Articles (Center for Genomic Regulation (CRG))

 

Enviaments recents

  • Guigó Serra, Roderic; Valcárcel, J. (Juan) (American Association for the Advancement of Science (AAAS), 2015)
    Prescribing splicing
  • Kuhlwilm, Martin; Prado Martínez, Javier, 1987-; Lalueza Fox, Carles, 1965-; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi (Nature Research, 2016)
    It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together ...
  • Rubio Martínez, Mercedes, 1980-; Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Fernández-Orth, Dietmar; Pantano Rubiño, Lorena, 1982-; Sarria-Trujillo, Yaris; Piqué-Borras, Maria; Vellve del Amo, Kilian; Agramunt, Silvia; Carreras Collado, Ramón; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Mayor, Alfredo (Public Library of Science (PLoS), 2018)
    Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize and ...
  • Espinar, Lorena; Schikora Tamarit, Miquel Àngel; Domingo, Júlia; Carey, Lucas, 1980- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Information that regulates gene expression is encoded throughout each gene but if different regulatory regions can be understood in isolation, or if they interact, is unknown. Here we measure mRNA levels for 10,000 open ...
  • de Manuel, Marc; Shiina, Takashi; Suzuki, Shingo; Dereuddre-Bosquet, Nathalie; Garchon, Henri-Jean; Tanaka, Masayuki; Congy-Jolivet, Nicolas; Aarnink, Alice; Le Grand, Roger; Marquès i Bonet, Tomàs, 1975-; Blancher, Antoine (Nature Publishing Group, 2018)
    In the Mauritian macaque experimentally inoculated with SIV, gene polymorphisms potentially associated with the plasma virus load at a set point, approximately 100 days post inoculation, were investigated. Among the 42 ...
  • Borràs, Eva; Sabido Aguade, Eduard (American Chemical Society (ACS), 2018)
    Data-independent acquisition methods that acquire fragment ions from virtually any peptide in a sample have expanded the benefits of low-throughput targeted proteomics to proteome-wide analyses. While these methods have ...
  • Makowski, Kamil; Vigevani, Luisa, 1985-; Albericio, Fernando; Valcárcel, J. (Juan); Álvarez, Mercedes (American Chemical Society (ACS), 2017)
    Important links exist between the process of pre-mRNA splicing and cancer, as illustrated by the frequent mutation of splicing factors in tumors and the emergence of various families of antitumor drugs that target components ...
  • Barbeira, Alvaro N.; Dickinson, Scott P.; Bonazzola, Rodrigo; Zheng, Jiamao; Wheeler, Heather E.; Torres, Jason M.; Torstenson, Eric S.; Shah Kaanan P.; Garcia, Tzintzuni; Edwards, Todd L.; Stahl, Eli A.; Huckins, Laura M.; GTEx Consortium; Nicolae, Dan L.; Cox, Nancy J.; Im, Hae Kyung (Nature Publishing Group, 2018)
    Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary ...
  • Faure, Andre J.; Schmiedel, Jörn M.; Lehner, Ben, 1978- (Elsevier, 2017)
    Isogenic cells in a common environment show substantial cell-to-cell variation in gene expression, often referred to as "expression noise." Here, we use multiple single-cell RNA-sequencing datasets to identify features ...
  • Ma, Siming; Avanesov, Andrei S.; Porter, Emily; Lee, Byung Cheon; Mariotti, Marco, 1984-; Zemskaya, Nadezhda; Guigó Serra, Roderic; Moskalev, Alexey A.; Gladyshev, Vadim N. (Wiley, 2018)
    Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling ...
  • Pascual-Reguant, Laura; Blanco, Enrique; Galan, Silvia; Le Dily, François; Cuartero, Yasmina; Serra-Bardenys, Gemma; Di Carlio, Valerio; Iturbide Martínez de Albéniz, Ane, 1989-; Cebrià i Costa, Joan Pau, 1989-; Nonell Mazelón, Lara; García de Herreros, Antonio; Di Croce, Luciano; Marti-Renom, Marc A.; Peiró Sales, Sandra (Nature Publishing Group, 2018)
    Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, ...
  • Carreté Muñoz, Laia, 1990-; Ksiezopolska, Ewa; Pegueroles Queralt, Maria Cinta; Gómez-Molero, Emilia; Saus Martínez, Ester; Iraola Guzman, Susana; Loska, Damian; Bader, Olivier; Fairhead, Cécile; Gabaldón Estevan, Juan Antonio, 1973- (Elsevier, 2018)
