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dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Ryder, Oliver A.
dc.contributor.author Eichler, Evan E.
dc.date.accessioned 2013-04-22T09:57:22Z
dc.date.available 2013-04-22T09:57:22Z
dc.date.issued 2009
dc.identifier.citation Marques-Bonet T, Ryder OA, Eichler EE. Sequencing primate genomes: what have we learned? Annu Rev Genomics Hum Genet. 2009; 10: 355-86. DOI: 10.1146/annurev.genom.9.081307.164420
dc.identifier.issn 1527-8204
dc.identifier.uri http://hdl.handle.net/10230/20563
dc.description.abstract We summarize the progress in whole-genome sequencing and analyses of primate genomes. These emerging genome datasets have broadened our understanding of primate genome evolution revealing unexpected and complex patterns of evolutionary change. This includes the characterization of genome structural variation, episodic changes in the repeat landscape, differences in gene expression, new models regarding speciation, and the ephemeral nature of the recombination landscape. The functional characterization of genomic differences important in primate speciation and adaptation remains a significant challenge. Limited access to biological materials, the lack of detailed phenotypic data and the endangered status of many critical primate species have significantly attenuated research into the genetic basis of primate evolution. Next-generation sequencing technologies promise to greatly expand the number of available primate genome sequences; however, such draft genome sequences will likely miss critical genetic differences within complex genomic regions unless dedicated efforts are put forward to understand the full spectrum of genetic variation.
dc.description.sponsorship This work was supported by a Marie Curie fellowship
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Annual Reviews Inc
dc.rights Posted with permission from the Annual Review of genomics and human genetics, Volume 10 © by Annual Reviews, http://www.annualreviews.org
dc.subject.other Genomes
dc.subject.other Primats -- Genètica
dc.title Sequencing primate genomes: what have we learned?
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1146/annurev.genom.9.081307.164420
dc.subject.keyword genome
dc.subject.keyword sequencing
dc.subject.keyword variation
dc.subject.keyword gene comparison
dc.subject.keyword speciation
dc.subject.keyword diversity
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/220278
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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