Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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  • Rodríguez-Fernández, Blanca; Sánchez Benavides, Gonzalo; Genius, Patricia; Minguillón, Carolina; Fauria, Karine; De Vivo, Immaculata; Navarro i Cuartiellas, Arcadi, 1969-; Molinuevo, José Luis; Gispert López, Juan Domingo; Sala Vila, Aleix; Vilor Tejedor, Natàlia, 1988-; Crous-Bou, Marta; ALFA Study (Elsevier, 2024)
    Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association ...
  • Pardo Palacios, Francisco J.; Carbonell Sala, Silvia; Lagarde, Julien; Guigó Serra, Roderic; Brooks, Angela N. (Nature Research, 2024)
    The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platforms, the ...
  • Grau Bové, Xavier; Subirana, Lucie; Meister, Lydvina; Soubigou, Anaël; Neto, Ana; Elek, Anamaria; Naranjo, Silvia; Fornas Carreño, Oscar; Gómez Skarmeta, José Luis; Tena, Juan J.; Irimia Martínez, Manuel; Bertrand, Stéphanie; Sebé-Pedrós, Arnau; Escriva, Hector (Nature Research, 2024)
    The emergence of new structures can often be linked to the evolution of novel cell types that follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are characterized by a complex body plan compared ...
  • Schrade, Lisa; Mah, Nancy; Bandrowski, Anita; Chen, Ying; Dewender, Johannes; Diecke, Sebastian; Hiepen, Christian; Lancaster, Madeline A.; Marquès i Bonet, Tomàs, 1975-; Martínez, Sira; Mueller, Sabine C.; Navara, Christopher; Prigione, Alessandro; Seltmann, Stefanie; Sochacki, Jaroslaw; Sutcliffe, Magdalena A.; Zywitza, Vera; Hildebrandt, Thomas B.; Kurtz, Andreas (MDPI, 2024)
    The documentation, preservation and rescue of biological diversity increasingly uses living biological samples. Persistent associations between species, biosamples, such as tissues and cell lines, and the accompanying data ...
  • Molnar, Cristina; Heinen, Jan Peter; Reina, José; Llamazares, Salud; Palumbo, Emilio; Pollarolo, Giulia; González, Cayetano (EMBO Press, 2024)
    Expression of the Drosophila cancer-germline (CG), X-linked, head-to-head gene pair TrxT and dhd is normally germline-specific but becomes upregulated in brain tumours caused by mutation in l(3)mbt. Here, we show that TrxT ...
  • Abad Cortel, Etna; Sandoz, Jérémy; Romero, Gerard; Zadra, Ivan; Urgel i Solas, Júlia; Borredat, Pablo; Kourtis, Savvas; Ortet Cortada, Laura; Martínez, Carlos; Weghorn, Donate; Sdelci, Sara; Janic, Ana (BioMed Central, 2024)
    Background: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, ...
  • Villanueva Cañas, José Luis, 1984-; Fernández Fuentes, Narcís; Saul, Dominik; Kosinsky, Robyn Laura; Teyssier, Catherine; Rogalska, Malgorzata; Pegenaute Pérez, Ferran; Oliva Miguel, Baldomero; Notredame, Cedric; Beato, Miguel; Sharma, Priyanka (Elsevier, 2024)
    Peptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that ...
  • Aya, Francisco; Lanuza Gracia, Pablo; González-Pérez, Abel; Bonnal, Sophie; Mancini, Estefanía; López Bigas, Núria; Arance, Ana; Valcárcel, J. (Juan) (Elsevier, 2024)
    Resistance to MAPK inhibitors (MAPKi), the main cause of relapse in BRAF-mutant melanoma, is associated with the production of alternative BRAF mRNA isoforms (altBRAFs) in up to 30% of patients receiving BRAF inhibitor ...