    Candida glabrata is an opportunistic fungal pathogen that ranks as the second most common cause of systemic candidiasis. Despite its genus name, this yeast is more closely related to the model yeast Saccharomyces cerevisiae ...
  • Rozen, Esteban J.; Roewenstrunk, Julia Maria, 1981-; Barallobre, María José; Di Vona, Chiara, 1981-; Jung, Carole; Figueiredo, Ana F.; Luna, Jeroni; Fillat i Fonts, Cristina; Arbonés de Rafael, Maria Lourdes, 1959-; Graupera, Mariona; Valverde, M. A. (Miguel Ángel), 1963-; Luna Gargantilla, Susana de la (Elsevier, 2018)
    Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells ...
  • Muntané, Gerard; Farré, Xavier; Rodríguez Pérez, Juan Antonio, 1985-; Pegueroles Queralt, Maria Cinta; Hughes, David; Magalhães, João Pedro de; Gabaldón Estevan, Juan Antonio, 1973-; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2018)
    Aging is a complex process affecting different species and individuals in different ways. Comparing genetic variation across species with their aging phenotypes will help understanding the molecular basis of aging and ...
  • Barriga de Vicente, Francisco Martín, 1983-; Montagni, Elisa, 1984-; Mana, Miyeko; Méndez Lago, María; Hernando-Momblona, Xavier; Sevillano, Marta; Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Buczacki, Simon J.A.; Gut, Marta; Heyn, Holger; Winton, Douglas J.; Yilmaz, Omer H.; Attolini, Camille Stephan-Otto; Gut, Ivo Glynne; Batlle Gómez, Eduard (Elsevier, 2017)
    Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features ...
  • Supek, Fran; Lehner, Ben, 1978- (Elsevier, 2017)
    Many processes can cause the same nucleotide change in a genome, making the identification of the mechanisms causing mutations a difficult challenge. Here, we show that clustered mutations provide a more precise fingerprint ...
  • Armaos, Alexandros; Cirillo, Davide; Tartaglia, Gian Gaetano (Oxford University Press, 2017)
    SUMMARY: Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (> 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction, (ii) pre-compiled ...
  • Ombrello, Michael J.; Arthur, Victoria L.; Remmers, Elaine F.; Hinks, Anne; Tachmazidou, Ioanna; Grom, Alexei A.; Foell, Dirk; Martini, Alberto; Gattorno, Marco; Özen, Seza; Prahalad, Sampath; Zeft, Andrew S.; Bohnsack, John F.; Ilowite, Norman T.; Mellins, Elizabeth D.; Russo, Ricardo; Len, Claudio; Hilario, Maria Odete E.; Oliveira, Sheila; Yeung, Rae S.M.; Rosenberg, Alan M.; Wedderburn, Lucy R.; Anton, Jordi; Haas, Johannes-Peter; Rosen-Wolff, Angela; Minden, Kirsten; Tenbrock, Klaus; Demirkaya, Erkan; Cobb, Joanna; Baskin, Elizabeth; Signa, Sara; Shuldiner, Emily; Duerr, Richard H.; Achkar, Jean-Paul; Kamboh, M. Ilyas; Kaufman, Kenneth M.; Kottyan, Leah C.; Pinto, Dalila; Scherer, Stephen W.; Docampo, Elisa; Estivill, Xavier, 1955-; Gül, Ahmet; Langefeld, Carl D.; Thompson, Susan; Zeggini, Eleftheria; Kastner, Daniel L.; Woo, Patricia; Thomson, Wendy (BMJ Publishing Group, 2017)
    OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions unified by the presence of chronic childhood arthritis without an identifiable cause. Systemic JIA (sJIA) is a rare form of JIA ...
  • Martinez-Marti, Alex; Felip, Enriqueta; Matito, Judit; Mereu, Elisabetta; Navarro, A.; Cedrés, S.; Pardo, N.; Martines de Castro, Ana; Remon, Jordi; Miquel, J.M.; Guillaumet-Adkins, Amy; Nadal, E.; Rodríguez Esteban, Gustavo; Arqués, O.; Fasani, R.; Nuciforo, Paolo G.; Heyn, Holger; Villanueva, A.; Palmer, Héctor G.; Vivancos Prellezo, Ana (Oxford University Press, 2017)
    BACKGROUND: Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the last line of targeted treatment of metastatic non-small-cell lung cancer (NSCLC) EGFR-mutant ...
  • Dewitte, Antoine; Lepreux, Sébastien; Villeneuve, Julien; Rigothier, Claire; Combe, Christian; Ouattara, Alexandre; Ripoche, Jean (Springer, 2017)
    Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum ...

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