Elvin L.; Michurina, Tatyana V.; Enikolopov, Grigori; Muthuswamy, Senthil K.; Mills, Alea A. (Elsevier, 2011)
    The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism of cellular senescence, causing a striking absence of stratified ...
  • Mortuza, Gulnahar; Cavazza, Tommaso, 1985-; García Mayoral, María Flor; Hermida, Dario; Peset, Isabel; Pedrero, Juan G.; Merino, Nekane; Blanco, Francisco; Lyngsø, Jeppe; Bruix, Marta; Pedersen, Jan Skov; Vernos, Isabelle, 1959-; Montoya, Guillermo (Nature Research, 2014)
    chTOG is a conserved microtubule polymerase that catalyses the addition of tubulin dimers to promote microtubule growth. chTOG interacts with TACC3, a member of the transforming acidic coiled-coil (TACC) family. Here we ...
  • Tejedor Vaquero, Juan Ramón, 1984-; Papasaikas, Panagiotis; Valcárcel, J. (Juan) (Elsevier, 2015)
    Alternative splicing of Fas/CD95 exon 6 generates either a membrane-bound receptor that promotes, or a soluble isoform that inhibits, apoptosis. Using an automatized genome-wide siRNA screening for alternative splicing ...
  • Papasaikas, Panagiotis; Tejedor Vaquero, Juan Ramón, 1984-; Vigevani, Luisa, 1985-; Valcárcel, J. (Juan) (Elsevier, 2015)
    Pre-mRNA splicing relies on the poorly understood dynamic interplay between >150 protein components of the spliceosome. The steps at which splicing can be regulated remain largely unknown. We systematically analyzed the ...
  • Cieslak, Agata; Gut, Marta; Gut, Ivo Glynne; Asnafi, Vahid (Rockefeller University Press, 2020)
    Cell differentiation is accompanied by epigenetic changes leading to precise lineage definition and cell identity. Here we present a comprehensive resource of epigenomic data of human T cell precursors along with an ...
  • Esteban, Laura Avino; Lonishin, Lyubov R.; Bobrovskiy, Daniil; Leleytner, Gregory; Bogatyreva, Natalya S.; Kondrashov, Fyodor A., 1979-; Ivankov, Dmitry N. (Oxford University Press, 2020)
    Motivation: Epistasis, the context-dependence of the contribution of an amino acid substitution to fitness, is common in evolution. To detect epistasis, fitness must be measured for at least four genotypes: the reference ...

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