  • Olalde Marquínez, Íñigo, 1987-; Capote, Juan; Del-Arco, María C.; Atoche, Pablo; Delgado, Teresa; González-Anton, Rafael; Pais, Jorge; Amills, Marcel; Lalueza Fox, Carles, 1965-; Ramírez, Oscar (BioMed Central, 2015)
    Background. Canarian Black (CB) pigs belong to an autochthonous and endangered breed, which is spread throughout the Canarian archipelago. It is commonly accepted that they represent a relic of the pig populations that ...
  • Nogueira, Cristina; Erlmann, Patrik; Villeneuve, Julien; Santos, António J. M.; Martínez-Alonso, Emma; Martínez-Menárguez, José Ángel; Malhotra, Vivek (eLife, 2014)
    TANGO1 binds and exports Procollagen VII from the endoplasmic reticulum (ER). In this study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is required for membrane fusion. Knockdown ...
  • Mantica, Federica; Iñiguez, Luis P.; Marquez, Yamile; Permanyer, Jon; Torres Méndez, Antonio; Cruz, Josefa; Franch-Marro, Xavier; Burguera, Demián; Martin, David; Irimia Martínez, Manuel (Nature Research, 2024)
    Regulation of gene expression is arguably the main mechanism underlying the phenotypic diversity of tissues within and between species. Here we assembled an extensive transcriptomic dataset covering 8 tissues across 20 ...
  • Ciampi, Ludovica; Serrano Pubull, Luis, 1982-; Irimia Martínez, Manuel (Wiley, 2024)
    Alternative Splicing (AS) programs serve as instructive signals of cell type specificity, particularly within the brain, which comprises dozens of molecularly and functionally distinct cell types. Among them, retinal ...
  • Sarkar, Soumyadeep; Ramos-Rodríguez, Mireia; Juan-Mateu, Jonàs; Pasquali, Lorenzo; Nakayasu, Ernesto S. (BioMed Central, 2024)
    Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream ...
  • Theissinger, Kathrin; European Reference Genome Atlas Consortium (Elsevier, 2023)
    The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main ...
  • Moon, Katherine L.; Huson, Heather J.; Morrill, Kathleen; Wang, Ming-Shan; Li, Xue; Srikanth, Krishnamoorthy; Zoonomia Consortium; Lindblad-Toh, Kerstin; Svenson, Gavin J.; Karlsson, Elinor K.; Shapiro, Beth (American Association for the Advancement of Science (AAAS), 2023)
    We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 ...
  • Christmas, Matthew J.; Valenzuela, Alejandro; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Karlsson, Elinor K. (American Association for the Advancement of Science (AAAS), 2023)
    Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least ...
  • Naranjo-Ortíz, Miguel A.; Brock, Matthias; Brunke, Sascha; Hube, Bernhard; Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers, 2016)
    Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions ...
  • Nachshon, Aharon; Abu-Toamih Atamni, Hanifa Jalal; Steuerman, Yael; Sheikh-Hamed, Roa'a; Dorman, Alexandra; Mott, Richard; Dohm, Juliana C.; Lehrach, Hans; Sultan, Marc; Shamir, Ron; Sauer, Sascha; Himmelbauer, Heinz; Iraqi, Fuad A.; Gat-Viks, Irit (Frontiers, 2016)
    A central challenge in pharmaceutical research is to investigate genetic variation in response to drugs. The Collaborative Cross (CC) mouse reference population is a promising model for pharmacogenomic studies because of ...
  • Murakami, Tetsuro; Gaetano Tartaglia, Gian; George-Hyslop, Peter St (Cell Press, 2015)
    The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC) domains of FUS drive its physiologically reversible assembly ...
  • Meijer, Harold J. G.; Mancuso, Francesco M.; Espadas, Guadalupe; Seidl, Michael F.; Chiva, Cristina; Govers, Francine; Sabidó Aguadé, Eduard, 1981- (American Society for Biochemistry and Molecular Biology (ASBMB), 2014)
    Oomycetes are filamentous organisms that cause notorious diseases, several of which have a high economic impact. Well known is Phytophthora infestans, the causal agent of potato late blight. Previously, in silico analyses ...

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