Articles (Center for Genomic Regulation (CRG))

 

Enviaments recents

  • Llop, Sabrina; Sunyer Deu, Jordi; Bustamante Pineda, Mariona; Broberg, Karin (Elsevier, 2017)
    Background: Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute ...
  • Meyer, Kyle A.; Marquès i Bonet, Tomàs, 1975-; Sestan, Nenad (Oxford University Press, 2017)
    Previous studies have found that genes which are differentially expressed within the developing human brain disproportionately neighbor conserved noncoding sequences (CNSs) that have an elevated substitution rate in humans ...
  • Spataro, Nino, 1984-; Rodríguez, Juan Antonio; Navarro i Cuartiellas, Arcadi, 1969-; Bosch Fusté, Elena (Oxford University Press, 2017)
    Do genes presenting variation that has been linked to human disease have different biological properties than genes that have never been related to disease? What is the relationship between disease and fitness? Are the ...
  • Martinez-Hernandez, Francisco; Fornas Carreño, Oscar; Lluesma Gomez, Monica; Bolduc, Benjamin; de la Cruz Peña, Maria Jose; Martínez Martínez, Joaquín; Anton, Josefa; Gasol, Josep M.; Rosselli, Riccardo; Rodriguez-Valera, Francisco; Sullivan, Matthew; Acinas, Silvia G.; Martinez Garcia, Manuel (Nature Publishing Group, 2017)
    Microbes drive ecosystems under constraints imposed by viruses. However, a lack of virus genome information hinders our ability to answer fundamental, biological questions concerning microbial communities. Here we apply ...
  • Santesmasses, Didac; Mariotti, Marco, 1984-; Guigó Serra, Roderic (Public Library of Science (PLoS), 2017)
    Selenocysteine (Sec) is known as the 21st amino acid, a cysteine analogue with selenium replacing sulphur. Sec is inserted co-translationally in a small fraction of proteins called selenoproteins. In selenoprotein genes, ...
  • Marchese, Domenica, 1986-; Livi, Carmen Maria; Tartaglia, Gian Gaetano (Humana Press (Springer Imprint), 2016)
    Protein–RNA interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of genes to host defense against pathogens. In this chapter we present ...
  • Iglesias-Platas, Isabel; Martin-Trujillo, Alex; Cirillo, Davide; Court, Franck; Guillaumet-Adkins, Amy; Camprubí, Cristina; Bourc'his, Deborah; Hata, Kenichiro; Feil, Robert; Tartaglia, Gian Gaetano; Arnaud, Philippe; Monk, David (Public Library of Science (PLoS), 2012)
    Genomic imprinting is a complex epigenetic mechanism of transcriptional control that utilizes DNA methylation and histone modifications to bring about parent-of-origin specific monoallelic expression in mammals. Genes ...
  • Koblik, Evgeny A.; Red'kin, Yaroslav A.; Meer, Margarita V., 1986-; Derelle, Romain; Golenkina, Sofia A.; Kondrashov, Fyodor A., 1979-; Arkhipov, Vladimir Y. (Public Library of Science (PLoS), 2011)
    Recent discovery of the Large-billed Reed Warbler (Acrocephalus orinus) in museums and in the wild significantly expanded our knowledge of its morphological traits and genetic variability, and revealed new data on geographical ...
  • Sebé-Pedrós, Arnau; Peña Paz, Marcia I.; Capella Gutiérrez, Salvador Jesús, 1985-; Antó Subirats, Meritxell; Gabaldón Estevan, Juan Antonio, 1973-; Ruiz-Trillo, Iñaki; Sabido Aguade, Eduard (Elsevier, 2016)
    Cell-specific regulation of protein levels and activity is essential for the distribution of functions among multiple cell types in animals. The finding that many genes involved in these regulatory processes have a premetazoan ...
  • Vidulin, Vedrana; Šmuc, Tomislav; Supek, Fran (Oxford University Press, 2016)
    MOTIVATION: The number of sequenced genomes rises steadily but we still lack the knowledge about the biological roles of many genes. Automated function prediction (AFP) is thus a necessity. We hypothesized that AFP approaches ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...
  • Ecker, Simone; Merkel, Angelika; BLUEPRINT Consortium; Paul, Dirk S. (BioMed Central, 2017)
    Background: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results: We apply a novel ...
  • Rendón-Anaya, Martha; Montero-Vargas, Josaphat M.; Saburido-Álvarez, Soledad; Vlasova, Anna; Capella Gutiérrez, Salvador Jesús, 1985-; Ordaz-Ortiz, José Juan; Aguilar, O.Mario; Vianello-Brondani, Rosana P.; Santalla, Marta; Delaye, Luis; Gabaldón Estevan, Juan Antonio, 1973-; Gepts, Paul; Winkler, Robert; Guigó Serra, Roderic; Delgado-Salinas, Alfonso; Herrera-Estrella, Alfredo (BioMed Central, 2017)
    Background: Modern civilization depends on only a few plant species for its nourishment. These crops were derived via several thousands of years of human selection that transformed wild ancestors into high-yielding ...
  • Malagarriga, Daniel; Villa, Alessandro E. P.; García Ojalvo, Jordi; Pons, Antonio J. (American Institute of Physics (AIP), 2017)
    Synchronization within the dynamical nodes of a complex network is usually considered homogeneous through all the nodes. Here we show, in contrast, that subsets of interacting oscillators may synchronize in different ways ...
  • Payer, Bernhard, 1975- (Elsevier, 2016)
    With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised ...
  • Hartasánchez Frenk, Diego Andrés, 1982-; Brasó-Vives, Marina; Fuentes-Díaz, Juanma; Vallés-Codina, Oriol; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2016)
    SUMMARY: SeDuS is the first flexible and user-friendly forward-in-time simulator of patterns of molecular evolution within segmental duplications undergoing interlocus gene conversion and crossover. SeDuS introduces known ...
  • Le Dily, François; Serra, François; Marti-Renom, Marc A. (Wiley, 2017)
    The genome is organized in a hierarchical fashion within the nucleus in interphase. This nonrandom folding of the chromatin fiber is thought to play important roles in the processing of the genetic information. Therefore, ...
  • Altimiras, Francisco; Uszczynska-Ratajczak, Barbara; Cámara, Francisco; Vlasova, Anna; Palumbo, Emilio; Newhouse, Stephen; Deacon, Robert M. J.; Farias, Leandro A. E.; Hurley, Michael J.; Loyola, David E.; Vásquez, Rodrigo A.; Dobson, Richard; Guigó Serra, Roderic; Cogram, Patricia (Frontiers, 2017)
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah; Uschner, Friedemann; Delgado, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, Edda; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Gaidt, Moritz M.; Ebert, Thomas S.; Chauhan, Dhruv; Schmidt, Tobias; Schmid-Burgk, Jonathan L.; Rapino, Francesca, 1982-; Robertson, Avril A. B.; Cooper, Matthew A.; Graf, T. (Thomas); Hornung, Veit (Elsevier, 2016)
    Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome ...

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