Articles (Center for Genomic Regulation (CRG))

 

Recent Submissions

  • Rispe, Claude; Fernández, Rosa; Gabaldón Estevan, Juan Antonio, 1973-; Guigó Serra, Roderic; Ripoll Cladellas, Aida; Tagu, Denis (BioMed Central, 2020)
    Background: Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied ...
  • Khan, Naazneen; de Manuel, Marc; Peyregne, Stephane; Do, Raymond; Prufer, Kay; Marquès i Bonet, Tomàs, 1975-; Varki, Nissi; Gagneux, Pascal; Varki, Ajit (Oxford University Press, 2020)
    Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" ...
  • Muyas Remolar, Francesc, 1992-; Zapata Ortiz, Luis, 1985-; Guigó Serra, Roderic; Ossowski, Stephan (BioMed Central, 2020)
    Background: Mosaic mutations acquired during early embryogenesis can lead to severe early-onset genetic disorders and cancer predisposition, but are often undetectable in blood samples. The rate and mutational spectrum of ...
  • Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973- (Nature Research, 2019)
    Gene clusters comprise genomically co-localized and potentially co-regulated genes that tend to be conserved across species. In eukaryotes, multiple examples of metabolic gene clusters are known, particularly among fungi ...
  • de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Gilbert, M Thomas (National Academy of Sciences, 2020)
    Lions are one of the world's most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old ...
  • Brasó-Vives, Marina, 1990-; Povolotskaya, Inna, 1986-; Hartasánchez Frenk, Diego Andrés, 1982-; Farré, Xavier; Fernández Callejo, Marcos; Raveendran, Muthuswamy; Harris, R. Alan; Rosene, Douglas L.; Lorente Galdós, Maria Belén; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Rogers, Jeffrey; Juan Sopeña, David Alejandro, 1975- (Public Library of Science (PLoS), 2020)
    The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources ...
  • Heredia Genestar, José María, 1985-; Marquès i Bonet, Tomàs, 1975-; Juan Sopeña, David Alejandro, 1975-; Navarro i Cuartiellas, Arcadi, 1969- (Nature Research, 2020)
    Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines ...
  • Ivanova, Tsvetomira Georgieva, 1978-; Maier, Michael, 1983-; Missarova, Alsu, 1990-; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas, 1980-; Mendoza, Manuel (Mendoza Palomares) (Nature Research, 2020)
    To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that ...
  • Escaramís, Geòrgia; Docampo, Elisa; Rabionet, Raquel (Oxford University Press, 2015)
    In the past decade, the view on genomic structural variation (SV) has been changed completely. SVs, previously considered rare events, are now recognized as the largest source of interindividual genetic variation affecting ...
  • Mereu, Elisabetta; Lafzi, Atefeh; Moutinho, Catia; Gut, Marta; Gut, Ivo Glynne; Heyn, Holger (Nature Research, 2020)
    Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being used to compile ...
  • Ritschka, Birgit,1985-; Knauer-Meyer, Tania; Sampaio Gonçalves, Daniel; Mas, Alba; Plassat, Jean-Luc; Durik, Matej; Jacobs, Hugues; Pedone, Elisa, 1985-; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that ...
  • Costa Borges, Nuno; Spath, Katharina; Miguel Escalada, Irene; Mestres, Enric; Balmaseda, Rosa; Serafín, Anna; Garcia Jiménez, Maria; Vanrell, Ivette; González, Jesús; Rink, Klaus; Wells, Dagan; Calderón, Gloria (eLife, 2020)
    The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2020)
    The question of how phenotypic and genomic complexity are inter-related and how they are shaped through evolution is a central question in biology that historically has been approached from the perspective of animals and ...
  • Pegueroles Queralt, Maria Cinta; Mixão, Verónica; Carreté Muñoz, Laia, 1990-; Molina, Manuel; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)
    SUMMARY: An increasing number of phased (i.e. with resolved haplotypes) reference genomes are available. However, the most genetic variant calling tools do not explicitly account for haplotype structure. Here, we present ...
  • Cruz Garcia, David; Brouwers, Nathalie; Malhotra, Vivek; Curwin, Amy (Rockefeller University Press, 2020)
    Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other ...
  • Alonso Alonso, Ruth; Mondéjar, Rufino; Martínez, Nerea; García Diaz, Nuria; Pérez, Cristina; Merino, David; Rodríguez, Marta; Esteve-Codina, Anna; Fusté, Berta; Gut, Marta; Burrows, Francis; Scholz, Catherine; Vaqué, José Pedro; Gualberto, Antonio; Piris, Miguel A. (Nature Research, 2020)
    Patients diagnosed with T-cell leukemias and T-cell lymphomas (TCLs) still have a poor prognosis and an inadequate response to current therapies, highlighting the need for targeted treatments. We have analyzed the potential ...
  • Blanco Picazo, Pedro; Fernández Orth, Dietmar; Brown Jaque, Maryury; Miró, Elisenda; Espinal, Paula; Rodríguez Rubio, Lorena; Muniesa, Maite; Navarro, Ferran (Nature Research, 2020)
    Bacteriophages are abundant in human biomes and therefore in human clinical samples. Although this is usually not considered, they might interfere with the recovery of bacterial pathogens at two levels: 1) by propagating ...
  • Chorostecki, Uciel; Molina, Manuel; Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)
    Inferring homology relationships across genes in different species is a central task in comparative genomics. Therefore, a large number of resources and methods have been developed over the years. Some public databases ...
  • Soler-Vila, Paula; Cuscó Pons, Pol, 1987-; Farabella, Irene; Di Stefano, Marco; Martí Renom, Marc A. (Oxford University Press, 2020)
    The rapid development of Chromosome Conformation Capture (3C-based techniques), as well as imaging together with bioinformatics analyses, has been fundamental for unveiling that chromosomes are organized into the so-called ...
  • Vives, Joaquim; Batlle Morera, Laura (BioMed Central, 2020)
    The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the fields of developmental and stem cell biology. We are currently establishing the foundations for translational applications ...

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